CN106236068A - A kind of cerebral blood flow measurement apparatus, system and the helmet - Google Patents
A kind of cerebral blood flow measurement apparatus, system and the helmet Download PDFInfo
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- CN106236068A CN106236068A CN201610724324.9A CN201610724324A CN106236068A CN 106236068 A CN106236068 A CN 106236068A CN 201610724324 A CN201610724324 A CN 201610724324A CN 106236068 A CN106236068 A CN 106236068A
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- 230000003727 cerebral blood flow Effects 0.000 title claims abstract description 56
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0064—Body surface scanning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
- A61B5/4064—Evaluating the brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
- A61B5/6803—Head-worn items, e.g. helmets, masks, headphones or goggles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7221—Determining signal validity, reliability or quality
Abstract
The invention discloses a kind of cerebral blood flow measurement apparatus, system and the helmet.Wherein, cerebral blood flow measurement apparatus includes least one set light supply apparatus and at least two groups detection device；Light supply apparatus includes single longitudinal mode crystal laser, light shifter and irradiation optical fiber；Single longitudinal mode crystal laser, its outfan is connected with the input of light shifter by optical fiber；Light shifter, its outfan irradiates optical fiber with at least two and is connected, for the beam of laser of input switches at least two bundle laser outputs；Irradiate optical fiber, be used for making laser emitting to position to be measured；Detection device includes single-mode fiber, collimator apparatus and silicon photomultiplier；Collimator apparatus, the reception window of the laser uniform that the single-mode fiber for receiving exports to silicon photomultiplier；Silicon photomultiplier, for being converted into the signal of telecommunication by the optical signal received and exporting.The present invention has the advantages such as Temporal sampling height, signal to noise ratio height, little, the good portability of volume.
Description
Technical field
The present invention relates to near-infrared imaging technology field, be specifically related to a kind of cerebral blood flow measurement apparatus, system and the helmet.
Background technology
Along with growth in the living standard, " rich man's disease " gets more and more, and the cardiovascular and cerebrovascular disease that thrombosis causes etc. is to people
Bring huge injury, in diagnosis and treatment, early find, early treatment, and therapeutic effect follow the trail of and have great significance, therefore
In modern medicine, blood flow measurement increasingly causes the attention of people.Such as, in brain science field, research finds when performing certain
During individual particular task, corticocerebral relevant position microvascular blood flow can significantly increase sharply.If brain neuroblastoma path or blood
Stream self-regulating function goes wrong, and can occur abnormal, imply that the compromised brain function of patient, therefore, mesh in blood flow measurement
Before propose a lot of bloodstream measurement device.
But, existing bloodstream measurement device also exists many disadvantages, and such as xenon enhanced CT is measured has radiation to human body
Damage, the Nuclear Magnetic Resonance Measurement cost intensive of arterial blood spin labeling, ultrasonic measurement is mainly sensitive to larger vessel flow speed, and laser is many
The penetration depth that Pu Le measures is only grade, and the penetration depth of laser speckle measurement is more shallow.
In order to overcome the many disadvantages in above-mentioned bloodstream measurement device, it is currently suggested one and utilizes near-infrared to spread from phase
Close spectrum (Diffuse Correlation Spectroscopy, DCS) technology tissue deep layer blood capillary red blood cell flow is carried out
The technology measured.This technology is the technology of a kind of noinvasive, low cost, and cardinal principle is to utilize near infrared light at 650-900nm ripple
The section high penetration to tissue and the sensitivity to erythrocyte, the reflective light intensity auto-correlation function that calculating blood flow causes declines
Deceleration, draws the blood flow rate of tissue deep layer (2-3cm) capillary vessel, and this technology is rapid in development in recent years, has
Response soon, the advantage such as the most accurate.But, the existing autocorrelation spectrum bloodstream measurement device utilizing this technology generally uses snowslide
As detector, there is the shortcomings such as big, the narrow dynamic range of volume in diode.
Summary of the invention
Therefore, the embodiment of the present invention to solve the technical problem that be bloodstream measurement device volume of the prior art big,
Narrow dynamic range.
To this end, a kind of cerebral blood flow measurement apparatus of the embodiment of the present invention, including least one set light supply apparatus and at least two groups
Detection device；
Described light supply apparatus includes single longitudinal mode crystal laser, light shifter and irradiation optical fiber；
Described single longitudinal mode crystal laser, its outfan is connected with the input of described light shifter by optical fiber, is used for
Produce the laser of long coherence length and export；
Described light shifter, its outfan irradiates optical fiber with at least two and is connected, for by the beam of laser switching of input
Become at least two bundle laser outputs；
Described irradiation optical fiber, is used for making laser emitting to position to be measured；
Described detection device includes single-mode fiber, collimator apparatus and silicon photomultiplier；
Described single-mode fiber, for receiving the coherent laser containing blood flow information and exporting；
Described collimator apparatus, the laser uniform that the described single-mode fiber for receiving exports is to described silicon photoelectricity
On the reception window of multiplier tube；
Described silicon photomultiplier, for being converted into the signal of telecommunication by the optical signal received and exporting.
Preferably, described collimator apparatus includes graded index prism.
Preferably, the quantity of described light supply apparatus is two groups, and one of which light supply apparatus is used for irradiating left brain, and another organizes light
Source apparatus is used for irradiating right brain.
Preferably, light supply apparatus described in two groups uses the mode of time-sharing multiplex to be irradiated left brain and right brain.
Preferably, described detection device is uniformly arranged in around described irradiation optical fiber.
Preferably, the quantity of described detection device is 16 groups, and wherein eight groups of detection devices are used for detecting left cerebral blood flow letter
Breath, another eight groups of detection devices are used for detecting right cerebral blood flow information.
A kind of helmet of the embodiment of the present invention, including above-mentioned cerebral blood flow measurement apparatus and shell；
Described cerebral blood flow measurement apparatus is positioned at described enclosure.
A kind of cerebral blood flow of the embodiment of the present invention measures system, including above-mentioned cerebral blood flow measurement apparatus, data acquisition packaging
Put and pulsed multi-photon counting assembly；
Described data acquisition unit, its input connects with the outfan of the silicon photomultiplier of described cerebral blood flow measurement apparatus
Connecing, its outfan is connected with the input of described pulsed multi-photon counting assembly, for exporting described silicon photomultiplier
Analogue signal carry out analog digital conversion and become digital signal and export；
Described pulsed multi-photon counting assembly, is used for carrying out pulse multi-photon counting and obtaining cerebral blood flow data.
The technical scheme of the embodiment of the present invention, has the advantage that
1. the cerebral blood flow measurement apparatus that the embodiment of the present invention provides, by arranging silicon photomultiplier (silicon photomultiplier
Array is better), reduce the volume of cerebral blood flow measurement apparatus, improve the dynamic range of device, and single-mode fiber connects
The laser received directly utilizes silicon photomultiplier after collimator apparatus (such as graded index prism) collimates to carry out photoelectricity and turns
Changing, whole module volume is the least, so opto-electronic conversion is moved to detection device, i.e. end of probe, lightray propagation is changed
Become propagation of electrical signals, it is to avoid when original employing avalanche diode is as detector, need several meters of long single-mode fibers to draw letter
Number and the motion artifacts that is readily incorporated, reduce motion artifacts the most to greatest extent, improve the capacity of resisting disturbance of signal.And
Because of without several meters of heavy long fibre bundles, if by mounted on the helmet for this cerebral blood flow measurement apparatus, then can significantly alleviate
The weight of the helmet, improves laminating degree and the comfort of the helmet.
2. the cerebral blood flow measurement apparatus that the embodiment of the present invention provides, improves light source by the way of time-sharing multiplex and utilizes
Rate.I.e. heighten light source instantaneous strength, to reduce influence of noise, improve signal to noise ratio, such that it is able to reducing the same of sampling time
Time ensure certainty of measurement.For avoiding high light intensity injury partial body's tissue, it is necessary to turn down dutycycle, constantly convert head measurement
Point, is equivalent to total light source (before switching) and is always held at high light intensity, and the output point light source of single after switching is operated in that high light intensity is low to be accounted for
The pulse mode of empty ratio, to ensure that average intensity, in safety range, improves whole device and completes a full brain scanning of high-quality
Temporal sampling.
3. the cerebral blood flow measurement apparatus that the embodiment of the present invention provides, is uniformly arranged in irradiation optical fiber by arranging detection device
Around, improve the comprehensive and accuracy that the level of disruption of coherent scattering light is measured by erythrocyte, thus carry further
High measurement accuracy.
4. the helmet that the embodiment of the present invention provides, by by cerebral blood flow measurement apparatus integral installation in enclosure, due to
It is all to electrically connect/wireless connections between cerebral blood flow measurement apparatus and external device (ED), it is not necessary to use heavy optical fiber to connect, and brain
Bloodstream measurement device itself has the advantage that volume is little, and therefore the helmet has advantage lightweight, that volume is little, portable, improves
The comfort level of the helmet.
5. the cerebral blood flow that the embodiment of the present invention provides measures system, by arranging pulsed multi-photon counting assembly, carries out
Pulse multi-photon is sampled, it is possible to acquisition time is reduced to 10ms magnitude, has higher imaging time resolution.
Accompanying drawing explanation
For the technical scheme being illustrated more clearly that in the specific embodiment of the invention, detailed description of the invention will be retouched below
In stating, the required accompanying drawing used is briefly described, it should be apparent that, the accompanying drawing in describing below is some realities of the present invention
Execute mode, for those of ordinary skill in the art, on the premise of not paying creative work, it is also possible to attached according to these
Figure obtains other accompanying drawing.
Fig. 1 is the theory diagram of a concrete example of the embodiment of the present invention 1 midbrain bloodstream measurement device；
Fig. 2 is the theory diagram of a concrete example of the light supply apparatus of the embodiment of the present invention 1；
Fig. 3 is the light supply apparatus of a concrete example and detection device scattergram in the embodiment of the present invention 1；
Fig. 4 is the theory diagram of a concrete example of the embodiment of the present invention 3 midbrain blood flow measurement system.
Reference: 1-light supply apparatus, 2-detects device, 11-single longitudinal mode crystal laser, 12-light shifter, and 13-shines
Penetrate optical fiber, 21-single-mode fiber, 22-collimator apparatus, 23-silicon photomultiplier, 221-graded index prism, 100-cerebral blood flow
Measurement apparatus, 200-data acquisition unit, 300-pulsed multi-photon counting assembly.
Detailed description of the invention
Below in conjunction with accompanying drawing, technical scheme is clearly and completely described, it is clear that described enforcement
Example is a part of embodiment of the present invention rather than whole embodiments.Based on the embodiment in the present invention, ordinary skill
The every other embodiment that personnel are obtained under not making creative work premise, broadly falls into the scope of protection of the invention.
In describing the invention, it should be noted that the orientation of the instruction such as term " interior ", " outward " or position relationship are base
In orientation shown in the drawings or position relationship, it is for only for ease of the description present invention and simplifies description rather than instruction or hint
The device of indication or element must have specific orientation, with specific azimuth configuration and operation, therefore it is not intended that to this
The restriction of invention.
In describing the invention, it should be noted that unless otherwise clearly defined and limited, term " is installed ", " phase
Even ", " connection " should be interpreted broadly, for example, it may be fixing connection, it is also possible to be to removably connect, or be integrally connected；Can
To be mechanical connection, it is also possible to be electrical connection；Can be to be joined directly together, it is also possible to be indirectly connected to by intermediary, it is also possible to
It is the connection of two element internals, can be wireless connections, it is also possible to be wired connection.For those of ordinary skill in the art
For, above-mentioned term concrete meaning in the present invention can be understood with concrete condition.
If additionally, the most non-structure of technical characteristic involved in invention described below difference embodiment
Become conflict just can be combined with each other.
Embodiment 1
The present embodiment provides a kind of cerebral blood flow measurement apparatus, such as, be applied to brain visual cortex is carried out comprehensive blood flow
(blood flow rate) is measured, as it is shown in figure 1, cerebral blood flow measurement apparatus 100 includes least one set light supply apparatus 1 and at least two groups
Detection device 2.
Light supply apparatus 1 includes single longitudinal mode crystal laser 11, light shifter 12 and irradiates optical fiber 13.Single longitudinal mode crystal laser
Device 11, its outfan is connected with the input of light shifter 12 by optical fiber, for producing the laser of long coherence length and exporting.
Preferably, this long coherence length can be more than 50 meters.Light shifter 12, its outfan irradiates optical fiber 13 even with at least two
Connect, for the beam of laser of input being switched at least two bundle laser outputs.Irradiate optical fiber 13, be used for making laser emitting to be measured
Amount position.
Detection device 2 includes single-mode fiber 21, collimator apparatus 22 and silicon photomultiplier (SiPM) 23.Single-mode fiber 21,
For receiving the coherent laser containing blood flow information and exporting.The laser erythrocytic scattering of menses etc. irradiating optical fiber 13 outgoing is disturbed
After action, received by single-mode fiber 21.Collimator apparatus 22, for uniformly going out the laser that the single-mode fiber 21 received exports
It is mapped on the reception window of silicon photomultiplier 23.Silicon photomultiplier 23, for being converted into telecommunications by the optical signal received
Number and export.Preferably, silicon photomultiplier 23 can be miniature or microminiature silicon photomultiplier.In imaging systems, single
Mode fiber is responsible for gathering the relevant light intensity containing blood flow information, and collimator apparatus is responsible for being incident upon uniform intensity SiPM photosurface
On.
Above-mentioned cerebral blood flow measurement apparatus, by arranging silicon photomultiplier (silicon photomultiplier array is better), subtracts
The little volume of cerebral blood flow measurement apparatus, improves the dynamic range of device, and the laser that single-mode fiber receives is through standard
After straight device (such as graded index prism) collimation, directly utilize silicon photomultiplier and carry out opto-electronic conversion, whole module volume
The least, so opto-electronic conversion to be moved to detection device, i.e. end of probe, lightray propagation is transformed into propagation of electrical signals,
Several meters of long single-mode fibers are needed to draw signals and be readily incorporated when avoiding original employing avalanche diode as detector
Motion artifacts, reduces motion artifacts the most to greatest extent, improves the capacity of resisting disturbance of signal.And because of without heavy number
The fibre bundle that rice is long, if by mounted on the helmet for this cerebral blood flow measurement apparatus, then can significantly alleviate the weight of the helmet, improves
The laminating degree of the helmet and comfort.
Preferably, as it is shown in figure 1, collimator apparatus 22 includes graded index (Grin) prism 221, have shape corpusculum light,
The advantage of simple in construction, such that it is able to reduce the volume of cerebral blood flow measurement apparatus further, alleviates the weight of cerebral blood flow measurement apparatus
Amount.
Preferably, as in figure 2 it is shown, the quantity of light supply apparatus 1 is two groups, one of which light supply apparatus 1 is used for irradiating left brain,
Another group light supply apparatus 1 is used for irradiating right brain.Each group of light supply apparatus 1 includes that two irradiate optical fiber 13.Preferably, two groups of light
Source apparatus 1 uses the mode of time-sharing multiplex to be irradiated left brain and right brain.By time-sharing multiplex left and right brain is circulated and sweeps
Retouch, to reach the highest temporal resolution.Light source utilization rate is improve by the way of time-sharing multiplex.I.e. heighten light source instantaneous by force
Degree, to reduce influence of noise, improves signal to noise ratio, such that it is able to ensure certainty of measurement while reducing the sampling time.For keeping away
Exempt from high light intensity injury partial body's tissue, it is necessary to turn down dutycycle, constantly conversion head measurement point, be equivalent to (the switching of total light source
Before) it being always held at high light intensity, the output point light source of single after switching is operated in the pulse mode of high light intensity low duty ratio, to ensure
Average intensity, in safety range, improves whole device and completes the Temporal sampling of a full brain scanning of high-quality.
Preferably, as it is shown on figure 3, detection device 2 is uniformly arranged in irradiation optical fiber 13 around.Preferably, detection device 2
Quantity be 16 groups (being not limited to 16 groups), wherein eight groups detection devices 2 be used for detecting left cerebral blood flow information, another eight groups of detections
Device 2 is used for detecting right cerebral blood flow information.Uniformly it is arranged in around irradiation optical fiber by arranging detection device, improves blood red
Comprehensive and the accuracy that the level of disruption of coherent scattering light is measured by cell, thus improve certainty of measurement further.
Embodiment 2
The present embodiment provides a kind of helmet, including cerebral blood flow measurement apparatus 100 and shell, the cerebral blood flow of above-described embodiment 1
Measurement apparatus 100 is positioned at enclosure.
The above-mentioned helmet, by by cerebral blood flow measurement apparatus integral installation in enclosure, due to cerebral blood flow measurement apparatus with
It is all electrical connection/wireless connections between external device (ED), it is not necessary to use heavy optical fiber to connect, and cerebral blood flow measurement apparatus itself
Having the advantage that volume is little, therefore the helmet has advantage lightweight, that volume is little, portable, improves the comfort level of the helmet.
Embodiment 3
The present embodiment provides a kind of cerebral blood flow to measure system, and as shown in Figure 4, the cerebral blood flow including above-described embodiment 1 is measured
Device 100, data acquisition unit 200 and pulsed multi-photon counting assembly 300.
Data acquisition unit 200, its input connects with the outfan of the silicon photomultiplier 23 of cerebral blood flow measurement apparatus 100
Connecing, its outfan is connected with the input of pulsed multi-photon counting assembly 300, for the mould to silicon photomultiplier 23 output
Plan signal carries out analog digital conversion and becomes digital signal and export.Preferably, data acquisition unit 200 includes A/D data collecting card.
Pulsed multi-photon counting assembly 300, is used for carrying out pulse multi-photon counting and obtaining cerebral blood flow data.Preferably
Ground, the process that pulsed multi-photon counting assembly 300 is carried out includes that photon counting filtration, Fourier transformation, clutter filter, from phase
Close function calculating etc..Preferably, blood flow calculates and takes light intensity auto-correlation algorithm, and its diffusion formula is
G1(r, τ) is auto-correlation function, DγDirectly related with rate of blood flow, μaR () is absorptance, μ 'sR () is scattering
Coefficient, k0For wave function, v is the light velocity, and S (r) is distribution of light sources, can be according to the erythrocyte disturbance journey to coherent scattering light
Degree, calculates rate of blood flow.
For example, as used the single longitudinal mode crystal laser of 40mW, 785nm, the number of photons of 3cm external detector is arrived about
For 5x107/ s, in minimum time window 0.1us, number of photons, up to 5, statistical significance can obtain very smooth from phase
Close curve.Even if blood flow slowly in the case of, 2ms the most enough takes a blood flow data point.For avoiding injuring human body group
Knit, and improve sample rate, dutycycle can be turned down.In the case of light source switching time (1-2ms) be can not ignore, full brain scanning
Need about 10ms.
Above-mentioned cerebral blood flow measures system, by arranging pulsed multi-photon counting assembly, carries out pulse multi-photon sampling, energy
Enough acquisition time is reduced to 10ms magnitude, utilizes fNIRS equipment (to be generally of submicrosecond level temporal resolution, at present with routine
The fastest 100ms) carry out brain imaging and compare, (during multichannel, the time of signals collecting divides to have higher imaging time resolution
Resolution theory expectation can reach the level of 10ms).Because the change of brain blood oxygen metabolism activity is to compare slowly, and also prolongs
Late, and cerebral blood flow (blood flow rate) is fast-changing with neural activity.
Obviously, above-described embodiment is only for clearly demonstrating example, and not restriction to embodiment.Right
For those of ordinary skill in the field, can also make on the basis of the above description other multi-form change or
Variation.Here without also cannot all of embodiment be given exhaustive.And the obvious change thus extended out or
Change among still in the protection domain of the invention.
Claims (8)
1. a cerebral blood flow measurement apparatus, it is characterised in that include least one set light supply apparatus (1) and at least two groups detection device
(2)；
Described light supply apparatus (1) includes single longitudinal mode crystal laser (11), light shifter (12) and irradiates optical fiber (13)；
Described single longitudinal mode crystal laser (11), its outfan is connected with the input of described light shifter (12) by optical fiber,
For producing the laser of long coherence length and exporting；
Described light shifter (12), its outfan irradiates optical fiber (13) with at least two and is connected, for the beam of laser by input
Switch at least two bundle laser outputs；
Described irradiation optical fiber (13), is used for making laser emitting to position to be measured；
Described detection device (2) includes single-mode fiber (21), collimator apparatus (22) and silicon photomultiplier (23)；
Described single-mode fiber (21), for receiving the coherent laser containing blood flow information and exporting；
Described collimator apparatus (22), the laser uniform being used for exporting the described single-mode fiber (21) received is to described silicon
On the reception window of photomultiplier tube (23)；
Described silicon photomultiplier (23), for being converted into the signal of telecommunication by the optical signal received and exporting.
Cerebral blood flow measurement apparatus the most according to claim 1, it is characterised in that described collimator apparatus (22) includes that gradient is rolled over
Penetrate rate prism (221).
Cerebral blood flow measurement apparatus the most according to claim 1 and 2, it is characterised in that the quantity of described light supply apparatus (1) is
Two groups, one of which light supply apparatus (1) is used for irradiating left brain, and another group light supply apparatus (1) is used for irradiating right brain.
Cerebral blood flow measurement apparatus the most according to claim 3, it is characterised in that light supply apparatus (1) described in two groups uses and divides
Left brain and right brain are irradiated by the mode of Shi Fuyong.
5. according to the cerebral blood flow measurement apparatus described in any one of claim 1-4, it is characterised in that described detection device (2) is equal
Even it is arranged in described irradiation optical fiber (13) around.
6. according to the cerebral blood flow measurement apparatus described in any one of claim 1-5, it is characterised in that described detection device (2)
Quantity is 16 groups, and wherein eight groups of detections device (2) are used for detecting left cerebral blood flow information, and another eight groups of detections device (2) are used for visiting
Survey right cerebral blood flow information.
7. a helmet, it is characterised in that include the cerebral blood flow measurement apparatus (100) as described in any one of claim 1-6 and
Shell；
Described cerebral blood flow measurement apparatus (100) is positioned at described enclosure.
8. a cerebral blood flow measures system, it is characterised in that include that the cerebral blood flow as described in any one of claim 1-6 measures dress
Put (100), data acquisition unit (200) and pulsed multi-photon counting assembly (300)；
The silicon photomultiplier (23) of described data acquisition unit (200), its input and described cerebral blood flow measurement apparatus (100)
Outfan connect, its outfan is connected with the input of described pulsed multi-photon counting assembly (300), be used for described silicon
The analogue signal that photomultiplier tube (23) exports carries out analog digital conversion and becomes digital signal and export；
Described pulsed multi-photon counting assembly (300), is used for carrying out pulse multi-photon counting and obtaining cerebral blood flow data.
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