CN106248651A - Raman spectrum enhancement device and method based on piezoelectric ceramic adjusting resonant cavity - Google Patents
Raman spectrum enhancement device and method based on piezoelectric ceramic adjusting resonant cavity Download PDFInfo
- Publication number
- CN106248651A CN106248651A CN201610902385.XA CN201610902385A CN106248651A CN 106248651 A CN106248651 A CN 106248651A CN 201610902385 A CN201610902385 A CN 201610902385A CN 106248651 A CN106248651 A CN 106248651A
- Authority
- CN
- China
- Prior art keywords
- raman spectrum
- raman
- piezoelectric ceramics
- laser
- resonator cavity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000001237 Raman spectrum Methods 0.000 title claims abstract description 35
- 239000000919 ceramic Substances 0.000 title claims abstract description 31
- 238000000034 method Methods 0.000 title claims abstract description 15
- 230000003287 optical effect Effects 0.000 claims abstract description 30
- 238000001069 Raman spectroscopy Methods 0.000 claims description 31
- 238000004458 analytical method Methods 0.000 claims description 15
- 238000012360 testing method Methods 0.000 claims description 6
- 238000009825 accumulation Methods 0.000 claims description 4
- 238000012216 screening Methods 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 3
- 230000008676 import Effects 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 15
- 238000001514 detection method Methods 0.000 abstract description 11
- 230000008901 benefit Effects 0.000 abstract description 6
- 238000005516 engineering process Methods 0.000 abstract description 4
- 238000001228 spectrum Methods 0.000 abstract description 4
- 230000035945 sensitivity Effects 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 2
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 description 6
- 230000002708 enhancing effect Effects 0.000 description 3
- 230000009931 harmful effect Effects 0.000 description 2
- 238000004451 qualitative analysis Methods 0.000 description 2
- 238000004445 quantitative analysis Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 1
- 238000001344 confocal Raman microscopy Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 238000002789 length control Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000004038 photonic crystal Substances 0.000 description 1
- 229910052573 porcelain Inorganic materials 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000004416 surface enhanced Raman spectroscopy Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
Landscapes
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Spectrometry And Color Measurement (AREA)
Abstract
The invention relates to a Raman spectrum enhancement device and a Raman spectrum enhancement method based on a piezoelectric ceramic adjusting resonant cavity, wherein the Raman spectrum enhancement device structurally comprises a laser diode, a calibration focusing device, an optical resonant cavity based on piezoelectric ceramic, a power meter, a light gathering device and a spectrum analyzer; the laser diode is connected with the calibration focusing device, the calibration focusing device is connected with the piezoelectric ceramic-based optical resonant cavity, the optical resonant cavity is connected with the power meter and the light condensing device, and the light condensing device is connected with the spectrum analyzer. The advantages are that: 1) the piezoelectric ceramic has small volume, high resolution, quick response, large thrust, no heating and no noise, can ensure that the output frequency of a light source is uniform and stable, and can also ensure that the energy of a laser beam is increased, thereby increasing the optical power; 2) the device has high enhancement effect, and can reach 10 in the detection of single-molecule substances4The effect is doubled; 3) the method greatly improves the sensitivity and provides possibility for applying the low-cost Raman spectrum technology to multi-component online gas detection.
Description
Technical field
The present invention relates to a kind of Raman spectrum intensifier based on piezoelectric ceramics regulation resonator cavity and Enhancement Method,
Belong to field of photoelectric technology.
Background technology
Raman scattering effect can reflect the vibration information of molecule, is being found and after the development of decades,
Have been widely used for molecular structure research, and achieve and qualitatively and quantitatively analyze material.With infrared spectrum and traditional analysis
Instrument is compared, no matter Raman spectrometer has the advantage of its uniqueness in analysis time, reliability, or the definition of spectrogram,
Therefore, Raman spectrum analysis method becomes one of gas or the preferable detection method of liquid.
But owing to raman scattering cross section area is only, so traditional Raman effect is one
Plant weak effect.For fluid sample, the Raman spectrum analysis method scope of application is still rather narrow, in detection enriched sample
Time just have acceptable application effect.In actual applications, when testing sample concentration is the lowest, obtain effective Raman light intensity
Being difficult to, in addition impurity and the contingent fluorescence phenomenon of non-testing sample, Raman spectrum analysis method ample scope for abilities subtracts the most significantly
Few.
Raman spectrum analysis method to want to be a kind of wide variety of detection technique, is necessary for strengthening Raman effect.For this
People have carried out substantial amounts of research, therefore develop various special Raman spectroscopy, obtain the Raman letter that intensity is bigger
Number.Such as: the enhancing of resonant check Raman spectrum, Confocal Raman microspectroscopy, surface enhanced raman spectroscopy, photonic crystal fiber is drawn
Graceful effects etc., all also exist limitation due to them, can only have respective advantage in different fields, it is impossible to become general
Method uses in industry spot.
Based on above-mentioned analysis, resolve this problem of Raman weak effect for Raman spectrum being detected the detection becoming general
Analysis means to replace various various analytical tool completely significant, and also will bring significant economic benefit.The present invention
Applying on the basis of existing laser instrument, improving chamber method for mode matching, and search out a kind of new chamber length and wavelength
Formula formula.Utilizing the inverse piezoelectric effect of piezoelectric ceramics, the deformation quantity produced under electric field action is the least, can reach nano level
Advantage, fine adjustment chamber is long.Thus reach the purpose that optical wavelength is mated with cavity length, make intracavity produce standing wave, laser merit
Rate strengthens because of interference, finally makes the Raman diffused light produced been significantly enhanced.
Summary of the invention
What the present invention proposed is a kind of Raman spectrum intensifier based on piezoelectric ceramics regulation resonator cavity and Enhancement Method,
It is intended to strengthen the signal of Raman spectrum, improves the spirit of Raman spectrum analysis instrument when to material qualitative and quantitative analysis and gas detecting
Sensitivity so that it is applied more accurately during Raman detection.
The technical solution of the present invention: a kind of Raman spectrum intensifier based on piezoelectric ceramics regulation resonator cavity, its
Structure is by laser diode, calibration focusing arrangement, optical resonator based on piezoelectric ceramics, energy meter, beam condensing unit and spectrum
Analyser forms；Wherein laser diode connects calibration focusing arrangement, and calibration focusing arrangement connects optical resonator, optical resonance
Chamber connects energy meter and beam condensing unit, and beam condensing unit connects spectroanalysis instrument.
The Enhancement Method of Raman spectrum intensifier based on piezoelectric ceramics regulation resonator cavity, the method includes walking as follows
Rapid:
1) laser diode is sent laser by calibration focusing arrangement collimate；
2) laser after calibration is introduced optical resonance intracavity, allow its at intracavity repeatedly roundtrip, by controlling piezoelectric ceramics
The piezoelectric voltage of device realizes the microvariations of cavity length, owing to the longitudinal mode of laser mates with the pattern generation of variable chamber, swashs
The constantly accumulation of light energy makes the laser beam energy of intracavity be gradually increased, and makes the power in resonator cavity constantly be strengthened；
3) obtain required Raman light by beam condensing unit screening further to light source frequency, then carry out the collection of Raman signal,
Raman spectrum analysis instrument is used to obtain the Raman spectrogram of enhanced sample.
Advantages of the present invention:
1) volume of piezoelectric ceramics is little, resolution is high, response is fast, thrust greatly, do not generate heat, do not produce noise, by controlling piezoelectricity
The piezoelectric voltage of pottery changes the distance of eyeglass in resonator cavity, and the output frequency being possible not only to make light source is uniform and stable, also may be used
So that laser beam energy increases, so that luminous power increases；
2) reinforced effects of this device is improved significantly, and uses high-precision resonator cavity to make Raman signal strengthen several quantity
Level, especially can reach 10 when detecting monomolecular substance4Effect about times；
3) sensitivity of the method is greatly improved, and can be not only used for macromolecular complex quality detection, it may also be used for trace level thing
Quality detection, more low cost Raman spectroscopy are applied in the online gas detecting of multicomponent provide possible.
Accompanying drawing explanation
Accompanying drawing 1 is Raman spectrum intensifier principle schematic based on piezoelectric ceramics regulation resonator cavity.
Accompanying drawing 2 is optical resonator structures schematic diagram.
Detailed description of the invention
As it is shown in figure 1, Raman spectrum intensifier based on piezoelectric ceramics regulation resonator cavity, its structure is by laser two pole
Pipe, calibration focusing arrangement, optical resonator based on piezoelectric ceramics, energy meter, beam condensing unit and spectroanalysis instrument composition；Wherein
Laser diode connect calibration focusing arrangement, calibration focusing arrangement connect optical resonator, optical resonator connect energy meter with
Beam condensing unit, beam condensing unit connects spectroanalysis instrument.
The temperature controller of described laser diode and a band temperature control is connected.
Faraday isolator (FIA) it is provided with in described calibration focusing arrangement.
As in figure 2 it is shown, optical resonator structures is packed by glass capsulation, optical resonator be provided with an import and one go out
Mouthful, it being provided with a pair reflecting mirror staggered relatively inside optical resonator, one of them reflecting mirror is provided with piezoelectric ceramics.
Described beam condensing unit includes a dichroic mirror and a collecting lens.
The Enhancement Method of Raman spectrum intensifier based on piezoelectric ceramics regulation resonator cavity, the method includes walking as follows
Rapid:
1) laser diode is sent laser by calibration focusing arrangement collimate；
2) by testing sample injection optics resonator cavity, the laser after calibration is introduced optical resonance intracavity, makes them many at intracavity
Secondary roundtrip, under the effect that cavity length controls, owing to the longitudinal mode of laser mates with the pattern generation of variable chamber, laser
The constantly accumulation of energy makes the laser beam energy of intracavity be gradually increased, and makes the power in resonator cavity constantly be strengthened；
3) obtain required Raman light by beam condensing unit screening further to light source frequency, then carry out the collection of Raman signal,
Raman spectrum analysis instrument is used to obtain the Raman spectrogram of enhanced sample.
During work, wavelength is that the light source of 532nm is collimated by gradient refractive index mirror, uses anamorphic prism to making light beam enter
Row circulation, then the reverse transfers light pair produced in light path is prevented due to a variety of causes by a faraday isolator (FIA)
The harmful effect that light source and light path system produce；After laser is introduced in resonator cavity, it is constrained on intracavity, owing to diffraction is imitated
The existence answered, mirror size cannot accomplish infinity in addition, and light beam is reflected every time, and the most only part light turns again to chamber
In, small part light can penetrate resonator cavity due to small absorbance；Allow in its laser cavity repeatedly roundtrip, made pottery by piezoelectricity
The inverse piezoelectric effect of porcelain, fine adjustment cavity length, reach the purpose that optical wavelength is mated with cavity length；Due to laser
Longitudinal mode produces with the pattern of variable chamber and mates, and the constantly accumulation of laser energy makes the laser beam energy of intracavity be gradually increased, from
And the power in resonator cavity is constantly strengthened；Required Raman light is obtained by dichroic mirror screening further to light source frequency, then
Carry out the collection of Raman signal, use Raman spectrum analysis instrument to obtain the Raman spectrogram of enhanced sample.
Embodiment
Choose laser diode that wavelength is 532nm as laser instrument, test for Raman detection below and make light source, then select
With gradient-index lens (L) as collimating lens, the light source dissipated is collimated, with anamorphic prism, light beam is gathered by (AP)
Collection, can effectively prevent the reverse transfers light pair produced in light path due to a variety of causes through a faraday isolator (FIA)
The harmful effect that light source and light path system produce, reduces reflection light stable to the spectral output power of light source to a great extent
Property produce impact.Enter in the Fabry-Perot optical resonator (SM) (PSM) being made up of the prism of high index of refraction, humorous
The intracavity that shakes is filled with material to be detected, and cavity, by the glass-coated sealed, is provided with an import and an outlet.Under resonator cavity
Side is sequentially placed a dichroic mirror and a collecting lens, and the Raman light of specific wavelength can be separated by dichroic mirror, in order to divides below
Analysis；The Raman light of specific wavelength is put together by collecting lens, delivers to Raman spectrum analysis instrument, does last detection, divides at spectrum
In analyzer, the Raman spectrum of Test Materials just be can be observed.It addition, be connected to energy meter outside resonator cavity to be convenient for measuring resonator cavity
Interior power.
The present invention uses the prism of high refraction to (SM) (PSM), and one of them prism is mounted with piezoelectric ceramics device,
By the inverse piezoelectric effect of piezoelectric ceramics, fine adjustment cavity length, reach the purpose that optical wavelength is mated with cavity length.
Mate owing to the pattern of longitudinal mode and the variable chamber of laser produces, laser energy constantly accumulate the laser beam energy making intracavity by
Cumulative greatly, thus the power in resonator cavity is constantly strengthened.
For the enhancing of specific light power, after the light source that laser diode sends enters Fabry-Perot optical resonator,
Allow it at intracavity repeatedly roundtrip, by regulation Resonant Intake System, make the laser beam energy of intracavity be gradually increased, thus improve and draw
Graceful light intensity.
Above describe present invention Raman spectrum intensifier based on piezoelectric ceramics regulation resonator cavity and Enhancement Method, real
Showed the enhancing of Raman signal when to material qualitative and quantitative analysis and gas detecting, by laser diode launch specific
Wavelength, and use Fabry-Perot optical resonator to make light source carry out multiple total reflection, reach to strengthen the purpose of luminous power,
Illustrating this optical resonator and strengthen the feasibility of Raman effect, being applied to gas detecting for low cost Raman technology provides
A solution.
Embodiment described above, only as an illustrative example of the present invention, not can only apply the present invention to
Above-mentioned reality.In the case of without departing from the spirit or essential characteristics of the present invention, the present invention can with other structures, form and its
His assembly, material and step realize.
Claims (6)
1. Raman spectrum intensifier based on piezoelectric ceramics regulation resonator cavity, it is characterised in that: structure is by laser diode, school
Quasi-focusing arrangement, optical resonator based on piezoelectric ceramics, energy meter, beam condensing unit and spectroanalysis instrument composition；Wherein laser
Diode connects calibration focusing arrangement, and calibration focusing arrangement connects optical resonator, and optical resonator connects energy meter and optically focused
Device, beam condensing unit connects spectroanalysis instrument.
Raman spectrum intensifier based on piezoelectric ceramics regulation resonator cavity the most according to claim 1, it is characterised in that:
The temperature controller of described laser diode and a band temperature control is connected.
Raman spectrum intensifier based on piezoelectric ceramics regulation resonator cavity the most according to claim 1, it is characterised in that:
Faraday isolator (FIA) it is provided with in described calibration focusing arrangement.
Raman spectrum intensifier based on piezoelectric ceramics regulation resonator cavity the most according to claim 1, it is characterised in that:
Described optical resonator is packed by glass capsulation, and optical resonator is provided with an import and an outlet, optical resonance
Intracavity portion is provided with a pair reflecting mirror staggered relatively, and one of them reflecting mirror is provided with piezoelectric ceramics.
Raman spectrum intensifier based on piezoelectric ceramics regulation resonator cavity the most according to claim 1, it is characterised in that:
Described beam condensing unit includes a dichroic mirror and a collecting lens.
6. use the Raman spectrum of Raman spectrum intensifier based on piezoelectric ceramics regulation resonator cavity as claimed in claim 1
Enhancement Method, it is characterised in that the method comprises the steps:
1) laser diode is sent laser by calibration focusing arrangement collimate；
2) by testing sample injection optics resonator cavity, the laser after calibration is introduced optical resonance intracavity, makes them many at intracavity
Secondary roundtrip, realizes the microvariations of cavity length by controlling the piezoelectric voltage of piezoelectric ceramics device, due to indulging of laser
Mould produces with the pattern of variable chamber and mates, and the constantly accumulation of laser energy makes the laser beam energy of intracavity be gradually increased, and makes humorous
The power of intracavity of shaking constantly is strengthened；
3) obtain required Raman light by beam condensing unit screening further to light source frequency, then carry out the collection of Raman signal,
Raman spectrum analysis instrument is used to obtain the Raman spectrogram of enhanced sample.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610902385.XA CN106248651A (en) | 2016-10-17 | 2016-10-17 | Raman spectrum enhancement device and method based on piezoelectric ceramic adjusting resonant cavity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610902385.XA CN106248651A (en) | 2016-10-17 | 2016-10-17 | Raman spectrum enhancement device and method based on piezoelectric ceramic adjusting resonant cavity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106248651A true CN106248651A (en) | 2016-12-21 |
Family
ID=57612639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610902385.XA Pending CN106248651A (en) | 2016-10-17 | 2016-10-17 | Raman spectrum enhancement device and method based on piezoelectric ceramic adjusting resonant cavity |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106248651A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108627477A (en) * | 2017-03-15 | 2018-10-09 | 中国计量科学研究院 | A kind of optical cavity structure |
| CN110412007A (en) * | 2019-07-19 | 2019-11-05 | 山东师范大学 | A kind of Raman spectrum base, preparation method and application |
| CN111413317A (en) * | 2020-04-29 | 2020-07-14 | 中国科学院长春光学精密机械与物理研究所 | Stimulated Raman gas sensing system based on annular optical fiber resonant cavity |
| WO2020169808A1 (en) | 2019-02-21 | 2020-08-27 | Laser-Laboratorium Göttingen e.V. | Method and apparatus for identifying volatile substances using resonator-amplified raman spectroscopy under reduced pressure |
| CN112751255A (en) * | 2020-12-14 | 2021-05-04 | 南京工业大学 | Raman laser enhancing device and method based on high nonlinear photonic crystal fiber |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1685217A (en) * | 2002-09-30 | 2005-10-19 | 英特尔公司 | Spectroscopic analysis system and method |
| CN101771238A (en) * | 2009-01-04 | 2010-07-07 | 福建福晶科技股份有限公司 | 765nm-780nm pulse laser for Raman spectrum analysis |
| CN104568897A (en) * | 2013-10-29 | 2015-04-29 | 苏州拉曼检测技术有限公司 | Raman spectrum enhancement device, raman spectrum enhancement system and raman spectrum enhancement method based on external resonant cavity technology |
| CN104777146A (en) * | 2015-03-30 | 2015-07-15 | 中国电子科技集团公司第三十八研究所 | All-optical-fiber raman spectrometer |
| CN105181674A (en) * | 2015-10-21 | 2015-12-23 | 南京工业大学 | Raman spectrum enhancement system and method based on photonic crystal fiber resonant cavity |
| CN105987895A (en) * | 2015-03-05 | 2016-10-05 | 陈利平 | Laser-raman spectrum gas analyzer |
-
2016
- 2016-10-17 CN CN201610902385.XA patent/CN106248651A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1685217A (en) * | 2002-09-30 | 2005-10-19 | 英特尔公司 | Spectroscopic analysis system and method |
| CN101771238A (en) * | 2009-01-04 | 2010-07-07 | 福建福晶科技股份有限公司 | 765nm-780nm pulse laser for Raman spectrum analysis |
| CN104568897A (en) * | 2013-10-29 | 2015-04-29 | 苏州拉曼检测技术有限公司 | Raman spectrum enhancement device, raman spectrum enhancement system and raman spectrum enhancement method based on external resonant cavity technology |
| CN105987895A (en) * | 2015-03-05 | 2016-10-05 | 陈利平 | Laser-raman spectrum gas analyzer |
| CN104777146A (en) * | 2015-03-30 | 2015-07-15 | 中国电子科技集团公司第三十八研究所 | All-optical-fiber raman spectrometer |
| CN105181674A (en) * | 2015-10-21 | 2015-12-23 | 南京工业大学 | Raman spectrum enhancement system and method based on photonic crystal fiber resonant cavity |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108627477A (en) * | 2017-03-15 | 2018-10-09 | 中国计量科学研究院 | A kind of optical cavity structure |
| WO2020169808A1 (en) | 2019-02-21 | 2020-08-27 | Laser-Laboratorium Göttingen e.V. | Method and apparatus for identifying volatile substances using resonator-amplified raman spectroscopy under reduced pressure |
| CN110412007A (en) * | 2019-07-19 | 2019-11-05 | 山东师范大学 | A kind of Raman spectrum base, preparation method and application |
| CN111413317A (en) * | 2020-04-29 | 2020-07-14 | 中国科学院长春光学精密机械与物理研究所 | Stimulated Raman gas sensing system based on annular optical fiber resonant cavity |
| CN111413317B (en) * | 2020-04-29 | 2021-09-21 | 中国科学院长春光学精密机械与物理研究所 | Stimulated Raman gas sensing system based on annular optical fiber resonant cavity |
| CN112751255A (en) * | 2020-12-14 | 2021-05-04 | 南京工业大学 | Raman laser enhancing device and method based on high nonlinear photonic crystal fiber |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106248651A (en) | Raman spectrum enhancement device and method based on piezoelectric ceramic adjusting resonant cavity | |
| US12092521B2 (en) | Method for quantifying solutions comprised of multiple analytes | |
| Hübner et al. | Integrated optical measurement system for fluorescence spectroscopy in microfluidic channels | |
| US8536542B2 (en) | Flow cytometry analysis across optical fiber | |
| CN104568897B (en) | Raman spectrum intensifier, system and method based on chamber exterior resonant cavity technology | |
| CN104280338A (en) | Raman enhanced measurement device and method and off-axis integral cavity structure applied to Raman enhanced measurement | |
| Kiselev et al. | Design and first applications of a flexible Raman micro-spectroscopic system for biological imaging | |
| Hamadani et al. | Nonequilibrium single molecule protein folding in a coaxial mixer | |
| WO2015151812A1 (en) | Fluorometric analyzer | |
| CN106568754A (en) | Optical system used for measuring liquid sample multiphoton fluorescence spectrum | |
| US9557293B2 (en) | High-throughput multi-laser wave mixing detection methods and apparatus | |
| US20180231459A1 (en) | Lab-on-chip near-infrared spectrometer for label-free molecular analysis of a sample | |
| Guenard et al. | Two-channel sequential single-molecule measurement | |
| Waechter et al. | 405 nm absorption detection in nanoliter volumes | |
| CN105445242B (en) | Special optical fiber biochemical sensor based on evanescent wave technology | |
| Dada | Laser-induced fluorescence detector with a fiber-coupled micro GRIN lens for capillary electrophoresis | |
| CN114112925B (en) | Liquid trace detection device and method | |
| Cui et al. | Spatial heterodyne offset Raman spectroscopy enabling rapid, high sensitivity characterization of materials’ interfaces | |
| Kawagishi et al. | Direct label-free measurement of the distribution of small molecular weight compound inside thick biological tissue using coherent Raman microspectroscopy | |
| CN203658266U (en) | Raman spectrum enhancement device and Raman spectrum enhancement system based on extra-resonant cavity technology | |
| CN211206261U (en) | Raman test auxiliary coupling adjustment real-time imaging system based on micro-structure optical fiber | |
| CN208155454U (en) | Femtosecond time resolution pumping and the two-in-one spectrometer system of broadband time-resolved CARS | |
| CN106525810B (en) | Raman spectrum liquid detecting method based on laser freuqency doubling and hollow-core fiber | |
| Dunsby et al. | Biophotonics applications of supercontinuum generation | |
| CN110231245A (en) | It is a kind of for obtaining the high-throughput detection system of trace quality and molecular structure information |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161221 |