CN106177240A - A kind of [Dan treating acute suppurative otitis media and preparation method - Google Patents
A kind of [Dan treating acute suppurative otitis media and preparation method Download PDFInfo
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Abstract
The invention discloses a kind of [Dan treating acute suppurative otitis media and preparation method, belong to pharmaceutical technology field；The raw material of [Dan composition of the present invention consists of: Folium Ilicis, Radix Crepidis elongatae, Herba Moslae, Rhizoma Donacis canniformis, Rhizoma soulieae vaginatae, Semen Cuscutae, Hibisci Mutabilis, Medulla passeris, Martianus dermestoides Chevr., Radix abutili indici, Radix Puerariae, Radix Berberidis Amurensis, chloramphenicol ear drop, oxymetazoline, iodine glycerol and crotamiton；[Dan of the present invention is with sterilization, antiinflammatory, pain relieving, evacuation of pus as Therapeutic Principle, selected thermal detoxification, reducing swelling and alleviating pain, the prescription of hemostasis removing heat from blood, Chinese and Western combines preparation, maximal efficiency improve Chinese medicine ingredients and Western medicine effect, play effect that is complementary and that promote, improve medicinal effects, the cell wall of pathogenic bacteria can be adsorbed in and change its permeability, thalline endoenzyme, coenzyme and metabolic intermediate is made to leak outside, and make tropina degeneration, thus play the effect of sterilization, its effect is wide and fast, effect is strong, has fabulous therapeutic effect to acute suppurative otitis media.
Description
Art
The present invention relates to pharmaceutical technology field, particularly relate to a kind of [Dan treating acute suppurative otitis media and preparation
Method.
Background technology
Acute suppurative otitis media is the acute suppurative inflammation that antibacterial infects the middle-ear mucosa caused.Primary disease is more common in
Child, clinically with otalgia, purulent ear, tympanum hyperemia, perforation as feature.Acute suppurative otitis media Main Pathogenic Bacteria is pneumonia
Streptococcus, hemophilus influenza, beta hemolytic streptococcus, staphylococcus and pseudomonas aeruginosa etc..
The clinical manifestation of acute suppurative otitis media is:
1. General Symptoms.Before the perforation of ear drum, General Symptoms is obvious, can have fear of cold, heating, asthenia, loss of appetite etc., children's
General Symptoms is the most relatively grown up seriously, can have high heat, faint from fear, often accompany the symptoms of digestive tract such as vomiting, diarrhoea, after the perforation of ear drum, body
Temperature is gradually reduced, and General Symptoms substantially alleviates.
2. otalgia.Patient feels ear deep dull pain or pulsation jumping pain, pain can through nervi trigeminus be radiated to homonymy volume, temporo,
Top, tooth or whole half side head, swallow, cough, sneeze time otalgia increase the weight of, otalgia violent person lie awake all night, irritated.Infant
Then cry and scream endlessly.After once spontaneous perforation or row myringotomy occurs in tympanum, pus is outwards led off, and pain is paused and subtracted.
3. tinnitus and auditory dysesthesia.Suffering from ear can have Pulsative tinnitus, audition to be gradually reduced, the violent person of otalgia, slight ear
Deaf can not be discovered by patient, after the perforation of ear drum, audition improves on the contrary, as pathological changes invades internal ear, may occur in which dizziness and phonosensitive nerve
Deaf.
4. otorrhea.After the perforation of ear drum, in ear has liquid to flow out, and is just that serosity is courageous and upright, becomes mucus purulence or even pus later
Property, as a lot of in secretions amount, prompting secretions, not only from tympanum, also comes from tympanic antrum, mastoid process.
In time, suitably, secretions drain is unobstructed in acute suppurative otitis media treatment, and after inflammatory resolution, the perforation of ear drum is many can be certainly
Row healing, the big multipotency of audition recovers normal, but malpractice or the person of being in a bad way, the perforation of ear drum, middle ear adhesions disease, drum can be left over
Hardening or be changed into chronic suppurative otitis media in room, even causes various complication.
Traditional treatment acute suppurative otitis media controls to infect by other antibacterials after being normally applied enough antibiotic, controls
Treatment means are single, typically can only relief of symptoms, it is impossible to fundamentally treat disease, for must thoroughly cure, prevent concurrent
Disease or transfer to chronic, needs a kind of new [Dan to treat acute suppurative otitis media.
Summary of the invention
The invention provides a kind of [Dan treating acute suppurative otitis media and preparation method, [Dan of the present invention with
Sterilization, antiinflammatory, pain relieving, evacuation of pus are Therapeutic Principle, selected thermal detoxification, reducing swelling and alleviating pain, the prescription of hemostasis removing heat from blood, and Chinese and Western combines joins
System, maximal efficiency improve Chinese medicine ingredients and Western medicine effect, played effect that is complementary and that promote, improve medicinal effects,
The cell wall of pathogenic bacteria can be adsorbed in and change its permeability, make thalline endoenzyme, coenzyme and metabolic intermediate leak outside, hinder antibacterial
Breathing and glycolytic cycle, and make tropina degeneration, thus play the effect of sterilization, its effect is wide and fast, and effect is strong, mark
Basis is the most double to be controlled, and has fabulous therapeutic effect to acute suppurative otitis media.
For achieving the above object, technical scheme is implemented as follows:
A kind of [Dan treating acute suppurative otitis media, it is characterised in that: described [Dan is become with Western medicine by Chinese medicine
Be grouped into, make described Chinese medicine ingredients raw material composition and parts by weight be: Folium Ilicis 63～93 parts, Radix Crepidis elongatae 62～92 parts,
Herba Moslae 60～90 parts, Rhizoma Donacis canniformis 59～89 parts, Rhizoma soulieae vaginatae 57～87 parts, Semen Cuscutae 55～85 parts, Hibisci Mutabilis 53～83 parts, Medulla passeris
51～81 parts, Martianus dermestoides Chevr. 49～79 parts, Radix abutili indici 48～78 parts, Radix Puerariae 47～77 parts, Radix Berberidis Amurensis 46～76 parts；Make described Western medicine
The raw material divided forms and parts by weight are: chloramphenicol ear drop 1.0～2.0 parts, oxymetazoline 0.8～1.7 parts, iodine glycerol 0.6
～1.5 parts, crotamiton 0.3～1.4 parts.
Described [Dan is made up of Chinese medicine and western medicine composition, makes raw material composition and the parts by weight of described Chinese medicine ingredients
For: Folium Ilicis 86 parts, Radix Crepidis elongatae 85 parts, Herba Moslae 83 parts, Rhizoma Donacis canniformis 82 parts, Rhizoma soulieae vaginatae 80 parts, Semen Cuscutae 78 parts, Hibisci Mutabilis 76
Part, Medulla passeris 74 parts, Martianus dermestoides Chevr. 72 parts, Radix abutili indici 71 parts, Radix Puerariae 70 parts, Radix Berberidis Amurensis 69 parts；Make the raw material composition of described western medicine composition
And parts by weight are: chloramphenicol ear drop 1.5 parts, oxymetazoline 1.4 parts, iodine glycerol 1.2 parts, crotamiton 1.0 parts.
Described [Dan is made up of Chinese medicine and western medicine composition, makes raw material composition and the parts by weight of described Chinese medicine ingredients
For: Folium Ilicis 79 parts, Radix Crepidis elongatae 78 parts, Herba Moslae 76 parts, Rhizoma Donacis canniformis 75 parts, Rhizoma soulieae vaginatae 73 parts, Semen Cuscutae 71 parts, Hibisci Mutabilis 69
Part, Medulla passeris 67 parts, Martianus dermestoides Chevr. 65 parts, Radix abutili indici 64 parts, Radix Puerariae 63 parts, Radix Berberidis Amurensis 62 parts；Make the raw material composition of described western medicine composition
And parts by weight are: chloramphenicol ear drop 1.3 parts, oxymetazoline 1.2 parts, iodine glycerol 0.9 part, crotamiton 0.7 part.
Described [Dan is made up of Chinese medicine and western medicine composition, makes raw material composition and the parts by weight of described Chinese medicine ingredients
For: Folium Ilicis 72 parts, Radix Crepidis elongatae 71 parts, Herba Moslae 69 parts, Rhizoma Donacis canniformis 68 parts, Rhizoma soulieae vaginatae 66 parts, Semen Cuscutae 64 parts, Hibisci Mutabilis 62
Part, Medulla passeris 60 parts, Martianus dermestoides Chevr. 58 parts, Radix abutili indici 57 parts, Radix Puerariae 56 parts, Radix Berberidis Amurensis 55 parts；Make the raw material composition of described western medicine composition
And parts by weight are: chloramphenicol ear drop 1.1 parts, oxymetazoline 0.9 part, iodine glycerol 0.7 part, crotamiton 0.5 part.
The preparation method of the [Dan of a kind of acute suppurative otitis media, comprises the following steps that:
(1) Folium Ilicis, Radix Crepidis elongatae, Medulla passeris, Martianus dermestoides Chevr. and Radix Berberidis Amurensis are put in container, add relative mixture quality 6～8 times
Amount distilled water immersion 2～after 3 days, add 3～4 times amount mass concentration be 45%～55% ethanol, be heated to reflux 2～3 little
Time, filter, obtain extracting solution；The medicinal residues obtained after filtering add the distilled water of relative medicinal residues quality 4～6 times amount, heat back
Flow 1～2 hour；Filter, obtain extracting solution；Merge twice extracting solution, filter, reclaim ethanol, obtain filtrate, standby；
(2) Herba Moslae, Rhizoma soulieae vaginatae and Hibisci Mutabilis are put into container, the saline soak of addition 6～8 times amount 2 days, filter out, in
Drying at 200 DEG C～280 DEG C, taking-up is dried in the air cool, grinds into powder, obtained the fine powder of 160 mesh in being placed in mortar, standby；
(3) Rhizoma Donacis canniformis and Radix Puerariae being mixed in container, the addition distilled water relative to 7～10 times of mixture quality is carried out
Soak, take out after being run through, section, it is placed in pot, sprays yellow wine and mix thoroughly, slow fire fried dry, taking-up is dried in the air cool, is placed in mortar
Grind into powder, obtained the fine powder of 140 mesh, standby；
(4) remove silt by naughty to Semen Cuscutae and Radix abutili indici warm water, be mixed in container, add relative mixture quality 6～8 times amount
Yellow wine leaching one night, exposed in the sun to drying, grind into powder in being placed in mortar, obtained the fine powder of 140 mesh, standby；
(5) oxymetazoline, iodine glycerol and crotamiton are mixed in container, add the mass concentration of 10 times amount be 75%～
85% ethanol, uniform stirring so that it is dissolve, obtain solution, standby；
(6) by the filtrate of step (1) gained, step (2), step (3), fine powder and step (5) gained of step (4) gained
Solution mixes, and adds chloramphenicol ear drop and the distilled water of 10 times amount, and instill sodium bicarbonate solution regulate pH value to 7.0～
7.5, homogenize 10～30 minutes with ultrasound wave at 0 DEG C～5 DEG C, embedding gland, under 121 DEG C of hot pressing, sterilizing 30 minutes, make
The [Dan of 30ml/ bottle, is the [Dan of described treatment acute suppurative otitis media.
The drug effect of Chinese medicine used by the present invention is as follows:
Folium Ilicis: wind and heat dispersing, improving eyesight is promoted the production of body fluid.For headache due to pathogenic wind-heat, toothache conjunctival congestion, ear aphtha, calentura excessive thirst, have loose bowels
Dysentery." Traditional Chinese Medicine in Sichuan will " carries: " can clearing away heat to dispel wind, relieving restlessness quenches one's thirst, and controlling headache, toothache, tinnitus, conjunctival congestion and dyspepsia has expectorant.”
Radix Crepidis elongatae: kidney-replenishing, replenishing QI and blood, strengthening the spleen and stomach.For neurasthenia, married woman's cold womb is infertile, and leucorrhea is leaked down, dizzy ear
Ring, nervous palpitation with a distress feeling, digestant for baby and malnutrition." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " controlling weakness, infirmities and diseases, vim and vigour decay, head
Dizzy tinnitus, nervous palpitation with a distress feeling, married woman leucorrhea is leaked down, and damages and superintends and directs wantonly two arteries and veins.”
Herba Moslae: diaphoresis expelling summer-heat, row water wet dissipation, during stomach warming is adjusted.Cold for the moon in summer sense cold fluid-retention, to have a headache and fever, aversion to cold is lossless, breast
Painful abdominal mass is suffered from abdominal pain, vomiting and diarrhoea, edema tinea pedis." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " evil removing of inducing sweat controls heatstroke headache, diarrhea due to summer-heat intestines and stomach pain, summer-heat
Cough, diaphoresis stomach warming, and in.”
Rhizoma Donacis canniformis: heat-clearing and toxic substances removing, relieving cough and relieving asthma, anti-inflammation and sterilization.For pulmonary tuberculosis, tracheitis, bronchitis, asthma, height
Heat, infantile measles, merge pneumonia, cold, fever, various dermatosiss.Modern medicine study confirms, Rhizoma Donacis canniformis is to dysentery bacterium, wound
Cold bacillus, bacillus pyocyaneus, staphylococcus etc. are inhibited.
Rhizoma soulieae vaginatae: clearing heat and relieving fidgetness, removing toxic substances and promoting subsidence of swelling.Irritated for calentura, severe palpitation, osteopyrexia and fever, pharyngitis, stomatitis,
Conjunctivitis, sore and toxic, diarrhea due to damp-heat, dysentery." Shaanxi Chinese herbal medicine " carries: " pathogenic fire purging dampness, clear away heart-fire relieving restlessness, anti-inflammation, strong
Stomach, controls pharyngitis, conjunctivitis, stomatitis, osteopyrexia and fever, nervous cardiopalmus, dysphoria, bacillary dysentery enteritis, ulcerative carbuncle toxic swelling." modern doctor
Learning research to confirm, Rhizoma soulieae vaginatae has the effect of bactericidal antiphlogistic.
Semen Cuscutae: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight antidiarrheal.For impotence and seminal emission, dripping urination, the enuresis is urinated
Frequently, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down." Japan hanako materia medica " carries: " mends five kinds of strain and seven kinds of impairment, controls
Let out essence, hematuria, moisten cardiopulmonary.”
Hibisci Mutabilis: heat-clearing and toxic substances removing, detumescence and apocenosis, cooling blood for hemostasis.For cough due to lung-heat, menorrhagia, leucorrhea, carbuncle skin ulcer
Furuncle, mastitis, lymphadenitis, parotitis, burn and scald, venom, traumatic injury.Modern medicine study confirms, Hibisci Mutabilis pair
Hemolytic streptococcus has stronger inhibitory action, and its leaf then has inhibitory action to staphylococcus aureus.
Medulla passeris: the kidney invigorating Xing Yang, skin moistening granulation promoting.For impotence due to deficiency of the kidney, deaf ear, chilblain." not Lu " carries: " main deafness.”
Martianus dermestoides Chevr.: blood circulation promoting and blood stasis dispelling, warming middle-JIAO is regulated the flow of vital energy.For epersalgia cough, spit blood, paralysis due to windstroke, traumatic injury, heart peratodynia,
Dysphagia and regurgitation." detailed outline is picked up any lost article from the road " carries: " promoting the circulation of blood divides, warming the spleen and stomach, and the five internal organs, muscle reinforcing and bone strengthening, dry and search wind, tonifying YANG road, control timidity.”
Radix abutili indici: clearing away heat-damp and promoting diuresis, has one's ideas straightened out and invigorates blood circulation.For stranguria with turbid discharge of coughing, have loose bowels, otitis media, throat moth." Luchuan book on Chinese herbal medicine " carries:
" diuretic, removes damp-heat in the urinary bladder, controls Hiccough and deaf, stranguria with turbid discharge hemorrhoid.”
Radix Puerariae: yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness only temperature.For typhoid fever, warming headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, dysentery of having loose bowels
Disease, skin eruption is impermeable, hypertension, angina pectoris, deaf.
Radix Berberidis Amurensis: heat clearing and damp drying, eliminating fire and detoxication.For bacillary dysentery, gastroenteritis, paratyphoid fever, dyspepsia, jaundice, liver
Hardening ascites, urinary system infection, acute nephritis, tonsillitis, stomatitis, bronchitis, otitis media, conjunctival congestion and swelling pain, outer sentiment
Dye.Modern medicine study confirm, Radix Berberidis Amurensis to dysentery bacterium, various streptococcus, staphylococcus, Diplococcus pneumoniae, various tulase,
Hemophilus pertussis, bacillus subtilis, hemophilus influenza, anthrax bacillus, escherichia coli, ameba, leptospira, golden yellow
Color staphylococcus, shigella flexneri all have inhibitory action.
The present invention compared with prior art, has the advantages that
[Dan of the present invention with sterilization, antiinflammatory, pain relieving, evacuation of pus as Therapeutic Principle, selected thermal detoxification, reducing swelling and alleviating pain, only
The prescription of blood removing heat from blood, Chinese and Western combines preparation, maximal efficiency improve Chinese medicine ingredients and Western medicine effect, played complementary and promoted
Effect, improve medicinal effects, the cell wall of pathogenic bacteria can be adsorbed in and change its permeability, make thalline endoenzyme, coenzyme and generation
Thank to intermediate product to leak outside, hinder breathing and the glycolytic cycle of antibacterial, and make tropina degeneration, thus play the work of sterilization
With, its effect is wide and fast, and effect is strong, and treating both the principal and secondary aspects of a disease has fabulous therapeutic effect to acute suppurative otitis media.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of [Dan composition of the present invention forms and weight is: Folium Ilicis 92 parts, Radix Crepidis elongatae 91 parts, Herba Moslae 89 parts, bamboo
Leaf any of several broadleaf plants 88 parts, Rhizoma soulieae vaginatae 86 parts, Semen Cuscutae 84 parts, Hibisci Mutabilis 82 parts, Medulla passeris 80 parts, Martianus dermestoides Chevr. 78 parts, Radix abutili indici 77 parts, Radix Puerariae 76
Part, Radix Berberidis Amurensis 75 parts, chloramphenicol ear drop 1.9 parts, oxymetazoline 1.6 parts, iodine glycerol 1.4 parts, crotamiton 1.3 parts.
The processing step of [Dan preparation method of the present invention is:
(1) Folium Ilicis, Radix Crepidis elongatae, Medulla passeris, Martianus dermestoides Chevr. and Radix Berberidis Amurensis are put in container, add relative mixture quality 6～8 times
Amount distilled water immersion 2～after 3 days, add 3～4 times amount mass concentration be 45%～55% ethanol, be heated to reflux 2～3 little
Time, filter, obtain extracting solution；The medicinal residues obtained after filtering add the distilled water of relative medicinal residues quality 4～6 times amount, heat back
Flow 1～2 hour；Filter, obtain extracting solution；Merge twice extracting solution, filter, reclaim ethanol, obtain filtrate, standby；
(2) Herba Moslae, Rhizoma soulieae vaginatae and Hibisci Mutabilis are put into container, the saline soak of addition 6～8 times amount 2 days, filter out, in
Drying at 200 DEG C～280 DEG C, taking-up is dried in the air cool, grinds into powder, obtained the fine powder of 160 mesh in being placed in mortar, standby；
(3) Rhizoma Donacis canniformis and Radix Puerariae being mixed in container, the addition distilled water relative to 7～10 times of mixture quality is carried out
Soak, take out after being run through, section, it is placed in pot, sprays yellow wine and mix thoroughly, slow fire fried dry, taking-up is dried in the air cool, is placed in mortar
Grind into powder, obtained the fine powder of 140 mesh, standby；
(4) remove silt by naughty to Semen Cuscutae and Radix abutili indici warm water, be mixed in container, add relative mixture quality 6～8 times amount
Yellow wine leaching one night, exposed in the sun to drying, grind into powder in being placed in mortar, obtained the fine powder of 140 mesh, standby；
(5) oxymetazoline, iodine glycerol and crotamiton are mixed in container, add the mass concentration of 10 times amount be 75%～
85% ethanol, uniform stirring so that it is dissolve, obtain solution, standby；
(6) by the filtrate of step (1) gained, step (2), step (3), fine powder and step (5) gained of step (4) gained
Solution mixes, and adds chloramphenicol ear drop and the distilled water of 10 times amount, and instill sodium bicarbonate solution regulate pH value to 7.0～
7.5, homogenize 10～30 minutes with ultrasound wave at 0 DEG C～5 DEG C, embedding gland, under 121 DEG C of hot pressing, sterilizing 30 minutes, make
The [Dan of 30ml/ bottle, is the [Dan of described treatment acute suppurative otitis media.
Usage and dosage: dripping ear and use, every day 3～4 times, each 1-2 drip, 2 days courses for the treatment of, 2～3 recoveries from illness courses for the treatment of；First
First dip normal saline with medical cotton stick to clean suffering from ear external auditory meatus, then by [Dan instill suffer from ear, drip ear time suffer from ear to
On, press lightly on the cartilage in auditory meatus mouth front with finger, make [Dan as deep as tympanum, on rear side of instillation 15 minutes, afterwards dripping
Ear fluid is poured out.
Embodiment 2
The raw material of [Dan composition of the present invention forms and weight is: Folium Ilicis 86 parts, Radix Crepidis elongatae 85 parts, Herba Moslae 83 parts, bamboo
Leaf any of several broadleaf plants 82 parts, Rhizoma soulieae vaginatae 80 parts, Semen Cuscutae 78 parts, Hibisci Mutabilis 76 parts, Medulla passeris 74 parts, Martianus dermestoides Chevr. 72 parts, Radix abutili indici 71 parts, Radix Puerariae 70
Part, Radix Berberidis Amurensis 69 parts, chloramphenicol ear drop 1.5 parts, oxymetazoline 1.4 parts, iodine glycerol 1.2 parts, crotamiton 1.0 parts.
The [Dan preparation method processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 3
The raw material of [Dan composition of the present invention forms and weight is: Folium Ilicis 79 parts, Radix Crepidis elongatae 78 parts, Herba Moslae 76 parts, bamboo
Leaf any of several broadleaf plants 75 parts, Rhizoma soulieae vaginatae 73 parts, Semen Cuscutae 71 parts, Hibisci Mutabilis 69 parts, Medulla passeris 67 parts, Martianus dermestoides Chevr. 65 parts, Radix abutili indici 64 parts, Radix Puerariae 63
Part, Radix Berberidis Amurensis 62 parts, chloramphenicol ear drop 1.3 parts, oxymetazoline 1.2 parts, iodine glycerol 0.9 part, crotamiton 0.7 part.
The [Dan preparation method processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 4
The raw material of [Dan composition of the present invention forms and weight is: Folium Ilicis 72 parts, Radix Crepidis elongatae 71 parts, Herba Moslae 69 parts, bamboo
Leaf any of several broadleaf plants 68 parts, Rhizoma soulieae vaginatae 66 parts, Semen Cuscutae 64 parts, Hibisci Mutabilis 62 parts, Medulla passeris 60 parts, Martianus dermestoides Chevr. 58 parts, Radix abutili indici 57 parts, Radix Puerariae 56
Part, Radix Berberidis Amurensis 55 parts, chloramphenicol ear drop 1.1 parts, oxymetazoline 0.9 part, iodine glycerol 0.7 part, crotamiton 0.5 part.
The [Dan preparation method processing step of the present embodiment and usage and dosage are same as in Example 1.
Clinical data:
1, case selection:
Selecting the acute suppurative otitis media patient 381 example clinical observation that my institute or outer court make a definite diagnosis, patient is randomly divided into three
Group, treatment group 127 example, wherein male 64 example, women 63 example, age 6～50 years old, 40 years old mean age, the course of disease 3 weeks～7 weeks.Right
According to group A127 example, wherein male 65 example, women 62 example, age 7～49 years old, 39 years old mean age, the course of disease 2 weeks～8 weeks.Matched group
B127 example, wherein male 66 example, women 61 example, age 6～49 years old, 50 years old mean age, the course of disease 3 weeks～8 weeks.Three groups of cases
The course of disease, degrees of symptoms are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group patient uses [Dan of the present invention, and every day 3～4 times, each 1-2 drip, 2 days courses for the treatment of, 2～3 treatments
Journey is fully recovered；First dip normal saline with medical cotton stick to clean suffering from ear external auditory meatus, then [Dan is instilled and suffer from ear, drip ear
Time suffer from ear upwards, press lightly on the cartilage in auditory meatus mouth front with finger, make [Dan as deep as tympanum, on rear side of instillation 15 points
Clock, after [Dan is poured out.
Control group A takes Cefpodoxime Proxetil capsule, oral, one after each meal, and adult's usual amounts is each 100mg, every day 2
Secondary, in using, can increase and decrease according to age and symptoms, for serious symptom or poor effect person, consumption can be increased, every time
200mg, takes for 2 times every day.
Matched group B takes Pien Tze Huang capsule, oral, 3 times on the one, one time 2, one to five year old child one time 1, or abide by doctor
Advise.
3, efficacy determination:
(1) cure: the transference cures such as otalgia tinnitus, auditory dysesthesia, fear of cold heating；Ear heals, and gets well.
(2) effective: above-mentioned symptom has been alleviated.
(3) invalid: above-mentioned symptom is unchanged.
4, result:
| Group | Number of cases | Cure | Effectively | Invalid | Cure rate | Total effective rate |
| Treatment group | 127 | 106 | 11 | 10 | 83.5% | 92.1% |
| Control group A | 127 | 89 | 15 | 23 | 70.1% | 81.9% |
| Matched group B | 127 | 67 | 29 | 31 | 52.8% | 75.6% |
Result above shows, treatment group cure rate and total effective rate are apparently higher than control group A, matched group B.
Model case is illustrated:
1, high ××, man, 7 years old, child.Patient twists one's ears and rub one's face as a sign of anxiety through often after throwing off a cold, unhappy, says adult
Words bradykinesia, is diagnosed as acute suppurative otitis media, and middle ear mucosa is congested, and in ear has pus.Use [Dan of the present invention 2
After the course for the treatment of, above transference cure, ear gets well, and follows up a case by regular visits to not recur so far.
2, not ××, female, 12 years old, child.Patient suffers from acute suppurative otitis media, and fear of cold generates heat, inappetence, private prosecution
There are pulsation jumping pain, auditory dysesthesia in ear deep.After using 1 course for the treatment of of [Dan of the present invention, symptom takes a turn for the better, and is continuing with 1 treatment
Journey, ear fully recovers, follows up a case by regular visits to not recur so far.
3, Du's ××, man, 21 years old, student.Patient is because being suffered from acute suppurative otitis media by courses of infection, and otoscopy is sent out
Existing tympanum limitation, to filling the air hyperemia, swelling, has pus to flow out, press pain on ear at perforation.Use 2 courses for the treatment of of [Dan of the present invention
After, symptom takes a turn for the better, and is continuing with 1 course for the treatment of, transference cure, not recurrence.
4, in ××, female, 37 years old, owner on one's own account.The recent conscious auris dextra of patient uncomfortable come my institute check, physical examination is sent out
There is slight tenderness sense in existing patient's mastoidale and tympanic antrum district, and mastoid region skin has mild redness, check and find tympanum pine under otoscope
Relaxation portion is congested, periphery and manubrium of malleus district have expansion, in radioactive blood vessel, have secretions to gush out after perforation.Use the present invention
After 3 courses for the treatment of of [Dan, transference cure, not recurrence.
5, side's ××, man, 43 years old, grade teacher.Patient causes acute suppurative otitis media because of upper respiratory tract infection, deaf
Tinnitus, auditory dysesthesia, had a strong impact on routine work and life.After using 1 course for the treatment of of [Dan of the present invention, symptom takes a turn for the better, and continues
Continuing and use 1 course for the treatment of, transference cure, ear gets well, and follows up a case by regular visits to not recur so far.
6, history ××, man, 50 years old, unemployed.Patient's private prosecution left ear otalgia, suppurates, and inappetence is paid attention to, the later stage
More serious, otalgia is radiated at homonymy head, tooth, auditory dysesthesia, and my institute checks then, finds mucosa of tympanic cavity hyperemia swelling
Very serious, tympanum blood capillary pressurized, it is diagnosed as acute suppurative otitis media.After using 1 course for the treatment of of [Dan of the present invention, disease
Shape substantially alleviates, and then uses and recovers 2 courses for the treatment of, ear normal, follows up a case by regular visits to not recur so far.
Claims (5)
1. the [Dan treating acute suppurative otitis media, it is characterised in that: described [Dan is by Chinese medicine and western medicine composition
Composition, raw material composition and the parts by weight of making described Chinese medicine ingredients are: Folium Ilicis 63～93 parts, and Radix Crepidis elongatae 62～92 parts are fragrant
Ru 60～90 parts, Rhizoma Donacis canniformis 59～89 parts, Rhizoma soulieae vaginatae 57～87 parts, Semen Cuscutae 55～85 parts, Hibisci Mutabilis 53～83 parts, Medulla passeris 51
～81 parts, Martianus dermestoides Chevr. 49～79 parts, Radix abutili indici 48～78 parts, Radix Puerariae 47～77 parts, Radix Berberidis Amurensis 46～76 parts；Make described western medicine composition
Raw material composition and parts by weight be: chloramphenicol ear drop 1.0～2.0 parts, oxymetazoline 0.8～1.7 parts, iodine glycerol 0.6～
1.5 parts, crotamiton 0.3～1.4 parts.
A kind of [Dan treating acute suppurative otitis media the most according to claim 1, it is characterised in that: described ear
Liquid is made up of Chinese medicine and western medicine composition, make described Chinese medicine ingredients raw material composition and parts by weight be: Folium Ilicis 86 parts, return to life from the nether world
Join 85 parts, Herba Moslae 83 parts, Rhizoma Donacis canniformis 82 parts, Rhizoma soulieae vaginatae 80 parts, Semen Cuscutae 78 parts, Hibisci Mutabilis 76 parts, Medulla passeris 74 parts, Martianus dermestoides Chevr. 72
Part, Radix abutili indici 71 parts, Radix Puerariae 70 parts, Radix Berberidis Amurensis 69 parts；Make described western medicine composition raw material composition and parts by weight be: chloromycetin
[Dan 1.5 parts, oxymetazoline 1.4 parts, iodine glycerol 1.2 parts, crotamiton 1.0 parts.
A kind of [Dan treating acute suppurative otitis media the most according to claim 1, it is characterised in that: described ear
Liquid is made up of Chinese medicine and western medicine composition, make described Chinese medicine ingredients raw material composition and parts by weight be: Folium Ilicis 79 parts, return to life from the nether world
Join 78 parts, Herba Moslae 76 parts, Rhizoma Donacis canniformis 75 parts, Rhizoma soulieae vaginatae 73 parts, Semen Cuscutae 71 parts, Hibisci Mutabilis 69 parts, Medulla passeris 67 parts, Martianus dermestoides Chevr. 65
Part, Radix abutili indici 64 parts, Radix Puerariae 63 parts, Radix Berberidis Amurensis 62 parts；Make described western medicine composition raw material composition and parts by weight be: chloromycetin
[Dan 1.3 parts, oxymetazoline 1.2 parts, iodine glycerol 0.9 part, crotamiton 0.7 part.
A kind of [Dan treating acute suppurative otitis media the most according to claim 1, it is characterised in that: described ear
Liquid is made up of Chinese medicine and western medicine composition, make described Chinese medicine ingredients raw material composition and parts by weight be: Folium Ilicis 72 parts, return to life from the nether world
Join 71 parts, Herba Moslae 69 parts, Rhizoma Donacis canniformis 68 parts, Rhizoma soulieae vaginatae 66 parts, Semen Cuscutae 64 parts, Hibisci Mutabilis 62 parts, Medulla passeris 60 parts, Martianus dermestoides Chevr. 58
Part, Radix abutili indici 57 parts, Radix Puerariae 56 parts, Radix Berberidis Amurensis 55 parts；Make described western medicine composition raw material composition and parts by weight be: chloromycetin
[Dan 1.1
Part, oxymetazoline 0.9 part, iodine glycerol 0.7 part, crotamiton 0.5 part.
5. a preparation method for the [Dan of the treatment acute suppurative otitis media as described in any one of Claims 1 to 4, its
It is characterised by: comprise the following steps that:
(1) Folium Ilicis, Radix Crepidis elongatae, Medulla passeris, Martianus dermestoides Chevr. and Radix Berberidis Amurensis are put in container, add relative mixture quality 6～8 times amount
Distilled water immersion 2～after 3 days, the mass concentration adding 3～4 times amount is 45%～55% ethanol, is heated to reflux 2～3 hours, mistake
Filter, obtains extracting solution；The medicinal residues obtained after filtering add the distilled water of relative medicinal residues quality 4～6 times amount, are heated to reflux 1～2
Hour；Filter, obtain extracting solution；Merge twice extracting solution, filter, reclaim ethanol, obtain filtrate, standby；
(2) Herba Moslae, Rhizoma soulieae vaginatae and Hibisci Mutabilis are put into container, the saline soak of addition 6～8 times amount 2 days, filter out, in 200 DEG C
～dry at 280 DEG C, taking-up is dried in the air cool, grinds into powder, obtained the fine powder of 160 mesh in being placed in mortar, standby；
(3) Rhizoma Donacis canniformis and Radix Puerariae being mixed in container, the addition distilled water relative to 7～10 times of mixture quality soaks
Bubble, takes out after being run through, and section is placed in pot, sprays yellow wine and mixes thoroughly, slow fire fried dry, and taking-up is dried in the air cool, grinds in being placed in mortar
End, obtained the fine powder of 140 mesh, standby；
(4) remove silt by naughty to Semen Cuscutae and Radix abutili indici warm water, be mixed in container, add the Huang of relative mixture quality 6～8 times amount
Steeping in wine one night, exposed in the sun to drying, grind into powder in being placed in mortar, obtained the fine powder of 140 mesh, standby；
(5) oxymetazoline, iodine glycerol and crotamiton being mixed in container, the mass concentration adding 10 times amount is 75%～85% second
Alcohol, uniform stirring so that it is dissolve, obtain solution, standby；
(6) by the filtrate of step (1) gained, step (2), step (3), fine powder and step (5) the gained solution of step (4) gained
Mixing, adds chloramphenicol ear drop and the distilled water of 10 times amount, and instills sodium bicarbonate solution and regulate pH value to 7.0～7.5, in
Homogenize 10～30 minutes with ultrasound wave at 0 DEG C～5 DEG C, embedding gland, sterilizing 30 minutes under 121 DEG C of hot pressing, make 30ml/ bottle
[Dan, be the [Dan of described treatment acute suppurative otitis media.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1137917A (en) * | 1996-03-29 | 1996-12-18 | 王继德 | Compound jiabing ear drops and preparation method thereof |
| CN1562076A (en) * | 2004-03-30 | 2005-01-12 | 卢利权 | Chinese-western compound preparation for treating ear diseases |
| CN1623572A (en) * | 2003-12-05 | 2005-06-08 | 韩播 | Anti-inflammation medicine |
-
2016
- 2016-08-22 CN CN201610697122.XA patent/CN106177240A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1137917A (en) * | 1996-03-29 | 1996-12-18 | 王继德 | Compound jiabing ear drops and preparation method thereof |
| CN1623572A (en) * | 2003-12-05 | 2005-06-08 | 韩播 | Anti-inflammation medicine |
| CN1562076A (en) * | 2004-03-30 | 2005-01-12 | 卢利权 | Chinese-western compound preparation for treating ear diseases |
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