CN106232161A - Telescopic drive arrangement for drug delivery device - Google Patents

Telescopic drive arrangement for drug delivery device Download PDF

Info

Publication number
CN106232161A
CN106232161A CN201580022281.3A CN201580022281A CN106232161A CN 106232161 A CN106232161 A CN 106232161A CN 201580022281 A CN201580022281 A CN 201580022281A CN 106232161 A CN106232161 A CN 106232161A
Authority
CN
China
Prior art keywords
assembly
drug delivery
cylinder
delivery device
motor sub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201580022281.3A
Other languages
Chinese (zh)
Inventor
B.G.拉森
C.S.安德森
J.霍霍特
F.豪加亚尔德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of CN106232161A publication Critical patent/CN106232161A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10—Tube connectors; Tube couplings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31513—Piston constructions to improve sealing or sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31546—Electrically operated dose setting, e.g. input via touch screen or plus/minus buttons
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16H—GEARING
    • F16H25/00—Gearings comprising primarily only cams, cam-followers and screw-and-nut mechanisms
    • F16H25/18—Gearings comprising primarily only cams, cam-followers and screw-and-nut mechanisms for conveying or interconverting oscillating or reciprocating motions
    • F16H25/20—Screw mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2481—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for biasing the ampoule out of the ampoule holder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31518—Piston or piston-rod constructions, e.g. connection of piston with piston-rod designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M2005/31588—Constructional features or modes of drive mechanisms for piston rods electrically driven
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10—Tube connectors; Tube couplings
    • A61M2039/1022—Tube connectors; Tube couplings additionally providing electrical connection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/14—Detection of the presence or absence of a tube, a connector or a container in an apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16H—GEARING
    • F16H25/00—Gearings comprising primarily only cams, cam-followers and screw-and-nut mechanisms
    • F16H25/18—Gearings comprising primarily only cams, cam-followers and screw-and-nut mechanisms for conveying or interconverting oscillating or reciprocating motions
    • F16H25/20—Screw mechanisms
    • F16H2025/2062—Arrangements for driving the actuator
    • F16H2025/2075—Coaxial drive motors

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Pulmonology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Being adapted to receive the drug delivery device of cylinder, described drug delivery device includes: has female driving and manages；Motor sub-assembly, described motor sub-assembly includes drive shaft and is adapted to be received in described driving pipe；Drive member, described drive member is attached to described drive shaft and has the external screw thread engaged with described driving pipe female thread.Described driving pipe be arranged as relative to described motor sub-assembly axially displaceable but non-rotatable, thus, the rotation of described drive member causes the axial non-rotating displacement of described driving pipe.In order to provide motility, described drive shaft is connected to described drive member via the first flexible joint, and described motor sub-assembly close end is connected to supporting construction via the second flexible joint.

Description

Telescopic drive arrangement for drug delivery device
Technical field
The present invention relates generally to telescopic drive mechanism.In particular aspects, the present invention relates to a kind of motorization medicine Delivery apparatus, this motorization drug delivery device is adapted to receive fills the cylinder of medicine and subsequently from its discharge dosage.
Background technology
In disclosure of the invention, treat diabetes referring especially to by subcutaneous drug delivery, but, this is only this The example of use of invention.
It is adapted to receive and fills the cylinder of medicine and discharge the most common durable drug delivery device class setting dosage from it Type is manually or to be driven by the spring enabled during dosage setting, and this includes axially displaceable The type of piston, the piston of this axially displaceable is had initial proximal position and is moved to far-end by piston rod.Subcutaneous medicine Thing delivers and carries out via entry needle, and this entry needle is arranged as being in fluid communication with cylinder.This device can be the form of a stroke or a combination of strokes or in more Form as the so-called doser of box-like.In order to improve convenience, user friendly and provide supplementary features, such as, row Going out detection and the storage of data, drug delivery device has been provided with electrically driven, and this electrically driven is generally in electronics Controlling the form of motor, this Electronic Control motor drives piston rod by arrangement of gears, such as, as US 6,514,230 Hes Shown in US 2011/306927.
Although motorization drug delivery device due to can make many trifling routine automatizatioies and bring to client multinomial good Place, but these devices are the biggest compared with conventional mechanicals, and therefore it is not readily portable and stores.Ask to solve this Topic, WO 03/099357 discloses a kind of pen-type drug delivery apparatus including drive arrangement, and this drive arrangement includes in a tubular form The piston rod of the form of main body, this tubular body can move in drug cartridge when being distally advanced, tubular body Limit internal void, wherein when tubular body is positioned in retraction proximal location, arrange motorization and drive assembly At least partially.This structure driving assembly is properly termed as " motor in piston ".This driving assembly can also be regarded as and stretches Contracting formula drives assembly, and wherein, inner motor drives assembly to be stationary part, and outer tubular main body is the telescopic section of movement.
Although motor design can produce compact design in piston, but this design relates to having a common boundary many with other parts multiple Individual mobile parts, these parts are arranged in the confined space.This design generally will produce following Machine Design: at this machinery In design, involved parts are by Over-constrained, and this can cause again device to break down and/or production cost increases And product recovery rate reduces.
In view of the problems referred to above, the motorization medicine that it is an object of the invention to provide motor type in a kind of piston delivers dress Putting and parts, these parts provide height reliability in the way of cost-effective.Another purpose is to provide a kind of general flexible Formula drives assembly, and this General expansion drives assembly the compactest and provides highly reliable in the way of cost-effective Property.
Summary of the invention
In disclosure of the invention, embodiment and aspect will be described, these embodiments and aspect will to one or Multiple above-mentioned purposes carry out processing or by from disclosed below and from the description of exemplary embodiment obvious purpose enter Row processes.
Therefore, according to the first aspect of the invention, it is provided that a kind of drug delivery device, this drug delivery device include every Room, this compartment is adapted to the cylinder filling medicine receiving and keeping to have the piston being axially movable.This device farther includes: Supporting construction；Have female driving to manage；Motor sub-assembly, this motor sub-assembly has distal portion and close end, described distal portion It is received in driving pipe including rotatable drive shaft and being adapted to；Including externally threaded drive member；And controller, this control Device processed is used for controlling motor sub-assembly.Drive pipe be arranged as relative to motor sub-assembly axially displaceable but non-rotatable, drive Guan Shi Ying Yu directly or indirectly engages and makes this piston axially to move with the piston of handling tube, thus discharges medicine from cylinder Thing, and motor sub-assembly is arranged as non-rotatable relative to supporting construction.Drive member external screw thread and driving pipe female thread screw thread Engage, so that the rotation of drive shaft causes the axial non-rotating displacement driving pipe relative to supporting construction.Motor sub-assembly near-end Portion is connected to supporting construction via the first flexible joint, and drive shaft is connected to drive member via the second flexible joint.Example As, flexible joint can in the same manner or differently in universal joint, helical spring or Oldham coupling (Oldham Coupling) form.
Had a driving assembly of flexible joint by offer, motor sub-assembly allows to move relative to underframe, such as, warpage or Person " swings ", as drive member allows relative to motor sub-assembly together with driving pipe and therefore moves also relative to underframe, Such as, warpage or " swing ", this layout also provides for desired rotation and transmits, so allows cost-effective design, for institute The tolerance of the parts needs related to is the strictest.Alternatively, it is contemplated that such as design, cost or space problem, can be by Only one flexible joint is incorporated in driving assembly design.
In the exemplary embodiment, drive shaft limits general axis, and the first flexible joint and the second flexible joint structure Make for prevent relative to this general axis between motor sub-assembly close end and supporting construction, correspondingly in drive shaft and driving Rotation between component and moving axially.
Controller and motor sub-assembly are adapted to: make driving pipe move in a distal direction thus discharge medicine from handling tube Thing, and make driving pipe move on contrary proximal direction so that driving pipe to retract from handling tube.Setting dress can be provided Putting, this setting device allows user to set drug dose to be discharged.
Drug delivery device may include that rechargable power supplies；And electrical cnnector, outside this electrical cnnector allows to connect Portion's power connector is to be charged power supply, and wherein, controller is adapted to detection instruction external power source and is connected to electrically connect Connect device condition and subsequently disabling discharge assembly, thus prevent when external power source is already attached to electrical cnnector can be from Handling tube discharges medicine.
In alternative constructions, it is provided that a kind of General expansion drives assembly, this General expansion drives assembly to include: bag Include the driving pipe of female thread；And motor sub-assembly, this motor sub-assembly has distal portion and close end, and this distal portion includes being adapted to It is received in the rotatable drive shaft in driving pipe.This driving assembly farther includes: drive member, and this drive member has and drives The external screw thread that dynamic pipe female thread is threadedly engaged, this drive member is connected to drive shaft；And mounting structure, this mounting structure adapts to In non-rotatably installing motor sub-assembly relative to supporting construction.Pipe is driven to be adapted to be arranged as can axially moving relative to motor sub-assembly Position but non-rotatable, wherein, the rotation of drive shaft cause drive pipe relative to motor sub-assembly and therefore relative to supporting construction Axial non-rotating displacement.Drive shaft is connected to drive member via the first flexible joint, and motor sub-assembly close end via Second flexible joint is connected to mounting structure.This assembly could be arranged to be combined with supporting construction.Driving assembly can be further At least some of including the controller circuitry for controlling motor sub-assembly.
As it is used herein, term " medicine " is intended to any flowable medical formulation, such as, liquid, solution, glue Body or Fine suspension, this flowable medical formulation can be in a controlled manner through such as intubating or the delivery of hollow needle Device, and comprise one or more pharmaceutical preparatioies.Representative drugs includes following medicine: such as, peptides (such as, insulin, The medicine comprising insulin, the medicine comprising GLP-1 and derivant thereof), protein and hormone, biologically-derived or activating agent, Based on hormone and the preparation of gene, nutrient formulation and other material of (distribution) form or liquid form in solid.Showing In the description of example embodiment, by the use with reference to the insulin comprising medicine, this includes its analog and with a kind of or many Plant the combination of other medicines.
Accompanying drawing explanation
Below in reference to accompanying drawing, the exemplary embodiment of the present invention is described further, in the accompanying drawings:
Fig. 1 schematically shows and includes that in piston, motor drives the first embodiment of the drug delivery device of assembly；
Fig. 2 shows the frontloader dynamicization drug delivery device including motor sub-assembly in piston；
Fig. 3 A and Fig. 3 B show in open mode and closed mode respectively before the detail view of handling tube keeper, this cylinder keeps Device is the type shown in Fig. 2 and can be used in combination with embodiments of the invention；
Fig. 4 shows the parts of the device shown in Fig. 2 in an exploded view；
Fig. 5 shows the motor gear assembly of the device shown in Fig. 2；
Fig. 6 shows the parts of the assembly shown in Fig. 5 in an exploded view；
Fig. 7 shows the sectional view of the drug delivery device of Fig. 2；And
Fig. 8 to Figure 10 shows that the sectional view of the drug delivery device of Fig. 2, motor gear assembly are moved in different operational situations Remove.
In the accompanying drawings, similar structure is mainly represented by similar reference.
Detailed description of the invention
When such as "up" and "down", " right " and " left ", " level " and terms such as " vertically " or similar are used below During relative expression, these expression formulas only refer to accompanying drawing and need not refer to actually used situation.Shown accompanying drawing is schematic generation Table figure, therefore, the structure of different structure and its relative size are intended to be only used for the purpose that example is stated.When term component or unit Part is when to limiting-members, and it is generally represented in these parts in described embodiment is unified parts, but, same component or Person's element can alternatively include multiple subassembly, and the parts as described by two or more could be arranged to unification portion Part, such as, is fabricated to single injection-molded part.Term " assembly " does not indicates that described parts are during given assembling process Offer unification or functional assembly must be provided, but being used only for the component representation that will accumulate in together is in merit Can go up the most relevant.
Before turning to the exemplary embodiment to the present invention to be described in detail, will be to having motor in telescopic piston The schematic representation driving the drug delivery device of assembly is described, in order to be more fully understood that the general work of this layout Principle.
More specifically, Fig. 1 schematically shows the first embodiment of illustrative drug delivery apparatus 200, this medicine Delivery apparatus 200 includes: front loading compartment portion 210, and the cylinder that this front loading compartment portion 210 is adapted to by being arranged in far-end keeps Device 211 is received and keeps filling the cylinder 202 of medicine；Major part 230, in telescopic piston, motor drives assembly 220 He 240 are arranged in this major part 230；And biasing assembly 255, this biasing assembly 255 provides far-end to guide on handling tube Bias force.Compartment portion and major part can rotatably or be securely connected to each other.Major part can be provided with or hold Receiving the supporting construction of other parts for device, such as, this supporting construction is the form of underframe or platform.
Driving assembly includes: has female outer piston and drives pipe 220；There is the motor gear of distal portion and close end Assembly 240, this distal portion includes the rotatable drive shaft limiting z-axis line, and drive member 241 is installed to this rotatable Drive shaft, this drive member 241 includes driving the external screw thread that engages of pipe female thread with piston.Motor gear assembly is arranged as phase For underframe not axially displaceable and non-rotatable, drive member not axially displaceable ground and be non-rotatably arranged on drive shaft On, and piston drive pipe be arranged as relative to underframe 230 and therefore also relative to motor sub-assembly axially displaceable but can not Rotating, thus, the rotation of drive shaft causes piston to drive the pipe axial non-rotating displacement relative to underframe, and piston drives pipe to adapt to Engage and make this piston axially to move to far-end in directly or indirectly with the piston of handling tube, thus discharge from cylinder Medicine.In the embodiment illustrated, piston drives pipe to be provided with far-end driving head 222, and this far-end driving head is adapted to and loads The piston 205 of cylinder 202 engage.
In order to make telescopic driving assembly run rightly, when outer tube drives forwards, all interfaces all allow for edge Considerably long distance freely translate and/or rotate, to this end, parts may be needed to have relatively closed tolerance to guarantee that parts are tieed up Hold mobility.Furthermore it may be desirable that, the size of telescopic driving assembly is made by making the gap between parts minimize Keep the least.This can additionally need small parts tolerance.
In order to process these problems, the embodiment shown in Fig. 1 provides special exercise joint to allow between parts Additional degree.More specifically, drive shaft is connected to drive member, and motor gear wheels via the first flexible joint 250 Part close end is connected to underframe via the second flexible joint 260, and this flexible joint is designed as providing rotation between the parts connected Twist lock is fixed, and allows parts relative to each other to bend or warpage.
With reference to Fig. 2, by including that in piston, motor drives the motorization pen-type drug delivery apparatus of assembly in further detail Embodiment be described.
More specifically, this pencil type apparatus includes cover (not shown) and major part, and this major part has near-end Main body or drive assembly portion 2 and far-end cylinder keeper portion 30,40, this driving assembly portion 2 has housing 80, and machine discharged by medicine Structure and the electronic device 70 being associated are arranged in this housing 80, and this far-end cylinder keeper portion 30,40 forms compartment 41(and sees figure 8) transparent tube 2, filling medicine can be arranged in this compartment 41 and by installing the cylinder keeper assembly holding to close end Put in place.Housing includes the opening 81 being adapted to receive display frame frame member (not shown), LCD(LCDs) and user Input key is arranged in this display frame frame member.After removing framing component, it can be seen that motorization output mechanism 10 and electronics The part of parts 70.A pair dosage setting input key (not shown) sets the expectation drug dose of display in LCD for manually, And then when the release button 90 being arranged in near-end activated, described expectation drug dose can be discharged.This device is designed as Opening is received to load new cylinder by user by the far-end in cylinder keeper assembly.
Cylinder includes: cylindrical body portion；There is the remote outlet portion of distal needle penetrable septum 3；There is circumferential edge 4 Proximal open end；And the piston 5(with the axially displaceable of proximal end face is shown in Fig. 7), this proximal end face allows the row of being formed The actuator piston going out mechanism's (seeing below) engages with piston.Cylinder can such as accommodate insulin, GLP-1 or growth hormone and join Side.Cylinder is provided with the far-end coupling arrangement of the form in needle hub base 6, and in shown example, this needle hub base 6 has combination Screw thread and bayonet socket coupling arrangement, combination screw thread and bayonet socket coupling arrangement be separately adapted to corresponding hub with needle assembly female thread or Person's bayonet socket coupling arrangement engages.Shown exemplary hub base farther includes to have the prominent of multiple point towards far-end Peripheral flange, the prominent coupling arrangement being used as cylinder keeper assembly of the plurality of point towards far-end, as hereafter will in further detail Ground describes.US 5,693,027 describes shown this kind of hub base.Alternatively, needle hub base can be formed as cylinder guarantor A part for holder, such as, in " Split type " hub base form, should have and be arranged in the two of retaining shoulder by " Split type " hub base Two parts on side, see below.
As shown, cylinder keeper assembly has the general appearance identical with conventional cartridge keeper, and this conventional cartridge keeps Device is detachably coupled to housing by such as thread connector or bayonet coupler, and can be by proximal openings by new Cylinder is received in this housing and removes cylinder from this housing, i.e. this keeper does not includes the release of the user operation added Or locking device.Instead, it appears that only the object of cylinder keeper itself actually activates in rotatable outer tubular The user operation coupling arrangement of the form of sleeve 40, this rotatable outer tubular actuating sleeve 40 by user operation with control in inner core The movement of the cylinder holding means of the form of keeper component 30, thus open and close the clamping shoulder being configured to clamping and holding cylinder Portion 35.More specifically, retaining shoulder 35 is provided with and multiple is circumferentially spaced the clamping tooth separated to provide multiple gap (see figure 3A), each tooth has triangular construction, and this triangular construction has the end of the point of near-end orientation, thus produces and have far-end Multiple gaps of structure of the point of orientation, this allow the above-described point towards far-end on cylinder prominent be received in tooth it Between thus when cylinder holding means has moved as engaging with cylinder as clamping device.Which provides one and look like biography After system, the easy-to-use front of loading attachment loads drug delivery device, and loading drug delivery device before this is easy-to-use is also by rotary moving Activating to install and remove cylinder, this similarity makes the use at the rear loading drug delivery device getting used to traditional type Family is prone to accept and adapt to.
This installation new cylinder when, outer tube member rotates such as 90 degree, and this action makes retaining shoulder 35 to far-end and slightly Micro-it is displaced outwardly, this cylinder allowing for removing installation.For ease of operation, when shoulder is moved, cylinder can also move to far-end Dynamic certain distance, by such as closing with the knee-joint forming retaining shoulder and/or by providing the attached of far-end guide offset power Add spring assembly (seeing below).Depending on the design of locking and actuating mechanism, retaining shoulder can stay in the open position, Or it automatically can be retracted when making outer tube member back rotation by return spring device.No matter whether it is provided with spring, Cylinder keeper all can be provided with locking device and be securely placed in open position or closed position with permission outer tube member, example As, locked by rotating spring.When inserting new cylinder, discharger is driven to necessarily be in following state: this state allows to insert tool There is the new cylinder of proximally-located piston.Hereafter the exemplary embodiment providing this function will be described.
The mechanical arrangement providing above-described user interface can be arranged in various ways, i.e. outer tubular sleeve The rotation of component makes retaining shoulder be moveable into and out.With reference to Fig. 3 A and Fig. 3 B, it can be seen that with the front load classes shown in Fig. 1 The cylinder keeper that type is identical, but this keeper has alternative constructions, i.e. circular rather than oval.Cylinder keeper 130 includes Two relative flexible arms 131, these two relative flexible arms 131 extend also from the near-end ring portion being arranged to axially directed slip And therefore non-rotatably engage with outer tubular sleeve component 140, each arm is provided with retaining shoulder 135.By this layout, clamping Shoulder will rotate together with outer tubular sleeve component and therefore rotate relative to housing 180 when axially moving.Institute In the embodiment illustrated, two relative windows 132 are formed in clamping components, in each arm one, each window be formed at outside Corresponding window 142 in tubular sleeve member aligns, and these two pair window moves together when rotation into alignment.Alternatively, clamping components and/ Or outer tubular sleeve component can fully or partly be manufactured by transparent material.Each retaining shoulder includes outer incline and curved Curved surface 137 and pair of angled edge portion 136, this outer incline and curved surface 137 are adapted to and outer tubular sleeve component 140 Corresponding curved distal end activate edge 147 and engage, inclined side is adapted to and the inner surface being arranged in actuating sleeve by this along portion 136 On a pair corresponding tilt actuation surfaces 146 engage.By this layout, when actuation surfaces 136 move to far-end and with set Cylinder actuation surfaces 146 is when being slidably engaged, and this tilt-activated surface 36 will outwards force retaining shoulder in its open position.Accordingly Ground, when making arm move proximally to, outside sweep surface 137 is pressed from both sides to it with activating in edge 147 engages and is therefore urged towards Hold in position.
In alternative embodiments, clamping components may be arranged to non-rotatable relative to main part, as actuating sleeve can To be arranged as the most axially moving or being moved by the combination of axially-movable and rotary motion.
Fig. 4 shows the exploded view of the motorization drug delivery device 1 shown in Fig. 1.This device includes: pipe generally Shape chassis member 10, generally cylindrical are discharged assembly 11, are included the biasing assembly 50 of biasing member, spring 65 and bullet Spring supporting member 60, this device farther includes: controls assembly 70, have the housing of the generally tubulose of near-end actuation button 90 80 and include the cylinder keeper assembly of rotatable outer actuating sleeve 40 and inner core keeper component 30.
Underframe includes: for the far-end connecting flange portion 11 of cylinder keeper assembly, be adapted to receive and install discharge assembly Tubular proximal portion 12 and be adapted to receive the intermediate tubular portion 13 of near-end inserting cylinder.Biasing member includes far-end ring portion 51 and multiple proximal extension leg section 54(at this be four), each leg section is included in the base portion 55 of its far-end, this base Seat portion 55 extends radially inward and is adapted to engage with the proximal leg edge inserting cylinder.In installation site, biasing member Being arranged as can axially sliding around intermediate tubular portion, wherein, supporting leg is received in and is formed at corresponding axial slots 14 therein In, during therefore base portion projects into the inside of pars intermedia.Spring support member is installed as being axially fixed on underframe, thus permits Permitted spring and far-end guide offset power is provided on biasing member.Discharging assembly is the form of motor sub-assembly in piston, such as institute above Describing, in this piston, motor sub-assembly includes: internal motor and gear-box drive assembly, and this gear-box drives assembly axially to pacify Fill and be locked to rotatably the near-end of underframe；And the outer piston pipe 20 of axially displaceable, the outer piston pipe of this axially displaceable 20 have and are adapted to the far-end driving head 22 that the piston with handling tube engages, and this piston tube includes being adapted to lead with the corresponding of underframe Carry out the multiple of non-rotating joint to device and be proximally directed prominent 23.As also described above, drive assembly to include being provided with Externally threaded cylindrical drive component, this external screw thread is arranged as corresponding threaded inwall 21 screw thread with piston tube (see figure 8) Engage, so that the rotation of drive member causes the axial non-rotating displacement of piston tube.Illustrate only piston tube in the diagram, Motor gear drives assembly to figure 5 illustrates and be described in greater detail below.Control assembly to have generally U-shaped structure, this U-shaped structure generally has PCB portion 71 and Part II, including most of electronic control parts of controller Being arranged in this PCB portion 71, rechargeable battery 72 is installed on the second portion.The two part is by near-end bridge part 74 even It is connected to each other and is oppositely arranged on the both sides of underframe.First " cylinder " being adapted to be controlled by biasing member (seeing below) is opened Close 73 to be arranged in PCB portion, and the second switch being adapted to be controlled by near-end actuation button 90 is arranged on bridge part.PCB Portion is connected to LCD by the flexible PCB portion (seeing below) allowing to move axially betwixt further and input key (does not shows Go out) and it is connected to the sensor device being arranged in piston tube far-end driving head 22.Housing is installed to connecting flange portion 11.
Forward a keeper assembly to, in the assembled state, cylinder keeper component 30 spin locking ground but axially displaceably Be arranged on actuating sleeve 40 internal, this actuating sleeve 40 axial lock ground but rotatably movably install to underframe connecting flange portion 11.Actuating sleeve has operating position and loading/unloading position, and in this operating position, oval sleeve rotating is and ovum Circular shell flushes and cylinder keeper component is retracted to its operation and closes holding position, in this loading/unloading position, oval Shape sleeve rotating is not for flushing with oval housing and cylinder keeper component extends to open " loaded " position to allow to remove cylinder And change new cylinder.
Cylinder keeper includes a pair relative flexible arm 31 that proximally ring portion extends, and each arm is equipped with far-end clamping part 35, this far-end clamping part 35 has multiple circumferentially-spaced clamping tooth towards near-end separated so that with above-described on cylinder Towards far-end point prominent joint.The opposed slot 32 of a pair portrait orientation is formed in arm, and this slit receives shape respectively The spline 42 of one-tenth portrait orientation on the inner surface of actuating sleeve, this provides the axially directed non-rotating joint with sleeve. Two relative gaps (window) 33 are formed between a keeper arm, each window and the corresponding window 43 being formed in outer tubular sleeve Alignment, these two pair window moves together when rotation into alignment.Corresponding with the embodiment of Fig. 3 B, when actuating sleeve revolves from operating position When turning, clamping part to far-end and laterally moves to its open position.Cylinder keeper component and arm are relative to the shifting of actuating sleeve Dynamic is that this guider is arranged between a keeper and/or underframe connecting flange portion by making guider cooperation control. In the embodiment illustrated, the moving axially by the cylinder keeper being received in corresponding flange portion guide rail 16 of cylinder keeper component Guide prominent 36 to control, and the transverse shifting of far-end clamping part is by the corresponding tilt surface being arranged on a keeper far-end And correspondingly controlled by actuating sleeve, i.e. it is similar to the layout shown in Fig. 3 A and Fig. 3 B.
Fig. 5 shows that motor gear not shown in FIG. 4 drives assembly 300.More specifically, assembly 300 includes pipe Shape major part 310, this tubular main portion 310 is made up of near-end motor sub-assembly 320 and far-end gear case assembly 330, and this is remote End gearbox 330 have limit the rotatable drive shaft 331(of z rotation axis and see Fig. 7).Being used for of controller circuitry controls horse The part reached can be incorporated in motor sub-assembly.This assembly farther includes distal circles cylindricality drive member 351, this far-end cylinder Shape drive member 351 has the external screw thread being adapted to be arranged as driving pipe female thread to engage with piston.Plate-like is had in proximal end arrangement Underframe adapter 361.Corresponding with the flexible joint described with reference to Fig. 1, drive assembly 300 to be provided with flexible joint, this flexibility connects Head is in far-end universal joint 350 with the form of near-end universal joint 360, and this far-end universal joint 350 is arranged in drive shaft and drives Between dynamic component, this near-end universal joint 360 is arranged between motor sub-assembly close end and underframe pipe close end.
It should be noted that the assembly that drives of Fig. 5 itself drives together with representing General expansion at the such as driving Guan Ye shown in Fig. 4 Move assembly, and it can be used in other design of the many relevant to compact and reliable telescopic driving assembly.
Go to Fig. 6, illustrate in further detail far-end universal joint 350.But conventional universal joints (or card steps on and connects Head) to arrange and be designed as axially being spaced between two the axle portions separated offer joint, shown universal joint then wraps Include the input link being partially positioned within outer output link.More specifically, this universal joint is arranged and is included: axle in a tubular form The input link of the form of adapter 353, this tubulose mandrel connector 353 is adapted to non-rotatably install on the driving shaft；In outward The tubulose output link of the form of threaded drive member 351；And connect the horizontal of this input link and this output link Component 357.Mandrel connector includes the relative flange 354 of a pair remote extension, each flange have be adapted to receive joint pin Hinge base 355.Drive member is included in a pair relative hinge base 356 of far-end, and this is to relative hinge base 356 are adapted to receive a pair joint pin.Cross member includes: first to relative laterally projecting joint pin 358, and this is first to phase To laterally projecting joint pin 358 be adapted to by fasten tion reception in the hinge base 355 of mandrel connector；And second To relative laterally projecting joint pin 359, the laterally projecting joint pin 359 that this second couple is relative is adapted to be connect by fastening effect Being contained in the hinge base 356 of drive member, this first pair of joint pin and this second pair of joint pin offset relative to each other 90 degree, Thus universal joint is provided in combination.
Being formed with far-end universal joint and compare, near-end universal joint 360 does not rotates during driving the operation of assembly.Near-end Universal joint includes: be adapted to non-rotatably install the tubular motor assembly connector 363 to motor sub-assembly near-end；It is adapted to non- The plate-like underframe adapter 361 being rotationally mounted in underframe pipe near-end；And connect the two adapter to form Universal connector The cross member 367 of head.The parts of proximal joint include that the pin corresponding with distal joint and pedestal, difference are that the two is even Connect device member cloth to be set to axially by each other.
By providing the driving assembly as described above with universal joint, motor gear drives assembly 300 to allow Moving relative to underframe, such as, warpage or " swing ", as drive member 351 allows relative to horse together with driving pipe 20 Reaching gear drive assembly and therefore move also relative to underframe, such as, warpage or " swing ", this layout also provides for desired Rotating transmission, so allow cost-effective design, the tolerance needed for involved parts is the strictest.
Fig. 7 shows the sectional view of the drug delivery device of Fig. 1, where it can be seen that have two ten thousand described above To the driving assembly of joint.Below with reference to Fig. 8, the feature of this device is described more fully.
Go to Fig. 8 to Figure 10, under different modes of operation, show the cross section of the drug delivery device 1 of Fig. 2 and Fig. 4 Figure, Fig. 8 shows the device being under initial empty, and under this initial empty, cylinder keeper cuts out and piston Pipe is fully retracted.In all Fig. 8 to Figure 10, discharge assembly only form in piston tube, eliminate for purpose clearly Motor and gear-box drive assembly.
More specifically, Fig. 8 shows the mobile biasing member 50 to distal-most position, in this distal-most position, far End ring portion 50 adjoins the corresponding stop surfaces on underframe, and base portion 55 is freely.Actuating sleeve 40 rotates to its operating position, And cylinder keeper component 30 is retracted to its closed position.As can be seen, along with biasing member is in its distal-most position, Cylinder switch 73 is under its non-actuating state, and this shows unloaded cylinder to controlling electronic device.Correspondingly, piston tube is positioned at it In retracted position.As can be seen, when cylinder keeper assembly activates to its open position, biasing member does not moves and cylinder is opened Close and keep not activating.
Other details multiple can be seen in fig. 8.Button 90 is received in housing proximal end opening and by annular brace Component 91 supports, and this annular support member 91 is by being locked to housing with prominent 92 of corresponding opening 82 joint in housing.Bullet Spring 95 provides on button and is proximally directed bias force, and this spring 95 is arranged between button and supporting member.It can be seen that adapt to It is arranged on bridge part in the above-mentioned second switch 75 controlled by near-end actuation button.The flexible-belt 76 with multiple conductor is arranged Having U-shaped bend pipe 77, this U-shaped bend pipe 77 is between PCB portion 71 and the sensor (not shown) being arranged in piston head, and this is corresponding Ground allows piston tube and piston head axially to advance together with the movement of U-shaped bend pipe.
Turn to Fig. 9, it can be seen that device has the cylinder of installation and shifted onto the work of almost distal-most position by piston tube Plug.Before arriving this state, there occurs following situation compared with the state of Fig. 4.When user expects handling tube, actuating sleeve Rotate to its loading/unloading position, and cylinder keeper retaining shoulder moves to its open position (see figure 10).As mentioned above Arriving, biasing member does not moves.Then user inserts new cylinder by distal openings in cylinder keeper, until cylinder proximal edge is sat Fall against the pedestal finger piece 55 of biasing member.Due to the biasing of spring, so user knows that cylinder is inserted the most completely initially Enter and should the most proximally not promote.Subsequently, user makes actuating sleeve be rotated back to its mode of operation, thus causes clamping Shoulder inwardly and moves proximally to, so that cylinder is retracted to its fully inserted position, thus also makes biasing member against spring Biasing moves proximally to, and this causes cylinder switch 73 to activated.Cylinder switch provides letter for cutting out to Setup Controller from opening actuating Number expression can assume that and there occurs following action: (i) cylinder already inserted into, and (ii) cylinder keeper has been switched off, and this initiates Driving head to far-end move into cylinder piston contact.In the embodiment illustrated, it is contemplated to by being arranged in driving head The detection contacted that electronic sensor device is driven between head with piston, such as, by using such as WO 2013/ Near-end detection disclosed in 144152.Alternatively, can be by being monitored detecting contact to the load on motor, such as, By electric current is monitored.This device has been started up and is ready for using now, during use, piston will be made to far End is mobile until cylinder has emptied, and goes out as shown in FIG. 9.As can be seen, the U-shaped bent portion 77 of flexible connector also to Far-end is moved.
Such as see from the description above normal loading process carried out, start motor control be based on an assumption that By closing the position that cylinder movement is loaded completely by cylinder keeper to it.But, add access customer and support during cylinder inserts The near-end that is biased towards spring forces cylinder, then biasing member will be made to move proximally to and activate cylinder switch.Owing to assume that This actuating is not that user has a mind to for it, and piston tube is advanced and can be postponed to carry out for several seconds again, in order to wait that user closes rightly Cylinder keeper.
Going to Figure 10, it can be seen that the cylinder keeper of this device is opened, biasing member promotes empty cylinder, and piston to far-end Pipe moves to its retracted position.Before arriving this state, there occurs following situation compared with the state of Fig. 5.When user expects When removing cylinder (this empties completely or partly empties), user makes actuating sleeve rotate and loads/unloading to it Position, thus cylinder keeper retaining shoulder moves to its open position, this allow by the far-end guide offset power of biasing member to Near-end promotes cylinder.In order to prevent cylinder from " penetrating " or skid off a keeper, can provide few between cylinder keeper and handling tube Amount frictional force.When biasing member is moved to far-end by spring, biasing member just disconnects and the joint of cylinder switch.Cylinder switch from Closing to activate provides signal to represent to Setup Controller to assume that and there occurs following two actions for opening: (i) cylinder keeper Having already turned on, and (ii) promoted the cylinder inserted by biasing member to far-end, this has initiated piston tube and has been retracted to it Fully retracted position, as seen in Figure 10.To take a moment owing to making piston tube retract, so user generally will be Piston tube has been fully retracted and has removed cylinder before, but, all it is entirely positioned in cylinder owing to being in the piston tube in all positions Inside keeper, so just protecting it not by accidental damage, after tradition, handling tube keeper is removing it from major part Back piston Guan Huicong device highlights, and this may result in it by accidental damage.During normal service condition, it can be assumed that piston Pipe is fully retracted when user inserts new cylinder, but, in order to prevent " the fastest " to insert new cylinder, user can obtain indicate with etc. Device to be instructed is already prepared to receive the signal of cylinder, such as, acoustical signal.
In description to exemplary embodiment above, the different knots to the function described by providing for different parts Structure and device have carried out a certain degree of description, and this describes degree and makes the design of the present invention for the reader having technology to be Significantly.Detailed configuration and the specification of different parts are counted as technical staff according to performed by the content listed in this specification The target of normal design proce.

Claims (8)

1. one kind drives assembly (300), and described driving assembly (300) including:
-supporting construction (10),
-include the driving pipe (20) of female thread (21),
-motor sub-assembly (310), described motor sub-assembly has distal portion and close end, and described distal portion includes rotatable drive shaft (331) and be adapted to be received in inside described driving pipe, and
-include the drive member (351) of external screw thread (352),
Wherein:
-described drive member external screw thread (352) is threadedly engaged with described driving pipe female thread (21),
-described motor sub-assembly (310) is arranged as non-rotatable relative to described supporting construction,
-described drive pipe (20) be arranged as relative to described motor sub-assembly axially displaceable but non-rotatable,
-described motor sub-assembly close end is connected to described supporting construction via the first flexible joint (350), and
-described drive shaft is connected to described drive member via the second flexible joint (360),
Wherein, the rotation of described drive shaft causes the axial non-rotating displacement relative to described supporting construction of the described driving pipe.
Driving assembly the most according to claim 1, wherein:
-described drive shaft (331) limits general axis, and
-described first flexible joint (350) and described second flexible joint (360) are configured to prevent relative to described general axis Between described motor sub-assembly close end and described supporting construction, correspondingly described drive shaft and described drive member it Between rotation and move axially.
3. according to the driving assembly described in claims 1 or 2, wherein, each described flexible joint all in universal joint, spiral Spring or the form of Oldham coupling.
Driving assembly the most according to any one of claim 1 to 3, wherein, if described driving pipe is relative to described Support structure axially displaceable but non-rotatable, the most described drive pipe (20) and described supporting construction include cooperate guide frame.
5. a drug delivery device (1), described drug delivery device (1) includes according to institute any one of Claims 1-4 The driving assembly stated, described drug delivery device (1) farther includes:
-compartment (41), described compartment (41) is adapted to the filling medicine receiving and keeping to have the piston (5) being axially movable Cylinder (2), and
-controller (70), described controller (70) is used for controlling described motor sub-assembly,
Wherein:
-described drive pipe (20) to be adapted to directly or indirectly to engage with the described piston of handling tube and directly or Person makes described piston axially move indirectly, thus discharges medicine from described cylinder.
Drug delivery device the most according to claim 5, wherein, described controller and described motor sub-assembly are adapted to, and make Described driving pipe moves in a distal direction thus discharges medicine from handling tube, and makes described driving pipe in contrary near-end side Move up so that described driving pipe is retracted from handling tube.
Drug delivery device the most according to any one of claim 1 to 6, described drug delivery device farther includes to set Determining device, described setting device allows user to set drug dose to be discharged.
8., according to the drug delivery device according to any one of claim 5 to 7, described drug delivery device includes:
-rechargable power supplies (72), and
-electrical cnnector, described electrically connect machine allow connect external power supply connector so that described power supply is charged,
Wherein, described controller be adapted to detection instruction external power source be connected to the condition of described electrical cnnector and prohibit subsequently With described discharge assembly, thus prevent to discharge medicine from handling tube when external power source is already attached to described electrical cnnector Thing.
CN201580022281.3A 2014-05-02 2015-04-29 Telescopic drive arrangement for drug delivery device Withdrawn CN106232161A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14166859 2014-05-02
EP14166859.0 2014-05-02
PCT/EP2015/059384 WO2015165992A1 (en) 2014-05-02 2015-04-29 Telescopic drive arrangement for drug delivery device

Publications (1)

Publication Number Publication Date
CN106232161A true CN106232161A (en) 2016-12-14

Family

ID=50588604

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580022281.3A Withdrawn CN106232161A (en) 2014-05-02 2015-04-29 Telescopic drive arrangement for drug delivery device

Country Status (5)

Country Link
US (1) US10137254B2 (en)
EP (1) EP3137135A1 (en)
JP (1) JP2017514603A (en)
CN (1) CN106232161A (en)
WO (1) WO2015165992A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111281781A (en) * 2020-04-15 2020-06-16 李虹 Health preserving instrument
CN112867521A (en) * 2018-10-03 2021-05-28 伊莱利利公司 Status sensing system in an injection device assembly

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3473550B1 (en) * 2017-10-17 2020-07-01 CESA, Compania Espanola de Sistemas Aeronauticos, S.A. Electrical telescopic strut construction

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003099357A1 (en) * 2002-05-24 2003-12-04 Eli Lilly And Company Medication injecting apparatus with fluid container piston-engaging drive member having internal hollow for accommodating drive member shifting mechanism
EP1801457A1 (en) * 2004-09-16 2007-06-27 Scientific Technologies Ltd. Method and device for power transmission with load-sensing thrust amplifying mechanism

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2598528A (en) 1948-12-20 1952-05-27 Louis O French Fuel injection apparatus
DE804455C (en) 1949-10-14 1951-04-23 Hauptner Instrumentenfabrik H Precision injection syringe
GB2044879B (en) 1979-03-29 1983-03-16 Ford J Drive mechanism for converting rotory to reciprocating motion and vice versa
US4639245A (en) 1985-12-20 1987-01-27 Oximetrix, Inc. Fluid infusion pump driver
WO1992004926A1 (en) 1990-09-21 1992-04-02 Novo Nordisk A/S Adaptor top
WO1997000091A1 (en) 1995-06-14 1997-01-03 Berney Jean Claude Linear-transmission syringe plunger
CN1243578C (en) 1998-01-30 2006-03-01 诺沃挪第克公司 An injection syringe
US6171286B1 (en) * 1999-04-20 2001-01-09 James R. Gross Self-aligning syringe plunger
US6514230B1 (en) 1999-10-12 2003-02-04 Novo Nordisk A/S Air shot mechanism for electronic injection devices
FR2809464B1 (en) 2000-05-26 2002-10-11 Commissariat Energie Atomique SCREW TRANSMISSION, NUT AND CABLE ATTACHED TO SCREW
WO2002034315A1 (en) 2000-10-27 2002-05-02 Novo Nordisk A/S A medication delivery device with telescopic piston rod
WO2002083209A1 (en) 2001-04-13 2002-10-24 Nipro Diabetes Systems Drive system for an infusion pump
FR2884722A1 (en) 2005-04-20 2006-10-27 Becton Dickinson France Soc Pa INJECTION ASSEMBLY AND ASSISTANCE DEVICE
US7887521B2 (en) 2006-05-17 2011-02-15 Alcon Research, Ltd. Ophthalmic injection system
US7703377B2 (en) 2006-08-19 2010-04-27 Stabilus Gmbh Bend-resistant piston/cylinder unit
JP5653217B2 (en) 2007-10-02 2015-01-14 メディモップ メディカル プロジェクツ、エル・ティー・ディー External drug pump
US9345836B2 (en) 2007-10-02 2016-05-24 Medimop Medical Projects Ltd. Disengagement resistant telescoping assembly and unidirectional method of assembly for such
EP2140897B1 (en) * 2008-06-30 2011-05-25 Animas Corporation Drive mechanism
EP2391408B1 (en) * 2008-12-31 2018-01-17 Roche Diabetes Care GmbH Portable medical fluid delivery device with drive screw articulated with reservoir plunger
WO2010100883A1 (en) 2009-03-04 2010-09-10 パナソニック株式会社 Drug infusion device
DK2451508T3 (en) 2009-07-08 2014-02-10 Novo Nordisk As FROZEN PROTECTED INJECTION DEVICE
EP2335755A1 (en) 2009-12-17 2011-06-22 Sanofi-Aventis Deutschland GmbH Device and method for delivery of two or more drug agents
EP2332600A1 (en) * 2009-12-09 2011-06-15 F. Hoffmann-La Roche AG A method of filling a container with a liquid drug
CN104136059B (en) 2012-02-24 2017-08-29 诺和诺德股份有限公司 Delivery device with preceding load characteristic
EP2830680A1 (en) 2012-03-27 2015-02-04 Novo Nordisk A/S Drug delivery device with piston proximity sensing
EP3102260A1 (en) 2014-02-03 2016-12-14 Novo Nordisk A/S Telescopic drive arrangement
WO2015121494A1 (en) 2014-02-17 2015-08-20 Novo Nordisk A/S Telescopic drive arrangement with oldham coupling

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003099357A1 (en) * 2002-05-24 2003-12-04 Eli Lilly And Company Medication injecting apparatus with fluid container piston-engaging drive member having internal hollow for accommodating drive member shifting mechanism
EP1801457A1 (en) * 2004-09-16 2007-06-27 Scientific Technologies Ltd. Method and device for power transmission with load-sensing thrust amplifying mechanism

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112867521A (en) * 2018-10-03 2021-05-28 伊莱利利公司 Status sensing system in an injection device assembly
CN112867521B (en) * 2018-10-03 2022-07-19 伊莱利利公司 Status sensing system in an injection device assembly
CN111281781A (en) * 2020-04-15 2020-06-16 李虹 Health preserving instrument

Also Published As

Publication number Publication date
US10137254B2 (en) 2018-11-27
JP2017514603A (en) 2017-06-08
EP3137135A1 (en) 2017-03-08
WO2015165992A1 (en) 2015-11-05
US20170143909A1 (en) 2017-05-25

Similar Documents

Publication Publication Date Title
CN103945881B (en) There is initial lock state, the centre note medical delivery device to state and drug delivery state
US20170175859A1 (en) Telescopic Drive Arrangement with Oldham Coupling
US20170007774A1 (en) Telescopic Drive Arrangement
CN104136059B (en) Delivery device with preceding load characteristic
CN101687080B (en) Device for administering a fluid active substance from a multi-chamber ampoule
CN107106761A (en) The interface of self orientation pressure jacket and pressure jacket to syringe
US20120041387A1 (en) Medicament Delivery Devices
CN101925374A (en) Device for injecting apportioned doses of liquid drug
CN105828856B (en) Motor-driven medicament delivery device with charging security feature
CN102802704A (en) Drug delivery device with cap functions for needle assembly
CN106714877A (en) Drug delivery device with cartridge centring feature
CN106456891A (en) Drug delivery device with indicator guidance
CN106232161A (en) Telescopic drive arrangement for drug delivery device
CN109641111A (en) The medicine delivery device that there is torque protection mechanism
CN106535963A (en) Nut assembly for medical device
CN103917263B (en) Including medical injection device and the medical infusion system of dosage limiter block
US11850402B2 (en) Automatic injection device with reusable portion
JP6715391B2 (en) Drug delivery device with mechanical locking system
CN107073214A (en) Drug delivery devices with actuator piston distal side feature
CN110382023A (en) Cap assembly with cylinder
KR20220160114A (en) AUTO-INJECTOR DEVICE EQUIPPED WITH RECONSTITUTION FUNCTIONALITY FOR MULTIPLE CHAMBER DRUG CARTRIDGE

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication
WW01 Invention patent application withdrawn after publication

Application publication date: 20161214