CN106038487A - Intravenous injection emulsion anesthetic for pregnant women - Google Patents

Intravenous injection emulsion anesthetic for pregnant women Download PDF

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Publication number
CN106038487A
CN106038487A CN201610539602.3A CN201610539602A CN106038487A CN 106038487 A CN106038487 A CN 106038487A CN 201610539602 A CN201610539602 A CN 201610539602A CN 106038487 A CN106038487 A CN 106038487A
Authority
CN
China
Prior art keywords
component
intravenous injection
anesthetic
injection emulsion
pregnant women
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610539602.3A
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Chinese (zh)
Inventor
孙剑
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Individual
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201610539602.3A priority Critical patent/CN106038487A/en
Publication of CN106038487A publication Critical patent/CN106038487A/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Abstract

The invention relates to an intravenous injection emulsion anesthetic for pregnant women. The intravenous injection emulsion anesthetic for pregnant women is prepared from a component A shown in the description, a component B which is polysorbate 80, a component C which is etomidate, a component D which is mepivacaine, and a component E which is non-cyclic amide.

Description

A kind of anemia of pregnant woman's intravenous injection emulsion anesthetis
Technical field
The present invention relates to a kind of anemia of pregnant woman's intravenous injection emulsion anesthetis.
Background technology
Anesthetics is requisite medicine in medical surgery, is generally divided into general anesthetic and local anesthetic, and complete Body anesthetics deeply suppresses cerebral cortex, makes people's mind disappear.Tradition use general anesthetic by ether and fluorochemical, But such medicine storage request is higher, and photodissociation, pyrolysis, poor stability easily occur, and deposits and there is impurity the most at once, impact anesthesia effect Really, when using especially for anemia of pregnant woman, cause Anesthetic safety accident.Therefore in the urgent need to developing the stable fiber crops that a kind of anemia of pregnant woman uses Liquor-saturated dose.
Summary of the invention
It is an object of the invention to provide one and deposit stable, free from admixture produces, use safe efficient, have no side effect Anemia of pregnant woman's intravenous injection emulsion anesthetis.
The technical scheme is that a kind of anemia of pregnant woman's intravenous injection emulsion anesthetis, comprising:
Component A:；
Component B: polysorbate80；
Component C: etomidate;
Component D: mepivacaine;
Component E: non-cyclic amides.
Described component A:B:C:D:E mass ratio=1.8:1:4:28:3.
Use this compound to prepare anesthetics, can avoid producing, store, transport in decompose and produce impurity, impact anesthesia Safety, improves safety in utilization.
Detailed description of the invention
A kind of anemia of pregnant woman's intravenous injection emulsion anesthetis, comprising:
Component A:；
Component B: polysorbate80；
Component C: etomidate;
Component D: mepivacaine;
Component E: non-cyclic amides.
Described component A:B:C:D:E mass ratio=1.8:1:4:28:3.

Claims (2)

1. anemia of pregnant woman's intravenous injection emulsion anesthetis, comprising:
Component A:；
Component B: polysorbate80；
Component C: etomidate;
Component D: mepivacaine;
Component E: non-cyclic amides.
A kind of anemia of pregnant woman's intravenous injection emulsion anesthetis the most according to claim 1, is characterized in that: described component A:B:C:D: E mass ratio=1.8:1:4:28:3.
CN201610539602.3A 2016-07-11 2016-07-11 Intravenous injection emulsion anesthetic for pregnant women Pending CN106038487A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610539602.3A CN106038487A (en) 2016-07-11 2016-07-11 Intravenous injection emulsion anesthetic for pregnant women

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610539602.3A CN106038487A (en) 2016-07-11 2016-07-11 Intravenous injection emulsion anesthetic for pregnant women

Publications (1)

Publication Number Publication Date
CN106038487A true CN106038487A (en) 2016-10-26

Family

ID=57185558

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610539602.3A Pending CN106038487A (en) 2016-07-11 2016-07-11 Intravenous injection emulsion anesthetic for pregnant women

Country Status (1)

Country Link
CN (1) CN106038487A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102844022A (en) * 2010-04-21 2012-12-26 帝国制药美国公司 Local anesthetic emulsion compositions and methods of making and using the same
CN104706587A (en) * 2013-12-16 2015-06-17 天津迈迪瑞康生物医药科技有限公司 Etomidate fat emulsion concentrated solution, preparation method and application thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102844022A (en) * 2010-04-21 2012-12-26 帝国制药美国公司 Local anesthetic emulsion compositions and methods of making and using the same
CN104706587A (en) * 2013-12-16 2015-06-17 天津迈迪瑞康生物医药科技有限公司 Etomidate fat emulsion concentrated solution, preparation method and application thereof

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WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20161026

WD01 Invention patent application deemed withdrawn after publication