CN106177324A - A kind of Chinese medicine oral liquid treating gastric ulcer - Google Patents
A kind of Chinese medicine oral liquid treating gastric ulcer Download PDFInfo
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- CN106177324A CN106177324A CN201610598270.6A CN201610598270A CN106177324A CN 106177324 A CN106177324 A CN 106177324A CN 201610598270 A CN201610598270 A CN 201610598270A CN 106177324 A CN106177324 A CN 106177324A
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- 239000003814 drug Substances 0.000 title claims abstract description 54
- 239000007788 liquid Substances 0.000 title claims abstract description 32
- 208000007107 Stomach Ulcer Diseases 0.000 title claims abstract description 26
- 201000005917 gastric ulcer Diseases 0.000 title claims abstract description 26
- 210000000582 semen Anatomy 0.000 claims abstract description 30
- 229940079593 drug Drugs 0.000 claims abstract description 23
- 241000218176 Corydalis Species 0.000 claims abstract description 15
- 241000217407 Margaritifera Species 0.000 claims abstract description 15
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- 238000002360 preparation method Methods 0.000 claims description 15
- 239000000706 filtrate Substances 0.000 claims description 12
- 230000006837 decompression Effects 0.000 claims description 6
- 239000012467 final product Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 238000004064 recycling Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 6
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract description 3
- 208000000718 duodenal ulcer Diseases 0.000 description 6
- 208000008469 Peptic Ulcer Diseases 0.000 description 4
- 208000011906 peptic ulcer disease Diseases 0.000 description 3
- 102000057297 Pepsin A Human genes 0.000 description 2
- 108090000284 Pepsin A Proteins 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 235000019621 digestibility Nutrition 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000001198 duodenum Anatomy 0.000 description 2
- 210000004211 gastric acid Anatomy 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229940111202 pepsin Drugs 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 208000010470 Ageusia Diseases 0.000 description 1
- 208000010728 Meckel diverticulum Diseases 0.000 description 1
- 241000736199 Paeonia Species 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 206010066969 Vitello-intestinal duct remnant Diseases 0.000 description 1
- 230000003872 anastomosis Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000002954 meckel diverticulum Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The present invention provides a kind of Chinese medicine oral liquid treating gastric ulcer, and described Chinese medicine oral liquid is made up of each crude drug of following mass fraction: Concha Margaritifera 15 20 parts, Herba Hyperici perforati 8 12 parts, 35 parts of Semen Persicae, Semen Podocarpi Macrophylli 46 parts, Rhizoma Corydalis 13 parts, Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae) 8 12 parts, Radix Tephrosiae purpureae 46 parts, Rhizoma Dioscoreae 46 parts, the Cortex Eucommiae 13 parts, Rhizoma Coptidis 46 parts, the Radix Paeoniae Alba 8 10 parts, Pericarpium Citri Reticulatae 46 parts, Herba Taraxaci 13 parts, Rhizoma Cyperi 26 parts.The Chinese medicine oral liquid of the present invention can effectively treat gastric ulcer, instant effect, and side effect is little, is not easy recurrence after drug withdrawal, tries out through 284 people, cures 230 people, alleviate 46 people, and cure rate reaches more than 81%, and effective percentage is up to more than 97%.
Description
Technical field
The present invention relates to a kind of Chinese medicine oral liquid treating gastric ulcer.
Background technology
Peptic Ulcers or peptic ulcer are a kind of common digestive tract disease, can betide esophagus, stomach or duodenum, also
Can betide near stomach-intestinal anastomosis mouth or contain in the Meckel diverticulum of gastric mucosa, because gastric ulcer and duodenal ulcer
Most common, therefore general so-called peptic ulcer refers to gastric ulcer and duodenal ulcer.Why it is referred to as digestibility is burst
Infections, is because previously thinking that gastric ulcer and duodenal ulcer are owing to mucosa autodigestion is formed by gastric acid and pepsin
, in fact gastric acid and pepsin are the one of the main reasons of ulcer, and also other reasons can form digestibility
Ulcer.Owing to gastric ulcer and the cause of disease of duodenal ulcer and clinical symptoms have many similarities, sometimes it is difficult to differentiate between being stomach
Ulcer or duodenal ulcer, be the most often diagnosed as peptic ulcer, or taste-blindness rate.If can specify routed
Infections is at stomach or duodenum, and that just can directly be diagnosed as gastric ulcer or duodenal ulcer.The medicine of existing treatment gastric ulcer,
Mostly being Western medicine, though there being certain curative effect, but side effect is big, and easily recurs after drug withdrawal.
Summary of the invention
In order to solve problems of the prior art, the invention provides a kind of Chinese medicine oral liquid treating gastric ulcer；
To this end, the present invention also provides for its preparation method and application.
The present invention provides a kind of Chinese medicine oral liquid treating gastric ulcer, and described Chinese medicine oral liquid is each by following mass fraction
Crude drug forms: Concha Margaritifera 15-20 part, Herba Hyperici perforati 8-12 part, Semen Persicae 3-5 part, Semen Podocarpi Macrophylli 4-6 part, Rhizoma Corydalis 1-3 part, Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae) 8-
12 parts, Radix Tephrosiae purpureae 4-6 part, Rhizoma Dioscoreae 4-6 part, Cortex Eucommiae 1-3 part, Rhizoma Coptidis 4-6 part, Radix Paeoniae Alba 8-10 part, Pericarpium Citri Reticulatae 4-6 part, Herba Taraxaci 1-3
Part, Rhizoma Cyperi 2-6 part.
As preferably, described Chinese medicine oral liquid is made up of each crude drug of following mass fraction: Concha Margaritifera 18 parts, pass through leaf even
Stick up 10 parts, 4 parts of Semen Persicae, Semen Podocarpi Macrophylli 5 parts, Rhizoma Corydalis 2 parts, Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae) 10 parts, Radix Tephrosiae purpureae 5 parts, Rhizoma Dioscoreae 5 parts, the Cortex Eucommiae 2 parts, Rhizoma Coptidis 5 parts, white
Chinese herbaceous peony 9 parts, Pericarpium Citri Reticulatae 5 parts, Herba Taraxaci 2 parts, Rhizoma Cyperi 4 parts.
The present invention also provides for the preparation method of above-mentioned Chinese medicine oral liquid, and step is as follows:
(1) take the Concha Margaritifera of formula ratio, Herba Hyperici perforati, Semen Persicae, Semen Podocarpi Macrophylli, Rhizoma Corydalis add the water of 8-12 times amount and first soak 30-45 and divide
Clock, then decoct 2-3 time, each 30-45 minute, collecting decoction, filter, obtain filtrate A；
(2) remaining crude drug of formula ratio is ground into coarse powder, adds 4-10 times of quality 70-95% ethanol, extract 2-4 time, each 1-
2h, filters, united extraction liquid, decompression recycling ethanol, obtains liquor B；
(3) filtrate A and liquor B being merged, be concentrated into 2 times amount, in making preparation, the final crude drug the most every 1mL of content 50%(is containing crude drug
0.5g), to obtain final product.
The present invention also provides for the application in the medicine of preparation treatment gastric ulcer of the above-mentioned Chinese medicine oral liquid.
The Chinese medicine oral liquid of the present invention can effectively treat gastric ulcer, instant effect, and side effect is little, is not easy multiple after drug withdrawal
Sending out, try out through 284 people, cure 230 people, alleviate 46 people, cure rate reaches more than 81%, and effective percentage is up to more than 97%.
Detailed description of the invention
Below example facilitates a better understanding of the present invention, but does not limit the present invention.Experiment in following embodiment
Method, if no special instructions, is conventional method.Test material used in following embodiment, if no special instructions, is city
Sell.
The Chinese medicine oral liquid of the treatment gastric ulcer of the present invention is made up of each component of following mass fraction:
Concha Margaritifera 15-20 part, Herba Hyperici perforati 8-12 part, Semen Persicae 3-5 part, Semen Podocarpi Macrophylli 4-6 part, Rhizoma Corydalis 1-3 part, Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae) 8-12 part, ash
Blade root 4-6 part, Rhizoma Dioscoreae 4-6 part, Cortex Eucommiae 1-3 part, Rhizoma Coptidis 4-6 part, Radix Paeoniae Alba 8-10 part, Pericarpium Citri Reticulatae 4-6 part, Herba Taraxaci 1-3 part, Rhizoma Cyperi
2-6 part.
The preparation method of the Chinese medicine oral liquid of the treatment gastric ulcer of the present invention is:
(1) take the Concha Margaritifera of formula ratio, Herba Hyperici perforati, Semen Persicae, Semen Podocarpi Macrophylli, Rhizoma Corydalis add the water of 8-12 times amount and first soak 30-45 and divide
Clock, then decoct 2-3 time, each 30-45 minute, collecting decoction, filter, obtain filtrate A；
(2) remaining crude drug of formula ratio is ground into coarse powder, adds 4-10 times of quality 70-95% ethanol, extract 2-4 time, each 1-
2h, filters, united extraction liquid, decompression recycling ethanol, obtains liquor B；
(3) filtrate A and liquor B being merged, be concentrated into 2 times amount, in making preparation, the final crude drug the most every 1mL of content 50%(is containing crude drug
0.5g), to obtain final product.
Every day twice, oral, it is 100ml each serving consumption, within 5 days, is a course for the treatment of.
Embodiment 1
The Chinese medicine oral liquid of the treatment gastric ulcer of the present invention is made up of each component of following mass fraction:
Concha Margaritifera 18 parts, Herba Hyperici perforati 10 parts, 4 parts of Semen Persicae, Semen Podocarpi Macrophylli 5 parts, Rhizoma Corydalis 2 parts, Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae) 10 parts, Radix Tephrosiae purpureae 5 parts, Rhizoma Dioscoreae 5
Part, the Cortex Eucommiae 2 parts, Rhizoma Coptidis 5 parts, the Radix Paeoniae Alba 9 parts, Pericarpium Citri Reticulatae 5 parts, Herba Taraxaci 2 parts, Rhizoma Cyperi 4 parts.
The preparation method of the Chinese medicine oral liquid of the treatment gastric ulcer of the present invention is:
(1) take the Concha Margaritifera of formula ratio, Herba Hyperici perforati, Semen Persicae, Semen Podocarpi Macrophylli, Rhizoma Corydalis add the water of 10 times amount and first soak 40 minutes, then
Decoct 2 times, each 40 minutes, collecting decoction, filter, obtain filtrate A；
(2) remaining crude drug of formula ratio is ground into coarse powder, adds 6 times of quality 80% ethanol, extract 3 times, each 1.5h, filter,
United extraction liquid, decompression recycling ethanol, obtain liquor B；
(3) filtrate A and liquor B being merged, be concentrated into 2 times amount, in making preparation, the final crude drug the most every 1mL of content 50%(is containing crude drug
0.5g), to obtain final product.
Embodiment 2
The Chinese medicine oral liquid of the treatment gastric ulcer of the present invention is made up of each component of following mass fraction:
Concha Margaritifera 15 parts, Herba Hyperici perforati 12 parts, 3 parts of Semen Persicae, Semen Podocarpi Macrophylli 6 parts, Rhizoma Corydalis 3 parts, Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae) 8 parts, Radix Tephrosiae purpureae 6 parts, Rhizoma Dioscoreae 4
Part, the Cortex Eucommiae 3 parts, Rhizoma Coptidis 4 parts, the Radix Paeoniae Alba 10 parts, Pericarpium Citri Reticulatae 4 parts, Herba Taraxaci 3 parts, Rhizoma Cyperi 2 parts.
The preparation method of the Chinese medicine oral liquid of the treatment gastric ulcer of the present invention is:
(1) take the Concha Margaritifera of formula ratio, Herba Hyperici perforati, Semen Persicae, Semen Podocarpi Macrophylli, Rhizoma Corydalis add the water of 12 times amount and first soak 30 minutes, then
Decoct 2 times, each 30 minutes, collecting decoction, filter, obtain filtrate A；
(2) remaining crude drug of formula ratio is ground into coarse powder, adds 10 times of quality 70% ethanol, extract 2 times, each 2h, filter,
United extraction liquid, decompression recycling ethanol, obtain liquor B；
(3) filtrate A and liquor B being merged, be concentrated into 2 times amount, in making preparation, the final crude drug the most every 1mL of content 50%(is containing crude drug
0.5g), to obtain final product.
Embodiment 3
The Chinese medicine oral liquid of the treatment gastric ulcer of the present invention is made up of each component of following mass fraction:
Concha Margaritifera 20 parts, Herba Hyperici perforati 8 parts, 5 parts of Semen Persicae, Semen Podocarpi Macrophylli 4 parts, Rhizoma Corydalis 1 part, Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae) 12 parts, Radix Tephrosiae purpureae 4 parts, Rhizoma Dioscoreae 6
Part, the Cortex Eucommiae 1 part, Rhizoma Coptidis 6 parts, the Radix Paeoniae Alba 8 parts, Pericarpium Citri Reticulatae 6 parts, Herba Taraxaci 1 part, Rhizoma Cyperi 6 parts.
The preparation method of the Chinese medicine oral liquid of the treatment gastric ulcer of the present invention is:
(1) take the Concha Margaritifera of formula ratio, Herba Hyperici perforati, Semen Persicae, Semen Podocarpi Macrophylli, Rhizoma Corydalis add the water of 8 times amount and first soak 30-45 minute,
Decoct 3 times again, each 30-45 minute, collecting decoction, filter, obtain filtrate A；
(2) remaining crude drug of formula ratio is ground into coarse powder, adds 4 times of quality 95% ethanol, extract 4 times, each 1h, filter, close
And extracting solution, decompression recycling ethanol, obtain liquor B；
(3) filtrate A and liquor B being merged, be concentrated into 2 times amount, in making preparation, the final crude drug the most every 1mL of content 50%(is containing crude drug
0.5g), to obtain final product.
Finally it is noted that the foregoing is only the preferred embodiments of the present invention, it is not limited to the present invention,
Although being described in detail the present invention with reference to previous embodiment, for a person skilled in the art, it still may be used
So that the technical scheme described in foregoing embodiments to be modified, or wherein portion of techniques feature is carried out equivalent.
All within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. made, should be included in the present invention's
Within protection domain.
Claims (4)
1. the Chinese medicine oral liquid treating gastric ulcer, it is characterised in that: described Chinese medicine oral liquid is each by following mass fraction
Crude drug forms: Concha Margaritifera 15-20 part, Herba Hyperici perforati 8-12 part, Semen Persicae 3-5 part, Semen Podocarpi Macrophylli 4-6 part, Rhizoma Corydalis 1-3 part, Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae) 8-
12 parts, Radix Tephrosiae purpureae 4-6 part, Rhizoma Dioscoreae 4-6 part, Cortex Eucommiae 1-3 part, Rhizoma Coptidis 4-6 part, Radix Paeoniae Alba 8-10 part, Pericarpium Citri Reticulatae 4-6 part, Herba Taraxaci 1-3
Part, Rhizoma Cyperi 2-6 part.
Chinese medicine oral liquid the most according to claim 1, it is characterised in that: described Chinese medicine oral liquid is by following mass fraction
Each crude drug forms: Concha Margaritifera 18 parts, Herba Hyperici perforati 10 parts, 4 parts of Semen Persicae, Semen Podocarpi Macrophylli 5 parts, Rhizoma Corydalis 2 parts, Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae) 10 parts, Radix Tephrosiae purpureae
5 parts, Rhizoma Dioscoreae 5 parts, the Cortex Eucommiae 2 parts, Rhizoma Coptidis 5 parts, the Radix Paeoniae Alba 9 parts, Pericarpium Citri Reticulatae 5 parts, Herba Taraxaci 2 parts, Rhizoma Cyperi 4 parts.
3. the preparation method of the Chinese medicine oral liquid described in claim 1 or 2, it is characterised in that: step is as follows:
(1) take the Concha Margaritifera of formula ratio, Herba Hyperici perforati, Semen Persicae, Semen Podocarpi Macrophylli, Rhizoma Corydalis add the water of 8-12 times amount and first soak 30-45 and divide
Clock, then decoct 2-3 time, each 30-45 minute, collecting decoction, filter, obtain filtrate A；
(2) remaining crude drug of formula ratio is ground into coarse powder, adds 4-10 times of quality 70-95% ethanol, extract 2-4 time, each 1-
2h, filters, united extraction liquid, decompression recycling ethanol, obtains liquor B；
(3) filtrate A and liquor B being merged, be concentrated into 2 times amount, in making preparation, the final crude drug the most every 1mL of content 50%(is containing crude drug
0.5g), to obtain final product.
4. the application in the medicine of preparation treatment gastric ulcer of the Chinese medicine oral liquid described in claim 1 or 2.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20220157172A (en) * | 2021-05-20 | 2022-11-29 | 주식회사 한국인삼공사 | A Composition For Preventing, Improving Or Treating Gastrointestinal Disorders Including Extract Of Eucommia Ulmoides Oliver And Extract Of Citrus Unshiu |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406793A (en) * | 2011-12-04 | 2012-04-11 | 许从玉 | Pharmaceutical composition for treating peptic ulcer |
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2016
- 2016-07-27 CN CN201610598270.6A patent/CN106177324A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406793A (en) * | 2011-12-04 | 2012-04-11 | 许从玉 | Pharmaceutical composition for treating peptic ulcer |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220157172A (en) * | 2021-05-20 | 2022-11-29 | 주식회사 한국인삼공사 | A Composition For Preventing, Improving Or Treating Gastrointestinal Disorders Including Extract Of Eucommia Ulmoides Oliver And Extract Of Citrus Unshiu |
| KR102682338B1 (en) | 2021-05-20 | 2024-07-09 | 주식회사 한국인삼공사 | A Composition For Preventing, Improving Or Treating Gastrointestinal Disorders Including Extract Of Eucommia Ulmoides Oliver And Extract Of Citrus Unshiu |
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