CN106075033A - A kind of Chinese medicine composition treating constipation - Google Patents

A kind of Chinese medicine composition treating constipation Download PDF

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CN106075033A
CN106075033A CN201610598217.6A CN201610598217A CN106075033A CN 106075033 A CN106075033 A CN 106075033A CN 201610598217 A CN201610598217 A CN 201610598217A CN 106075033 A CN106075033 A CN 106075033A
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medicine composition
chinese medicine
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张志杰
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8967—Lilium, e.g. tiger lily or Easter lily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The present invention provides a kind of Chinese medicine composition treating constipation, and described Chinese medicine composition is made up of each crude drug of following mass fraction: Rhizoma Atractylodis Macrocephalae (parched) 58 parts, Bulbus Lilii 15 18 parts, Radix Platycodonis 13 parts, 24 parts of Radix Glycyrrhizae, 24 parts of Semen Armeniacae Amarum, Herba Centellae 13 parts, Cortex clausenae lansii 35 parts, Radix Bupleuri 12 parts, Pericarpium Granati 12 15 parts, Pericarpium Citri Reticulatae 13 parts.The Chinese medicine composition of the present invention can effectively treat constipation, instant effect, and side effect is little, is not easy recurrence after drug withdrawal, tries out through 321 people, cures 231 people, alleviate 74 people, and cure rate reaches more than 72%, and effective percentage is up to more than 95%.

Description

A kind of Chinese medicine composition treating constipation
Technical field
The present invention relates to a kind of Chinese medicine composition treating constipation.
Background technology
Constipation is one of common clinical card, refers to the not normal caused constipation of large intestine conduction, defecation excessive cycle；Or Cycle is the longest, but excrement matter is dry and hard, and it is difficult to discharge；Or excrement matter is not hard, though there being awareness of defecation, but the disease that defecation is the most smooth.Constipation is clinical Common complicated symptom rather than a kind of disease, be primarily referred to as that defecation frequency reduces, feces amount reduces, feces is dry and hard, defecation expense Power etc..When above-mentioned symptom exists more than 2 kinds simultaneously, diagnosable for symptomatic constipation.Generally it is reduced to main with stool, one As every 2～3 days or longer time defecation once (or ＜ 3 times weekly) be constipation.The medicine of existing treatment constipation, mostly is Western medicine, though there being certain curative effect, but side effect is big, and easily recurs after drug withdrawal.
Summary of the invention
In order to solve problems of the prior art, the invention provides a kind of Chinese medicine composition treating constipation；For This, the present invention also provides for its preparation method and application.
The present invention provides a kind of Chinese medicine composition treating constipation, each former by following mass fraction of described Chinese medicine composition Material medicine composition: Rhizoma Atractylodis Macrocephalae (parched) 5-8 part, Bulbus Lilii 15-18 part, Radix Platycodonis 1-3 part, Radix Glycyrrhizae 2-4 part, Semen Armeniacae Amarum 2-4 part, Herba Centellae 1-3 part, Huang Skin bark 3-5 part, Radix Bupleuri 1-2 part, Pericarpium Granati 12-15 part, Pericarpium Citri Reticulatae 1-3 part.
As preferably, described Chinese medicine composition is made up of each crude drug of following mass fraction: Rhizoma Atractylodis Macrocephalae (parched) 6 parts, Bulbus Lilii 16 Part, Radix Platycodonis 2 parts, 3 parts of Radix Glycyrrhizae, 3 parts of Semen Armeniacae Amarum, Herba Centellae 2 parts, Cortex clausenae lansii 4 parts, Radix Bupleuri 1.5 parts, Pericarpium Granati 14 parts, Pericarpium Citri Reticulatae 2 Part.
The present invention also provides for the preparation method of above-mentioned Chinese medicine composition, and step is as follows:
(1) take the Radix Platycodonis of formula ratio, Radix Glycyrrhizae, Semen Armeniacae Amarum, Herba Centellae add the water of 8-12 times amount and first soak 30-45 minute, then decoct 1-2 Secondary, each 30-45 minute, collecting decoction, filter, obtain filtrate A；
(2) remaining crude drug of formula ratio is ground into coarse powder, adds 4-10 times of quality 70-95% ethanol, extract 2-4 time, each 1- 2h, filters, united extraction liquid, decompression recycling ethanol, obtains liquor B；
(3) filtrate A and liquor B being merged, be concentrated into 2 times amount, in making preparation, the final crude drug the most every 1mL of content 50%(is containing crude drug 0.5g), to obtain final product.
The present invention also provides for the application in the medicine of preparation treatment constipation of the above-mentioned Chinese medicine composition.
The Chinese medicine composition of the present invention can effectively treat constipation, instant effect, and side effect is little, is not easy recurrence after drug withdrawal, Trying out through 321 people, cure 231 people, alleviate 74 people, cure rate reaches more than 72%, and effective percentage is up to more than 95%.
Detailed description of the invention
Below example facilitates a better understanding of the present invention, but does not limit the present invention.Experiment in following embodiment Method, if no special instructions, is conventional method.Test material used in following embodiment, if no special instructions, is city Sell.
The Chinese medicine composition of the treatment constipation of the present invention is made up of each component of following mass fraction:
Rhizoma Atractylodis Macrocephalae (parched) 5-8 part, Bulbus Lilii 15-18 part, Radix Platycodonis 1-3 part, Radix Glycyrrhizae 2-4 part, Semen Armeniacae Amarum 2-4 part, Herba Centellae 1-3 part, wampee Skin 3-5 part, Radix Bupleuri 1-2 part, Pericarpium Granati 12-15 part, Pericarpium Citri Reticulatae 1-3 part.
The preparation method of the Chinese medicine composition of the treatment constipation of the present invention is:
(1) take the Radix Platycodonis of formula ratio, Radix Glycyrrhizae, Semen Armeniacae Amarum, Herba Centellae add the water of 8-12 times amount and first soak 30-45 minute, then decoct 1-2 Secondary, each 30-45 minute, collecting decoction, filter, obtain filtrate A；
(2) remaining crude drug of formula ratio is ground into coarse powder, adds 4-10 times of quality 70-95% ethanol, extract 2-4 time, each 1- 2h, filters, united extraction liquid, decompression recycling ethanol, obtains liquor B；
(3) filtrate A and liquor B being merged, be concentrated into 2 times amount, in making preparation, the final crude drug the most every 1mL of content 50%(is containing crude drug 0.5g), to obtain final product.
Every day twice, oral, it is 50ml each serving consumption, within 5 days, is a course for the treatment of.
Embodiment 1
The Chinese medicine composition of the treatment constipation of the present invention is made up of each component of following mass fraction:
Rhizoma Atractylodis Macrocephalae (parched) 6 parts, Bulbus Lilii 16 parts, Radix Platycodonis 2 parts, 3 parts of Radix Glycyrrhizae, 3 parts of Semen Armeniacae Amarum, Herba Centellae 2 parts, Cortex clausenae lansii 4 parts, Radix Bupleuri 1.5 Part, Pericarpium Granati 14 parts, Pericarpium Citri Reticulatae 2 parts.
The preparation method of the Chinese medicine composition of the treatment constipation of the present invention is:
(1) take the Radix Platycodonis of formula ratio, Radix Glycyrrhizae, Semen Armeniacae Amarum, Herba Centellae add the water of 10 times amount and first soak 40 minutes, then decoct 1 time, every time 40 minutes, collecting decoction, filter, obtain filtrate A；
(2) remaining crude drug of formula ratio is ground into coarse powder, adds 6 times of quality 80% ethanol, extract 3 times, each 1.5h, filter, United extraction liquid, decompression recycling ethanol, obtain liquor B；
(3) filtrate A and liquor B being merged, be concentrated into 2 times amount, in making preparation, the final crude drug the most every 1mL of content 50%(is containing crude drug 0.5g), to obtain final product.
Embodiment 2
The Chinese medicine composition of the treatment constipation of the present invention is made up of each component of following mass fraction:
Rhizoma Atractylodis Macrocephalae (parched) 5 parts, Bulbus Lilii 18 parts, Radix Platycodonis 1 part, 4 parts of Radix Glycyrrhizae, 2 parts of Semen Armeniacae Amarum, Herba Centellae 3 parts, Cortex clausenae lansii 5 parts, Radix Bupleuri 1 part, Pericarpium Granati 15 parts, Pericarpium Citri Reticulatae 1 part.
The preparation method of the Chinese medicine composition of the treatment constipation of the present invention is:
(1) take the Radix Platycodonis of formula ratio, Radix Glycyrrhizae, Semen Armeniacae Amarum, Herba Centellae add the water of 12 times amount and first soak 30 minutes, then decoct 2 times, every time 30 minutes, collecting decoction, filter, obtain filtrate A；
(2) remaining crude drug of formula ratio is ground into coarse powder, adds 10 times of quality 70% ethanol, extract 2 times, each 2h, filter, United extraction liquid, decompression recycling ethanol, obtain liquor B；
(3) filtrate A and liquor B being merged, be concentrated into 2 times amount, in making preparation, the final crude drug the most every 1mL of content 50%(is containing crude drug 0.5g), to obtain final product.
Embodiment 3
The Chinese medicine composition of the treatment constipation of the present invention is made up of each component of following mass fraction:
Rhizoma Atractylodis Macrocephalae (parched) 8 parts, Bulbus Lilii 15 parts, Radix Platycodonis 3 parts, 2 parts of Radix Glycyrrhizae, 4 parts of Semen Armeniacae Amarum, Herba Centellae 1 part, Cortex clausenae lansii 3 parts, Radix Bupleuri 2 parts, Pericarpium Granati 12 parts, Pericarpium Citri Reticulatae 3 parts.
The preparation method of the Chinese medicine composition of the treatment constipation of the present invention is:
(1) take the Radix Platycodonis of formula ratio, Radix Glycyrrhizae, Semen Armeniacae Amarum, Herba Centellae add the water of 8 times amount and first soak 45 minutes, then decoct 1 time, every time 45 minutes, collecting decoction, filter, obtain filtrate A；
(2) remaining crude drug of formula ratio is ground into coarse powder, adds 4 times of quality 95% ethanol, extract 4 times, each 1h, filter, close And extracting solution, decompression recycling ethanol, obtain liquor B；
(3) filtrate A and liquor B being merged, be concentrated into 2 times amount, in making preparation, the final crude drug the most every 1mL of content 50%(is containing crude drug 0.5g), to obtain final product.
Finally it is noted that the foregoing is only the preferred embodiments of the present invention, it is not limited to the present invention, Although being described in detail the present invention with reference to previous embodiment, for a person skilled in the art, it still may be used So that the technical scheme described in foregoing embodiments to be modified, or wherein portion of techniques feature is carried out equivalent. All within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. made, should be included in the present invention's Within protection domain.

Claims (4)

1. the Chinese medicine composition treating constipation, it is characterised in that: each former by following mass fraction of described Chinese medicine composition Material medicine composition: Rhizoma Atractylodis Macrocephalae (parched) 5-8 part, Bulbus Lilii 15-18 part, Radix Platycodonis 1-3 part, Radix Glycyrrhizae 2-4 part, Semen Armeniacae Amarum 2-4 part, Herba Centellae 1-3 part, Huang Skin bark 3-5 part, Radix Bupleuri 1-2 part, Pericarpium Granati 12-15 part, Pericarpium Citri Reticulatae 1-3 part.
Chinese medicine composition the most according to claim 1, it is characterised in that: described Chinese medicine composition is by following mass fraction Each crude drug forms: Rhizoma Atractylodis Macrocephalae (parched) 6 parts, Bulbus Lilii 16 parts, Radix Platycodonis 2 parts, 3 parts of Radix Glycyrrhizae, 3 parts of Semen Armeniacae Amarum, Herba Centellae 2 parts, Cortex clausenae lansii 4 Part, Radix Bupleuri 1.5 parts, Pericarpium Granati 14 parts, Pericarpium Citri Reticulatae 2 parts.
3. the preparation method of the Chinese medicine composition described in claim 1 or 2, it is characterised in that: step is as follows:
(1) take the Radix Platycodonis of formula ratio, Radix Glycyrrhizae, Semen Armeniacae Amarum, Herba Centellae add the water of 8-12 times amount and first soak 30-45 minute, then decoct 1-2 Secondary, each 30-45 minute, collecting decoction, filter, obtain filtrate A；
(2) remaining crude drug of formula ratio is ground into coarse powder, adds 4-10 times of quality 70-95% ethanol, extract 2-4 time, each 1- 2h, filters, united extraction liquid, decompression recycling ethanol, obtains liquor B；
(3) filtrate A and liquor B being merged, be concentrated into 2 times amount, in making preparation, the final crude drug the most every 1mL of content 50%(is containing crude drug 0.5g), to obtain final product.
4. the application in the medicine of preparation treatment constipation of the Chinese medicine composition described in claim 1 or 2.
CN201610598217.6A 2016-07-27 2016-07-27 A kind of Chinese medicine composition treating constipation Pending CN106075033A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102225117A (en) * 2011-05-22 2011-10-26 李晶 Traditional Chinese medicine pill for tonifying qi and relaxing bowels

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102225117A (en) * 2011-05-22 2011-10-26 李晶 Traditional Chinese medicine pill for tonifying qi and relaxing bowels

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