CN106215243A - A kind of novel hydrophilic antiseep absorbable medical film and preparation method thereof - Google Patents

A kind of novel hydrophilic antiseep absorbable medical film and preparation method thereof Download PDF

Info

Publication number
CN106215243A
CN106215243A CN201610794410.7A CN201610794410A CN106215243A CN 106215243 A CN106215243 A CN 106215243A CN 201610794410 A CN201610794410 A CN 201610794410A CN 106215243 A CN106215243 A CN 106215243A
Authority
CN
China
Prior art keywords
layer
spinning
hydrophilic
preparation
antiseep
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610794410.7A
Other languages
Chinese (zh)
Inventor
张新燕
万隆
刘超
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHANGHAI DIVINE MEDICAL TECHNOLOGY Co Ltd
Original Assignee
SHANGHAI DIVINE MEDICAL TECHNOLOGY Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHANGHAI DIVINE MEDICAL TECHNOLOGY Co Ltd filed Critical SHANGHAI DIVINE MEDICAL TECHNOLOGY Co Ltd
Priority to CN201610794410.7A priority Critical patent/CN106215243A/en
Publication of CN106215243A publication Critical patent/CN106215243A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/222—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/045—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/28—Layered products comprising a layer of synthetic resin comprising synthetic resins not wholly covered by any one of the sub-groups B32B27/30 - B32B27/42
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B33/00—Layered products characterised by particular properties or particular surface features, e.g. particular surface coatings; Layered products designed for particular purposes not covered by another single class
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
    • B32B5/22—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by the presence of two or more layers which are next to each other and are fibrous, filamentary, formed of particles or foamed
    • B32B5/24—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by the presence of two or more layers which are next to each other and are fibrous, filamentary, formed of particles or foamed one layer being a fibrous or filamentary layer
    • B32B5/26—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by the presence of two or more layers which are next to each other and are fibrous, filamentary, formed of particles or foamed one layer being a fibrous or filamentary layer another layer next to it also being fibrous or filamentary
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2250/00—Layers arrangement
    • B32B2250/03—3 layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2250/00—Layers arrangement
    • B32B2250/20—All layers being fibrous or filamentary
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2250/00—Layers arrangement
    • B32B2250/24—All layers being polymeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2262/00—Composition or structural features of fibres which form a fibrous or filamentary layer or are present as additives
    • B32B2262/02—Synthetic macromolecular fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/728—Hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/73—Hydrophobic

Abstract

The invention discloses a kind of novel hydrophilic antiseep absorbable medical film and preparation method thereof, described medical films includes: hydrophilic layer absorbed layer and anti-leakage layer；Described hydrophilic layer, absorbed layer and anti-leakage layer laminated structure successively, forms hydrophilic antiseep absorbable medical film；Described hydrophilic layer is for organizing docile with damage, and described absorbed layer is for the tissue hydrops of absorptive tissue seepage, and described anti-leakage layer is for preventing the seepage of tissue fluid.A kind of novel hydrophilic antiseep absorbable medical film of the present invention and preparation method thereof, possess hydrophilic layer, absorbed layer, anti-leakage layer, while making absorbed layer can be good at absorptive tissue sepage and ensure that tissue sepage will not leak into surrounding tissue, improve the sticking nature of product, absorbability, leakproof, bring great convenience to surgical field, especially have great prospect repairing of cerebral dura mater (spinal meninges) defect in the application replaced.

Description

A kind of novel hydrophilic antiseep absorbable medical film and preparation method thereof
Technical field
The present invention relates to field of medical article technology, particularly relate to a kind of novel hydrophilic antiseep absorbable medical film and Preparation method.
Background technology
At present, viscous gram absorbable medical film commercially occupies the biggest component, is widely used in surgical operation postoperative Prevent being adhered.Also there is a lot of similar absorbable medical film on market, all due to the unicity of its structure, be difficult to accomplish sticking nature Good, absorption sepage completely and prevents the feature that seepage property is good from all possessing, and single its scope of application that also can limit of structure, It is difficult to repairing and the replacement of dura defect.
Summary of the invention
The technical problem to be solved is: provide a kind of novel hydrophilic antiseep absorbable medical film and preparation thereof Method, it is possible to improve the sticking nature of product, absorbability, leakproof, can be applicable to the repairing of cerebral dura mater (spinal meninges) defect and replaces Change.
For solving above-mentioned technical problem, the technical scheme is that
Thering is provided a kind of novel hydrophilic antiseep absorbable medical film, described medical films includes: hydrophilic layer absorbed layer and antiseepage Drop ply；Described hydrophilic layer, absorbed layer and anti-leakage layer laminated structure successively, forms hydrophilic antiseep absorbable medical film；Described Hydrophilic layer is for organizing docile with damage, and described absorbed layer is used for the tissue hydrops of absorptive tissue seepage, described anti-leakage layer In the seepage preventing tissue fluid.
Also provide for the preparation method of a kind of novel hydrophilic antiseep absorbable medical film, comprise the steps:
Taking a certain amount of spinning liquid, spinning parameter is fltting speed 18mL/h, receiving range 23cm, and spinning syringe needle footpath is 1.07um, spinning voltage is 19KV, prepares hydrophilic layer；
Taking a certain amount of spinning liquid, spinning parameter is fltting speed 15mL/h, receiving range 23cm, and spinning syringe needle footpath is 0.67um, spinning voltage is 21KV, prepares absorbed layer；
Taking a certain amount of spinning liquid, spinning parameter is fltting speed 12mL/h, receiving range 23cm, and spinning syringe needle footpath is 0.5um, spinning voltage is 23KV, prepares anti-leakage layer；
Wherein, hydrophilic layer, absorbed layer, anti-leakage layer are to spin successively to be sequentially overlapped on same reception paper, i.e. can be made into Novel hydrophilic antiseep absorbable medical film.
Wherein, in above-mentioned novel hydrophilic antiseep absorbable medical film, described spinning liquid be acetone, ethyl acetate, six Fluorine isopropanol, dichloromethane, N, one or both in N-dimethylformamide, aqueous acetic acid and chloroform.
Wherein, in above-mentioned preparation method, described hydrophilic layer is Polyethylene Glycol, chitosan, gelatin and polylactic acid-glycolic base second One in acid.
Wherein, in above-mentioned preparation method, described absorbed layer is in polylactic acid, the lactide of lactide-and poly-own ester A kind of.
Wherein, in above-mentioned preparation method, described absorbed layer is the electrostatic spinning nano fiber film of fiber fluffy.
Wherein, in above-mentioned preparation method, described anti-leakage layer is in polylactic acid, the lactide of lactide-and poly-own ester One.
Wherein, in above-mentioned preparation method, described anti-leakage layer is the electrostatic spinning nano fiber film that fiber is fine and close.
Have employed technique scheme, the invention have the benefit that
Compared with prior art, a kind of novel hydrophilic antiseep absorbable medical film of the present invention and preparation method thereof, tool Standby hydrophilic layer, absorbed layer, anti-leakage layer so that while absorbed layer can be good at absorptive tissue sepage and ensure tissue sepage Surrounding tissue will not be leaked into, improve the sticking nature of product, absorbability, leakproof, bring pole to surgical field Big facility, especially has great prospect repairing of cerebral dura mater (spinal meninges) defect in the application replaced.
Accompanying drawing explanation
Fig. 1 is the structural representation of the novel hydrophilic antiseep absorbable medical film of the present invention；
In figure: 1 is hydrophilic layer；2 is absorbed layer；3 is anti-leakage layer.
Detailed description of the invention
Below in conjunction with the accompanying drawings and embodiment, the detailed description of the invention of the present invention is described in further detail.Hereinafter implement Example is used for illustrating the present invention, but can not be used for limiting the scope of the present invention.
As it is shown in figure 1, the novel hydrophilic antiseep absorbable medical film of the present invention includes: hydrophilic layer 1, absorbed layer 2 and anti- Seepage floor 3.This hydrophilic layer 1, absorbed layer 2 and anti-leakage layer 3 laminated structure successively, form hydrophilic antiseep absorbable medical film.
Hydrophilic layer 1, absorbed layer 2 and anti-leakage layer 3 pass sequentially through layer upon layer electrostatic spinning laminated structure, and electrostatic spinning is third Ketone, ethyl acetate, hexafluoroisopropanol, dichloromethane, N, one in N-dimethylformamide, aqueous acetic acid and chloroform or Two kinds so that hydrophilic layer 1, absorbed layer 2 and antiseep 3 are fitted by layer upon layer electrostatic spinning successively.
Specifically, hydrophilic layer 1 for and damage tissue docile, this hydrophilic layer 1 be Polyethylene Glycol, chitosan, gelatin and One in poly lactic-co-glycolic acid, has absorbable structure.
Absorbed layer 2 is for the tissue hydrops of absorptive tissue seepage, and this absorbed layer 2 be polylactic acid, the lactide of lactide-and gathers One in own ester, is formed as the electrostatic spinning nano fiber film of fiber fluffy, has the water absorption for fiber fluffy and can absorb Structural material.
Anti-leakage layer 3 is for preventing the seepage of tissue fluid, and this anti-leakage layer 3 be polylactic acid, the lactide of lactide-and poly-own One in ester, this anti-leakage layer 3 is the electrostatic spinning nano fiber film that fiber is fine and close, has the densification preventing tissue fluid seepage Property can absorb structural material.
Art finishes, and is placed in by medical films at wound, open and flat, flicking docile, is sewed up by wound.Specifically, medical films is placed in At tissue injury so that hydrophilic layer 1 and the good docile of wound tissue, the tissue fluid at wound will be deep into polylactic acid layers, logical Crossing absorbed layer 2 and suck tissue fluid in fluffy fibre structure, anti-leakage layer 3 prevents the tissue fluid seepage that absorbed layer 2 sucks.Cause This, this novel medical films can be widely used in surgery and various surgical operation wound, and sticking nature is good, the green peace of material Entirely, easy and simple to handle, can be by Matrix absorption, it is not necessary to second operation take out, expand the scope of application of this class absorbable medical film, especially It is repairing and the replacement of cerebral dura mater (spinal meninges) defect.
The preparation method of the novel hydrophilic antiseep absorbable medical film of the present invention, comprises the steps:
Taking a certain amount of spinning liquid, spinning parameter is fltting speed 18mL/h, receiving range 23cm, and spinning syringe needle footpath is 1.07um, spinning voltage is 19KV, prepares hydrophilic layer；
Taking a certain amount of spinning liquid, spinning parameter is fltting speed 15mL/h, receiving range 23cm, and spinning syringe needle footpath is 0.67um, spinning voltage is 21KV, prepares absorbed layer；
Taking a certain amount of spinning liquid, spinning parameter is fltting speed 12mL/h, receiving range 23cm, and spinning syringe needle footpath is 0.5um, spinning voltage is 23KV, prepares anti-leakage layer；
Wherein, hydrophilic layer, absorbed layer, anti-leakage layer are to spin successively to be sequentially overlapped on same reception paper, i.e. can be made into Novel hydrophilic antiseep absorbable medical film.
This preparation method is specifically introduced below by several embodiments.
[embodiment one]
Preparation of spinning solution: take a certain amount of poly lactic-co-glycolic acid and join for 6%-15% with mass ratio with hexafluoroisopropanol Spinning liquid A processed, its optimal proportioning is poly lactic-co-glycolic acid 50 grams with hexafluoroisopropanol with mass ratio is 8% to be configured to spin Silk liquid A；Taking a certain amount of polylactic acid and prepare spinning liquid B with mass ratio for 10%-18% with acetone, its optimal proportioning is poly-breast Acid 50 grams and acetone are 16% to be configured to spinning liquid B with mass ratio；Taking a certain amount of polylactic acid and N, N-dimethylformamide is with matter Amount prepares spinning liquid B than for 9%-16%, and its optimal proportioning is polylactic acid 50 grams and N, and N-dimethylformamide with mass ratio is 13% is configured to spinning liquid from C；
The preparation of hydrophilic layer: draw each 20mL of spinning liquid A with disposable injection injection device 4, spinning parameter is fltting speed 18mL/h, receiving range 23cm, spinning syringe needle footpath is 1.07um, and spinning voltage is 19KV；
The preparation of water accepting layer: draw each 40mL of spinning liquid B with disposable injection injection device 4, spinning parameter is fltting speed 15mL/h, receiving range 23cm, spinning syringe needle footpath is 0.67um, and spinning voltage is 21KV；
The preparation of anti-leakage layer: draw each 30mL of spinning liquid C with disposable injection injection device 4, spinning parameter is for advancing speed Degree 12mL/h, receiving range 23cm, spinning syringe needle footpath is 0.5um, and spinning voltage is 23KV；
Its hydrophilic layer, absorbed layer, anti-leakage layer are to spin successively to be sequentially overlapped on same reception paper, make hydrophilic antiseepage Leakage absorbable medical film I.
[embodiment two]
Preparation of spinning solution: take a certain amount of chitosan and prepare spinning liquid A with mass ratio for 6%-15% with aqueous acetic acid, Its optimal proportioning be poly-50 grams of shell be 8% to be configured to spinning liquid A with aqueous acetic acid with mass ratio；Take a certain amount of poly-(third The lactide of lactide-) prepare spinning liquid B with mass ratio for 8%-18% with chloroform, its optimal proportioning be poly-(lactide- Lactide) 50 grams be 9% to be configured to spinning liquid B with chloroform with mass ratio；Take a certain amount of polylactic acid and chloroform with Mass ratio is that 6%-16% prepares spinning liquid B, and its optimal proportioning is polylactic acid 50 grams with chloroform with mass ratio is 8% to join Make spinning liquid from C；
The preparation of hydrophilic layer: draw each 20mL of spinning liquid A with disposable injection injection device 4, spinning parameter is fltting speed 18mL/h, receiving range 23cm, spinning syringe needle footpath is 1.07um, and spinning voltage is 19KV；
The preparation of water accepting layer: draw each 40mL of spinning liquid B with disposable injection injection device 4, spinning parameter is fltting speed 15mL/h, receiving range 23cm, spinning syringe needle footpath is 0.67um, and spinning voltage is 21KV；
The preparation of anti-leakage layer: draw each 30mL of spinning liquid C with disposable injection injection device 4, spinning parameter is for advancing speed Degree 12mL/h, receiving range 23cm, spinning syringe needle footpath is 0.5um, and spinning voltage is 23KV；
Its hydrophilic layer, absorbed layer, anti-leakage layer are to spin successively to be sequentially overlapped on same reception paper, make hydrophilic antiseepage Leakage absorbable medical film II.
[embodiment three]
Preparation of spinning solution: take a certain amount of poly lactic-co-glycolic acid and join for 6%-15% with mass ratio with hexafluoroisopropanol Spinning liquid A processed, its optimal proportioning is poly lactic-co-glycolic acid 50 grams with hexafluoroisopropanol with mass ratio is 10% to be configured to spin Silk liquid A；Taking a certain amount of poly-(lactide-lactide) and prepare spinning liquid B with mass ratio for 8%-18% with chloroform, it is Good proportioning is poly-(lactide-lactide) 50 grams with chloroform with mass ratio is 9% to be configured to spinning liquid B；Take a certain amount of Polylactic acid and chloroform prepare spinning liquid B with mass ratio for 6%-16%, its optimal proportioning is polylactic acid 50 grams and three Chloromethanes is 10% to be configured to spinning liquid from C with mass ratio；
The preparation of hydrophilic layer: draw each 20mL of spinning liquid A with disposable injection injection device 4, spinning parameter is fltting speed 18mL/h, receiving range 23cm, spinning syringe needle footpath is 1.07um, and spinning voltage is 19KV；
The preparation of water accepting layer: draw each 40mL of spinning liquid B with disposable injection injection device 4, spinning parameter is fltting speed 15mL/h, receiving range 23cm, spinning syringe needle footpath is 0.67um, and spinning voltage is 21KV；
The preparation of anti-leakage layer: draw each 30mL of spinning liquid C with disposable injection injection device 4, spinning parameter is for advancing speed Degree 12mL/h, receiving range 23cm, spinning syringe needle footpath is 0.5um, and spinning voltage is 23KV；
Its hydrophilic layer, absorbed layer, anti-leakage layer are to spin successively to be sequentially overlapped on same reception paper, make hydrophilic antiseepage Leakage absorbable medical film III.
The performance test of hydrophilic antiseep absorbable medical film
1, hydrophilic test
2, antiseep test
The animal experiment of hydrophilic antiseep absorbable medical film:
Laboratory animal is local beasle dog, and unification is provided by The 2nd Army Medical College.To newly purchased dog breeders 2 weeks, observe Experiment is entered after their health, growth promoter situation and nursing custom.Specific embodiments is to be shaved by dog after intravenous anesthesia Capillus, is placed in animal on special-purpose operating table, ventricumbent position.The crown hits exactly, longitudinally slit scalp, uses Single-pole electric knife after entering scalp Along sagittal suture, side opens about 0.5 centimetre, is individually separated bilateral top muscle group, with detacher separation periosteum, exposes Double Tops portion skull The skull plate of 4cm × 3cm, opens skull with High speed drill mill, and High speed drill mill Double Tops portion skull, it is left that Double Tops portion forms 1cm × 2cm Right dura defect.First test sample is taken out from packaging bag, be trimmed to the size of 1.5cm × 2.5cm, just to cover Living the defect after excision cerebral dura mater, 3/0 not damaged wire discontinuous sewing, test sample four limit is respectively sewed up a pin, is tied a knot during stitching Being close to i.e. stop, make artificial dura mater and primary dura mater not stay lacuna as far as possible, involutory smooth, needle gage is uniform.After having closed cerebral dura mater, The most uniformly it is sprinkled into wound with penicillin sodium powder, strengthens prevention anastomotic stoma and infect.With round needle, No. 1 silk suture muscle, epidural is double Film drainage strip is put in side, and scalp is with No. 4 wire discontinuous sewings.
Post operation sends Animal House back to after animal is completely clear-headed, stops fluid infusion, and full diet is raised.3d after animal surgery In, 2 times/d of penicillin, 800,000 units/time intramuscular injection, 2 times/d of chloromycetin, 0.5g/ intramuscular injection；Post operation 4 6d, blue or green 1 time/d of mycin, 800,000 units/time intramuscular injection, 1 time/d, 0.5g/ intramuscular injection of chloromycetin.Simultaneously observe animal normal The physiological activity of feed, drinking-water and other each side is normal, the dyskinesia simultaneously caused without central nervous system injury and other is different Often.
The animal experiment tracking result of hydrophilic antiseep absorbable medical film:
As it has been described above, a kind of novel hydrophilic antiseep absorbable medical film of the present invention, possess hydrophilic layer, absorbed layer, prevent Seepage floor so that while absorbed layer can be good at absorptive tissue sepage and ensure that tissue sepage will not leak into group around Knit, improve the sticking nature of product, absorbability, leakproof, bring great convenience to surgical field, especially exist Repairing of cerebral dura mater (spinal meninges) defect has great prospect in the application replaced.
The above-mentioned description to embodiment is to be understood that for ease of those skilled in the art and apply this Bright.These embodiments obviously easily can be made various amendment by person skilled in the art, and described herein General Principle is applied in other embodiments without through performing creative labour.Therefore, the invention is not restricted to enforcement here Example, those skilled in the art should be the present invention's according to the announcement of the present invention, the improvement made for the present invention and amendment Within protection domain.

Claims (8)

1. a novel hydrophilic antiseep absorbable medical film, it is characterised in that described medical films includes: hydrophilic layer (1), absorption Layer (2) and anti-leakage layer (3)；Described hydrophilic layer (1), absorbed layer (2) and anti-leakage layer (3) laminated structure successively, formed hydrophilic Antiseep absorbable medical film；Described hydrophilic layer (1) is for organizing docile with damage, and described absorbed layer (2) is used for absorptive tissue The tissue hydrops of seepage, described anti-leakage layer (3) is for preventing the seepage of tissue fluid.
2. the method preparing novel hydrophilic antiseep absorbable medical film as claimed in claim 1, it is characterised in that bag Include following steps:
Taking a certain amount of spinning liquid, spinning parameter is fltting speed 18mL/h, receiving range 23cm, and spinning syringe needle footpath is 1.07um, spinning voltage is 19KV, prepares hydrophilic layer；
Taking a certain amount of spinning liquid, spinning parameter is fltting speed 15mL/h, receiving range 23cm, and spinning syringe needle footpath is 0.67um, spinning voltage is 21KV, prepares absorbed layer；
Taking a certain amount of spinning liquid, spinning parameter is fltting speed 12mL/h, receiving range 23cm, and spinning syringe needle footpath is 0.5um, spinning voltage is 23KV, prepares anti-leakage layer；
Wherein, hydrophilic layer, absorbed layer, anti-leakage layer are to spin successively to be sequentially overlapped on same reception paper, i.e. can be made into novel Hydrophilic antiseep absorbable medical film.
Preparation method the most according to claim 2, it is characterised in that described spinning liquid is that acetone, ethyl acetate, hexafluoro are different Propanol, dichloromethane, N, one or both in N-dimethylformamide, aqueous acetic acid and chloroform.
Preparation method the most according to claim 2, it is characterised in that described hydrophilic layer (1) be Polyethylene Glycol, chitosan, One in gelatin and poly lactic-co-glycolic acid.
Preparation method the most according to claim 2, it is characterised in that described absorbed layer (2) is polylactic acid, lactide- One in lactide and poly-own ester.
Preparation method the most according to claim 2, it is characterised in that described absorbed layer (2) is the Static Spinning of fiber fluffy Nano fibrous membrane.
Preparation method the most according to claim 2, it is characterised in that described anti-leakage layer (3) be polylactic acid, lactide- Lactide and the one in poly-own ester.
Preparation method the most according to claim 2, it is characterised in that described anti-leakage layer (3) is the electrostatic that fiber is fine and close Spinning nanometer fiber membrane.
CN201610794410.7A 2016-08-31 2016-08-31 A kind of novel hydrophilic antiseep absorbable medical film and preparation method thereof Pending CN106215243A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610794410.7A CN106215243A (en) 2016-08-31 2016-08-31 A kind of novel hydrophilic antiseep absorbable medical film and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610794410.7A CN106215243A (en) 2016-08-31 2016-08-31 A kind of novel hydrophilic antiseep absorbable medical film and preparation method thereof

Publications (1)

Publication Number Publication Date
CN106215243A true CN106215243A (en) 2016-12-14

Family

ID=58075311

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610794410.7A Pending CN106215243A (en) 2016-08-31 2016-08-31 A kind of novel hydrophilic antiseep absorbable medical film and preparation method thereof

Country Status (1)

Country Link
CN (1) CN106215243A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114803160A (en) * 2021-01-27 2022-07-29 宁波方太厨具有限公司 Moisture absorption bag and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101559242A (en) * 2009-05-22 2009-10-21 广州迈普再生医学科技有限公司 Nano artificial dura mater capable of being used as medicine sustained-release system and preparation method thereof
JP2011219879A (en) * 2010-04-05 2011-11-04 Teijin Ltd Fiber composite
CN103418031A (en) * 2012-05-17 2013-12-04 天津市康尔医疗器械有限公司 Absorbable endocranium healing patch and preparation method thereof
CN105194737A (en) * 2014-05-30 2015-12-30 广州迈普再生医学科技有限公司 Tissue repair support and its preparation method and use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101559242A (en) * 2009-05-22 2009-10-21 广州迈普再生医学科技有限公司 Nano artificial dura mater capable of being used as medicine sustained-release system and preparation method thereof
JP2011219879A (en) * 2010-04-05 2011-11-04 Teijin Ltd Fiber composite
CN103418031A (en) * 2012-05-17 2013-12-04 天津市康尔医疗器械有限公司 Absorbable endocranium healing patch and preparation method thereof
CN105194737A (en) * 2014-05-30 2015-12-30 广州迈普再生医学科技有限公司 Tissue repair support and its preparation method and use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114803160A (en) * 2021-01-27 2022-07-29 宁波方太厨具有限公司 Moisture absorption bag and preparation method thereof

Similar Documents

Publication Publication Date Title
CN106029361B (en) Substitute the substrates multilayer and application thereof of tissue
CN106581779A (en) Skin burn repair material and preparing method thereof
RU2577709C2 (en) Anisotropic composite implants for tissue reinforcement with orientation labels and methods for manufacturing them
CN103800097B (en) A kind of tissue repair fibrous membrane and manufacture method thereof and application
CN103948960B (en) A kind of containing nanometer silver porous silicone rubber/polyurethane double-layered artificial skin and preparation method thereof
CN106492274B (en) Tissue repair tunica fibrosa and its preparation method and application and tissue repair product
CN103800942B (en) Pelvic floor patch
US20160045296A1 (en) Fiber membranes for repairing tissue and products and preparation method thereof
CN105555328B (en) film and manufacturing method
JP2011161231A (en) Vacuum patch for rapid wound closure
CN101358382A (en) Antibacterial nano fiber material and preparation method thereof
CN102600018A (en) Medical dressing with cooling function and wound healing prompting function and preparation method of medical dressing
CN108478866A (en) Tissue recovery support, preparation method and use
CN105919694A (en) Multi-layer electrospun membrane and use thereof
CN109528352A (en) A kind of shape-memory polymer carries medicine intestinal stent and preparation method thereof
CN106215243A (en) A kind of novel hydrophilic antiseep absorbable medical film and preparation method thereof
KR101190503B1 (en) nanofiber sheet with core-shell structure
Hall et al. Artificial skin
CN102920528A (en) Hollowed-out membrane used as hernia patch and preparation method thereof
EP3801653A1 (en) Absorbent biophotonic fiber system
CN202477853U (en) Special X-ray detectable gauze piece for operation
US20200276379A1 (en) Tissue cuff
CN204158424U (en) A kind of implant device for the treatment of fistula
CN106806933B (en) Use of polyamide gauze as wound dressing
CN110742708A (en) Fixing and sewing method for preventing rodentia animal wound skin from shrinking and application thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20161214