CN106176746A - A kind of child's injecting narcotic - Google Patents

A kind of child's injecting narcotic Download PDF

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Publication number
CN106176746A
CN106176746A CN201610539601.9A CN201610539601A CN106176746A CN 106176746 A CN106176746 A CN 106176746A CN 201610539601 A CN201610539601 A CN 201610539601A CN 106176746 A CN106176746 A CN 106176746A
Authority
CN
China
Prior art keywords
component
child
injecting narcotic
narcotic
injecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610539601.9A
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Chinese (zh)
Inventor
孙剑
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201610539601.9A priority Critical patent/CN106176746A/en
Publication of CN106176746A publication Critical patent/CN106176746A/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a kind of child's injecting narcotic, comprising: component A:

Description

A kind of child's injecting narcotic
Technical field
The present invention relates to a kind of child's injecting narcotic.
Background technology
Anesthetics is requisite medicine in medical surgery, is generally divided into general anesthetic and local anesthetic, and complete Body anesthetics deeply suppresses cerebral cortex, makes people's mind disappear.Tradition use general anesthetic by ether and fluorochemical, But such medicine storage request is higher, and photodissociation, pyrolysis, poor stability easily occur, and deposits and there is impurity the most at once, impact anesthesia effect Really, when using especially for child, cause Anesthetic safety accident.Therefore in the urgent need to developing the stable fiber crops that a kind of child uses Liquor-saturated dose.
Summary of the invention
It is an object of the invention to provide one and deposit stable, free from admixture produces, use safe efficient, have no side effect Child's injecting narcotic.
The technical scheme is that a kind of child's injecting narcotic, comprising:
Component A:,
In formula: R1 is the alkyl of 1-4 carbon atom；R2 is benzyl；R3 is the alkylcarboxyalkyl of most 8 carbon atoms；
Component B: polysorbate80；
Component C: etomidate;
Component D: mepivacaine;
Component E: lignocaine and WS-23 are by quality 2:1 eutectic mixture.
Described component A:B:C:D:E mass ratio=1.5:0.8:4:28:2.5.
Use this compound to prepare anesthetics, can avoid producing, store, transport in decompose and produce impurity, impact anesthesia Safety, improves safety in utilization.
Detailed description of the invention
A kind of child's injecting narcotic, comprising:
Component A:,
In formula: R1 is the alkyl of 1-4 carbon atom；R2 is benzyl；R3 is the alkylcarboxyalkyl of most 8 carbon atoms；
Component B: polysorbate80；
Component C: etomidate;
Component D: mepivacaine;
Component E: lignocaine and WS-23 are by quality 2:1 eutectic mixture.
Described component A:B:C:D:E mass ratio=1.5:0.8:4:28:2.5.

Claims (2)

1. child's injecting narcotic, comprising:
Component A:,
In formula: R1 is the alkyl of 1-4 carbon atom；R2 is benzyl；R3 is the alkylcarboxyalkyl of most 8 carbon atoms；
Component B: polysorbate80；
Component C: etomidate;
Component D: mepivacaine;
Component E: lignocaine and WS-23 are by quality 2:1 eutectic mixture.
A kind of child's injecting narcotic the most according to claim 1, is characterized in that: described component A:B:C:D:E mass ratio= 1.5:0.8:4:28:2.5.
CN201610539601.9A 2016-07-11 2016-07-11 A kind of child's injecting narcotic Pending CN106176746A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610539601.9A CN106176746A (en) 2016-07-11 2016-07-11 A kind of child's injecting narcotic

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610539601.9A CN106176746A (en) 2016-07-11 2016-07-11 A kind of child's injecting narcotic

Publications (1)

Publication Number Publication Date
CN106176746A true CN106176746A (en) 2016-12-07

Family

ID=57473094

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610539601.9A Pending CN106176746A (en) 2016-07-11 2016-07-11 A kind of child's injecting narcotic

Country Status (1)

Country Link
CN (1) CN106176746A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101765582A (en) * 2007-04-26 2010-06-30 奥斯拜客斯制药有限公司 Deuterium-labelled ketamine
US20100303718A1 (en) * 2003-10-08 2010-12-02 David Anderson Stabilized Uncoated Particles of Reversed Liquid Crystalline Phase Materials
CN104706587A (en) * 2013-12-16 2015-06-17 天津迈迪瑞康生物医药科技有限公司 Etomidate fat emulsion concentrated solution, preparation method and application thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100303718A1 (en) * 2003-10-08 2010-12-02 David Anderson Stabilized Uncoated Particles of Reversed Liquid Crystalline Phase Materials
CN101765582A (en) * 2007-04-26 2010-06-30 奥斯拜客斯制药有限公司 Deuterium-labelled ketamine
CN104706587A (en) * 2013-12-16 2015-06-17 天津迈迪瑞康生物医药科技有限公司 Etomidate fat emulsion concentrated solution, preparation method and application thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
史新华 等: "利多卡因联合依托咪酯在老年人无痛胃镜中的应用", 《世界临床药物》 *

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WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20161207

WD01 Invention patent application deemed withdrawn after publication