CN106124686A - A kind of method of quality control of removing heat from the lung and dissipating phlegm antitussive medicine - Google Patents
A kind of method of quality control of removing heat from the lung and dissipating phlegm antitussive medicine Download PDFInfo
- Publication number
- CN106124686A CN106124686A CN201610778920.5A CN201610778920A CN106124686A CN 106124686 A CN106124686 A CN 106124686A CN 201610778920 A CN201610778920 A CN 201610778920A CN 106124686 A CN106124686 A CN 106124686A
- Authority
- CN
- China
- Prior art keywords
- lung
- removing heat
- medicine
- quality control
- dissipating phlegm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present invention relates to the method for quality control of a kind of removing heat from the lung and dissipating phlegm antitussive medicine, at lung clearing cough suppressing phlegm transforming medicinal ball on the basis of primary standard, establish the thin-layer identification method of Radix Peucedani, filter out favorable reproducibility, revised quality standard in specificity is strong, spot development is clear, result easily judges method inclusive criteria, improve the quality control of medicine, the qualitative detection making medicine is more accurate, and quality is more prone to control.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to the detection method of Chinese medicine, the especially quality of lung clearing cough suppressing phlegm transforming medicinal ball
Control method.
Background technology
Lung clearing cough suppressing phlegm transforming medicinal ball prescription: Radix Scutellariae 96g, Radix Trichosanthis 48g, Bulbus Fritillariae Thunbergii 24g, Fructus Aurantii (removing flesh parched with bran) 24g, Radix Platycodonis
24g, Cortex Mori (processed with honey) 24g, Radix Et Rhizoma Rhei 12g, Rhizoma Anemarrhenae 12g, 12g Radix Ophiopogonis, Exocarpium Citri Grandis 12g, Semen Armeniacae Amarum (peeling fry) 12g, front
12g, Radix Stemonae 12g, Radix Glycyrrhizae 3g recklessly.
Preparation method: by above 14 tastes, be ground into fine powder, sieve, mixing, with water pill, it is dried, to obtain final product.
Function cures mainly: lung heat clearing, reduces phlegm, antitussive.The cough yellow sputum caused for lung-heat expectorant, chest and diaphragm is not smooth, hoarseness of having sore throat, greatly
Dry stool is dry.
Clearing heat in the lung this prescription of relieving cough and resolving phlegm ball with Radix Scutellariae, Radix Trichosanthis as principal agent, the clear eliminating the pathogens from the lung scorching phlegm syndrome of intestines and internal organs of the body internal organs；With Radix Peucedani,
Radix Platycodonis, Bulbus Fritillariae Thunbergii are that auxiliary abundant expectoration due to lung-heat of controlling is coughed；Relievining asthma with Semen Armeniacae Amarum, Cortex Mori, stemona root cough relieving, Radix Ophiopogonis, the Rhizoma Anemarrhenae nourish lung yin,
Radix Et Rhizoma Rhei is equipped with Radix Trichosanthis and rushes down large intestine internal organs heat, with Exocarpium Citri Grandis, Fructus Aurantii activating QI to eliminate phlegm, and prevents Radix Et Rhizoma Rhei, Radix Scutellariae from rushing down clearly too, for assistant
Medicine；Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.Full side ten four Chinese medicines work in coordination with onset, are exclusively used in the cough yellow sputum that treatment abundant expectoration due to lung-heat causes, and chest and diaphragm is not
Freely, hoarseness of having sore throat, it is hard and dry.For bronchitis, the pneumonia person that occurs above-mentioned symptom.
Existing standard is recorded in the 7th (Chinese medicine one-tenth of " Drug Standard of Ministry of Public Health of the Peoples Republic of China " in 1993 version
Square preparation) page 172 (WS3-B-1433-93).Its quality standard only defines appearance character, microscopical identification and Elsholtzia
The thin-layer identification method of material, it is impossible to the fundamentally control product inherent quality of qualitative, quantitative.Through retrieval, find no pass clearing heat in the lung
The patent documentation of Zhisou-Huatan tablet detection method.
Summary of the invention
(1) it is an object of the invention to provide a kind of can the quality control of qualitative detection a kind of removing heat from the lung and dissipating phlegm antitussive medicine
Method, this method has that detection means is simple, testing result feature more accurately.
(2) technical scheme that the present invention is concrete:
Prepared by test sample: take this product 5g, finely ground, and add diethyl ether 20ml, supersound process 15 minutes, filters, and filtrate is evaporated, and residue adds three
Chloromethanes 1ml makes dissolving, as need testing solution.
Prepared by control medicinal material solution: separately take Radix Peucedani control medicinal material 1 g, be made in the same way of control medicinal material solution.
Thin layer chromatography condition: according to thin layer chromatography (four annex general rules 0502 of " Chinese Pharmacopoeia " version in 2015) test, inhale
Take each 2 μ l of above two solution, put respectively on same silica gel g thin-layer plate, with petroleum ether (60 ~ 90 DEG C)-ethyl acetate-first
Acid (7 3 0.1) is developing solvent, launches, and takes out, dries, put and inspect under ultra-violet lamp (365nm).
Result judge: contrast test sample, control medicinal material, the chromatogram of negative control sample, wherein test sample with compare medicine
On wood color spectrum relevant position, the speckle of aobvious same color this, person be qualified.
(3) advantages of the present invention and good effect are: the present invention, sets up at lung clearing cough suppressing phlegm transforming medicinal ball on the basis of primary standard
The thin-layer identification method of Radix Peucedani, filters out favorable reproducibility, specificity is strong, spot development is clear, result easily judges method is received
Entering revised quality standard in standard, improve the quality control of medicine, the qualitative detection making medicine is more accurate, and quality is more
Add and be easily controlled.
With detailed description of the invention, the present invention is elaborated below in conjunction with the accompanying drawings, not the restriction to invention.All according to
This area equivalent that the disclosure of invention is carried out, belongs to protection scope of the present invention.
Accompanying drawing explanation
Fig. 1 is the thin layer identification color spectrogram of Radix Peucedani of the present invention, the most from left to right: Radix Peucedani control medicinal material, Radix Peucedani comparison medicine
Material, 20060605 batches of test samples, 20060610 batches of test samples, 20060615 batches of test samples, negative samples.
Detailed description of the invention
Embodiment 1
One, material
Test sample: lung clearing cough suppressing phlegm transforming medicinal ball, Lerentang Pharmaceutical Factory, Zhongxin Pharmaceutical Group Co., Ltd., Tianj, lot number:
160801、160802、160803。
Control medicinal material: Radix Peucedani control medicinal material, National Institute for Food and Drugs Control, lot number 120951-200704.
Prepared by negative control: the technique announced according to pharmacopeia and the prescription preparation drug sample without Radix Peucedani.
Two, detection
The preparation of need testing solution: take this product 5g, finely ground, add diethyl ether 20ml, supersound process 15 minutes, filters, and filtrate is evaporated, residual
Slag adds chloroform 1ml makes dissolving,.
The preparation of control medicinal material solution: take Radix Peucedani control medicinal material 1g, prepare by the preparation method of need testing solution.
The preparation of medical material solution: take Radix Peucedani medical material 1g, prepare by the preparation method of need testing solution.
Prepared by negative controls: prepare the sample without Radix Peucedani according to prescription and technique, take this sample by need testing solution
Prepared by preparation method.
Chromatographic condition: adsorbent: silica gel G
Developing solvent: petroleum ether (60～90 DEG C)-ethyl acetate-formic acid (7 3 0.1)
Colour developing: put and inspect under ultra-violet lamp (365nm).
Result judge: contrast test sample, control medicinal material, the chromatogram of negative control sample, wherein test sample with compare medicine
On wood color spectrum relevant position, the speckle of aobvious same color this, person be qualified.
Three, result
Three batches of test samples (20060605,20060610,20060615) differentiate as stated above.In test sample chromatograph, with front
Control medicinal material chromatograph relevant position is identical fluorescence mottle recklessly, and negative noiseless.
Claims (2)
1. the method for quality control of a removing heat from the lung and dissipating phlegm antitussive medicine, it is characterised in that use thin layer chromatography to differentiate removing heat from the lung and dissipating phlegm
Radix Peucedani in antitussive drug prescription.
The method of quality control of a kind of removing heat from the lung and dissipating phlegm antitussive medicine the most according to claim 1, it is characterised in that: described thin
Layer chromatography differentiates that in prescription, the method for Radix Peucedani is:
1. the preparation of need testing solution: take this product 5g, finely ground, add diethyl ether 20ml, supersound process 15 minutes, filters, and filtrate is evaporated,
Residue adds chloroform 1ml makes dissolving, as need testing solution；
2. the preparation of reference substance solution: take Radix Peucedani control medicinal material 1 g, makes control medicinal material solution with 1. method；
3. thin layer condition: draw each 2 μ l of above two solution, put respectively on same silica gel g thin-layer plate, with petroleum ether (60 ~
90 DEG C)-ethyl acetate-formic acid (7 3 0.1) is developing solvent, launches, take out, dry, put and inspect under ultra-violet lamp (365nm)；
In test sample chromatograph, on position corresponding with control medicinal material chromatograph, the fluorescence speckle of aobvious same color.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610778920.5A CN106124686A (en) | 2016-08-31 | 2016-08-31 | A kind of method of quality control of removing heat from the lung and dissipating phlegm antitussive medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610778920.5A CN106124686A (en) | 2016-08-31 | 2016-08-31 | A kind of method of quality control of removing heat from the lung and dissipating phlegm antitussive medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106124686A true CN106124686A (en) | 2016-11-16 |
Family
ID=57272564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610778920.5A Pending CN106124686A (en) | 2016-08-31 | 2016-08-31 | A kind of method of quality control of removing heat from the lung and dissipating phlegm antitussive medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106124686A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6383525B1 (en) * | 2000-12-14 | 2002-05-07 | Globoasia L.L.C. | Herbal compositions for treating immunological disorders |
| CN1515272A (en) * | 2003-01-08 | 2004-07-28 | 江苏康缘药业股份有限公司 | Chinese medicine composition for curing cough, its preparation method and quality control method |
| CN101190282A (en) * | 2006-11-22 | 2008-06-04 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Sugar-free compound traditional Chinese medicinal preparation for treating upper respiratory tract infection and quality control method thereof |
| CN102048864A (en) * | 2009-11-03 | 2011-05-11 | 天津中新药业集团股份有限公司达仁堂制药厂 | Quality control method of children lung clearing pills serving as Chinese medicinal preparation |
| CN102297926A (en) * | 2011-07-12 | 2011-12-28 | 刘金伶 | Rapid TLC identification and three-component simultaneous quantitative determination method for antitussive tablets |
| JP4998151B2 (en) * | 2007-08-29 | 2012-08-15 | 株式会社ツムラ | Purification method of pesticide residues in crude drug samples |
| CN103869041A (en) * | 2012-12-08 | 2014-06-18 | 迪沙药业集团有限公司 | Quality control method for cough-relieving oral pharmaceutical composition |
-
2016
- 2016-08-31 CN CN201610778920.5A patent/CN106124686A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6383525B1 (en) * | 2000-12-14 | 2002-05-07 | Globoasia L.L.C. | Herbal compositions for treating immunological disorders |
| CN1515272A (en) * | 2003-01-08 | 2004-07-28 | 江苏康缘药业股份有限公司 | Chinese medicine composition for curing cough, its preparation method and quality control method |
| CN101190282A (en) * | 2006-11-22 | 2008-06-04 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Sugar-free compound traditional Chinese medicinal preparation for treating upper respiratory tract infection and quality control method thereof |
| JP4998151B2 (en) * | 2007-08-29 | 2012-08-15 | 株式会社ツムラ | Purification method of pesticide residues in crude drug samples |
| CN102048864A (en) * | 2009-11-03 | 2011-05-11 | 天津中新药业集团股份有限公司达仁堂制药厂 | Quality control method of children lung clearing pills serving as Chinese medicinal preparation |
| CN102297926A (en) * | 2011-07-12 | 2011-12-28 | 刘金伶 | Rapid TLC identification and three-component simultaneous quantitative determination method for antitussive tablets |
| CN103869041A (en) * | 2012-12-08 | 2014-06-18 | 迪沙药业集团有限公司 | Quality control method for cough-relieving oral pharmaceutical composition |
Non-Patent Citations (4)
| Title |
|---|
| SONG YUELIN 等: "Research progress of the studies on the roots of Peucedanum praeruptorum dunn (Peucedani radix)", 《PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES》 * |
| 国家药典委员会编: "《国家药品标准 新药转正标准 第88册》", 31 August 2011, 北京：中国医药科技出版社 * |
| 姬志勤 等 主编: "《农药活性天然产物及其分离技术》", 31 January 2010, 北京：化学工业出版社 * |
| 韩邦兴 等: "开花与栽培对紫花前胡显微及化学成分的影响", 《中国中医药科技》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2022036795A1 (en) | Method for identifying composition for dispelling dampness and detoxicating | |
| CN101396486B (en) | Traditional Chinese medicine composition for treating cough and asthma and preparation and quality control method thereof | |
| CN101366876A (en) | Traditional Chinese medicine preparation for treating throat irritation and preparation method thereof | |
| CN107019739B (en) | Houttuynia cordata, scutellaria baicalensis and isatis root oral liquid and preparation method thereof and product quality control method | |
| CN106124686A (en) | A kind of method of quality control of removing heat from the lung and dissipating phlegm antitussive medicine | |
| CN106389562A (en) | Pudilan Xiaoyan granules, preparation method thereof, and product quality control method | |
| CN106324176A (en) | Quality control method of medicine for clearing lung, eliminating phlegm and relieving coughs | |
| CN106226453A (en) | A kind of method of quality control of removing heat from the lung and dissipating phlegm antitussive medicine | |
| CN105412281A (en) | Traditional Chinese medicinal composition for treating allergic asthma and preparation method thereof | |
| CN106248859A (en) | A kind of method of quality control of removing heat from the lung and dissipating phlegm antitussive medicine | |
| CN106198842A (en) | A kind of method of quality control of removing heat from the lung and dissipating phlegm antitussive medicine | |
| CN102225144B (en) | Traditional Chinese medicine compound for treating cough and asthma and preparation method thereof | |
| CN107929545A (en) | A kind of Chinese medicine compound prescription for treating Small pulmonary nodule | |
| CN102258665B (en) | Inspection method of Chinese medicinal composition for treating cough and asthma | |
| CN101670088B (en) | Traditional Chinese medicine composite for treating acute/chronic bronchitis | |
| CN106110132A (en) | A kind of compositions with removing heat from the lung and dissipating phlegm antitussive effect and preparation method thereof | |
| CN106290649A (en) | A kind of method of quality control of removing heat from the lung and dissipating phlegm antitussive medicine | |
| CN106138665A (en) | A kind of Chinese medicine composition for treating chicken pneumonia | |
| CN105738554A (en) | Thin-layer chromatography detection method for rhizoma anemarrhenae for antipyretic and antitoxic powder | |
| CN107782838A (en) | A kind of clearing lung and eliminating phlegm stops the method for quality control for medicine of coughing | |
| CN106226441A (en) | A kind of method of quality control of removing heat from the lung and dissipating phlegm antitussive medicine | |
| CN111588742A (en) | Application of myrrh sesquiterpene extract in preparation of chronic obstructive pulmonary disease medicine | |
| CN110448649A (en) | The preparation process of eliminating pestilence and relieving toxicity particle | |
| CN107328890A (en) | The thin-layered chromatography detection method of curcuma zedoary in a kind of Fushengkang piece | |
| CN108815438A (en) | A kind of pharmaceutical composition for treating chronic obstructive pulmonary disease |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161116 |
|
| WD01 | Invention patent application deemed withdrawn after publication |