CN106215220A - A kind of wound dressing of NEW TYPE OF COMPOSITE crosslinking pulullan polysaccharide - Google Patents
A kind of wound dressing of NEW TYPE OF COMPOSITE crosslinking pulullan polysaccharide Download PDFInfo
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- CN106215220A CN106215220A CN201610825671.0A CN201610825671A CN106215220A CN 106215220 A CN106215220 A CN 106215220A CN 201610825671 A CN201610825671 A CN 201610825671A CN 106215220 A CN106215220 A CN 106215220A
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- Prior art keywords
- pulullan polysaccharide
- solution
- wound
- carboxylated
- new type
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/225—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
Abstract
The present invention relates to biomedical materials field, the wound dressing of a kind of NEW TYPE OF COMPOSITE crosslinking pulullan polysaccharide, including carboxylated pulullan polysaccharide, carboxymethyl chitosan, sodium alginate and hyaluronic acid；Wound surface is had holding to moisten by the present invention, antibacterial action；Not having thermosensitive response, safe and nontoxic, the compatibility is good；There is certain pliability and intensity, too much sepage can either be absorbed, Moist healing environment, accelerating wound healing, adhesion wound can also be provided for wound simultaneously, not result in secondary damage；Promoting healing curative effect is obvious.
Description
Technical field
The present invention relates to biomedical materials field, the wound of a kind of NEW TYPE OF COMPOSITE crosslinking pulullan polysaccharide applies
Material.
Background technology
Pulullan polysaccharide is a kind of outer water soluble polysaccharide of the born of the same parents produced by Aureobasidium pullulans fermentation, owing to it is nontoxic,
Film property, biocompatibility well waits good characteristic to be studied by numerous scholars.Research shows, this novel high polymer polysaccharide
Material water retention property is excellent, can be effectively prevented the dehydration of cell and biological tissue, and in molecular structure, hydroxyl is numerous, permissible
It is chemically modified, grafting functional biomolecule or medicine, has and promote cell growth or the effect of suppression antibacterial.
Chitosan is that the chitin being widely present by nature obtains through deacetylation, and itself and derivant are equal
Having the effects such as hemostasis, pain relieving and suppression growth of microorganism, these have positive meaning for the healing of wound surface；Therefore shell gathers
Sugar has been supplied in the necks such as artificial skin, osseous tissue renovating material, self-absorption operation suture thread, wound dressing and Thermosensitive Material Used for Controlled Releasing of Medicine
Territory.
Sodium alginate forms hydrogel in wound surface when using, and can not only provide, to wound healing, the environment moistened, and
And be gradually biodegradable in sepage at wound healing process, wound surface there is no residual fiber left, when it contacts with wound exudate
Time, the sodium alginate of solubility is generated by ion exchange, fiber can be transformed into viscosity by calcium ion slowly that displace
Sodium alginate soln, newborn tissue will not damage again because of the adhesion of dressing, can accelerate wound surface hemostasis.
Along with improving constantly of modern medical service level, traditional dressing can not meet people and repair variety classes wound
Multiple requirement.Owing to wound surface form and healing phases are different, the requirement to wound dressing is also not quite similar, therefore homogenous material system
Standby wound dressing can not meet the overall needs of wound healing；Compound dressing be by two or more different materials (or with
Kind of material multi-form) covering that formed, the deficiency of the wound dressing that its appearance compensate for single or monotype material is made.
Summary of the invention
In order to solve the problems referred to above, the present invention provides the wound dressing of a kind of NEW TYPE OF COMPOSITE crosslinking pulullan polysaccharide, to wound
Face has holding moistening and antibacterial action, it is possible to accelerating wound healing, adhesion wound, does not results in secondary damage.
The technical solution adopted for the present invention to solve the technical problems is: the wound of a kind of NEW TYPE OF COMPOSITE crosslinking pulullan polysaccharide
Mouth dressing, including carboxylated pulullan polysaccharide, carboxymethyl chitosan, sodium alginate and hyaluronic acid；Utilize anhydride hydrolysis after with
Hydroxyl generation esterification, makes the hydroxyl on pulullan polysaccharide main chain by the carboxylated modification of part, then utilizes this modified material
Material is prepared by the way of secondary lyophilizing cross-links with carboxymethyl chitosan, sodium alginate and hyaluronic acid.
The preparation method of described carboxylated pulullan polysaccharide is as follows:
(1) weighing 13 ~ 18 g pulullan polysaccharides to be placed in 300 mL deionized waters, stirring makes it dissolve；
(2) after pulullan polysaccharide thoroughly dissolves, add DMAP and NaOH and make pH value of solution 8 ~ 9, stir 1 ~ 2 at 65 DEG C little
Time；
(3) in above-mentioned reaction solution add succinic anhydride 25 ~ 28 g, regulation reaction solution pH be 8 ~ 9,65 DEG C stir 22 ~
26 hours；
(4), after reaction solution is cooled to room temperature, reactant liquor is slowly added dropwise the cooling 80 % ethanol/water of 1400 ~ 1600 mL
Mixed liquor settles, precipitation is collected by filtration；
(5) repeat the above steps 2 ~ 3 times, until sedimentation liquid pH is close to neutral；
(6) precipitation collected is vacuum dried and pulverizes, obtain carboxylated pulullan polysaccharide.
The preparation method of the wound dressing of a kind of NEW TYPE OF COMPOSITE crosslinking pulullan polysaccharide is as follows:
(1) weigh carboxylated pulullan polysaccharide according to the mass fraction of 1 ~ 5 wt%, stir and be dissolved in deionized water, preparation
Carboxylated pulullan polysaccharide solution a；
(2) carboxymethyl chitosan is dissolved in deionized water, is configured to the carboxymethyl chitosan that mass fraction is 1 ~ 5 wt% molten
Liquid b；
(3) with deionized water, sodium alginate preparation is become the sodium alginate soln c of 7 ~ 15 wt%；
(4) carboxylated pulullan polysaccharide solution a, carboxymethyl chitosan solution b and sodium alginate soln c are according to 3 ~ 8:2.5 ~ 7:
The quality of 0.5 ~ 1.5, than mix homogeneously, stands after being cooled to room temperature, adds the hyalomitome of interpolation 0.3 ~ 1.5 % in this solution
Acid, is stirred until homogeneous；
(5) measure the above-mentioned solution of same volume to pour in 24 orifice plates, be placed in 3 ~ 6 DEG C of environment standing and remove after bubble solution
Carry out lyophilization process, obtain uncrosslinked spongy material；
(6) material is taken out from 24 orifice plates, be soaked in the ethanol solution of 75 ~ 85 % containing EDCI/NHS, at room temperature hand over
Connection reaction 22 ~ 26 hours；
(7) after having reacted, use deionized water soaking and washing, remove catalyst, again carry out lyophilization, obtain a kind of novel
The wound dressing of composite crosslinking pulullan polysaccharide.
The invention has the beneficial effects as follows that the wound dressing of a kind of NEW TYPE OF COMPOSITE crosslinking pulullan polysaccharide has holding to wound surface
Moistening, antibacterial action；Not having thermosensitive response, safe and nontoxic, the compatibility is good；There is certain pliability and intensity, can either inhale
Receive too much sepage, Moist healing environment, accelerating wound healing, adhesion wound can also be provided for wound simultaneously, not result in
Secondary damage；Promoting healing curative effect is obvious.
Detailed description of the invention:
Embodiment one
The preparation method of described carboxylated pulullan polysaccharide is as follows:
(1) weigh 15 g pulullan polysaccharides to be placed in 300 mL deionized waters, be stirred continuously and make it dissolve；
(2) after pulullan polysaccharide thoroughly dissolves, adding DMAP and NaOH, keep pH value of solution 8 ~ 9,65 DEG C of heated and stirred 1 are little
Time；
(3) in above-mentioned reaction solution, it is dividedly in some parts totally 26 g succinic anhydrides regulate reactant liquor pH, makes it stable 8 ~ 9, continue
Continue stirring reaction 24 hours at 65 DEG C；
(4) after question response liquid is cooled to room temperature, take off device, reactant liquor is slowly added dropwise the cooling 80 % second of 1500 mL
Alcohol/water mixed liquid settles, precipitation is collected by filtration；
(5) repeat the above steps 2 ~ 3 times, until sedimentation liquid pH is close to neutral；
(6) precipitation collected is vacuum dried and pulverizes, obtain carboxylated pulullan polysaccharide.
The preparation method of the wound dressing of a kind of NEW TYPE OF COMPOSITE crosslinking pulullan polysaccharide is as follows:
(1) weigh carboxylated pulullan polysaccharide according to the mass fraction of 3 wt%, stir and be dissolved in deionized water, prepare carboxylic
Base pulullan polysaccharide solution a；
(2) weigh carboxymethyl chitosan, be dissolved in deionized water, be configured to the carboxymethyl chitosan that mass fraction is 3 wt%
Solution b；
(3) with deionization, sodium alginate preparation is become the sodium alginate soln c of 8 wt%；
(4) carboxylated pulullan polysaccharide solution a, carboxymethyl chitosan solution b and sodium alginate soln c are according to 5:4.5:0.5's
Quality, than mix homogeneously, stands after being cooled to room temperature, adds the hyaluronic acid adding 1 %, be stirred until homogeneous in this solution；
(5) measure the above-mentioned solution of same volume to pour in 24 orifice plates, be placed in 4 DEG C of environment standing, after removing bubble, solution is entered
Row lyophilization processes, and obtains uncrosslinked spongy material；
(6) being taken out from 24 orifice plates by material, be soaked in the ethanol solution of 80 % containing EDCI/NHS, at room temperature crosslinking is anti-
Answer 24 hours；
(7) after having reacted, use deionized water soaking and washing, remove catalyst, again carry out lyophilization, obtain a kind of new
The wound dressing of type composite crosslinking pulullan polysaccharide.
Embodiment two
The preparation method of described carboxylated pulullan polysaccharide is as follows:
(1) weighing 13g pulullan polysaccharide to be placed in 300 mL deionized waters, stirring makes it dissolve；
(2) after pulullan polysaccharide thoroughly dissolves, add DMAP and NaOH and make pH value of solution 8 ~ 9, stir 1.5 at 65 DEG C little
Time；
(3) adding succinic anhydride 27 g in above-mentioned reaction solution, regulation reaction solution pH is 8 ~ 9, little 65 DEG C of stirrings 22
Time；
(4), after reaction solution is cooled to room temperature, reactant liquor is slowly added dropwise the cooling 80 % ethanol/water mixing of 1600 mL
Liquid settles, precipitation is collected by filtration；
(5) repeat the above steps 2 ~ 3 times, until sedimentation liquid pH is close to neutral；
(6) precipitation collected is vacuum dried and pulverizes, obtain carboxylated pulullan polysaccharide.
The preparation method of the wound dressing of a kind of NEW TYPE OF COMPOSITE crosslinking pulullan polysaccharide is as follows:
(1) weigh carboxylated pulullan polysaccharide according to the mass fraction of 2 wt%, stir and be dissolved in deionized water, prepare carboxylic
Base pulullan polysaccharide solution a；
(2) carboxymethyl chitosan is dissolved in deionized water, is configured to the carboxymethyl chitosan solution that mass fraction is 2 wt%
b；
(3) with deionized water, sodium alginate preparation is become the sodium alginate soln c of 7wt%；
(4) carboxylated pulullan polysaccharide solution a, carboxymethyl chitosan solution b and sodium alginate soln c are according to 7:2.5:0.5's
Quality, than mix homogeneously, stands after being cooled to room temperature, adds the hyaluronic acid of interpolation 0.3 ~ 1.5 % in this solution, and stirring is extremely
Uniformly；
(5) measure the above-mentioned solution of same volume to pour in 24 orifice plates, be placed in 5 DEG C of environment after standing removes bubble solution is entered
Row lyophilization processes, and obtains uncrosslinked spongy material；
(6) being taken out from 24 orifice plates by material, be soaked in the ethanol solution of 75 % containing EDCI/NHS, at room temperature crosslinking is anti-
Answer 22 hours；
(7) after having reacted, use deionized water soaking and washing, remove catalyst, again carry out lyophilization, obtain a kind of novel
The wound dressing of composite crosslinking pulullan polysaccharide.
Embodiment three
The preparation method of described carboxylated pulullan polysaccharide is as follows:
(1) weighing 16 g pulullan polysaccharides to be placed in 300 mL deionized waters, stirring makes it dissolve；
(2) after pulullan polysaccharide thoroughly dissolves, add DMAP and NaOH and make pH value of solution 8 ~ 9, stir 2 hours at 65 DEG C；
(3) adding succinic anhydride 25 g in above-mentioned reaction solution, regulation reaction solution pH is 8 ~ 9, little 65 DEG C of stirrings 26
Time；
(4), after reaction solution is cooled to room temperature, reactant liquor is slowly added dropwise the cooling 80 % ethanol/water mixing of 1400 mL
Liquid settles, precipitation is collected by filtration；
(5) repeat the above steps 2 ~ 3 times, until sedimentation liquid pH is close to neutral；
(6) precipitation collected is vacuum dried and pulverizes, obtain carboxylated pulullan polysaccharide.
The preparation method of the wound dressing of a kind of NEW TYPE OF COMPOSITE crosslinking pulullan polysaccharide is as follows:
(1) weigh carboxylated pulullan polysaccharide according to the mass fraction of 5 wt%, stir and be dissolved in deionized water, prepare carboxylic
Base pulullan polysaccharide solution a；
(2) carboxymethyl chitosan is dissolved in deionized water, is configured to the carboxymethyl chitosan solution that mass fraction is 3 wt%
b；
(3) with deionized water, sodium alginate preparation is become the sodium alginate soln c of 10 wt%；
(4) carboxylated pulullan polysaccharide solution a, carboxymethyl chitosan solution b and sodium alginate soln c are according to the quality of 3:6:1
Ratio mix homogeneously, stands after being cooled to room temperature, adds the hyaluronic acid adding 1.5 %, be stirred until homogeneous in this solution；
(5) measure the above-mentioned solution of same volume to pour in 24 orifice plates, be placed in 3 DEG C of environment after standing removes bubble solution is entered
Row lyophilization processes, and obtains uncrosslinked spongy material；
(6) being taken out from 24 orifice plates by material, be soaked in the ethanol solution of 85 % containing EDCI/NHS, at room temperature crosslinking is anti-
Answer 24 hours；
(7) after having reacted, use deionized water soaking and washing, remove catalyst, again carry out lyophilization, obtain a kind of novel
The wound dressing of composite crosslinking pulullan polysaccharide.
Claims (3)
1. the wound dressing of a NEW TYPE OF COMPOSITE crosslinking pulullan polysaccharide, it is characterised in that include carboxylated pulullan polysaccharide, carboxylic
Methyl chitosan, sodium alginate and hyaluronic acid.
The wound dressing of NEW TYPE OF COMPOSITE the most according to claim 1 crosslinking pulullan polysaccharide, it is characterised in that described carboxyl
The preparation method changing pulullan polysaccharide is as follows: (1) weighs 13 ~ 18 g pulullan polysaccharides and is placed in 300 mL deionized waters, stirring
Make it dissolve；(2) after pulullan polysaccharide thoroughly dissolves, add DMAP and NaOH make pH value of solution 8 ~ 9,65 DEG C stir 1 ~
2 hours；(3) adding succinic anhydride 25 ~ 28 g in above-mentioned reaction solution, regulation reaction solution pH is 8 ~ 9,65 DEG C of stirrings
22 ~ 26 hours；(4), after reaction solution is cooled to room temperature, reactant liquor is slowly added dropwise cooling 80 % of 1400 ~ 1600 mL
Ethanol/water mixed liquor settles, precipitation is collected by filtration；(5) repeat the above steps 2 ~ 3 times, until during sedimentation liquid pH is close
Property；(6) precipitation collected is vacuum dried and pulverizes, obtain carboxylated pulullan polysaccharide.
The wound dressing of NEW TYPE OF COMPOSITE the most according to claim 1 crosslinking pulullan polysaccharide, it is characterised in that preparation side
Method is as follows: (1) weighs carboxylated pulullan polysaccharide according to the mass fraction of 1 ~ 5 wt%, stirs and is dissolved in deionized water, system
Standby carboxylated pulullan polysaccharide solution a；(2) being dissolved in deionized water by carboxymethyl chitosan, being configured to mass fraction is 1 ~ 5
Carboxymethyl chitosan solution b of wt%；(3) with deionized water, sodium alginate preparation is become the sodium alginate soln of 7 ~ 15 wt%
c；(4) carboxylated pulullan polysaccharide solution a, carboxymethyl chitosan solution b and sodium alginate soln c according to 3 ~ 8:2.5 ~ 7:0.5 ~
The quality of 1.5, than mix homogeneously, stands after being cooled to room temperature, adds the hyaluronic acid of interpolation 0.3 ~ 1.5 %, stir in this solution
Mix to uniformly；(5) measuring the above-mentioned solution of same volume to pour in 24 orifice plates, it is right to be placed in 3 ~ 6 DEG C of environment after standing removes bubble
Solution carries out lyophilization process, obtains uncrosslinked spongy material；(6) material is taken out from 24 orifice plates, be soaked in and contain
In the ethanol solution of 75 ~ 85 % of EDCI/NHS, at room temperature cross-linking reaction 22 ~ 26 hours；(7) after having reacted, spend from
Sub-water soaking cleans, and removes catalyst, again carries out lyophilization, obtains the wound of a kind of NEW TYPE OF COMPOSITE crosslinking pulullan polysaccharide
Dressing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610825671.0A CN106215220A (en) | 2016-09-18 | 2016-09-18 | A kind of wound dressing of NEW TYPE OF COMPOSITE crosslinking pulullan polysaccharide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610825671.0A CN106215220A (en) | 2016-09-18 | 2016-09-18 | A kind of wound dressing of NEW TYPE OF COMPOSITE crosslinking pulullan polysaccharide |
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|---|---|
| CN106215220A true CN106215220A (en) | 2016-12-14 |
Family
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Family Applications (1)
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|---|---|---|---|
| CN201610825671.0A Pending CN106215220A (en) | 2016-09-18 | 2016-09-18 | A kind of wound dressing of NEW TYPE OF COMPOSITE crosslinking pulullan polysaccharide |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281556A (en) * | 2017-05-31 | 2017-10-24 | 苏州蔻美新材料有限公司 | It is a kind of to prevent the biomaterial of peritoneal adhesion |
| CN107675359A (en) * | 2017-09-25 | 2018-02-09 | 湖南农业大学 | A kind of Propiram/sodium alginate composite fiber film and its preparation method and application |
| CN108478846A (en) * | 2018-04-20 | 2018-09-04 | 薛春玲 | A kind of medical hemostatic antiseptic dressing and preparation method thereof |
| CN109758604A (en) * | 2019-01-14 | 2019-05-17 | 北京方诣生物医药有限公司 | A kind of skin repair preparation and its preparation method and application |
| CN110743033A (en) * | 2019-10-23 | 2020-02-04 | 辽宁燕阳医疗设备有限公司 | Medical dressing |
| CN111450030A (en) * | 2020-04-24 | 2020-07-28 | 山东星之诚生物科技有限公司 | Preparation method of alginate skin care emulsion |
| CN114028357A (en) * | 2021-09-28 | 2022-02-11 | 山东弥美生物科技股份有限公司 | Pullulan soft capsule and preparation method thereof |
| CN115260337A (en) * | 2022-08-15 | 2022-11-01 | 山东弥美生物科技股份有限公司 | Arginine grafted carboxylated pullulan polysaccharide and preparation method and application thereof |
| CN115737887A (en) * | 2022-11-07 | 2023-03-07 | 河北大学 | Skin wound dressing and preparation method thereof |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281556A (en) * | 2017-05-31 | 2017-10-24 | 苏州蔻美新材料有限公司 | It is a kind of to prevent the biomaterial of peritoneal adhesion |
| CN107675359B (en) * | 2017-09-25 | 2019-11-26 | 湖南农业大学 | A kind of Propiram/sodium alginate composite fiber film and its preparation method and application |
| CN107675359A (en) * | 2017-09-25 | 2018-02-09 | 湖南农业大学 | A kind of Propiram/sodium alginate composite fiber film and its preparation method and application |
| CN108478846A (en) * | 2018-04-20 | 2018-09-04 | 薛春玲 | A kind of medical hemostatic antiseptic dressing and preparation method thereof |
| CN109758604B (en) * | 2019-01-14 | 2022-05-24 | 北京方诣生物医药有限公司 | Skin repair preparation and preparation method and application thereof |
| CN109758604A (en) * | 2019-01-14 | 2019-05-17 | 北京方诣生物医药有限公司 | A kind of skin repair preparation and its preparation method and application |
| CN110743033A (en) * | 2019-10-23 | 2020-02-04 | 辽宁燕阳医疗设备有限公司 | Medical dressing |
| CN110743033B (en) * | 2019-10-23 | 2021-12-28 | 辽宁燕阳医疗设备有限公司 | Medical dressing |
| CN111450030A (en) * | 2020-04-24 | 2020-07-28 | 山东星之诚生物科技有限公司 | Preparation method of alginate skin care emulsion |
| CN114028357A (en) * | 2021-09-28 | 2022-02-11 | 山东弥美生物科技股份有限公司 | Pullulan soft capsule and preparation method thereof |
| CN115260337A (en) * | 2022-08-15 | 2022-11-01 | 山东弥美生物科技股份有限公司 | Arginine grafted carboxylated pullulan polysaccharide and preparation method and application thereof |
| CN115260337B (en) * | 2022-08-15 | 2023-11-03 | 山东弥美生物科技股份有限公司 | Arginine grafted carboxylated pullulan and preparation method and application thereof |
| CN115737887A (en) * | 2022-11-07 | 2023-03-07 | 河北大学 | Skin wound dressing and preparation method thereof |
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