CN1062447C - "Zhenmi" eye drops - Google Patents
"Zhenmi" eye drops Download PDFInfo
- Publication number
- CN1062447C CN1062447C CN95105295A CN95105295A CN1062447C CN 1062447 C CN1062447 C CN 1062447C CN 95105295 A CN95105295 A CN 95105295A CN 95105295 A CN95105295 A CN 95105295A CN 1062447 C CN1062447 C CN 1062447C
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- China
- Prior art keywords
- corneal
- distilled water
- mel
- eyedrop
- raw material
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to an eyedrop prepared from distilled water and the main raw materials of 0.1 to 10% of water soluble pearl powder and 2 to 20% of honey. The eyedrop is suitable for treating the eye diseases of xerophthalmia, corneal xerosis, corneal epithelium denudation and erosion, corneal canker, cornea burn, electric ophthalmia malnutritional ophthalmia, etc. The eyedrop has the characteristics of convenient use, conspicuous curative effect, high effective rate of more than 95%, high effectual rate of 80%, easy storage, lower cost than that of like medicines, etc.
Description
The present invention relates to treat the outer medicinal liquid of ophthalmic, be specially the eye drop that mainly contains Margarita powder, Mel.
To the treatment xerophthalmia, corneal epithelium strips off and rotten to the corn, cornea chemical burn and thermal burn, corneal ulcer and some nutritional labeling lack the ophthalmics such as keratopathy that cause, usually use fiber link albumen (FN) Drug therapy, this is a kind of glycoprotein that extracts from blood plasma, during clinical practice, can only now prepare the medicinal liquid for preparing, only can preserve 10 days at 4 ℃, very easy inefficacy, necessary fresh preparation brings very big inconvenience to the patient; " the Solcosery Eye Gel eye lamb " of Shi Yonging in recent years, it is the lamb shape medicine of a kind of extract preparation from Ox blood serum, and is convenient not as aqueous solution during use, and costs an arm and a leg, and is difficult to be accepted by general patient.Therefore, still there is not a kind of comparatively ideal medicine at present.
The object of the invention, provide a kind of easy to use, low price, be applicable to treatment eye and bitot's patches disease, corneal epithelium strips off and ophthalmics such as erosion, corneal ulcer, cornea essential layer damaged (excision), corneal dystrophy, cornea burn be the eye drop that the preparation of raw material of main component forms with the natural Chinese medicines.
Eye drop of the present invention, selecting traditional natural drug Margarita powder with obvious medical treatment and health-care effect and Mel for use is that primary raw material is formulated with distilled water, used Margarita powder is a kind of water soluble Margarita ultrafine powder, be that traditional Margarita powder is through hydrolyzed product, they are mixture of low peptide and aminoacid etc., very easily be absorbed by the body, its drug effect can be fully used.Eye drop of the present invention is a kind of water soluble Margarita ultrafine powder with 0.1-10% (weight), and 2-20% (weight) Mel is primary raw material, the eye drop that is made into distilled water.Its making step is at first with Mel sterilization, and elimination impurity is formed with other raw material, is made into medicinal liquid with distilled water, decontamination after filtration again, and sterilization, Eye drops ampoule is gone in packing then, promptly can be used for clinical.The raw material of eye drop is formed (weight):
Water soluble Margarita ultrafine powder 0.1-10%
Mel 2-20%
Vitamin B
20.01-0.1%
Vitamin A 5u-100u%
Tween 80 0.15%
Aqua methnae 1-10%
It is light yellow clear liquid that distilled water adds to 100 eye drops finished of preparation; Containing N is to answer 〉=26.0 μ g/ml; PH value should be 5.5～6.5.Described aqua methnae is the aqua methnae of conventional method preparation in the pharmacy.
Eye drop of the present invention, have exogenous additional corneal nutrition, promote corneal epithelium and essential layer pathological changes healing, cornea rebirth blood vessel disappears gradually or effects such as locking, promotion lacrimal secretion.Therefore be applicable to treatment eye and bitot's patches disease, corneal epithelium strips off and erosion, corneal ulcer, cornea essential layer damaged (excision), electric ophthalmia, explosive keratitis, corneal dystrophy, the cornea soda acid is burnt and ocular disease such as face crack adhesion; The medication of Mucosa of lip post-transplantation can promote healing.Observe through animal acute toxicity test, safe and reliable in the dosage range, have no side effect, clinical trial splashes in the face, and one time 1-2 drips, and 3-6 time on the one, the 3-30 days course of treatment, therapeutic effect is remarkable; Effective percentage reaches more than 95%, obvious effective rate 80%; Be enclosed in lucifuge, cool dark place storage life 1 year, easy to use, cheap, be easy in the general population, apply.
Embodiment 1
Mel is in 40 fens kinds of 100 ℃ of sterilizations, cool to about 50 ℃, and with sintered filter funnel decompress filter, elimination impurity, it is stand-by to obtain the pure Mel of clear; Get the vitamin A power of 10u and go into 1.5g Tween 80 and dissolved in distilled water; Take by weighing water soluble Margarita ultrafine powder (production of the greatly healthy pearl nutritive health-care product in Zhuhai factory) 50g, Mel (decontamination of having sterilized) 100g, vitamin B
220mg, aqua methnae (aqua methnae of preparing according to a conventional method in the hospital pharmacy) 10ml is in the 2000ml vial, distilled water is added to total amount 1000ml stir, then with the admixing medical solutions that is made into, reuse sintered filter funnel decompress filter, filtrate is divided in the infusion bottle of 500ml, sterilized 40 minutes for 100 ℃, the cooling back is sub-packed in the plastics Eye drops ampoule under purifying aseptic condition, carries out quality testing: the light yellow clear liquid of outward appearance, PH6.5, osmotic pressure 309; N content-26 μ g/ml.It is a small amount of that this product is got in discriminating (1), puts on filter paper, adds ninhydrin solution 1-2 and drip, and toasts a moment, displaing amaranth; (2) it is an amount of to get this product, drips the ammonium oxalate test solution and imitates and drip the emulsion that is white in color, static appearance precipitation; (3) get this product 1ml, drip 4 of alkaline cupric tartrate test solutions, heating is the red precipitate of Red copper oxide.
* pressing 63 page of first method of two appendix of 90 years versions of Chinese Pharmacopoeia measures
Embodiment 2-3
The compound method step and detect with embodiment 1, only write out a prescription as follows:
Example 2 examples 3
Water soluble Margarita ultrafine powder 20g 10g
Mel 50g 200g
Vitamin B
250mg 30mg
Vitamin A 50u 40u
Aqua methnae 20ml 50ml
Tween 80 1.5g 1.5g
Distilled water adds to 1000ml 1000ml
Claims (2)
1, a kind of external used medicine for the treatment of ophthalmic, it is characterized in that water soluble Margarita ultrafine powder with the 0.1-10% weight portion, the Mel of 2-20% weight portion is primary raw material, with the eye drop that distilled water is mixed with, its making step is with Mel sterilization, elimination impurity, with other raw material, be made into medicinal liquid with distilled water, refilter, sterilization.
2, the external used medicine of treatment ophthalmic as claimed in claim 1 is characterized in that the raw material weight of described eye drop consists of:
Water soluble Margarita ultrafine powder 0.1-10%
Mel 2-20%.
Vitamin B
20.01-0.1%
Vitamin A 5u-100u%
Tween 80 0.15%
Aqua methnae 1-10%
Distilled water adds to 100
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95105295A CN1062447C (en) | 1995-05-30 | 1995-05-30 | "Zhenmi" eye drops |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95105295A CN1062447C (en) | 1995-05-30 | 1995-05-30 | "Zhenmi" eye drops |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1136923A CN1136923A (en) | 1996-12-04 |
| CN1062447C true CN1062447C (en) | 2001-02-28 |
Family
ID=5075450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95105295A Expired - Fee Related CN1062447C (en) | 1995-05-30 | 1995-05-30 | "Zhenmi" eye drops |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1062447C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1090484C (en) * | 1998-03-09 | 2002-09-11 | 杜玉枝 | Eye drops for curing electric ophthalimia |
| CN109223856A (en) * | 2017-07-04 | 2019-01-18 | 重庆沐沐瞳视力保健有限公司 | A kind of eyedrops with supplement eye nutrient function |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1033154A (en) * | 1987-11-20 | 1989-05-31 | 李际云 | A kind of collyrium |
-
1995
- 1995-05-30 CN CN95105295A patent/CN1062447C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1033154A (en) * | 1987-11-20 | 1989-05-31 | 李际云 | A kind of collyrium |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1136923A (en) | 1996-12-04 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |