CN106237078A - 一种调理脾虚的中药组合物 - Google Patents

一种调理脾虚的中药组合物 Download PDF

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CN106237078A
CN106237078A CN201610746289.0A CN201610746289A CN106237078A CN 106237078 A CN106237078 A CN 106237078A CN 201610746289 A CN201610746289 A CN 201610746289A CN 106237078 A CN106237078 A CN 106237078A
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Abstract

本发明提供了一种调理脾虚的中药组合物,其特征在于,该中药组合物重量份数计为党参、黄芪、白术、茯苓、怀山药、芡实、莲子肉、黄精、炙甘草各5‑30份。该中药组合物原料药材来源广,制剂成本低,各组分协调配合,调理脾虚效果显著。

Description

一种调理脾虚的中药组合物
技术领域
本发明属于中药制剂领域,具体涉及一种调理脾虚的中药组合物。
背景技术
脾虚,指脾气虚弱的病理现象,是一种慢性疾病,。多因饮食失调.劳逸失度,或久病体虚所引起。包括脾气虚、脾阳虚、中气下陷、脾不统血等证型。多因饮食失调.劳逸失度,或久病体虚所引起。脾有运化食物中的营养物质和输布水液以及统摄血液等作用。脾虚则运化失常,并可出现营养障碍,水液失于布散而生湿酿痰,或发生失血等症。主要病情有呕吐、泄泻、水肿、出血、经闭、带下、四肢逆冷、小儿多涎等。
中医认为脾胃为后天之本,慢性疾病能否向愈与胃气之盛衰关系极大,对于慢性胃炎的治疗须不忘维护胃气,用药取其平和,不用大温大热、大苦大寒之品,遇脾胃虚寒者以益气健脾为主,使补气而不壅滞,不碍胃,并常佐理气通降之品,以宣畅气机。
发明内容
本发明旨在提供一种调理脾虚的中药组合物。
为实现上述发明目的,本发明一种调理脾虚的中药组合物,具体实施方案为:
本发明所述一种调理脾虚的中药组合物,其特征在于,该中药组合物包括党参、黄芪、白术、茯苓、怀山药、芡实、莲子肉、黄精、炙甘草。
进一步地,该中药组合物重量份数计为党参、黄芪、白术、茯苓、怀山药、芡实、莲子肉、黄精、炙甘草各5-30份。
进一步地,该中药组合物重量份数计为党参、黄芪、白术、茯苓、怀山药、芡实、莲子肉、黄精、炙甘草各10-20份。
进一步地,该中药组合物重量份数计为党参、黄芪、白术、茯苓、怀山药、芡实、莲子肉、黄精、炙甘草各18份。
本发明所述一种调理脾虚的中药组合物,所述中药制剂的制备方法包括以下步骤:
1)按中药组方分别称取各味药材,洗去杂质,干燥后分别粉碎,过60-80目筛,备用;
2)取党参、黄芪、白术、茯苓、怀山药、芡实、莲子肉、黄精、炙甘草粗粉,加入药材总量5-10倍量的水浸泡1-3小时,然后煎煮1-4次,每次1-2小时,过滤并保留滤渣,合并滤液,滤液真空减压浓缩至60℃条件下测相对密度为1.05-1.15的浓缩液,得水提浓缩液;
3)往步骤2)中的滤渣中加入药材总量5-10倍量体积分数为60-80%的乙醇,回流提取2-3次,过滤,合并滤液,滤液真空减压浓缩至60℃条件下测相对密度为1.05-1.15的浓缩液,得醇提浓缩液;
4)合并步骤2)和3)浓缩液,干燥,将浸膏粉碎,制剂。
本发明所述一种调理脾虚的中药组合物,该中药组合物可以制成颗粒剂、片剂、胶囊剂。
本发明所述一种调理脾虚的中药组合物,该中药制剂及各组成成分在调理脾虚中的应用。
本发明处方及配伍分析:
党参:党参:甘,平。归脾、肺经。补中益气,健脾益肺。用于脾肺虚弱,气短心悸,食少便溏,虚喘咳嗽,内热消渴。
芡实:味甘,涩,性平。归脾、肾经。具有益肾固精,补脾止泻,祛湿止带的功能。
莲子肉:甘、涩、平,。具有补脾、益肺、养心、益肾和固肠等作用。
黄精:甘,平。归脾、肺、肾经。黄精的功效主要是滋肾润肺,补脾益气。
炙甘草:甘,平。归心、肺、脾、胃经。功效:补脾益气、润肺止咳、缓急止痛、缓和药性、清热解毒。
黄芪:味甘,性微温,归肝、脾、肺、肾经。有益气固表、敛汗固脱、托疮生肌、利水消肿之功效。
白术: 味苦,甘,性温。归脾、胃经。健脾益气,燥湿利水,止汗,安胎。用于脾虚食少,腹胀泄泻,痰饮眩悸,水肿,自汗,胎动不安。
茯苓: 味甘、淡,性平。归心、肺、脾、肾经。利水渗湿,健脾,宁心。
怀山药: 性平,味甘;归肺、脾、肾经。 益肾气,健脾胃,止泻痢,化痰涎,润肤的功效。
本发明处方以党参、黄芪、黄精、芡实为君药,补中益气、固本培元,莲子肉、白术、茯苓、怀山药为臣药,健脾益气,补肾养心,利水渗湿,炙甘草调和诸药、缓和药性,诸药共奏补脾益气功效。
本发明优点:该中药组合物原料药材来源广,制剂成本低,各组分协调配合,具有疗效好、标本兼治、侧重调理的治疗优势; 调理脾虚效果显著。
具体实施方式
下面实施例只为进一步说明本发明,不以任何形式限制本发明范围。
实施例1
处方:党参、黄芪、白术、茯苓、怀山药、芡实、莲子肉、黄精、炙甘草各18份。
实施例2
处方:党参、黄芪、白术、茯苓、怀山药、芡实、莲子肉、黄精、炙甘草各15份。
实施例3
处方:党参、黄芪、白术、茯苓、怀山药、芡实、莲子肉、黄精、炙甘草各20份。
实施例4
处方:党参、黄芪、白术、茯苓、怀山药、芡实、莲子肉、黄精、炙甘草各25份。
实施例5
处方:党参、黄芪、白术、茯苓、怀山药、芡实、莲子肉、黄精、炙甘草各10份。
实施例6
处方:党参、黄芪、白术、茯苓、怀山药、芡实、莲子肉、黄精、炙甘草各30份。
实施例7
处方:党参、黄芪、白术、茯苓、怀山药、芡实、莲子肉、黄精、炙甘草各28份。
实施例1-7制备工艺为:
1)按中药组方分别称取各味药材,洗去杂质,干燥后分别粉碎,过60-80目筛,备用;
2)取党参、黄芪、白术、茯苓、怀山药、芡实、莲子肉、黄精、炙甘草粗粉,加入药材总量5-10倍量的水浸泡1-3小时,然后煎煮1-4次,每次1-2小时,过滤并保留滤渣,合并滤液,滤液真空减压浓缩至60℃条件下测相对密度为1.05-1.15的浓缩液,得水提浓缩液;
3)往步骤2)中的滤渣中加入药材总量5-10倍量体积分数为60-80%的乙醇,回流提取2-3次,过滤,合并滤液,滤液真空减压浓缩至60℃条件下测相对密度为1.05-1.15的浓缩液,得醇提浓缩液;
4)合并步骤2)和3)浓缩液,干燥,将浸膏粉碎,制剂。
实验例1:
1、一般资料 选取100例脾虚患者临床志愿者,年龄20-65岁,平均年龄为40岁;病程6个月-18年,平均病程为8年。症状:有呕吐、泄泻、水肿、出血、经闭、带下、四肢逆冷、小儿多涎等。
2、治疗方法 服用本发明实施例1制备的中药颗粒剂,每日3次,一次一袋,7天一个疗程,共2个疗程。 3、治疗结果 根据临床观察,经2个疗程治疗后,痊愈58人,明显好转29人,有效6人,无效7人,总有效率93%。

Claims (7)

1.一种调理脾虚的中药组合物,其特征在于,该中药组合物包括党参、黄芪、白术、茯苓、怀山药、芡实、莲子肉、黄精、炙甘草。
2.根据权利要求1所述一种调理脾虚的中药组合物,其特征在于,该中药组合物重量份数计为党参、黄芪、白术、茯苓、怀山药、芡实、莲子肉、黄精、炙甘草各5-30份。
3.根据权利要求1所述一种调理脾虚的中药组合物,其特征在于,该中药组合物重量份数计为党参、黄芪、白术、茯苓、怀山药、芡实、莲子肉、黄精、炙甘草各10-20份。
4.根据权利要求1所述一种调理脾虚的中药组合物,其特征在于,该中药组合物重量份数计为党参、黄芪、白术、茯苓、怀山药、芡实、莲子肉、黄精、炙甘草各18份。
5.根据权利要求1-4任一所述一种调理脾虚的中药组合物,其特征在于,所述中药制剂的制备方法包括以下步骤:
1)按中药组方分别称取各味药材,洗去杂质,干燥后分别粉碎,过60-80目筛,备用;
2)取党参、黄芪、白术、茯苓、怀山药、芡实、莲子肉、黄精、炙甘草粗粉,加入药材总量5-10倍量的水浸泡1-3小时,然后煎煮1-4次,每次1-2小时,过滤并保留滤渣,合并滤液,滤液真空减压浓缩至60℃条件下测相对密度为1.05-1.15的浓缩液,得水提浓缩液;
3)往步骤2)中的滤渣中加入药材总量5-10倍量体积分数为60-80%的乙醇,回流提取2-3次,过滤,合并滤液,滤液真空减压浓缩至60℃条件下测相对密度为1.05-1.15的浓缩液,得醇提浓缩液;
4)合并步骤2)和3)浓缩液,干燥,将浸膏粉碎,制剂。
6.根据权利要求5所述一种调理脾虚的中药组合物,其特征在于该中药组合物可以制成颗粒剂、片剂、胶囊剂。
7.根据权利要求6所述一种调理脾虚的中药组合物,其特征在于该中药制剂及各组成成分在调理脾虚中的应用。
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107212391A (zh) * 2017-06-19 2017-09-29 耿书海 一种调理糖尿病用粥伴侣食品及其制备方法
CN108450615A (zh) * 2018-04-20 2018-08-28 江西中医药大学 一种中药抗疲劳养神茶及制备方法
CN108669496A (zh) * 2018-05-23 2018-10-19 安徽省六尺春翠农业科技有限公司 一种黄精养胃保健品及其制备方法
CN108939031A (zh) * 2018-09-20 2018-12-07 江西景德中药股份有限公司 健脾养血的中药组合物及其制备方法和应用
CN109349562A (zh) * 2018-09-11 2019-02-19 贵州黔西南喀斯特区域发展研究院 一种黄精补气益脾粉及其制备方法
CN112587626A (zh) * 2021-01-11 2021-04-02 宫锦龙 一种调理五脏六腑的中药及其制备方法
CN112891481A (zh) * 2019-12-04 2021-06-04 易小佳 一种小儿健脾醒胃泡澡中药包

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
刘莹: "《黄帝内经养生一对一》", 30 November 2014, 上海科学普及出版社 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107212391A (zh) * 2017-06-19 2017-09-29 耿书海 一种调理糖尿病用粥伴侣食品及其制备方法
CN108450615A (zh) * 2018-04-20 2018-08-28 江西中医药大学 一种中药抗疲劳养神茶及制备方法
CN108669496A (zh) * 2018-05-23 2018-10-19 安徽省六尺春翠农业科技有限公司 一种黄精养胃保健品及其制备方法
CN109349562A (zh) * 2018-09-11 2019-02-19 贵州黔西南喀斯特区域发展研究院 一种黄精补气益脾粉及其制备方法
CN108939031A (zh) * 2018-09-20 2018-12-07 江西景德中药股份有限公司 健脾养血的中药组合物及其制备方法和应用
CN112891481A (zh) * 2019-12-04 2021-06-04 易小佳 一种小儿健脾醒胃泡澡中药包
CN112587626A (zh) * 2021-01-11 2021-04-02 宫锦龙 一种调理五脏六腑的中药及其制备方法

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