CN106110207A - 一种用于不孕症的中药组合物 - Google Patents
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Abstract
本发明涉及一种用于不孕症的中药组合物及其服用方法,它是由下列原料药物组成的:柴胡、白芍、当归、党参、白术、香附、茯苓、熟地、山药、菟丝子、枸杞子、益母草、续断、郁金、甘草、鹿角霜、紫石英、肉桂、丹参、首乌藤、红花、芡实、山萸肉、三棱,上述药物水煎服,一天一剂,来月经第3天开始,服7剂。本发明的中药组合物均采用天然的中草药,具有补脾益气、燥湿化痰、舒肝解郁、养肝固肾、益精填髓、理气调冲、调经止痛、暖宫散寒、活血化瘀、养血安胎的功效,总有效率达87.2%。
Description
技术领域
本发明涉及一种传统草药的未确定结构的医用配制品,具体地说是一种用于不孕症的中药组合物。
背景技术
不孕的医学定义为一年未采取任何避孕措施,性生活正常而没有成功妊娠。不孕是一种常见的问题,大约影响到至少10%~15%的育龄夫妇。不孕症多由常见的妇科疾病引起,少数也可由全身性疾病引起,近年来,随着环境污染的加重、社会成员性观念的开放和人们生活方式的转变,不孕症发病率呈逐年上升趋势。西医多用服用激素类药物、人工授精、试管婴儿等方法,但西药副作用大,人工授精、试管婴儿手术痛苦、成功率低、费用高昂,孕后妊娠反应严重,给患者及家庭带来严重的精神和经济负担。
经云:女子“二七天癸至,任脉通,太冲脉盛,月事以时下,故有子。”中医认为本病的发生,因先天禀赋不足,房室不节,肾精不充,冲任脉虚,或肾阴不足,胞宫虚冷;或素体虚弱,阴血不足,胞脉失养;或情志不畅,肝气郁结,气血失和;或素体肥胖、恣食膏粱厚味,脾肾阳虚,蕴生痰湿,气机阻滞,冲任不通;或血瘀凝结,症瘕积聚,积于胞中等引起。主要是由于肾气虚衰、精血不足、肝郁气滞、痰湿阻滞等造成冲任气血功能失调,致使机体不能摄精成孕。本发明根据中医理论,针对不孕症的发病机理,以补脾益气、燥湿化痰、舒肝解郁、养肝固肾、益精填髓、理气调冲、调经止痛、暖宫散寒、活血化瘀、养血安胎为治疗原则,以达到标本兼治的目的。
发明内容
本发明的目的就是为了克服上述现有的技术不足,根据中医理论,通过数年的药物筛选和反复临床验证,提供一种具有补脾益气、燥湿化痰、舒肝解郁、养肝固肾、益精填髓、理气调冲、调经止痛、暖宫散寒、活血化瘀、养血安胎的功能,配伍合理,药源广,成本低,疗效显著,无副作用的用于不孕症的中药组合物。
本发明解决其技术问题所采用的技术方案是:一种用于不孕症的中药组合物,其特征在于它是由下列重量配比的原料药物组成的:柴胡5-15g,白芍10-30g,当归10-30g,党参10-20g,白术10-20g,香附10-20g,茯苓10-20g,熟地20-40g,山药20-40g,菟丝子10-20g,枸杞子10-30g,益母草10-30g,续断10-20g,郁金5-15g,甘草5-15g,鹿角霜5-15g,紫石英5-15g,肉桂2-4g,丹参10-30g,首乌藤10-20g,红花10-20g,芡实10-20g,山萸肉10-20g,三棱5-15g。
本发明的优选技术方案是:一种用于不孕症的中药组合物,其特征在于它是由下列重量配比的原料药物组成的:柴胡10g,白芍20g,当归20g,党参15g,白术15g,香附15g,茯苓12g,熟地30g,山药30g,菟丝子15g,枸杞子20g,益母草20g,续断12g,郁金10g,甘草10g,鹿角霜10g,紫石英10g,肉桂3g,丹参20g,首乌藤15g,红花15g,芡实15g,山萸肉15g,三棱10g。
一种用于不孕症的中药组合物的服用方法,其特征在于它的服用方法:水煎服,每日1剂,分早晚两次服用,来月经第3天开始,服7剂。
本发明中药组合物是在传统中医理论和临床经验指导下,精选药物组方,其原料成本低,用于不孕症疗效高,无毒副作用。本发明中药组合物中:柴胡【性味】辛、苦,微寒【归经】归肝、胆经【功能主治】解表退热,疏肝解郁,升举阳气。主治外感发热,寒热往来,疟疾,肝郁胁痛乳胀,头痛头眩,月经不调,气虚下陷之脱肛,子宫脱垂,胃下垂。白芍【性味】苦、酸,微寒【归经】归肝,脾经【功能主治】养血柔肝,缓中止痛,敛阴收汗。主治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,月经不调,崩漏,带下。当归【性味】甘、辛、温【归经】归肝、心、脾经【功能主治】具有补血,活血,调经止痛,润肠通便的功效。主治血虚、血瘀诸症,眩晕头痛,心悸肢麻,月经不调,经闭,痛经,崩漏,结聚,虚寒腹痛,痿痹,赤痢后重,肠燥便难,跌打肿痛,痈疽疮疡。白术【性味】甘、苦,温【归经】归脾、胃经【功能主治】补脾,益胃,燥湿,和中,安胎,主治脾胃气弱,不思饮食,倦怠少气,虚胀,泄泻,痰饮,水肿,黄疸,湿痹,小便不利,头晕,自汗,胎气不安。香附【性味】辛、微苦、微甘,平【归经】归肝、脾、三焦经【功能主治】疏肝解郁,调经止痛,理气调中,安胎。主治胁肋胀痛,乳房胀育,疝气疼痛,月经不调,脘腹痞满疼痛,嗳气吞酸、呕恶,经行腹痛,崩漏带下,胎动不安。茯苓【性味】甘、淡,平【归经】归心、脾、肾经【功能主治】利水消肿,渗湿,健脾,宁心。主治小便不利,水肿胀满,痰饮咳逆,呕逆,恶阻,泄泻,遗精,淋浊,惊悸,健忘等症。熟地【性味】甘,微温【归经】归肝、肾经【功能主治】补血滋润,益精填髓。主治血虚萎黄,眩晕心悸,月经不调,崩不止,肝肾阴亏,潮热盗汗,遗精阳痿,不育不孕,月经不调,崩漏下血,腰膝酸软,耳鸣耳聋,头目昏花,须发早白,消渴,便秘,肾虚喘促。山药【性味】甘,平【归经】归脾、肺、肾经【功能主治】具有健脾补肺、益胃补肾、固肾益精、聪耳明目、助五脏、强筋骨、长志安神、延年益寿的功效。主治脾胃虚弱、倦怠无力、食欲不振、久泄久痢、肺气虚燥、痰喘咳嗽、肾气亏耗、腰膝酸软、下肢痿弱、消渴尿频、遗精早泄、带下白浊、皮肤赤肿、肥胖等病症。菟丝子【性味】辛、甘,平【归经】归肝、脾、肾经,【功能主治】补肾益精,养肝明目,固胎止泄。主治腰膝酸痛,遗精,阳痿早泄,不育,消渴,淋浊,遗尿,目昏耳鸣,胎动不安,流产,泄泻。枸杞子【性味】甘,平【归经】归肝、肾经【功能主治】补肾益精,养肝明目,补血安神,生津止渴,润肺止咳。主治肝肾阴亏,腰膝酸软,头晕,目眩,目昏多泪,虚劳咳嗽,消渴,遗精。益母草【性味】苦、辛,微寒【归经】归肝、心包经【功能主治】具有活血调经,利尿消肿的功效。用于月经不调,痛经,经闭,恶露不尽,水肿尿少,急性肾炎水肿。续断【性味】苦、辛,微温【归经】归肝、肾经【功能主治】补肝肾,强筋骨,调血脉,续折伤,止崩漏。主治腰背酸痛,足膝无力,胎漏,崩漏,带下,遗精,跌打损伤,金疮,痔漏,痈疽疮肿。郁金【性味】辛、苦,寒【归经】归肝、心、肺经【功能主治】活血止痛,行气解郁,清心凉血,利胆退黄。主治胸胁刺痛,胸痹心痛,经闭痛经,乳房胀痛,热病神昏,癫痫发狂,血热吐衄,黄疸尿赤。甘草【性味】甘,平【归经】归心、脾、肺、胃经【功能主治】有补脾益气,润肺止咳,清热解毒,缓解止痛,缓和药性的功效。鹿角霜【性味】咸、涩,温【归经】归肝、肾经【功能主治】温肾助阳,收敛止血。主治脾肾阳虚,白带过多,遗尿尿频,崩漏下血,疮疡不敛。紫石英【性味】味辛、甘,温,无毒【归经】归心、肝、肺、肾经【功能主治】镇心安神,降逆气,暖子宫。主治心悸,怔忡,惊痫,肺寒咳逆上气,女子宫寒不孕。肉桂【性味】辛、甘,大热【归经】归心、肝、脾、肾经【功能主治】补火助阳,引火归源,散寒止痛,活血通经。用于阳痿,宫冷,腰膝冷痛,肾虚作喘,阳虚眩晕,目赤咽痛,心腹冷痛,虚寒吐泻,寒疝,奔豚,经闭,痛经。丹参【性味】苦,微寒【归经】归心、肝经【功能主治】活血调经,祛瘀止痛,凉血消痈,清心除烦。主治月份经不调,经闭,痛经,产后瘀痛,癥瘕积聚,胸腹刺痛,风湿痹痛,疮疡痈肿,热病神志昏迷,心悸失眠,肝硬化,冠心病。首乌藤【性味】甘,平【归经】归心、肝经【功能主治】养血安神,祛风通络。主治失眠多梦,血虚身痛,风湿痹痛;外治皮肤瘙痒。红花【性味】辛,温【归经】归心、肝经【功能主治】活血通经,散瘀止痛。用于经闭,痛经,恶露不行,症瘕痞块,跌扑损伤,疮疡肿痛。芡实【性味】甘、涩,平【归经】归脾、肾经【功能主治】益肾固精,补脾止泻,祛湿止带。用于梦遗滑精,遗尿尿频,脾虚久泻,白浊,带下。山萸肉【性味】酸、涩,微温【归经】归肝、肾经【功能主治】补益肝肾,涩精止汗,固虚脱。主治肝肾不足之腰酸遗精、头晕目眩、月经过多以及尿频、自汗等症。三棱【性味】辛、涩,凉【归经】归脾、肝经【功能主治】破血行气,消积止。主治症瘕痞块,瘀滞经闭,痛经,食积胀痛,跌年伤痛。本发明具有补脾益气、燥湿化痰、舒肝解郁、养肝固肾、益精填髓、理气调冲、调经止痛、暖宫散寒、活血化瘀、养血安胎的功效,对不孕症达到标本兼治的目的。
本发明组合物的组分均采用天然的中草药,其配制简便、药源广、成本低。其遵循中医的处方用药原则,各种组分药物采用水煎服用。经临床应用验证,其疗效显著,作用可靠,药性平和,未出现毒副作用,总有效率87.2%。
具体实施方式
实施例1:一种用于不孕症的中药组合物,它是由下列重量配比的原料药物组成的:柴胡5g,白芍12g,当归15g,党参10g,白术10g,香附20g,茯苓20g,熟地35g,山药35g,菟丝子18g,枸杞子22g,益母草22g,续断13g,郁金15g,甘草15g,鹿角霜15g,紫石英15g,肉桂2g,丹参30g,首乌藤12g,红花12g,芡实16g,山萸肉16g,三棱8g,服用方法:水煎服,每日1剂,分早晚两次服用,来月经第3天开始,服7剂。
实施例2:一种用于不孕症的中药组合物,它是由下列重量配比的原料药物组成的:柴胡15g,白芍10g,当归30g,党参20g,白术20g,香附10g,茯苓10g,熟地25g,山药25g,菟丝子10g,枸杞子10g,益母草10g,续断10g,郁金8g,甘草8g,鹿角霜8g,紫石英8g,肉桂3g,丹参25g,首乌藤16g,红花16g,芡实12g,山萸肉12g,三棱5g,服用方法同上。
实施例3:一种用于不孕症的中药组合物,它是由下列重量配比的原料药物组成的:柴胡8g,白芍30g,当归10g,党参13g,白术13g,香附13g,茯苓15g,熟地20g,山药20g,菟丝子12g,枸杞子15g,益母草15g,续断15g,郁金12g,甘草12g,鹿角霜12g,紫石英12g,肉桂4g,丹参22g,首乌藤10g,红花10g,芡实20g,山萸肉20g,三棱12g,服用方法同上。
实施例4:一种用于不孕症的中药组合物,它是由下列重量配比的原料药物组成的:柴胡12g,白芍25g,当归25g,党参18g,白术18g,香附18g,茯苓14g,熟地40g,山药40g,菟丝子20g,枸杞子30g,益母草15g,续断18g,郁金14g,甘草14g,鹿角霜13g,紫石英13g,肉桂4g,丹参20g,首乌藤18g,红花18g,芡实10g,山萸肉10g,三棱14g,服用方法同上。
实施例5:一种用于不孕症的中药组合物,它是由下列重量配比的原料药物组成的:柴胡9g,白芍28g,当归28g,党参17g,白术17g,香附16g,茯苓18g,熟地32g,山药32g,菟丝子16g,枸杞子28g,益母草28g,续断20g,郁金5g,甘草5g,鹿角霜5g,紫石英5g,肉桂2g,丹参10g,首乌藤20g,红花20g,芡实18g,山萸肉18g,三棱15g,服用方法同上。
本发明实施例中的中药组合物按常规的水煎法制取药剂。具体方法如下:取本发明组方的原料药物药物放入容器中,先加水浸泡,加冷水漫过药面,浸泡20~30分钟,再加水没过药面约12厘米,进行第一次煎煮,先用武火煎煮,煮沸后用文火煎煮30~35分钟,滤出取药液汁200ml;第二煎煮,加水没过药面约10厘米,水沸后煎煮25~30分钟,滤出取药液汁200ml。两次煎煮取得药液汁合并。
一种用于不孕症的中药组合物,临床疗效总结:
一、一般性资料:
本中药组合物应用于临床观察病78例,年龄26~38岁。病程最短者2年,最长者达5年。
二、用法用量:
临床应用时,组合物中的组分、用量根据患者的体重、年龄及症状酌情增减。7剂为一疗程,一天一剂,水煎两遍取汁约400ml,分早、晚两次饭前半小时温热服用,来月经第3天开始,服7剂。
三、疗效标准:
有效:怀孕。
无效:临床症状无变化,未孕。
四、治疗效果:临床观察病例中,服药1-6个疗程,有效68例,无效10例。治疗期间未发生毒副作用。
五、典型病例:
1、汪某,女,28岁,婚后三年不孕,患者常年痛经,经检查患有多囊卵巢,卵泡发育不良,后服用本发明的中药组合物制备的药剂3个疗程,现已怀孕7个月。
2、林某,女,35岁,多次人工流产后,五年不孕,B超显示子宫内膜受损,服用本发明的中药组合物制备的药剂4个疗程,已怀孕生子。
3、郭某,女,30岁,婚后两年不孕,于2013年2月就诊,经医院检查,卵泡发育不良,后服用本发明的中药组合物制备的药剂2个疗程,现已怀孕。
Claims (2)
1.一种用于不孕症的中药组合物,其特征在于它是由下列重量配比的原料药物组成的:柴胡5-15g,白芍10-30g,当归10-30g,党参10-20g,白术10-20g,香附10-20g,茯苓10-20g,熟地20-40g,山药20-40g,菟丝子10-20g,枸杞子10-30g,益母草10-30g,续断10-20g,郁金5-15g,甘草5-15g,鹿角霜5-15g,紫石英5-15g,肉桂2-4g,丹参10-30g,首乌藤10-20g,红花10-20g,芡实10-20g,山萸肉10-20g,三棱5-15g。
2.根据权利要求1所述的一种用于不孕症的中药组合物,其特征在于它是由下列重量配比的原料药物组成的:柴胡10g,白芍20g,当归20g,党参15g,白术15g,香附15g,茯苓12g,熟地30g,山药30g,菟丝子15g,枸杞子20g,益母草20g,续断12g,郁金10g,甘草10g,鹿角霜10g,紫石英10g,肉桂3g,丹参20g,首乌藤15g,红花15g,芡实15g,山萸肉15g,三棱10g。
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