CN106179148A - The microreactor of a kind of accurate amplification, preparation method and applications - Google Patents
The microreactor of a kind of accurate amplification, preparation method and applications Download PDFInfo
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- CN106179148A CN106179148A CN201610574054.8A CN201610574054A CN106179148A CN 106179148 A CN106179148 A CN 106179148A CN 201610574054 A CN201610574054 A CN 201610574054A CN 106179148 A CN106179148 A CN 106179148A
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- 230000003321 amplification Effects 0.000 title claims abstract description 20
- 238000003199 nucleic acid amplification method Methods 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 238000007599 discharging Methods 0.000 claims abstract description 58
- 238000006243 chemical reaction Methods 0.000 claims abstract description 33
- 239000007788 liquid Substances 0.000 claims abstract description 32
- 238000010146 3D printing Methods 0.000 claims abstract description 12
- 230000008859 change Effects 0.000 claims abstract description 11
- 239000007787 solid Substances 0.000 claims abstract description 10
- 239000006193 liquid solution Substances 0.000 claims abstract description 5
- 239000000463 material Substances 0.000 claims description 14
- 238000004088 simulation Methods 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 7
- 238000003860 storage Methods 0.000 claims description 7
- 238000004140 cleaning Methods 0.000 claims description 6
- 230000004044 response Effects 0.000 claims description 5
- 238000012805 post-processing Methods 0.000 claims description 4
- 208000026817 47,XYY syndrome Diseases 0.000 claims description 3
- 230000001788 irregular Effects 0.000 claims description 3
- 238000006555 catalytic reaction Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 12
- 239000012530 fluid Substances 0.000 abstract description 6
- 239000000126 substance Substances 0.000 abstract description 6
- 238000007639 printing Methods 0.000 abstract description 5
- 238000005516 engineering process Methods 0.000 abstract description 3
- 230000008676 import Effects 0.000 abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 239000007789 gas Substances 0.000 description 9
- 230000008901 benefit Effects 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 230000008569 process Effects 0.000 description 5
- 238000000605 extraction Methods 0.000 description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 229910052802 copper Inorganic materials 0.000 description 3
- 239000010949 copper Substances 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 238000007598 dipping method Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 230000005514 two-phase flow Effects 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000000975 co-precipitation Methods 0.000 description 1
- 238000004581 coalescence Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000021110 pickles Nutrition 0.000 description 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00819—Materials of construction
- B01J2219/00835—Comprising catalytically active material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00851—Additional features
- B01J2219/00855—Surface features
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00851—Additional features
- B01J2219/00858—Aspects relating to the size of the reactor
- B01J2219/0086—Dimensions of the flow channels
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micromachines (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The present invention relates to the microreactor of a kind of accurate amplification, preparation method and applications, belong to micro-chemical technology field.This microreactor accurately amplified includes charging aperture, at least 2 passages, discharging opening and connection pipeline, connecting the discharge pipe that pipeline includes being connected between connecting tube and passage with the discharging opening between the feed pipe being connected between charging aperture with passage, at least 2 passages, the feed entrance of feed pipe is to the gradual change from big to small of discharging inlet tubing diameter.This microreactor accurately amplified uses 3D printing technique and fluid mechanical emulation analog systems to combine printing and prepares.This microreactor can be applied in gas liquid reaction, reactive liquid solution, liquid-solid reaction, liquid-liquid reaction and liquid-liquid-solid reaction.The present invention solves the difficult problem that microreactor the most promising this chemical industry equipment accurately amplifies, achieve the integrated of thousands of microchannels, import and export the connection of main channel and thousands of the passages in inside, it is ensured that the temperature of each passage, pressure, flow pattern are highly consistent.
Description
Technical field
The present invention relates to the microreactor of a kind of accurate amplification, preparation method and applications, belong to micro-chemical technology field.
Background technology
Unique advantages such as it is high that microreactor has heat and mass efficiency, green, safety, and it is revolutionary to become chemical industry equipment
New results, there is boundless application prospect.Microreactor can realize moment of material and uniformly mixes and pass efficiently
Heat, therefore many reactions that cannot realize in conventional reactor can realize in microreactor.And microreactor
Micro-word table shows that the passage of process fluid in micron level rather than refers to that the overall dimensions of micro-reactor apparatus is little or the yield of product
Little.Microreactor can include thousands of microchannel in theory, therefore can also realize the highest yield.
But existing problem is, production has the microreactor of thousands of microchannel and is strictly hang-up.Perfect condition
Under, microreactor amplifies use " port number superposition (Numbering up) " mode, i.e. increases the mode of functional unit, but
It is that this mode means that and wants thousands of microchannels of process, and each passage is also possible to the knot with complexity
Structure, the structure of the contact channel between main channel and this thousands of passages is more complicated, because also needing to ensure that each leads to
The temperature in road, pressure, flow pattern are the most highly consistent.Therefore, the most current way amplifying microreactor is to take one
The amplification mode of kind compromise: " reaction chamber expansion ", such as, expanded as grade even Centimeter Level by micron order.The most permissible
It is greatly improved the treating capacity of reactor, reduces the pressure in passage.But, this scheme but can change some bases of microreactor
Eigen, such as by stably stratified flow or slug flow then become traditional turbulent flow, micron-sized stable fluid-flow contact becomes liquid
Drip the unstable contact of continuous coalescence, controlled knowable mass transfer interface becomes uncontrollable mass transfer interface, thus reduce micro-instead
Answer reaction efficiency or the selectivity of process so that the advantage of micro fluid reaction cannot give full play to.Multiple passages are carried it addition, use
Lamination of metal plates method can realize the increase of number of active lanes, but the connection between its main channel and thousands of of inside passage
Still it is difficult to, and the sealing of passage, encapsulation etc. are the most extremely difficult.
The 3D printing technique developed rapidly in recent years also begins to for producing microreactor, but does not but have solve accurately
Ground amplifies a difficult problem for microreactor.
Summary of the invention
The problem existed for above-mentioned prior art and deficiency, the present invention provides the microreactor of a kind of accurate amplification, system
Preparation Method and application thereof.The present invention solves the difficult problem that microreactor the most promising this chemical industry equipment accurately amplifies, it is achieved
Thousands of microchannels integrated, imports and exports the connection of main channel and inside thousands of passages, and guarantees that each leads to
The temperature in road, pressure, flow pattern are the most highly consistent, and the present invention is achieved through the following technical solutions.
The microreactor of a kind of accurate amplification, including charging aperture, at least 2 passages, discharging opening and connection pipeline, connecting tube
Road include the connecting tube between the feed pipe being connected between charging aperture with passage, at least 2 passages and passage and discharging opening it
Between connect discharge pipe, the feed entrance of feed pipe is to the gradual change from big to small of discharging inlet tubing diameter.
The feed entrance of described feed pipe is gradient to 0.2mm to discharging inlet tubing diameter from 0.5mm.
Described connection pipeline is Y type symmetrically or non-symmetrically, T-shaped, double-Y shaped, double-T shaped, Ψ type, camber, the one of notch cuttype
Kind or multiple combination.
Described passage is straight channel, the passage with multiple wedge shapes or arc area, curved channel, helical duct, broken line lead to
The combination of one or more in road, sieve aperture passage, irregular passage.
Single passage is provided with single heat exchange unit.
Described heat exchange unit includes single heat exchanger channels and connects pipeline and liquid in-out mouth.
Described passage is micron order or grade.
Dipping, reaction solidification, heat-treating methods is used to be provided with catalyst on described passage.
The port number that described microreactor comprises is thousands of the most.
The port number that described microreactor comprises is no less than 100.
The port number that described microreactor comprises is no less than 1000.
The port number that described microreactor comprises is not less than 10000.
The port number that described microreactor comprises is no less than 100000.
The port number that described microreactor comprises is no less than 1000000.
The port number that described microreactor comprises is no less than 10000000.
The port number that described microreactor comprises is no less than 100000000.
The microreactor of above-mentioned accurate amplification is micro-mixer and/or micro-heat exchanger.
In above-mentioned passage, the flow pattern of each phase is the combination of one or more of laminar flow, slug flow, drip or turbulent flow.
The microreactor preparation method of a kind of accurate amplification, it specifically comprises the following steps that
(1) response characteristic of single passage to be amplified, charging aperture, discharging opening and connection pipeline is studied, determine single
The structure of passage, size, pressure, flow, flow pattern, the optimum of temperature；
(2) structure of single passage that step (1) obtained, size, pressure, flow, flow pattern, the optimum of temperature are input to 3D
In printer model, the most integrated 2 passages, and add connection pipeline, it is achieved between each passage and passage and charging aperture and
Linking between discharging opening, it is thus achieved that accurately amplify the 3D printer model of microreactor；
(3) the 3D printer model accurately amplifying microreactor step (2) obtained carries out analogue simulation, optimizes and includes charging
Mouth, discharging opening, each connection pipeline, the structure of each passage and size；
(4) the 3D impression block accurately amplifying microreactor that step (2) is obtained by the structure after step (3) optimizes and size
Type is modified, and repeats analogue simulation and amendment, number of repetition according to circumstances depending on, obtain final 3D printer model；
(5) select 3D printing device according to required precision and printed material, step (4) is obtained final 3D printer model input
In the 3D print software that selected 3D printing device is corresponding, carry out two dimensionization slicing treatment, successively increase material and print, beat according to selected
The difference of print type carries out corresponding post processing, the microreactor accurately amplified.
In the 3D printer model of described step (2), charging aperture is two micro-liquid storage pipes of capsule, and the micro-liquid storage pipe of capsule passes through
Y-shaped structure leads to feed pipe interface channel；Discharging opening is split-phase pipeline, is provided with a diameter of at the top of split-phase pipeline and bottom
The drain pipe of 5mm.
The analogue simulation software of described step (3) is COMSOL, fluent or MATLAB.
In described step (5), post processing is the cleaning on microreactor surface, the cleaning of passage and dredging.
Described amended 3D printer model is pressed equal along Z-direction by above-mentioned steps (5) two dimensionization slicing treatment
Thickness is divided into a series of X-Y scheme.
A kind of application of the microreactor of accurate amplification, the microreactor of described accurate amplification is single-phase or heterogeneous reaction,
Including gas liquid reaction, reactive liquid solution, liquid-solid reaction, liquid-liquid reaction and liquid-liquid-solid reaction.
Described gas liquid reaction is GAS ABSORPTION, aeration, gas eluting.
Described reactive liquid solution is liquid liquid solvent extraction, organic synthesis.
Described liquid-solid reaction is coprecipitation solid particle.
The invention has the beneficial effects as follows:
(1) present invention solves the difficult problem that microreactor the most promising this chemical industry equipment accurately amplifies, it is achieved that Cheng Qianshang
Ten thousand microchannels integrated, imports and exports the connection of main channel and thousands of the passages in inside, and guarantee each passage temperature,
Pressure, flow pattern are the most highly consistent.
(2) present invention ensure that on the basis of improve microreactor treating capacity in the order of magnitude micro fluid reaction heat transfer passes
The advantage of matter, is significant.
(3) operational approach of the present invention is simple, strong operability, wide adaptability, can select different former according to no system
The advantages such as material, have broad application prospects.
Accompanying drawing explanation
Fig. 1 is the embodiment of the present invention 1 microreactor perspective view；
Fig. 2 is the embodiment of the present invention 1 microreactor perspective view；
Fig. 3 is the embodiment of the present invention 1 microreactor reaction channel zone cross-sectional schematic diagram.
In figure: the charging aperture of a-material A, the charging aperture of b-material B, c-feed pipe, d-reaction channel region, e-discharging
District, the single heat exchanger channels of f-, the single passage of g-.
Detailed description of the invention
Below in conjunction with the accompanying drawings and detailed description of the invention, the invention will be further described.
Embodiment 1
This microreactor accurately amplified, including charging aperture, 1000 passages, discharging opening and connection pipeline, connects pipeline and includes
The discharge nozzle being connected between connecting tube and passage with discharging opening between the feed pipe that is connected between charging aperture with passage, passage
Road, the feed entrance of feed pipe is to the gradual change from big to small of discharging inlet tubing diameter；Wherein the feed entrance of feed pipe arrives
Discharging inlet tubing diameter is gradient to 0.2mm from 0.5mm, and single passage is provided with single heat exchange unit, and heat exchange unit includes list
Individual heat exchanger channels and connect pipeline and liquid in-out mouth (as shown in Figure 3).
The microreactor accurately amplified is applied during liquid liquid solvent extraction, is related specifically to the extraction that copper ferrum separates
Reaction.
This microreactor preparation method accurately amplified, it specifically comprises the following steps that
(1) response characteristic of single passage to be amplified, charging aperture, discharging opening and connection pipeline is studied, determine single
The structure of passage is the optimum of straight channel, size, pressure, flow, flow pattern, temperature；
(2) structure of single passage step (1) obtained is straight channel, a size of 0.3 × 0.2 × 140mm(height, wide, length),
Pressure is 0.2Mpa, two phase flow respectively 0.01L/min, flow pattern is double interfaces laminar flow, temperature for room temperature, pH value be 1.5,
Feed pipe is input in 3D printer model for double " Y ", integrated 1000 passages, and adds connection pipeline, it is achieved each passage
Between and passage with charging aperture and discharging opening between be connected, it is thus achieved that accurately amplify the 3D printer model of microreactor, at this
During charging aperture be two diameter 10mm, it is each logical that a height of micro-liquid storage pipe of 50mm capsule is further ensured that water-oil phase enters
Pressure during road is consistent, and the feed entrance of double Y-shaped feed pipes is gradient to 0.2mm to discharging inlet tubing diameter from 0.5mm,
Discharging opening is diameter 20mm, the split-phase pipeline of high 50mm, has the drain pipe of a diameter of 5mm respectively will at its top and bottom
Oil, water biphase extraction reactor (perspective view as it is shown in figure 1, perspective view as shown in Figure 2)；
(3) the 3D printer model accurately amplifying microreactor step (2) obtained carries out being simulated by COMSOL software emulation,
Optimize and include charging aperture, discharging opening, each connection pipeline, the structure of each passage and size, concretely comprise the following steps: passage knot is set
Structure a size of global variable, carries out the parameters such as physical arrangement modeling, the difference viscosity of annex solution liquid two-phase extraction system, density,
Add CFD Laminar Flow and pipeline flow module, add in computing module channel size and the scanning of structural parameters and add
Enter majorized function, be simulated calculating, obtain the structural parameters optimized；
(4) the 3D impression block accurately amplifying microreactor that step (2) is obtained by the structure after step (3) optimizes and size
Type is modified, and repeats analogue simulation and amendment, number of repetition according to circumstances depending on, obtain final 3D printer model；
(5) select 3D printing device according to required precision and printed material, step (4) is obtained final 3D printer model input
In the 3D print software that selected 3D printing device is corresponding, carry out two dimensionization slicing treatment, use class ABS light-cured resin, adopt
Print with SLA laser curing forming technique, successively increase material and print, print after terminating, use ethanol clear at ultrasound wave immediately
In washing trough, cleaning prints the reactor surface obtained and inner passage, employing pump inject ethanol in passage, dredges inner passage,
Dry, the microreactor being amplified.
Being applied to by the microreactor of the present invention in the extractive reaction that copper ferrum separates, specific experiment result and parameter compare sees
Table 1.
Table 1
By the experiment of the extractive reaction that the copper ferrum of embodiment 1 separates, the microreactor of the present invention ensure that each passage
Temperature, pressure, flow pattern highly consistent, on the basis of improve microreactor treating capacity in the order of magnitude, ensure that miniflow simultaneously
The advantage of precursor reactant heat and mass.
Embodiment 2
This microreactor accurately amplified, including charging aperture, 10000 passages, discharging opening and connection pipeline, connects pipeline and includes
The discharge nozzle being connected between connecting tube and passage with discharging opening between the feed pipe that is connected between charging aperture with passage, passage
Road, the feed entrance of feed pipe is to the gradual change from big to small of discharging inlet tubing diameter；Wherein the feed entrance of feed pipe arrives
Discharging inlet tubing diameter is gradient to 0.2mm from 0.5mm, and single passage is provided with single heat exchange unit, and heat exchange unit includes list
Individual heat exchanger channels and connect pipeline and liquid in-out mouth (as shown in Figure 3).
The GAS ABSORPTION applied in gas liquid reaction by the microreactor accurately amplified, is related specifically to sig water and absorbs sulfur
Change the reaction of hydrogen.
This microreactor preparation method accurately amplified, it specifically comprises the following steps that
(1) response characteristic of single passage to be amplified, charging aperture, discharging opening and connection pipeline is studied, determine single
The structure of passage is the optimum of straight channel, size, pressure, flow, flow pattern, temperature；
(2) structure of single passage step (1) obtained is that inside has the helical channel of wedge-shape diversion bank, a size of diameter
0.23mm, pressure are 0.2Mpa, pressure is 0.3Mpa, gas-liquid flow respectively 50mL/min and 20mL/min, flow pattern are slug
Stream, passage length are 240mm, and temperature is 60 DEG C, feed pipe is input in 3D printer model for " Y ", and integrated 10000 lead to
Road, and add connection pipeline, it is achieved being connected between each passage and between passage with charging aperture and discharging opening, it is thus achieved that accurately
Amplifying the 3D printer model of microreactor, charging aperture is two a diameter of 30mm in the process, a height of micro-liquid storage of 80mm capsule
Pressure when pipe is further ensured that aqueous vapor biphase entrance each passage is consistent, and the feed entrance of Y-shaped feed pipe is to discharging
Inlet tubing diameter is gradient to 0.2mm from 0.5mm, and discharging opening is a diameter of 30mm, and the split-phase pipeline of a height of 80mm, at its top
The drain pipe of a diameter of 5mm is had respectively by biphase for gas and water extraction reactor with bottom；
(3) the 3D printer model accurately amplifying microreactor step (2) obtained carries out being simulated by fluent software emulation,
Optimize and include charging aperture, discharging opening, each connection pipeline, the structure of each passage and size；
(4) the 3D impression block accurately amplifying microreactor that step (2) is obtained by the structure after step (3) optimizes and size
Type is modified, and repeats analogue simulation and amendment, number of repetition according to circumstances depending on, obtain final 3D printer model
(5) select 3D printing device according to required precision and printed material, step (4) is obtained final 3D printer model input
In the 3D print software that selected 3D printing device is corresponding, carry out two dimensionization slicing treatment, be divided into by equal thickness and one be
Two bit pattern of row, then use metal sintering 3D Method of printing to obtain the microreactor of Ti alloy material of acid-alkali-corrosive-resisting；
After printing terminates, immediately use ethanol clear up in ultrasonic cleaner printing obtain reactor surface and inner passage, adopt
In passage, inject ethanol with pump, dredge inner passage, dry, the microreactor being amplified.
Use grinding machine to remove the burr of reactor surface, use pickle to carry out the cleaning in pipeline, then use compressed air
Blow internal residual liquid and residue off, obtain the microreactor product with 10000 passages.
The microreactor of the present invention is applied to sig water and absorbs the reaction of hydrogen sulfide gas, specific experiment result and parameter
Contrast is shown in Table 2.
Table 2
Absorbed the experiment of stink damp precursor reactant by the sig water of embodiment 2, the microreactor of the present invention ensure that respectively
The temperature of individual passage, pressure, flow pattern are highly consistent, ensure on the basis of improve microreactor treating capacity in the order of magnitude simultaneously
The advantage of micro fluid reaction heat and mass.
Embodiment 3
This microreactor accurately amplified, including charging aperture, 100 passages, discharging opening and connection pipeline, connect pipeline include into
Expect the discharge nozzle being connected between connecting tube and passage with discharging opening between the feed pipe being connected between mouth and passage, passage
Road, the feed entrance of feed pipe is to the gradual change from big to small of discharging inlet tubing diameter；Wherein the feed entrance of feed pipe arrives
Discharging inlet tubing diameter is gradient to 0.2mm from 0.5mm, and single passage is provided with single heat exchange unit, and heat exchange unit includes list
Individual heat exchanger channels and connect pipeline and liquid in-out mouth (as shown in Figure 3).
The GAS ABSORPTION applied in reactive liquid solution by the microreactor accurately amplified, particularly to for In3+And Fe3+、
Zn2+Microfluid extract and separate.
This microreactor preparation method accurately amplified, it specifically comprises the following steps that
(1) response characteristic of single passage to be amplified, charging aperture, discharging opening and connection pipeline is studied, determine single
The structure of passage is the optimum of straight channel, size, pressure, flow, flow pattern, temperature；
(2) structure of the single passage that step (1) is obtained be straight channel, a size of 0.6 × 0.05 × 140mm(width, height,
Long), pressure be 0.2Mpa, two phase flow respectively 0.01 L/min, flow pattern laminar flow, temperature be room temperature, pH value be 0.432, enter
Pipe material is that Y-shaped is input in 3D printer model, integrated 100 passages, and adds connection pipeline, it is achieved between each passage
And being connected between passage with charging aperture and discharging opening, it is thus achieved that accurately amplify the 3D printer model of microreactor, in this process
Middle charging aperture is that two micro-liquid storage pipes of capsule are consistent to pressure when being further ensured that the water phase and an oil phase each passage of entrance, Y-shaped
The feed entrance of feed pipe is gradient to 0.2mm to discharging inlet tubing diameter from 0.5mm, and discharging opening is a diameter of 30mm, high
For the split-phase pipeline of 80mm, the drain pipe of a diameter of 5mm is had oil, the biphase extraction of water to be reacted respectively at its top and bottom
Device；
(3) the 3D printer model accurately amplifying microreactor step (2) obtained carries out being simulated by fluent software emulation,
Optimize and include charging aperture, discharging opening, each connection pipeline, the structure of each passage and size；
(4) the 3D impression block accurately amplifying microreactor that step (2) is obtained by the structure after step (3) optimizes and size
Type is modified, and repeats analogue simulation and amendment, number of repetition according to circumstances depending on, obtain final 3D printer model
(5) select 3D printing device according to required precision and printed material, step (4) is obtained final 3D printer model input
In the 3D print software that selected 3D printing device is corresponding, carry out two dimensionization slicing treatment, by using class ABS light-cured resin,
SLA laser curing forming technique is used to print；Immediately use ethanol clear up in ultrasonic cleaner printing obtain anti-
Answer device surface and inner passage, employing pump to inject ethanol in passage, dredge inner passage, dry, the micro-reaction being amplified
Device.
The microreactor of the present invention is applied to In3+And Fe3+、Zn2+Microfluid extract and separate, specific experiment result and
Parameter compares and is shown in Table 3.
Table 3
In by embodiment 33+And Fe3+、Zn2+Microfluid extract and separate reaction experiment understand, the microreactor of the present invention
Ensure that the temperature of each passage, pressure, flow pattern are highly consistent, simultaneously at the base improving microreactor treating capacity in the order of magnitude
The advantage of micro fluid reaction heat and mass is ensure that on plinth.
Embodiment 4
This microreactor accurately amplified, including charging aperture, not less than 10000 passages, discharging opening and connection pipeline, connecting tube
Road includes being connected between the connecting tube between the feed pipe being connected between charging aperture with passage, passage and passage with discharging opening
Discharge pipe, the feed entrance of feed pipe is to the gradual change from big to small of discharging inlet tubing diameter；The feed entrance of feed pipe
It is gradient to 0.2mm from 0.5mm to discharging inlet tubing diameter；Connecting pipeline is asymmetric Y type and notch cuttype combination；Passage is
Straight channel and curved channel combination, single passage is provided with single heat exchange unit, heat exchange unit include single heat exchanger channels and
Connecting pipeline and liquid in-out mouth, passage is micron order or grade.
The microreactor of above-mentioned accurate amplification can be applied in liquid-liquid reacts.
Embodiment 5
This microreactor accurately amplified, including charging aperture, not less than 10000000 passages, discharging opening and connection pipeline, even
Adapter road includes connecting between the connecting tube between the feed pipe being connected between charging aperture with passage, passage and passage and discharging opening
The discharge pipe connect, the feed entrance of feed pipe is to the gradual change from big to small of discharging inlet tubing diameter；The charging of feed pipe
Entrance is gradient to 0.2mm to discharging inlet tubing diameter from 0.5mm；Connecting pipeline is asymmetric double-T shaped, camber and Ψ type group
Close；Passage is curved channel, helical duct, broken line passage, sieve aperture passage and curved channel combination, and single passage is provided with single
Heat exchange unit, heat exchange unit includes single heat exchanger channels and connects pipeline and liquid in-out mouth, and passage is micron order or grade.
The microreactor of above-mentioned accurate amplification can be applied in liquid-liquid-solid reacts.
Embodiment 6
This microreactor accurately amplified, including charging aperture, not less than 10000000 passages, discharging opening and connection pipeline, even
Adapter road includes connecting between the connecting tube between the feed pipe being connected between charging aperture with passage, passage and passage and discharging opening
The discharge pipe connect, the feed entrance of feed pipe is to the gradual change from big to small of discharging inlet tubing diameter；The charging of feed pipe
Entrance is gradient to 0.2mm to discharging inlet tubing diameter from 0.5mm；Connecting pipeline is Y type；Passage is curved channel, single logical
Road is provided with single heat exchange unit, and heat exchange unit includes single heat exchanger channels and connects pipeline and liquid in-out mouth, and passage is micro-
Meter level or grade, passage uses dipping method be provided with metallic platinum catalyst.
The microreactor of above-mentioned accurate amplification can be applied in liquid-liquid-solid reacts.
Above in association with accompanying drawing, the detailed description of the invention of the present invention is explained in detail, but the present invention is not limited to above-mentioned
Embodiment, in the ken that those of ordinary skill in the art are possessed, it is also possible to before without departing from present inventive concept
Put that various changes can be made.
Claims (13)
1. the microreactor of an accurate amplification, it is characterised in that: include charging aperture, at least 2 passages, discharging opening and connecting tube
Road, connect pipeline include the connecting tube between the feed pipe being connected between charging aperture with passage, at least 2 passages and passage and
The discharge pipe connected between discharging opening, the feed entrance of feed pipe is to the gradual change from big to small of discharging inlet tubing diameter.
The microreactor of accurate amplification the most according to claim 1, it is characterised in that: the feed entrance of described feed pipe
It is gradient to 0.2mm from 0.5mm to discharging inlet tubing diameter.
The microreactor of accurate amplification the most according to claim 1, it is characterised in that: described connection pipeline is symmetrical or not
Symmetrical Y type, T-shaped, double-Y shaped, double-T shaped, Ψ type, camber, the combination of one or more of notch cuttype.
The microreactor of accurate amplification the most according to claim 1, it is characterised in that: described passage be straight channel, band many
One in individual wedge shape or the passage of arc area, curved channel, helical duct, broken line passage, sieve aperture passage, irregular passage
Or several combinations.
5. according to the microreactor accurately amplified described in claim 1 or 4, it is characterised in that: single passage is provided with single
Heat exchange unit, heat exchange unit includes heat exchanger channels and connects pipeline and liquid in-out mouth.
6. the microreactor accurately amplified described in claim 1, it is characterised in that: described passage is straight channel, it is multiple to carry
One in wedge shape or the passage of arc area, curved channel, helical duct, broken line passage, sieve aperture passage, irregular passage or
Several combinations.
7. according to the microreactor accurately amplified described in claim 1 or 4, it is characterised in that: described passage be micron order or
Grade.
8. according to the microreactor accurately amplified described in claim 1 or 4, it is characterised in that: described passage is provided with catalysis
Agent.
9. the microreactor preparation method according to the arbitrary described accurately amplification in 1,2,3 and 6, it is characterised in that concrete steps
As follows:
(1) response characteristic of single passage to be amplified, charging aperture, discharging opening and connection pipeline is studied, determine single
The structure of passage, size, pressure, flow, flow pattern, the optimum of temperature；
(2) structure of single passage that step (1) obtained, size, pressure, flow, flow pattern, the optimum of temperature are input to 3D
In printer model, the most integrated 2 passages, and add connection pipeline, it is achieved between each passage and passage and charging aperture and
Linking between discharging opening, it is thus achieved that accurately amplify the 3D printer model of microreactor；
(3) the 3D printer model accurately amplifying microreactor step (2) obtained carries out analogue simulation, optimizes and includes charging
Mouth, discharging opening, each connection pipeline, the structure of each passage and size；
(4) the 3D impression block accurately amplifying microreactor that step (2) is obtained by the structure after step (3) optimizes and size
Type is modified, and repeats analogue simulation and amendment, number of repetition according to circumstances depending on, obtain final 3D printer model；
(5) select 3D printing device according to required precision and printed material, step (4) is obtained final 3D printer model input
In the 3D print software that selected 3D printing device is corresponding, carry out two dimensionization slicing treatment, successively increase material and print, beat according to selected
The difference of print type carries out corresponding post processing, the microreactor accurately amplified.
10. according to the microreactor preparation method accurately amplified described in 9, it is characterised in that: the 3D impression block of described step (2)
In type, charging aperture is two micro-liquid storage pipes of capsule, and the micro-liquid storage pipe of capsule leads to feed pipe interface channel by Y-shaped structure；Go out
Material mouth is split-phase pipeline, is provided with the drain pipe of a diameter of 5mm at the top of split-phase pipeline and bottom.
11. according to the microreactor preparation method accurately amplified described in 9, it is characterised in that: the analogue simulation of described step (3)
Software is COMSOL, fluent or MATLAB.
12. according to the microreactor preparation method accurately amplified described in 9, it is characterised in that: in described step (5), post processing is
The cleaning on microreactor surface, the cleaning of passage and dredging.
13. 1 kinds of application according to the arbitrary described microreactor accurately amplified of claim 1,2,3 and 6, it is characterised in that:
The microreactor of described accurate amplification is single-phase or heterogeneous reaction, including gas liquid reaction, reactive liquid solution, liquid-solid reaction, liquid-liquid
Reaction and liquid-liquid-solid react.
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| CN108486364A (en) * | 2018-05-31 | 2018-09-04 | 昆明理工大学 | A kind of microfluid extraction of 3D printing expands reactor and its application |
| CN108553939A (en) * | 2018-05-31 | 2018-09-21 | 昆明理工大学 | A kind of 3D printing multi-pore channel microreactor and its application |
| CN108771884A (en) * | 2018-05-08 | 2018-11-09 | 昆明理工大学 | A kind of combined type hybrid extraction device and method |
| CN110408921A (en) * | 2019-07-04 | 2019-11-05 | 广东省新材料研究所 | A kind of nozzle and its processing method |
| JP2020509332A (en) * | 2017-02-28 | 2020-03-26 | ゼネラル・エレクトリック・カンパニイ | Additional heat exchanger |
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| CN106179148B (en) | 2018-10-02 |
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