CN106109545A - 一种地锦草鲜榨冷冻干燥粉末饮片及其制备工艺 - Google Patents

一种地锦草鲜榨冷冻干燥粉末饮片及其制备工艺 Download PDF

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CN106109545A
CN106109545A CN201610583320.3A CN201610583320A CN106109545A CN 106109545 A CN106109545 A CN 106109545A CN 201610583320 A CN201610583320 A CN 201610583320A CN 106109545 A CN106109545 A CN 106109545A
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herba euphorbiae
euphorbiae humifusae
decoction pieces
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徐漫
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

本发明公布了一种地锦草鲜榨冷冻干燥粉末饮片及其制备工艺。该工艺在地锦草药材采收后，净选、淋洗，并趁鲜压榨，滤取药汁。药渣再加水搅拌，过滤压榨。所得药汁合并后减压浓缩，冷冻干燥，收集冻干产物，经粉碎后真空包装。此法制备的地锦草粉末饮片，最大限度地同时保留了药材中的极性和非极性有效成分。饮片利于储运，方便调剂，质量可控，疗效可靠，对保障中医药临床疗效具有重要的意义。本法的推广实施，将有显著的社会意义和经济效益。

Description

一种地锦草鲜榨冷冻干燥粉末饮片及其制备工艺
技术领域
本发明属于中药材加工领域，尤其涉及中药地锦草饮片的加工工艺。
背景技术
中药地锦草为大戟科植物地锦Euphorbia humifusa Willd. 或斑地锦Euphorbia maculata L . 的干燥全草。其性味辛平，有清热解毒，凉血止血，利湿退黄之功效。用于痢疾，泄泻，咯血，尿血，便血，崩漏，疮疖痈肿，湿热黄疸。
常用的地锦草饮片的加工方式为：夏、秋二季采收，除去杂质，晒干，再打包储运。此类草药饮片，体积庞大，卫生学指标差，容易污染和霉变，质量很难保证，不利于配方调剂和确保其临床疗效，甚至给患者带来隐性的危害。
目前，市场上也有地锦草药材经过提取后制成的颗粒饮片销售。颗粒饮片的制备过程，提取不仅耗时耗能，而且因常用大量的水做溶媒，药材中的非极性有效成分很难被提取出来。此外，由于提取用的地锦草药材也是干燥并经过长时间储藏的，因此，有效成分的损失也是很大的。为了确保地锦草药材的临床有效、质量稳定，一种新型的地锦草饮片及其制备工艺亟待开发。
发明内容
本发明公布了 “一种地锦草鲜榨冷冻干燥粉末饮片及其制备工艺”。本工艺可以最大限度的保留地锦草药材中的极性和非极性有效成分，避免药材在现有的饮片加工和储运过程中引起的有效成分的丢失和药材品质的下降，减少药材受霉菌等的污染，对确保地锦草饮片的质量稳定和临床安全有效具有重要的意义。
为了实现上述目的，本发明的技术方案为：
在地锦草采收期采集其全草，净选，洗涤后，趁鲜压榨，药渣加入1~5倍量的水，搅拌5~30min，板框压滤机压滤取汁，所剩药渣再压榨取汁，合并三次药汁，40~120目筛过滤，得地锦草药汁。将得到的地锦草药汁于40~75℃条件下减压浓缩至相对密度为1.05~1.25的浸膏，并将此浸膏于-20~-80℃冰箱中冻结6~24小时，再冷冻干燥，压力为0.06~0.09MPa，温度为-15~-40℃，冷冻时间为12~48小时，收集冻干物后,经粉碎，过筛，包装即可。
在产品包装袋的标签上，印刷上品名、药用部位、种植地、饮片生产商、生产日期、主要成分含量、性味归经、功能主治、用法用量、毒副作用及禁忌证等信息。袋内附上地锦草的薄层鉴别图谱和/或高效液相特征图谱，作为产品的“身份证”。此外，在产品的包装袋上，印有二维码，通过扫描可以链接获取产品的原植物照片、药材照片、饮片照片、性状及显微鉴别特征等信息。
本发明的有益之处在于：
新鲜采集的地锦草药材，净选洗涤后直接压榨、过滤、减压浓缩、冷冻干燥，所得到的粉末饮片，可以最大限度地保留药材中的有效成分。 这种饮片体积较之于传统饮片体积大大地减小，真空包装，使得饮片质量更加稳定，利于储运和临床调剂，具有十分显著的社会意义和经济意义。
具体实施方式
实施例1
将新鲜采集的地锦草药材，净选，用水洗去泥沙，趁鲜用压榨机压榨取汁。所得药渣加3倍量的自来水，搅拌20min，板框压滤机压榨取汁。剩下的药渣再用压榨机压榨取汁。将上述3次药汁合并，用100目筛网过滤。滤液减压浓缩，温度设定为65℃。在浓缩所得浸膏相对密度为1.15时，将浸膏于-80℃冰箱中冻结6小时。取出东结物，冷冻干燥，压力为0.09Mpa，温度为-20℃，干燥24小时。取出冻干物，低温粉碎，过80目筛，水分含量不高于12%，装袋，1kg/袋，加入袋装抗氧剂和干燥剂，真空封装，贴签即可。
实施例2
将新鲜采集的地锦草药材，净选，用水洗去泥沙，趁鲜用压榨机压榨取汁。所得药渣加5倍量的自来水，搅拌30min，板框压滤机压榨取汁。剩下的药渣再用压榨机压榨取汁。将上述3次药汁合并，用80目筛网过滤。滤液减压浓缩，温度设定为70℃。在浓缩所得浸膏相对密度为1.10时，将浸膏于-80℃冰箱中冻结8小时。取出东结物，冷冻干燥，压力为0.08Mpa，温度为-40℃，干燥48小时。取出冻干物，低温粉碎，过60目筛，水分含量不高于12%，装袋，1kg/袋，加入袋装抗氧剂和干燥剂，真空封装，贴签即可。
以上实施例，仅为说明本项发明的技术思想，不能凭此限定本发明的保护范围 凡是按照本发明提出的技术思想，在技术方案基础上所做的任何改动，均落入本发明保护的范围之内。

Claims (2)

1.一种地锦草鲜榨冷冻干燥粉末饮片及其制备工艺，其特征在于：在地锦草采收期采集其全草，净选，洗涤后，趁鲜压榨，药渣加入1~5倍量的水，搅拌5~30min，板框压滤机压滤取汁，所剩药渣再压榨取汁，合并三次药汁，40~120目筛过滤，得地锦草药汁。
2.根据权利要求1所述的一种地锦草鲜榨冷冻干燥粉末饮片及其制备工艺，其特征在于：将得到的地锦草药汁于40~75℃条件下减压浓缩至相对密度为1.05~1.25的浸膏，并将此浸膏于-20~-80℃冰箱中冻结6~24小时，再冷冻干燥，压力为0.06~0.09MPa，温度为-15~-40℃，冷冻时间为12~48小时，收集冻干物后,经粉碎，过筛，包装即可。
CN201610583320.3A 2016-07-24 2016-07-24 一种地锦草鲜榨冷冻干燥粉末饮片及其制备工艺 Pending CN106109545A (zh)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107320507A (zh) * 2017-08-25 2017-11-07 芜湖天成普阳中药科技有限公司 一种凌霄花鲜榨冷冻干燥粉末饮片的制备工艺
CN107375407A (zh) * 2017-08-25 2017-11-24 徐漫 一种透骨草鲜榨冷冻干燥粉末饮片的制备工艺
CN107375411A (zh) * 2017-08-25 2017-11-24 徐漫 一种鸡骨草鲜榨冷冻干燥粉末饮片的制备工艺
CN107412452A (zh) * 2017-08-25 2017-12-01 徐自升 一种败酱草鲜榨冷冻干燥粉末饮片的制备工艺

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105213661A (zh) * 2015-11-14 2016-01-06 芜湖天成普阳中药科技有限公司 一种芦荟鲜榨冷冻干燥粉末饮片及其制备工艺
CN105213459A (zh) * 2015-11-14 2016-01-06 芜湖天成普阳中药科技有限公司 一种仙人掌鲜榨冷冻干燥粉末饮片及其制备工艺
CN105213453A (zh) * 2015-11-14 2016-01-06 芜湖天成普阳中药科技有限公司 一种蒲公英鲜榨冷冻干燥粉末饮片及其制备工艺
CN105213552A (zh) * 2015-11-14 2016-01-06 芜湖天成普阳中药科技有限公司 一种白花蛇舌草鲜榨冷冻干燥粉末饮片及其制备工艺
CN105287859A (zh) * 2015-11-22 2016-02-03 徐漫 一种泡桐花鲜榨冷冻干燥粉末饮片及其制备工艺
CN105362309A (zh) * 2015-11-14 2016-03-02 芜湖天成普阳中药科技有限公司 一种马齿苋鲜榨冷冻干燥粉末饮片及其制备工艺

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105213661A (zh) * 2015-11-14 2016-01-06 芜湖天成普阳中药科技有限公司 一种芦荟鲜榨冷冻干燥粉末饮片及其制备工艺
CN105213459A (zh) * 2015-11-14 2016-01-06 芜湖天成普阳中药科技有限公司 一种仙人掌鲜榨冷冻干燥粉末饮片及其制备工艺
CN105213453A (zh) * 2015-11-14 2016-01-06 芜湖天成普阳中药科技有限公司 一种蒲公英鲜榨冷冻干燥粉末饮片及其制备工艺
CN105213552A (zh) * 2015-11-14 2016-01-06 芜湖天成普阳中药科技有限公司 一种白花蛇舌草鲜榨冷冻干燥粉末饮片及其制备工艺
CN105362309A (zh) * 2015-11-14 2016-03-02 芜湖天成普阳中药科技有限公司 一种马齿苋鲜榨冷冻干燥粉末饮片及其制备工艺
CN105287859A (zh) * 2015-11-22 2016-02-03 徐漫 一种泡桐花鲜榨冷冻干燥粉末饮片及其制备工艺

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107320507A (zh) * 2017-08-25 2017-11-07 芜湖天成普阳中药科技有限公司 一种凌霄花鲜榨冷冻干燥粉末饮片的制备工艺
CN107375407A (zh) * 2017-08-25 2017-11-24 徐漫 一种透骨草鲜榨冷冻干燥粉末饮片的制备工艺
CN107375411A (zh) * 2017-08-25 2017-11-24 徐漫 一种鸡骨草鲜榨冷冻干燥粉末饮片的制备工艺
CN107412452A (zh) * 2017-08-25 2017-12-01 徐自升 一种败酱草鲜榨冷冻干燥粉末饮片的制备工艺

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