CN106109616A - A kind of gel treating child's impetigo and preparation method thereof - Google Patents
A kind of gel treating child's impetigo and preparation method thereof Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a kind of gel treating child's impetigo and preparation method thereof, relate to technical field of Chinese medicines, its effective ingredient includes the raw material of following weight portion: Rhizoma Coptidis 58 parts, Basil Essential 0.001 0.002 parts, Herba Scutellariae Barbatae 47 parts, cortex toonae 35 parts, Radix Gentianae 35 parts, Radix Arnebiae (Radix Lithospermi) 23 parts, Alumen 0.01 0.02 parts, 0.1 0.2 parts of Gypsum Fibrosum, the mechanism of gel prepared by the present invention is heat-clearing and toxic substances removing, damp eliminating is subsided a swelling, timid necrotic tissue and promoting muscle growing, killing parasites for relieving itching, it has good killing action for the pathogen causing impetigo, and can promote skin as early as possible heal elimination scar print；Preferable with the biocompatibility of skin, make ingredient quickly penetrate into, play drug effect, and gel can extend pharmaceutical release time, instant effect, therapeutic effect is notable.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly to a kind of gel treating child's impetigo and preparation side thereof
Method.
Background technology
Impetigo is a kind of suppurative dermatosis caused by pyococcus, is commonly called as " impetigo ", is mainly in summer and autumn
Joint, has contagion and the characteristic of self inoculation infection, easily popular in child, the pathogen gold that predominantly solidification prunus mume (sieb.) sieb.et zucc. is positive
Staphylococcus aureus or beta hemolytic streptococcus are individually or mixed infection.The Symptoms of this disease is: from the beginning of for point-like erythema
Or little pimple, rapidly go to foxtail millet grain, the vesicle of Semen Pisi sativi or bigger, around have blush；After 1-2 day, vesicle becomes pustule, pustule wall
Thin fragile, expose rotten to the corn face etc. after breaking.At present, the medicine of state's internal therapy impetigo is more, based on western medicine antibiotics, and treatment cost
With height, take effect slowly or there is no effect at all.
Summary of the invention
In view of this, the present invention provides a kind of instant effect, and therapeutic effect is notable, the treatment child's impetigo having no side effect
Gel and preparation method thereof.
In order to realize foregoing invention purpose, the present invention provides techniques below scheme:
A kind of gel treating child's impetigo, its effective ingredient includes the raw material of following weight portion: Rhizoma Coptidis 5-8 part,
Basil Essential 0.01-0.02 part, Herba Scutellariae Barbatae 4-7 part, cortex toonae 3-5 part, Radix Gentianae 3-5 part, Radix Arnebiae (Radix Lithospermi) 2-3 part, Alumen 0.01-
0.02 part, Gypsum Fibrosum 0.1-0.2 part.
The present invention also has a following additional technical feature:
Preferably, its effective ingredient includes the raw material of following weight portion: Rhizoma Coptidis 6 parts, Basil Essential 0.015 part, Herba Scutellariae Barbatae 5
Part, cortex toonae 4 parts, Radix Gentianae 4 parts, Radix Arnebiae (Radix Lithospermi) 2.5 parts, Alumen 0.01 part, 0.15 part of Gypsum Fibrosum.
Preferably, described gel also includes preservative.
The present invention also provides for the preparation method of the gel of the treatment child's impetigo stated, and comprises the following steps:
Step one, Rhizoma Coptidis mass fraction be the ethanol of 30% 70 DEG C of reflux, extract, 60 minutes, filter, prepared Rhizoma Coptidis carries
Take liquid；
Step 2, cortex toonae join as carrying out reflux, extract, in the water of its quality 10-12 times, filter, and prepared Tonnae Sinensis carries
Take liquid；
Step 3, Rhizoma Coptidis extract is blended in 50 DEG C with Tonnae Sinensis extracting solution under the conditions of evaporation and concentration the closeest when becoming 50 DEG C
Degree is the extractum of 1.15-1.25, prepares Rhizoma Coptidis, cortex toonae extract；
Step 4, by Herba Scutellariae Barbatae, Radix Gentianae, after Radix Arnebiae (Radix Lithospermi) mixing, boiling 2 hours, filters, obtains first-time filtrate, and filtering residue is again
Secondary boiling 1 hour, filters and obtains secondary filtrate, and merging relative density when twice filtrate is condensed into 50 DEG C is 1.15-1.25
Extractum, prepare mixed extract；
Step 5, by Alumen, Gypsum Fibrosum use 1-2 part distilled water dissolve after mix with Rhizoma Coptidis, Tonnae Sinensis extract, mixed extract
Add Basil Essential after conjunction and mix homogeneously obtains effective mixture；
Step 6, carbomer is joined in the water into its quality 100 times, after stirring stands swelling 20 hours, use three second
Hydramine regulation pH value, to 4.7-4.9, obtains carbomer solution, joins carbomer solution after uniformly being mixed with propylene glycol by azone
In, stir, obtain carbomer gel, the most by weight carbomer 0.4-0.7 part, propylene glycol 1-1.5 part, azone 1-
1.5 parts, triethanolamine be mass fraction be the triethanolamine aqueous solution of 10%；
Step 7, effective mixture is joined in carbomer gel, stir, reuse described triethanolamine
Aqueous solution regulation pH value, to 4.8-5.0, to obtain final product.
Preferably, step 6 regulates pH value to 4.8 with triethanolamine.
Preferably, described propylene glycol is 1:1 with the mass ratio of azone.
Preferably, described Basil Essential steam method extracts or commercial, and quintessence oil mass concentration is more than 95%.
Using method: three times a day, each consumption depending on wound surface size, first punctures pustule with sterile needle before medicine-feeding, wipes dry
Pus, then dip in the gel even application of the upper present invention in affected part by health swab stick, scabbing comes off can stop the drug of topical application.
Taboo item:
1, avoid edible oil during medication and explode sticky, solid hard cold, food nondigestible and excitatory.
2, forbid taking orally.
Compared to the prior art the present invention, has an advantage in that:
The mechanism of gel prepared by the present invention is heat-clearing and toxic substances removing, and damp eliminating is subsided a swelling, timid necrotic tissue and promoting muscle growing, killing parasites for relieving itching, its pin
The pathogen causing impetigo is had good killing action, and can promote that skin heals elimination scar print as early as possible；
The gel of the present invention is preferable with the biocompatibility of skin, makes ingredient quickly penetrate into, and plays drug effect, and solidifying
Colloid can extend pharmaceutical release time, instant effect, and therapeutic effect is notable；
Impetigo is typically grown at the corners of the mouth or other position of face, and the gel of the present invention is filbert gel, smears rear phase
It is unlikely to affect very much attractive in appearance for existing ointment；
The gel of the present invention is raw materials used to be easy to get, and preparation technology is simple, does not use the expensive Chinese medicines such as Borneolum Syntheticum
Material, saves production cost, improves the economic benefit of manufacturing enterprise.
Detailed description of the invention
Following discloses some embodiments of the present invention, those skilled in the art can be suitably modified work according to present disclosure
Skill parameter realizes.Special needs to be pointed out is, all similar replacements and change are aobvious and easy for a person skilled in the art
Seeing, they are considered as being included in the present invention.Method and the application of the present invention are described by preferred embodiment,
Related personnel substantially in without departing from present invention, spirit and scope, method described herein and application can be modified or
Suitably change and combination, realize and apply the technology of the present invention.
Embodiment 1
Preparation raw material: Rhizoma Coptidis 600g, Basil Essential (Britain's AA net) 1.5g, Herba Scutellariae Barbatae 500g, cortex toonae 400g, Radix Gentianae
400g, Radix Arnebiae (Radix Lithospermi) 250g, Alumen 1g, Gypsum Fibrosum 15g, carbomer 50g, propylene glycol 120g, azone 120g, mass fraction is the three of 10%
Aqueous ethanolamine volume, deionized water volume；
Prepare in accordance with the following methods:
Step one, Rhizoma Coptidis with for ethanol that 5 times of mass fractions of its quality are 30% in 70 DEG C of reflux, extract, 60 minutes, mistake
Filter, prepares Rhizoma Coptidis extract；
Step 2, cortex toonae join in the water for its quality 10 times and carry out reflux, extract, filter, and prepare Tonnae Sinensis and extract
Liquid；
Step 3, Rhizoma Coptidis extract and Tonnae Sinensis extracting solution are mixed 50 DEG C under the conditions of be placed in vacuum rotary evaporator evaporation
Concentrating, obtaining 50 DEG C of relative densities is the extractum of 1.21, prepares Rhizoma Coptidis, cortex toonae extract；
Step 4, by Herba Scutellariae Barbatae, Radix Gentianae, be incorporated as in the water of its four times of quality decocting 2 hours after Radix Arnebiae (Radix Lithospermi) mixing, mistake
Filter, obtains first-time filtrate, and filtering residue is incorporated as Herba Scutellariae Barbatae, Radix Gentianae, the soak by water of three times of quality of Radix Arnebiae (Radix Lithospermi) mixture 1 hour, mistake again
Filter obtains secondary filtrate, and merging relative density when twice filtrate is concentrated to give 50 DEG C is the extractum of 1.22, prepares mixed extract；
Step 5, by Alumen, Gypsum Fibrosum use 100g distilled water dissolve after mix with Rhizoma Coptidis, Tonnae Sinensis extract, mixed extract
Add Basil Essential after conjunction and mix homogeneously obtains effective mixture；
Step 6, carbomer is added in 5000g water, after stirring stands swelling 20 hours, regulate pH value with triethanolamine
To 4.8, obtain carbomer solution, join in carbomer solution after azone is uniformly mixed with propylene glycol, stir, it is thus achieved that
Carbomer gel；
Step 7, effective mixture is joined in carbomer gel, stir, use described triethanolamine water-soluble
Liquid regulation pH value, to 4.8-5.0, obtains the gel 1 of the present invention.
Embodiment 2
Preparation raw material: Rhizoma Coptidis 800g, Basil Essential 2g, Herba Scutellariae Barbatae 400g, cortex toonae 300g, Radix Gentianae 500g, Radix Arnebiae (Radix Lithospermi)
300g, Alumen 2g, Gypsum Fibrosum 10g, carbomer 50g, propylene glycol 120g, azone 120g, mass fraction is the triethanolamine water of 10%
Solution volume；
The gel 2 of the present invention is prepared according to the method for embodiment 1.
Embodiment 3
Preparation raw material: Rhizoma Coptidis 500g, Basil Essential 1g, Herba Scutellariae Barbatae 700g, cortex toonae 500g, Radix Gentianae 300g, Radix Arnebiae (Radix Lithospermi)
200g, Alumen 1g, Gypsum Fibrosum 20g, carbomer 60g, propylene glycol 150g, azone 150g, mass fraction is the triethanolamine water of 10%
Solution volume；
The gel 3 of the present invention is prepared according to the method for embodiment 1.
Embodiment 4 clinical therapeutic efficacy
Select hospital to come child 90 example gone to a doctor, age distribution 4-12 year, the course of disease is 1-12 days, medical patient is divided into
3 groups, the sum that often group patient adds up the time is identical, and A group uses the Chinese medicine gel of the present invention, and B group uses existing
Western medicine impetigo ointment, C group uses existing Chinese medicine impetigo ointment, three groups of child's using effects is carried out Outcome measure, sentences
Severed finger be designated as starting the time of scabbing (my god), scab the retrogressing scar time (my god), move back after scar the scar print removal time (my god), more than for have
The meansigma methods often organized of statistics in the case of effect, effectively represents impetigo transference cure, invalid does not cures for impetigo, treatment effect
Fruit is shown in Table 1.
The judgement of impetigo is: from the beginning of for point-like erythema or little pimple, rapidly go to foxtail millet grain, the vesicle of Semen Pisi sativi or bigger,
Around there is blush；After 1-2 day, vesicle becomes pustule, and pustule wall is thin fragile, exposes rotten to the corn face etc. after breaking.
Table 1 each medication effect table
Table 1 is visible, and the cure time of A group is total up to 5 days, hence it is evident that be better than 8 days of B group and 7.5 days of C group, and A group
Curing effective percentage is 100%, hence it is evident that higher than other two groups, it was demonstrated that the gel effect of the present invention is notable, is worthy to be popularized.It addition,
For the patient in sick time 3 days, the healing time of the gel of the present invention was 3-5 days, for sick time more than 3 days
Patient, the healing time of the gel of the present invention is 4-6 days, it is seen then that the gel of the present invention is controlled for the patient that the course of disease is shorter
Time more is fast.After using the gel of the present invention, after getting up early, can find that symptom is obviously improved, this is because the gel of the present invention
Agent penetration is strong, good with skin-friendliness, after especially smearing before sleeping evening, can preferably penetrate into rotten flesh, sterilization at night
Removing the necrotic tissue and promoting granulation, plays multiple effect and causes, and existing Western medicine effect of drugs is only eliminating inflammation and expelling toxin, without promoting muscle growth functions；Existing
The effect of Chinese medicinal ointment predominantly antiinflammatory is dispelled swollen, and its bactericidal effect is the strongest.In general, the gel multiple-effect of the present invention is closed
One, it is more suitable for impetigo patient and uses.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For Yuan, under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (5)
1. the gel treating child's impetigo, it is characterised in that its effective ingredient includes the raw material of following weight portion: yellow
Even 5-8 part, Basil Essential 0.01-0.02 part, Herba Scutellariae Barbatae 4-7 part, cortex toonae 3-5 part, Radix Gentianae 3-5 part, Radix Arnebiae (Radix Lithospermi) 2-3 part, in vain
Vitriol 0.01-0.02 part, Gypsum Fibrosum 0.1-0.2 part.
The gel for the treatment of child's impetigo the most according to claim 1, it is characterised in that its effective ingredient includes following
The raw material of weight portion: Rhizoma Coptidis 6 parts, Basil Essential 0.015 part, Herba Scutellariae Barbatae 5 parts, cortex toonae 4 parts, Radix Gentianae 4 parts, Radix Arnebiae (Radix Lithospermi) 2.5 parts,
Alumen 0.01 part, 0.15 part of Gypsum Fibrosum.
The gel for the treatment of child's impetigo the most according to claim 1, it is characterised in that described Basil Essential quality is dense
Degree is more than 90%.
4. the preparation method of the gel of the treatment child's impetigo described in any one of claim 1-3, it is characterised in that include
Following steps:
Step one, Rhizoma Coptidis mass fraction are the ethanol of 30% reflux, extract, 60 minutes under the conditions of 70 DEG C, filter, and prepare Rhizoma Coptidis
Extracting solution；
Step 2, cortex toonae join as carrying out reflux, extract, in the water of its quality 10-12 times, filter, and prepare Tonnae Sinensis extracting solution；
Step 3, Rhizoma Coptidis extract and Tonnae Sinensis extracting solution are mixed 50 DEG C under the conditions of evaporation and concentration become relative density to be 1.15-
The extractum of 1.25, prepares Rhizoma Coptidis, cortex toonae extract；
Step 4, by Herba Scutellariae Barbatae, Radix Gentianae, after Radix Arnebiae (Radix Lithospermi) mixing, boiling 2 hours, filters, obtains first-time filtrate, and filtering residue adds again
Soak by water 1 hour, filters and obtains secondary filtrate, and merging relative density when twice filtrate is condensed into 50 DEG C is the leaching of 1.15-1.25
Cream, prepares mixed extract；
Step 5, will Alumen, Gypsum Fibrosum use 1-2 part distilled water dissolve after mix with Rhizoma Coptidis, Tonnae Sinensis extract, mixed extract after
Add Basil Essential and mix homogeneously obtains effective mixture；
Step 6, carbomer is incorporated as in the water of its quality 100 times, after stirring stands swelling 20 hours, adjusts with triethanolamine
Joint pH value, to 4.7-4.9, obtains carbomer solution, joins in carbomer solution, stir after uniformly being mixed with propylene glycol by azone
Mix uniformly, obtain carbomer gel, the most by weight carbomer 0.4-0.7 part, propylene glycol 1-1.5 part, azone 1-1.5
Part, triethanolamine be mass fraction be the triethanolamine aqueous solution of 10%；
Step 7, effective mixture is joined in carbomer gel, stir, use described triethanolamine aqueous solution to adjust
Joint pH value, to 4.8-5.0, to obtain final product.
The preparation method of the gel for the treatment of child's impetigo the most according to claim 4, it is characterised in that described step
With triethanolamine regulation pH value to 4.8 in six.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610594582.XA CN106109616A (en) | 2016-07-26 | 2016-07-26 | A kind of gel treating child's impetigo and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610594582.XA CN106109616A (en) | 2016-07-26 | 2016-07-26 | A kind of gel treating child's impetigo and preparation method thereof |
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| CN106109616A true CN106109616A (en) | 2016-11-16 |
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| CN201610594582.XA Pending CN106109616A (en) | 2016-07-26 | 2016-07-26 | A kind of gel treating child's impetigo and preparation method thereof |
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| CN (1) | CN106109616A (en) |
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2016
- 2016-07-26 CN CN201610594582.XA patent/CN106109616A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 叶世龙: "《头面损容性疾病治疗方》", 31 January 2000, 广东科技出版社 * |
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Application publication date: 20161116 |
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| RJ01 | Rejection of invention patent application after publication |