CN106215246B - Chitosan/polyethylene glycol lubricating sol and preparation method and application thereof - Google Patents
Chitosan/polyethylene glycol lubricating sol and preparation method and application thereof Download PDFInfo
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- CN106215246B CN106215246B CN201610619365.1A CN201610619365A CN106215246B CN 106215246 B CN106215246 B CN 106215246B CN 201610619365 A CN201610619365 A CN 201610619365A CN 106215246 B CN106215246 B CN 106215246B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/10—Materials for lubricating medical devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Abstract
The invention discloses a chitosan/polyethylene glycol lubricating sol, a preparation method and application thereof, wherein the mass fraction of the chitosan/polyethylene glycol lubricating sol is as follows: 1-2 wt% of glacial acetic acid, 1-2.5 wt% of chitosan and 5-50 wt% of polyethylene glycol. The chitosan/polyethylene glycol sol prepared by the invention has biocompatibility and biodegradability, is expected to be used for artificial joints, is green in preparation process, does not generate pollutant emission, has an average friction coefficient of less than 0.01 under the conditions of a specific pressure of 1.4-7.0MPa and a sliding speed of 24mm/s, and has good lubricating property.
Description
Technical Field
The invention belongs to the field of biological tribology, and particularly relates to a chitosan/polyethylene glycol lubricating sol, and a preparation method and application thereof.
Background
The artificial joint replacement surgery is an effective means for treating arthritis, and with the tendency that the social situation of aging population of China is aggravated and the number of unrecoverable fracture cases caused by various wounds is gradually increased, more and more people carry out the artificial joint replacement surgery. Joint replacement surgery is widely used worldwide due to definite curative effect, short postoperative rehabilitation time and mature technology. After the joint replacement operation, the joint capsule secreting synovial fluid is cut off, the artificial joint takes body fluid as a lubricant, and the lubricating effect of the body fluid is poor, so that the service life of the artificial joint is seriously influenced. The need to prevent the wear of the artificial joint and to prolong the life of the artificial joint is increasingly urgent.
The ultra-high molecular weight polyethylene has long molecular chain and few side chains, and only weak van der Waals force exists between two adjacent chains, so that the molecules can slide easily. Because the ultra-high molecular weight polyethylene has excellent physiological inertia and physiological adaptability, the ultra-high molecular weight polyethylene becomes an ideal medical polymer material. The CoCrMo alloy not only has good corrosion resistance, abrasion resistance and thermal fatigue resistance, but also has good heat transfer property and low thermal expansion coefficient, and the Young modulus of the CoCrMo alloy is 220-234MPa which is far higher than that of materials such as stainless steel and the like. Although the performance of the artificial joint made of the ultra-high molecular weight polyethylene and the CoCrMo alloy is excellent, no effective lubricating adhesive can effectively prolong the service life of the artificial joint.
Disclosure of Invention
The invention aims to provide a chitosan/polyethylene glycol lubricating sol and a preparation method thereof, so as to solve the technical problems.
In order to achieve the purpose, the invention adopts the following technical scheme:
the preparation method of the chitosan/polyethylene glycol lubricating sol comprises the following steps: dissolving glacial acetic acid, chitosan and polyethylene glycol in water, fully dissolving and uniformly stirring to obtain chitosan/polyethylene glycol lubricating sol; the chitosan/polyethylene glycol lubricating sol comprises the following components in percentage by mass: 1-2 wt% of glacial acetic acid, 1-2.5 wt% of chitosan and 5-50 wt% of polyethylene glycol.
Furthermore, the polyethylene glycol is one or more polyethylene glycols with the molecular weight of 600-.
Furthermore, the chitosan is one or more of chitosan with the molecular weight of 60-90 ten thousand, and the deacetylation of the chitosan is more than or equal to 90.0 percent.
Further, the chitosan/polyethylene glycol lubricating sol comprises the following components in percentage by mass: 1 wt% of glacial acetic acid, 2.2 wt% of chitosan with 70 ten thousand molecular weight and 30 wt% of polyethylene glycol with 2000 molecular weight.
Further, the chitosan/polyethylene glycol lubricating sol comprises the following components in percentage by mass: 1 wt% of glacial acetic acid, 2 wt% of chitosan with molecular weight of 80 ten thousand and 30 wt% of polyethylene glycol with molecular weight of 2000.
The chitosan/polyethylene glycol lubricating sol prepared by the preparation method of the chitosan/polyethylene glycol lubricating sol.
Further, the average friction coefficient of the chitosan/polyethylene glycol lubricating sol is less than 0.01 under the conditions that the specific pressure is 1.4-7.0MPa and the sliding speed is 24 mm/s.
Use of a chitosan/polyethylene glycol lubricating sol for lubricating an artificial joint.
Now, compared with the prior art, the invention has the following advantages:
1. the prepared chitosan/polyethylene glycol lubricating sol has good biocompatibility and biodegradability.
2. The preparation process is green and free of pollutant emission, and large-scale preparation can be carried out.
3. The prepared chitosan/polyethylene glycol sol has an average friction coefficient of less than 0.01 under the conditions of a specific pressure of 1.4-7.0MPa and a sliding speed of 24mm/s, and has good lubricating performance.
Drawings
FIG. 1 shows the average friction coefficient of the sample of example 1 at different specific pressures, with ultra-high molecular weight polyethylene as a pin and CoCrMo alloy as a mating, and a sliding speed of 24 mm/s.
FIG. 2 shows the average friction coefficients of the sample of example 5 and other materials, in which ultra-high molecular weight polyethylene was used as a pin and CoCrMo alloy was used as a counter, the sliding speed was 24mm/s, and the specific pressure was 4.2 MPa.
Detailed Description
Example 1
Dissolving glacial acetic acid, chitosan and polyethylene glycol in water, and fully dissolving and uniformly stirring. The mass fraction is as follows: 1 wt% of glacial acetic acid, 2.2 wt% of chitosan with 70 ten thousand molecular weight and 30 wt% of polyethylene glycol with 2000 molecular weight.
Example 2
Dissolving glacial acetic acid, chitosan and polyethylene glycol in water, and fully dissolving and uniformly stirring. The mass fraction is as follows: glacial acetic acid 1.5 wt%, chitosan with molecular weight of 80 ten thousand 2.5 wt%, polyethylene glycol with molecular weight of 2500.5 wt% and polyethylene glycol with molecular weight of 1500.5 wt%.
Example 3
Dissolving glacial acetic acid, chitosan and polyethylene glycol in water, and fully dissolving and uniformly stirring. The mass fraction is as follows: 1 wt% of glacial acetic acid, 1 wt% of 60 ten thousand molecular weight chitosan and 25 wt% of 4000 molecular weight polyethylene glycol.
Example 4
Dissolving glacial acetic acid, chitosan and polyethylene glycol in water, and fully dissolving and uniformly stirring. The mass fraction is as follows: glacial acetic acid 2 wt%, chitosan with molecular weight of 90 ten thousand 2.5 wt% and polyethylene glycol with molecular weight of 600 50 wt%.
Example 5
Dissolving glacial acetic acid, chitosan and polyethylene glycol in water, and fully dissolving and uniformly stirring. The mass fraction is as follows: 1 wt% of glacial acetic acid, 2 wt% of chitosan with molecular weight of 80 ten thousand and 30 wt% of polyethylene glycol with molecular weight of 2000.
The experiment uses ultra-high molecular weight polyethylene pin and CoCrMo alloy to carry out pin-disc friction experiment, under the conditions of 4.2MPa of specific pressure and 24mm/s of sliding speed, the average friction coefficient of 2 wt% of 80 ten thousand molecular weight chitosan solution is 0.0683, and the average friction coefficient of 30 wt% of 2000 molecular weight polyethylene glycol is 0.0453. In natural animal cartilage joints, the friction coefficient between cartilage is 0.001-0.03, and the specific pressure of cartilage surface is 3-18 MPa. The chitosan/polyethylene glycol sol prepared by the invention has an average friction coefficient of less than 0.01 under the conditions of a specific pressure of 1.4-7.0MPa and a sliding speed of 24mm/s, and has good lubricating performance.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (4)
1. The preparation method of the chitosan/polyethylene glycol lubricating sol is characterized by comprising the following steps: dissolving glacial acetic acid, chitosan and polyethylene glycol in water, fully dissolving and uniformly stirring to obtain chitosan/polyethylene glycol lubricating sol; the chitosan/polyethylene glycol lubricating sol comprises the following components in percentage by mass: 1 wt% of glacial acetic acid, 2 wt% of chitosan with molecular weight of 80 ten thousand and 30 wt% of polyethylene glycol with molecular weight of 2000;
deacetylation of chitosan is more than or equal to 90.0%;
when the prepared chitosan/polyethylene glycol lubricating sol is subjected to a pin-disc friction experiment by taking ultra-high molecular weight polyethylene as a pin and a CoCrMo alloy as a matching pair, the average friction coefficient is less than 0.01 under the conditions of a specific pressure of 1.4-7.0MPa and a sliding speed of 24 mm/s.
2. The chitosan/polyethylene glycol lubricous sol prepared by the method of claim 1.
3. The chitosan/polyethylene glycol lubricating sol of claim 2, wherein the chitosan/polyethylene glycol lubricating sol has an average friction coefficient of less than 0.01 under the conditions of a specific pressure of 1.4-7.0MPa and a sliding speed of 24 mm/s.
4. Use of the chitosan/polyethylene glycol lubricating sol of claim 3 for lubricating an artificial joint with ultra-high molecular weight polyethylene as a pin and a CoCrMo alloy as a companion.
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| CN106215246B true CN106215246B (en) | 2019-12-24 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107349478A (en) * | 2017-06-08 | 2017-11-17 | 西安交通大学 | Sodium glycero-phosphate/chitosan/polyethylene glycol sustained-release gel and its production and use |
| CN107349477A (en) * | 2017-06-08 | 2017-11-17 | 西安交通大学 | Surface Texture filling graphene oxide slow release lubricant gel and its production and use |
| CN110522953B (en) * | 2018-05-24 | 2022-02-15 | 中国科学院兰州化学物理研究所 | Bionic joint lubricant and preparation method thereof |
| CN111268742A (en) * | 2020-02-12 | 2020-06-12 | 西安工程大学 | Preparation method of ferroferric oxide quantum dots |
Citations (5)
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|---|---|---|---|---|
| EP0499164A1 (en) * | 1991-02-12 | 1992-08-19 | C.R. Bard, Inc. | Injectable compositions to replace lubricating body fluids |
| CN101502675A (en) * | 2008-02-04 | 2009-08-12 | 山东省药学科学院 | Suspension of hyaluronic acid or salt thereof containing macromolecule hydrogel for injection and preparation method thereof |
| CN102872156A (en) * | 2012-10-09 | 2013-01-16 | 姜志银 | Lubricant containing hyaluronic acid |
| CN105213739A (en) * | 2015-11-13 | 2016-01-06 | 辛耀禄 | Medicine for the treatment of osteoarthritis and preparation method thereof |
| CN105601896A (en) * | 2016-01-15 | 2016-05-25 | 西安交通大学 | Artificial joint oriented low-friction injectable lubrication sol and method for preparing same |
-
2016
- 2016-08-01 CN CN201610619365.1A patent/CN106215246B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0499164A1 (en) * | 1991-02-12 | 1992-08-19 | C.R. Bard, Inc. | Injectable compositions to replace lubricating body fluids |
| CN101502675A (en) * | 2008-02-04 | 2009-08-12 | 山东省药学科学院 | Suspension of hyaluronic acid or salt thereof containing macromolecule hydrogel for injection and preparation method thereof |
| CN102872156A (en) * | 2012-10-09 | 2013-01-16 | 姜志银 | Lubricant containing hyaluronic acid |
| CN105213739A (en) * | 2015-11-13 | 2016-01-06 | 辛耀禄 | Medicine for the treatment of osteoarthritis and preparation method thereof |
| CN105601896A (en) * | 2016-01-15 | 2016-05-25 | 西安交通大学 | Artificial joint oriented low-friction injectable lubrication sol and method for preparing same |
Non-Patent Citations (1)
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| 可注射性壳聚糖基生物复合材料的研究;陈涛;《中国优秀博硕士学位论文全文数据库 (硕士) 工程科技Ⅰ辑》;20060615;第2006年卷(第06期);正文第30页，33页，36页，40页 * |
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