CN106236317A - A kind of trace injection instrument - Google Patents

A kind of trace injection instrument Download PDF

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Publication number
CN106236317A
CN106236317A CN201610740405.8A CN201610740405A CN106236317A CN 106236317 A CN106236317 A CN 106236317A CN 201610740405 A CN201610740405 A CN 201610740405A CN 106236317 A CN106236317 A CN 106236317A
Authority
CN
China
Prior art keywords
injection
slide unit
trace
syringe
module
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610740405.8A
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Chinese (zh)
Inventor
李骁健
赵君
刘冰
邓春山
张立
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen Institute of Advanced Technology of CAS
Original Assignee
Shenzhen Institute of Advanced Technology of CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenzhen Institute of Advanced Technology of CAS filed Critical Shenzhen Institute of Advanced Technology of CAS
Priority to CN201610740405.8A priority Critical patent/CN106236317A/en
Publication of CN106236317A publication Critical patent/CN106236317A/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals

Abstract

Embodiments provide a kind of trace injection instrument, wherein, described trace injection instrument includes: be relatively fixed propelling locating module and the injection module of connection, described propelling locating module is for the positioning instruction of receiving control apparatus, drive described injection module lock onto target injection position, described injection module, for the injection instruction of receiving control apparatus, carries out locating injection for described targeted injection position.Use the embodiment of the present invention, convenient and swift property and the accuracy of micro-injection can be improved.

Description

A kind of trace injection instrument
Technical field
The present invention relates to technical field of medical instruments, particularly relate to a kind of trace injection instrument.
Background technology
At present, the existing scheme that animal brain cortex carries out microinjection is manually to regulate stereotaxic instrument by employing, and The mode of manual precession Hamilton micro-syringe carries out microinjection operation in brain, but finds in actual practice, Yong Huren There is bigger error for manually regulation and searching injection position, automaticity is low, user operation is the easiest;It addition, Manual operation makes syringe needle produce larger vibration in progradation, can destroy cerebral tissue, and the flow velocity injecting dose is the most unstable, Individual injection is caused to differ greatly.It is thus desirable to the microinjection scheme of a kind of intelligence.
Summary of the invention
Embodiment of the present invention technical problem to be solved is, it is provided that a kind of trace injection instrument, can promote micro-injection Convenient and swift property and accuracy.
On the one hand, the embodiment of the present invention is open provides a kind of trace injection instrument, and described trace injection instrument includes: the most solid The fixed propelling locating module connected and injection module, described propelling locating module, for the positioning instruction of receiving control apparatus, drives Dynamic described injection module lock onto target injection position, described injection module is for the injection instruction of receiving control apparatus, for institute State targeted injection position and carry out locating injection.
The most alternatively, described propelling locating module includes: the first slide unit and the first motor, fixing of described first slide unit Hold be connected fixing with described first motor;
When receiving the positioning instruction of control equipment, described first motor drives described first slide unit and described note Penetrate module searches and lock the targeted injection position indicated by described positioning instruction.
The most alternatively, described injection module includes the second slide unit, the second motor and syringe, described second slide unit Fixing end is fixing with the sliding end of described first slide unit and described second motor respectively to be connected, the sliding end of described second slide unit and Described syringe is fixing to be connected;
When the injection receiving control equipment instructs, described second motor drives described injection by described second slide unit Device carries out locating injection for described targeted injection position.
The most alternatively, described trace injection instrument also includes: stuck-module, and described stuck-module includes fixing bar cramp, institute The sliding end of one end and described first slide unit of stating fixing bar cramp is connected, and the other end of described fixing bar cramp is provided with fixation clamp, For clamping and fix described syringe.
The most alternatively, described syringe includes capillary tube pin, the sliding end of described second slide unit with away from described capillary Syringe needle one end of pipe pin is fixing to be connected.
The most alternatively, described syringe includes piston, imbibition cylinder, capillary tube pin, the sliding end of described second slide unit with Described piston is fixing to be connected, and described piston is connected with described imbibition cylinder inwall, and described capillary tube pin is in the way of screw socket or buckle Being arranged on described imbibition cylinder, during to instruct in the injection receiving control equipment, described second motor is sliding by described second Platform drives the piston movement of described syringe, and described targeted injection position is carried out locating injection.
The most alternatively, described capillary tube pin is that capillary tube hot-drawn forms, and the internal diameter of described capillary tube is less than 1mm.
The most alternatively, described capillary tube refers to non-metallic conduit or grass tube.
The most alternatively, described syringe is marked with silicone oil, to carry out micro-in the syringe needle one end near described capillary tube pin Amount sucks or injection.
The most alternatively, the second slide unit includes any one in slide bar, rotation screw rod, pushing ram, described first motor Stepper motor or driver is included with described second motor.
It can be seen that the open a kind of trace injection instrument proposed of the embodiment of the present invention includes that the propelling being relatively fixed connection is fixed Position module and injection module, described propelling locating module, for the positioning instruction of receiving control apparatus, drives described injection module Lock onto target injection position, described injection module is for the injection instruction of receiving control apparatus, for described targeted injection position Carry out locating injection;So automatically, intelligently to it can carry out locating injection according to the actual demand of animal, improve micro- The convenient and swift property of amount injection and accuracy.
Accompanying drawing explanation
In order to be illustrated more clearly that the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing In having technology to describe, the required accompanying drawing used is briefly described, it should be apparent that, the accompanying drawing in describing below is only this Some embodiments of invention, for those of ordinary skill in the art, on the premise of not paying creative work, it is also possible to Other accompanying drawing is obtained according to these accompanying drawings.
Fig. 1 is the structural representation of a kind of trace injection instrument of the embodiment of the present invention;
Fig. 2 is the structural representation of a kind of trace injection instrument of another embodiment of the present invention.
Detailed description of the invention
In order to make those skilled in the art be more fully understood that the present invention program, below in conjunction with in the embodiment of the present invention Accompanying drawing, is clearly and completely described the technical scheme in the embodiment of the present invention, it is clear that described embodiment is only The embodiment of a present invention part rather than whole embodiments.Based on the embodiment in the present invention, ordinary skill people The every other embodiment that member is obtained under not making creative work premise, all should belong to the model of present invention protection Enclose.
Term " first ", " second " and " the 3rd " in description and claims of this specification and above-mentioned accompanying drawing (as Fruit exists) etc. be for distinguishing different object, not for describing particular order.Additionally, term " includes " and they are any Deformation, it is intended that cover non-exclusive comprising.Such as contain series of steps or the process of unit, method, system, product Or equipment is not limited to step or the unit listed, but the most also include step or the unit do not listed, or can Selection of land also includes other step intrinsic for these processes, method, product or equipment or unit.
Refer to Fig. 1, be the structural representation of a kind of trace injection instrument of the embodiment of the present invention, the institute of the embodiment of the present invention State trace injection instrument can include advancing locating module 10 and injection module 11, described propelling locating module 10 and described injection mould Block 11 mutually and is relatively fixed connection, and described propelling locating module 10 may be used for receiving control equipment (such as controller) During the positioning instruction sent here, described propelling locating module 10 can drive this propelling locating module 10 and described injection module 11 Move according to the desired guiding trajectory indicated by described positioning instruction/advance so that described injection module 11 find and lock with The targeted injection position that described positioning instruction is corresponding;Further, receive from control equipment when described injection module 11 During the injection instruction sended over, described injection module 11 can carry out the medicine of correspondence for the targeted injection position of above-mentioned locking Product injection or medicine suck.
It can be seen that the open a kind of trace injection instrument proposed of the embodiment of the present invention includes that the propelling being relatively fixed connection is fixed Position module and injection module, described propelling locating module, for the positioning instruction of receiving control apparatus, drives described injection module Lock onto target injection position, described injection module is for the injection instruction of receiving control apparatus, for described targeted injection position Carry out locating injection;So automatically, intelligently to it can carry out locating injection according to the actual demand of animal, improve micro- The convenient and swift property of amount injection and accuracy.
Please also refer to Fig. 2, being the structural representation of a kind of trace injection instrument of another embodiment of the present invention, the present invention is real The described trace injection instrument executing example can include above-mentioned propelling locating module 10 and injection module 11, and wherein, described propelling is fixed Position module 10 includes: the first slide unit 1 and the first motor 2, and the fixing end 100 of described first slide unit is fixed with described first motor 2 Connect;
When receiving the positioning instruction of control equipment, described first motor 2 drives described first slide unit 1 and described The targeted injection position indicated by described positioning instruction is searched and locked to injection module 11.
In implementing, shown in Figure 2, the fixing end 100 of described first slide unit 1 can respectively with the first motor 2, brain Stereotaxic instrument 3, fixing connection, the sliding end 101 of described first slide unit 1 can fixing with described injection module 11 be connected, its In, when needs carry out drug injection to animal, described brain solid positioner 3 can stereoscopic localized animal institute in three dimensions Position, further above-mentioned sliding stand 1 is fixed on the Z axis handle end of described brain solid positioner 3.Described first electronic Machine 2 can have the driver of outside or controller to be controlled driving, and user/system self-defined can will input/deposit alternatively Control/the positioning instruction of storage is stored in the single-chip microcomputer of controller, and wherein said positioning instruction can include that user/system is made by oneself The information such as the such as predetermined movement track of justice setting, move distance, goal-selling position location, the embodiment of the present invention does not limits Fixed.When described first motor 2 receives control/positioning instruction that described controller (i.e. controlling equipment) sends over, institute Stating the first motor 2 can drive the first sliding stand 1 to carry out the slip of desired guiding trajectory, simultaneously according to the instruction of described positioning instruction Also fix, with the sliding end 101 of described first slide unit 1, the described injection module 11 being connected after driving and do the fortune of same trajectories OK, so described injection module is searched and determine correspondence want animal is injected targeted injection position (as Cortex position).
The most alternatively, described injection module 11 includes the second slide unit the 4, second motor 5 and syringe 6, described second The fixing end 400 of slide unit 4 is fixed be connected with the sliding end 101 of described first slide unit and described second motor 5 respectively, and described second The sliding end 401 of slide unit is fixing with described syringe 6 to be connected;
When the injection receiving control equipment instructs, described second motor 5 drives described note by described second slide unit 4 Emitter 6 carries out locating injection for described targeted injection position.
In implementing, the sliding end 101 of described first slide unit 1 can also be fixing even with the fixing end 401 of the second slide unit 4 Connecing, the fixing end 401 of described second slide unit 4 can also be electrically connected with described second motor 5, the slip of described second slide unit 4 End is fixed with described syringe 6 and is connected, so after above-mentioned first motor 2 receives positioning instruction, can drive simultaneously after Second slide unit the 4, second motor 5 and syringe 6 move together so that syringe 6 find/lock onto correspondence target note Penetrate position.Further after described targeted injection position is found/locked onto to described syringe, if described second motor 5 When receiving the injection instruction from control equipment (such as peripheral control unit), described second motor 5 can drive described second Slide unit 4 carry out correspondence slide up and down, allow its conflict described syringe 6, or give described 6 one power of syringe effect make Described syringe 6 carries out the Drug fixed position location of correspondence for the position (the most above-mentioned targeted injection position locked onto) currently stopped Injection.Or, the sliding end 401 of described second slide unit 4 can also fixing with a catch bar 7 (such as a thin stainless steel) connect Connecing, described catch bar 7 is fixing with described syringe 6 to be connected, and so after described second motor receives injection instruction, passes through Slide described second sliding stand 4, promotes described catch bar 7 described syringe 6 of conflicting to enter for described targeted injection position simultaneously Row locating injection.Alternatively, user/system self-defined control/injection instruction by input/storage can be stored in controller and set In the single-chip microcomputer of standby (such as controller), wherein said injection instruction can include the dosage of drug for injection, injection start time, with And inject the information such as end time, the embodiment of the present invention is not construed as limiting.
The most alternatively, described trace injection instrument also includes: stuck-module 12, and described stuck-module 12 includes fixing bar cramp 8, one end 80 of described fixing bar cramp is connected with the sliding end 101 of described first slide unit, and the other end 81 of described fixing bar cramp sets It is equipped with fixation clamp 9, is used for clamping and fix described syringe 6.
Tool sees Fig. 2 and understands, and described trace injection instrument also includes a fixing bar cramp 8, one end 80 of described fixing bar cramp Fixing with the fixing end 400 of the sliding end 101 of described first slide unit 1, described second slide unit 4 it is connected, described fixing bar cramp another One end 81 be/is provided with a fixation clamp 82, and described fixation clamp 82 is used for clamping and fix described syringe 6, in order to described Syringe 6 produces the phenomenons such as position offsets or rocks during carrying out locating injection.
The most alternatively, described syringe 6 includes capillary tube pin 60, the sliding end of described second slide unit 4 40 with away from institute State the fixing connection in syringe needle one end of capillary tube pin.
When described syringe 6 is only a microinjection pin, during such as capillary tube pin, the fixation clamp of the most described fixing bar cramp 8 82 just can be clamped on described microinjection pin, and the sliding end 401 of described second sliding stand 4 can be with described microinjection pin Tail end is fixedly connected, or it is permissible with the catch bar 7 that sliding end 400 lower end of described second sliding stand 4 is connected to see Fig. 2 It is inserted in the tail end pipe of described microinjection pin.
The most alternatively, described syringe 6 includes piston 61, imbibition cylinder 62, capillary tube pin 60, described second slide unit 4 Sliding end 401 is fixing with described piston 61 to be connected, and described piston 61 is connected with described imbibition cylinder 62 inwall, described capillary tube pin 60 It is arranged in the way of screw socket or buckle on described imbibition cylinder 62, during to instruct in the injection receiving control equipment, described the Two motors drive the piston movement of described syringe by described second slide unit, and described targeted injection position carries out location note Penetrate.
When described syringe 6 is the syringe including piston 61, imbibition cylinder 62, capillary tube pin 60, wherein said The annexation of syringe 6 and described second slide unit 4 can be: the sliding end 401 of described second slide unit 4 or with described second The catch bar 7 that sliding end 401 lower end of slide unit 4 connects can directly be connected with described piston 61, and described piston 61 has can pacify Being contained in described imbibition cylinder 62, contact with imbibition cylinder 62 inwall this described, described capillary tube pin 60 is with screw socket or the side of buckle Formula is arranged on described imbibition cylinder 62, so makes when described second motor 5 receives injection instruction, sliding by described second Platform 4 pushes directly on or indirectly promotes described piston through described catch bar 7, and then owing to air pressure relation promotes described imbibition cylinder 62 carry out medicine absorption or the injection of correspondence by described capillary tube pin 60.
Alternatively, the direction of the axle that first above-mentioned slide unit the 1, second slide unit 4 and catch bar 7 are oppositely arranged can be mutual Parallel, that is to say that above-mentioned first slide unit the 1, second slide unit 4 and catch bar 7 can be with control instruction (such as positioning instruction and injections Instruction) in the glide direction (such as sliding up and down direction) of indicated desired guiding trajectory consistent.
The most alternatively, described capillary tube pin 60 forms for capillary tube hot-drawn, and the internal diameter of described capillary tube is less than 1mm.
The most alternatively, described capillary tube refers to non-metallic conduit or grass tube.
Preferably, the syringe 6 in the trace injection instrument that the embodiment of the present invention is provided can use capillary tube pin, described Capillary tube pin may refer to that capillary tube carries out hot-drawn and forms the capillary tube pin that pin is made, can be by thrusting capillary tube backshank end Catch bar 7 drive carry out correspondence medicine suck and injection.Wherein, described capillary tube pin can be by nonmetallic materials (such as glass Glass, plastics etc.) prepare, the internal diameter of described capillary tube pin can be less than or equal to 1mm (millimeter).
The most alternatively, described syringe 6 is marked with silicone oil, to carry out micro-in the syringe needle one end near described capillary tube pin Amount sucks or injection.
The most alternatively, the second slide unit 4 includes any one in slide bar, rotation screw rod, pushing ram, described first motor 2 and described second motor 5 include stepper motor or driver.
Alternatively, the described syringe 6 in the embodiment of the present invention can have been injected a certain amount of silicone oil, or note in advance Full silicone oil, in order in the suction or the injection that use described syringe 6 to carry out trace medicine.Preferably, the embodiment of the present invention is carried Second slide unit 4 of confession can include slide bar, rotate in screw rod, pushing ram any one, the embodiment of the present invention provided the One motor 2 and the second motor 5 can be to include stepper motor, driver or for driving in described trace injection instrument a parts Carrying out components and parts or the equipment moved, the embodiment of the present invention is not construed as limiting.
It can be seen that propelling locating module and injection module are combined formation micro-injection by the embodiment of the present invention Instrument, and two modules can the control of receiving control apparatus (such as single-chip microcomputer), it is achieved the automatic injection of automatic programmable, keeps away Exempt from human error;On the other hand, the embodiment of the present invention can also use disposable or droppable hot-drawn capillary tube pin to carry out generation For traditional Hamilton pin, quick-replaceable syringe needle can be realized, improve operating efficiency, reduce cost.
The above, above example only in order to technical scheme to be described, is not intended to limit;Although with reference to front State embodiment the present invention has been described in detail, it will be understood by those within the art that: it still can be to front State the technical scheme described in each embodiment to modify, or wherein portion of techniques feature is carried out equivalent;And these Amendment or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.

Claims (10)

1. a trace injection instrument, it is characterised in that described trace injection instrument includes: be relatively fixed the propelling locating module of connection And injection module, described propelling locating module, for the positioning instruction of receiving control apparatus, drives described injection module to lock mesh Mark injection position, described injection module is for the injection instruction of receiving control apparatus, and it is fixed to carry out for described targeted injection position Position injection.
2. trace injection instrument as claimed in claim 1, it is characterised in that described propelling locating module includes: the first slide unit and First motor, the fixing end of described first slide unit is fixing with described first motor to be connected;
When receiving the positioning instruction of control equipment, described first motor drives described first slide unit and described injection mould The targeted injection position indicated by described positioning instruction is searched and locked to block.
3. trace injection instrument as claimed in claim 1, it is characterised in that described injection module includes the second slide unit, the second electricity Machine and syringe, the fixing end of described second slide unit is fixed with the sliding end of described first slide unit and described second motor respectively Connecting, the sliding end of described second slide unit is fixing with described syringe to be connected;
When the injection receiving control equipment instructs, described second motor drives described syringe needle by described second slide unit Described targeted injection position is carried out locating injection.
4. the trace injection instrument as described in any one in claim 1-3, it is characterised in that described trace injection instrument also wraps Including: stuck-module, described stuck-module includes fixing bar cramp, one end of described fixing bar cramp and the sliding end of described first slide unit Connecting, the other end of described fixing bar cramp is provided with fixation clamp, is used for clamping and fix described syringe.
5. trace injection instrument as claimed in claim 3, it is characterised in that described syringe includes capillary tube pin, described second The sliding end of slide unit is fixed with the syringe needle one end away from described capillary tube pin and is connected.
6. trace injection instrument as claimed in claim 3, it is characterised in that described syringe includes piston, imbibition cylinder, capillary tube Pin, the sliding end of described second slide unit is fixing with described piston to be connected, and described piston is connected with described imbibition cylinder inwall, described hair Tubule pin is arranged on described imbibition cylinder in the way of screw socket or buckle, during to instruct in the injection receiving control equipment, and institute State the second motor and driven the piston movement of described syringe by described second slide unit, and carry out described targeted injection position determining Position injection.
7. the trace injection instrument as described in claim 5 or 6, it is characterised in that described capillary tube pin is that capillary tube hot-drawn forms, The internal diameter of described capillary tube is less than 1mm.
8. trace injection instrument as claimed in claim 7, it is characterised in that described capillary tube refers to that non-metallic conduit or glass are led Pipe.
9. the trace injection instrument as described in claim 5 or 6, it is characterised in that be marked with silicone oil in described syringe, with close Syringe needle one end of described capillary tube pin carries out trace suction or injection.
10. the trace injection instrument as described in any one in claim 1-3, it is characterised in that the second slide unit includes slide bar, turns Any one in dynamic screw rod, pushing ram, described first motor and described second motor include stepper motor or driver.
CN201610740405.8A 2016-08-26 2016-08-26 A kind of trace injection instrument Pending CN106236317A (en)

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CN201610740405.8A CN106236317A (en) 2016-08-26 2016-08-26 A kind of trace injection instrument

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Application Number Priority Date Filing Date Title
CN201610740405.8A CN106236317A (en) 2016-08-26 2016-08-26 A kind of trace injection instrument

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106730149A (en) * 2017-03-10 2017-05-31 王燕青 A kind of vein puncture device, system and venipuncture control method
CN109758626A (en) * 2019-03-05 2019-05-17 魏国敏 A kind of Respiratory Medicine expectoration device

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0092712A2 (en) * 1982-04-28 1983-11-02 B. Braun-SSC AG Pressure infusion apparatus for medical applications
CN1224364A (en) * 1996-07-01 1999-07-28 法玛西雅和厄普约翰公司 Injection device and method for its operation
WO2005102416A1 (en) * 2004-04-27 2005-11-03 Rodney Brian Savage Medical fluid injector
CN201384591Y (en) * 2009-04-17 2010-01-20 蒋常文 Brain solid positioner
CN203463247U (en) * 2013-09-25 2014-03-05 中国科学技术大学 Injection pump and injection system
CN104083230A (en) * 2014-07-23 2014-10-08 山东大学 Device used for replacing experimental tools and guaranteeing positioning accuracy for stereotaxic apparatus conveniently and rapidly and application method of device
CN104703641A (en) * 2012-08-15 2015-06-10 赛诺菲-安万特德国有限公司 Autoinjector

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0092712A2 (en) * 1982-04-28 1983-11-02 B. Braun-SSC AG Pressure infusion apparatus for medical applications
CN1224364A (en) * 1996-07-01 1999-07-28 法玛西雅和厄普约翰公司 Injection device and method for its operation
WO2005102416A1 (en) * 2004-04-27 2005-11-03 Rodney Brian Savage Medical fluid injector
CN201384591Y (en) * 2009-04-17 2010-01-20 蒋常文 Brain solid positioner
CN104703641A (en) * 2012-08-15 2015-06-10 赛诺菲-安万特德国有限公司 Autoinjector
CN203463247U (en) * 2013-09-25 2014-03-05 中国科学技术大学 Injection pump and injection system
CN104083230A (en) * 2014-07-23 2014-10-08 山东大学 Device used for replacing experimental tools and guaranteeing positioning accuracy for stereotaxic apparatus conveniently and rapidly and application method of device

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106730149A (en) * 2017-03-10 2017-05-31 王燕青 A kind of vein puncture device, system and venipuncture control method
WO2018161620A1 (en) * 2017-03-10 2018-09-13 王燕青 Venipuncture device, system, and venipuncture control method
CN106730149B (en) * 2017-03-10 2020-04-21 中国人民解放军总医院第五医学中心 Venipuncture device and system
CN109758626A (en) * 2019-03-05 2019-05-17 魏国敏 A kind of Respiratory Medicine expectoration device

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