CN106109512A - A kind of preparation method of cocoa polyphenol chewable tablet - Google Patents
A kind of preparation method of cocoa polyphenol chewable tablet Download PDFInfo
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- CN106109512A CN106109512A CN201610477188.8A CN201610477188A CN106109512A CN 106109512 A CN106109512 A CN 106109512A CN 201610477188 A CN201610477188 A CN 201610477188A CN 106109512 A CN106109512 A CN 106109512A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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Abstract
The present invention relates to the preparation method of a kind of cocoa polyphenol chewable tablet, belong to polyphenol processing technique field.For polyphenol health food due to medicament need disintegrating procedue, drug-eluting slowly, absorb slow, bioavailability is the highest, carry and take inconvenience, the problem that can not take medicine on time under exsiccosis, the present invention provides the preparation method of a kind of cocoa polyphenol chewable tablet.The present invention uses cocoa fresh fruit to be raw material, through shelling, bakes and banks up with earth, peeling, after grinding prepare cocoa powder, by extract after cocoa powder defat in cocoa rich in polyphenol, make cocoa polyphenol extracting solution, make powder after concentrate drying, mix with sucrose, lactose, mannitol, citric acid, add starch slurry and bind, sieve after granulating by squeezing and pressing method, interpolation magnesium stearate, as lubricant, with singly filling tablet machine compression molding, the most i.e. obtains cocoa polyphenol chewable tablet.
Description
Technical field
The present invention relates to the preparation method of a kind of cocoa polyphenol chewable tablet, belong to polyphenol processing technique field.
Background technology
Cacao bean has higher nutritive value, is the primary raw material of beverage industries and chocolate industry.Wherein rich in many
Phenol, is the natural component in cacao bean, is also composition the most useful to health in chocolate, and content reaches 4 times of Folium Camelliae sinensis.
Polyphenol is to confer to the composition of cocoa products chocolate peculiar flavour, and compared with other food, in cacao bean, the content of polyphenol is special
The highest.Polyphenolic substance has plurality of health care functions, is a kind of Natural antioxidant, has suppression virus activity, antibacterial, anti-lures
Become, treatment neurodegenerative diseases and the effect such as anticancer, and free radical, defying age, radioprotective in there is catcher body, subtract
Many effects such as fertilizer, blood fat reducing and anti-cancer.Additionally, it is for immune disease, particularly to acquired immune deficiency syndrome (AIDS), also have
Good prevention and therapeutic efficiency, and safe without toxic side effect, be referred to as " the 7th class nutrient ".At present about the biology of polyphenol
Research in terms of Huo Xing is the most quite varied and deep, and it has obtained the general of people to the unique effect in terms of human health
All over accreditation, in fields such as oils and fats, food, medicine, beverage, cosmetics and health product, cocoa polyphenol the most progressively replaces original use
Chemical raw material, application continues to increase, and application prospect is boundless.At present, conventional polyphenol health food mostly is tea-drinking,
Or mix the tablet swallowed with water, due to medicament need disintegrating procedue, drug-eluting slowly, absorb slow, bioavailability is the highest, take
Inconvenience taken by band, and the shortcoming such as can not take medicine on time under exsiccosis, should not old man, child, paralytic, swallow difficulty and stomach
The patient of intestinal function difference takes.Therefore, the preparation technology of polyphenol health food is studied, is significant.
Summary of the invention
The technical problem to be solved: need disintegrating procedue, drug-eluting due to medicament for polyphenol health food
Slowly, absorb slow, bioavailability is the highest, carry and take inconvenience, the problem that can not take medicine on time under exsiccosis, the present invention
The preparation method of a kind of cocoa polyphenol chewable tablet is provided.The present invention uses cocoa fresh fruit to be raw material, through shelling, bakes and banks up with earth, peeling, mill
Prepare cocoa powder after broken, by extract after cocoa powder defat in cocoa rich in polyphenol, make cocoa polyphenol extracting solution, concentrate dry
Make powder after dry, mix with sucrose, lactose, mannitol, citric acid, add starch slurry and bind, sieve after granulating by squeezing and pressing method,
Interpolation magnesium stearate, as lubricant, with singly filling tablet machine compression molding, the most i.e. obtains cocoa polyphenol chewable tablet.
For solving above-mentioned technical problem, the technical solution used in the present invention is:
(1) weigh 500 ~ 800g cocoa fresh fruit, shell and process to obtain cacao bean, with 85 ~ 100 DEG C of deionized waters soak cacao beans 10 ~
15min, takes out cacao bean and is placed in 40 ~ 50 DEG C of baking ovens and is dried 2 ~ 3h, dried cacao bean is added baking machine, 125 ~
After baking and banking up with earth 1 ~ 2h at 130 DEG C, it is put into skinning machine peeling, then inserts pulverizer pulverizing, cross 100 mesh sieves, obtain cocoa powder；
(2) weigh 80 ~ 100g above-mentioned cacao bean powder, add 300 ~ 320mL normal hexane, keep temperature 37 ~ 40 DEG C, use agitator
Stirring 3 ~ 4h, stands 20 ~ 30min, separates upper strata yellow liquid, repeats aforesaid operations the most colourless to supernatant liquid, filters, will filter
Slag is inserted and is dried 5 ~ 6h in 10 ~ 15 DEG C of cold drying casees, obtains degreased cocoa powder；
(3) weighing the above-mentioned degreased cocoa powder of 50 ~ 60g, adding 500 ~ 600mL mass concentration is 60% ethanol solution, is placed in 45 ~ 50
In DEG C shaking bath, after ultrasonic 1 ~ 2h, insert centrifuge, be centrifuged 10 ~ 15min with 6000 ~ 8000r/min, filter, take supernatant
Liquid, obtains cocoa polyphenol extracting solution；
(4) above-mentioned cocoa polyphenol extracting solution Rotary Evaporators is evaporated to the 30 ~ 40% of original volume, pours evaporating dish into also
It is placed in 90 ~ 95 DEG C of drying baker, is dried 1 ~ 3h, dried solid is added pulverizer and pulverizes, cross 100 mesh sieves, obtain cocoa many
Phenol powder；
(5) weighing 5 ~ 6g sucrose respectively, 2 ~ 3g lactose, 5 ~ 6g mannitol, 0.2 ~ 0.3g citric acid, mix homogeneously, by mixture
Pulverizing with pulverizer, cross 100 mesh sieves, obtain mix powder, be separately added into 4 ~ 5g above-mentioned cocoa polyphenol powder, 16 ~ 18g mass is dense
Degree is 10 ~ 12% starch slurries, and 0.2 ~ 0.3g magnesium stearate stirs, and crosses 20 mesh sieves by squeezing and pressing method, and the granule after sieving is put
Enter in 60 ~ 65 DEG C of drying baker, be dried after 30 ~ 40min, then with singly filling tabletting machine, dry 30 in 60 ~ 65 DEG C of drying baker ~
35min, obtains cocoa polyphenol chewable tablet.
The application process of the present invention: swallow, chew containing sucking or take after water-dispersible, every day one after each meal 1 ~ 2, entrance
Chewing 10 ~ 15s or containing sucking 40 ~ 50s, after taking one month, rate and blood-lipid decreased 3 ~ 5%, passive protective physical fitness improves 5 ~ 8%, under morbidity rate
Fall 10 ~ 12%, in cocoa polyphenol chewable tablet prepared by the present invention, polyphenol content is 150 ~ 180mg/g.
The method have the benefit that:
(1) the cocoa polyphenol chewable tablet form that prepared by the present invention is complete, and smooth surface, uniform color, excellent flavor, mouthfeel is thin
Greasy, tasty and refreshing, hardness is moderate, and chewiness is good；
(2) the cocoa polyphenol chewable tablet polyphenol content that prepared by the present invention is high, drug-eluting is rapidly, absorption is fast, bioavailability is high,
Easy to carry, steady quality, taking convenience.
Detailed description of the invention
Weigh 500 ~ 800g cocoa fresh fruit, shell and process to obtain cacao bean, with 85 ~ 100 DEG C of deionized waters soak cacao beans 10 ~
15min, takes out cacao bean and is placed in 40 ~ 50 DEG C of baking ovens and is dried 2 ~ 3h, dried cacao bean is added baking machine, 125 ~
After baking and banking up with earth 1 ~ 2h at 130 DEG C, it is put into skinning machine peeling, then inserts pulverizer pulverizing, cross 100 mesh sieves, obtain cocoa powder；Claim
Take 80 ~ 100g above-mentioned cacao bean powder, add 300 ~ 320mL normal hexane, keep temperature 37 ~ 40 DEG C, stir 3 ~ 4h with agitator,
Stand 20 ~ 30min, separate upper strata yellow liquid, repeat aforesaid operations to supernatant liquid to the most colourless, filter, filtering residue is inserted 10 ~
15 DEG C of cold drying casees are dried 5 ~ 6h, obtain degreased cocoa powder；Weigh the above-mentioned degreased cocoa powder of 50 ~ 60g, add 500 ~ 600mL
Mass concentration is 60% ethanol solution, is placed in 45 ~ 50 DEG C of shaking baths, after ultrasonic 1 ~ 2h, inserts centrifuge, with 6000 ~
8000r/min is centrifuged 10 ~ 15min, filters, takes supernatant, obtain cocoa polyphenol extracting solution；Above-mentioned cocoa polyphenol extracting solution is revolved
Turn evaporation under reduced pressure and be concentrated into the 30 ~ 40% of original volume, pour evaporating dish into and be placed in 90 ~ 95 DEG C of drying baker, be dried 1 ~ 3h, will
Dried solid adds pulverizer and pulverizes, and crosses 100 mesh sieves, obtains cocoa polyphenol powder；Weigh 5 ~ 6g sucrose, 2 ~ 3g breast respectively
Sugar, 5 ~ 6g mannitol, 0.2 ~ 0.3g citric acid, mix homogeneously, mixture pulverizer is pulverized, crosses 100 mesh sieves, obtain mixture
Powder, is separately added into 4 ~ 5g above-mentioned cocoa polyphenol powder, and 16 ~ 18g mass concentration is 10 ~ 12% starch slurries, 0.2 ~ 0.3g stearic acid
Magnesium, stirs, and crosses 20 mesh sieves by squeezing and pressing method, and the granule after sieving is inserted in 60 ~ 65 DEG C of drying baker, is dried 30 ~ 40min
After, then with singly filling tabletting machine, 60 ~ 65 DEG C of drying baker are dried 30 ~ 35min, obtain cocoa polyphenol chewable tablet.
Example 1
Weigh 500g cocoa fresh fruit, shell and process to obtain cacao bean, soak cacao bean 10min with 85 DEG C of deionized waters, take out cocoa
Bean is placed in 40 DEG C of baking ovens and is dried 2h, dried cacao bean is added baking machine, after baking and banking up with earth 1h, is put at 125 DEG C
Skinning machine is removed the peel, then inserts pulverizer pulverizing, crosses 100 mesh sieves, obtains cocoa powder；Weigh 80g above-mentioned cacao bean powder, add
300mL normal hexane, keeps temperature 37 DEG C, stirs 3h with agitator, stands 20min, separates upper strata yellow liquid, repeats above-mentioned behaviour
Make, to supernatant liquid to colourless, to filter, filtering residue is inserted 10 DEG C of cold drying casees are dried 5h, obtain degreased cocoa powder；Weigh 50g
Above-mentioned degreased cocoa powder, adding 500mL mass concentration is 60% ethanol solution, is placed in 45 DEG C of shaking baths, after ultrasonic 1h, puts
Enter centrifuge, be centrifuged 10min with 6000r/min, filter, take supernatant, obtain cocoa polyphenol extracting solution；Above-mentioned cocoa polyphenol is carried
Take liquid Rotary Evaporators and be evaporated to the 30% of original volume, pour evaporating dish into and be placed in 90 DEG C of drying baker, be dried 1h, will
Dried solid adds pulverizer and pulverizes, and crosses 100 mesh sieves, obtains cocoa polyphenol powder；Weigh 5g sucrose, 2g lactose, 5g respectively
Mannitol, 0.2g citric acid, mix homogeneously, mixture pulverizer is pulverized, crosses 100 mesh sieves, obtain mix powder, add respectively
Entering 4g above-mentioned cocoa polyphenol powder, 16g mass concentration is 10% starch slurry, and 0.2g magnesium stearate stirs, uses squeezing and pressing method mistake
20 mesh sieves, the granule after sieving is inserted in 60 DEG C of drying baker, after being dried 30min, then with singly filling tabletting machine, does at 60 DEG C
Dry case is dried 30min, obtains cocoa polyphenol chewable tablet.
The application process of the present invention: swallow, chew containing sucking or take after water-dispersible, every day one after each meal 1, entrance nozzle
Chewing 10s or containing sucking 40s, after taking one month, rate and blood-lipid decreased 3%, passive protective physical fitness improves 5%, and morbidity rate declines 10%, the present invention
In the cocoa polyphenol chewable tablet of preparation, polyphenol content is 150mg/g.
Example 2
Weigh 600g cocoa fresh fruit, shell and process to obtain cacao bean, soak cacao bean 12min with 90 DEG C of deionized waters, take out cocoa
Bean is placed in 45 DEG C of baking ovens and is dried 2.5h, dried cacao bean is added baking machine, after baking and banking up with earth 1.5h at 128 DEG C, by it
Insert skinning machine peeling, then insert pulverizer pulverizing, cross 100 mesh sieves, obtain cocoa powder；Weigh 90g above-mentioned cacao bean powder, add
Enter 310mL normal hexane, keep temperature 38 DEG C, stir 3.5h with agitator, stand 25min, separate upper strata yellow liquid, repeat on
State operation the most colourless to supernatant liquid, filter, filtering residue is inserted 12 DEG C of cold drying casees are dried 5.5h, obtain degreased cocoa powder；
Weighing the above-mentioned degreased cocoa powder of 55g, adding 550mL mass concentration is 60% ethanol solution, is placed in 48 DEG C of shaking baths, ultrasonic
After 1.5h, insert centrifuge, be centrifuged 12min with 7000r/min, filter, take supernatant, obtain cocoa polyphenol extracting solution；By above-mentioned
Cocoa polyphenol extracting solution Rotary Evaporators is evaporated to the 35% of original volume, pours evaporating dish into and is placed in 92 DEG C of drying baker,
It is dried 1.5h, dried solid is added pulverizer and pulverizes, cross 100 mesh sieves, obtain cocoa polyphenol powder；Weigh 5.5g sugarcane respectively
Sugar, 2.5g lactose, 5.5g mannitol, 0.2g citric acid, mix homogeneously, mixture pulverizer is pulverized, crosses 100 mesh sieves,
Mix powder, is separately added into 4.5g above-mentioned cocoa polyphenol powder, and 17g mass concentration is 11% starch slurry, 0.2g magnesium stearate,
Stirring, cross 20 mesh sieves by squeezing and pressing method, the granule after sieving is inserted in 62 DEG C of drying baker, after being dried 35min, then with singly filling
Tabletting machine, is dried 32min in 62 DEG C of drying baker, obtains cocoa polyphenol chewable tablet.
The application process of the present invention: swallow, chew containing sucking or take after water-dispersible, every day one after each meal 1, entrance nozzle
Chewing 12s or containing sucking 45s, after taking one month, rate and blood-lipid decreased 4%, passive protective physical fitness improves 6%, and morbidity rate declines 11%, the present invention
In the cocoa polyphenol chewable tablet of preparation, polyphenol content is 160mg/g.
Example 3
Weigh 800g cocoa fresh fruit, shell and process to obtain cacao bean, soak cacao bean 15min with 100 DEG C of deionized waters, take out cocoa
Bean is placed in 50 DEG C of baking ovens and is dried 3h, dried cacao bean is added baking machine, after baking and banking up with earth 2h, is put at 130 DEG C
Skinning machine is removed the peel, then inserts pulverizer pulverizing, crosses 100 mesh sieves, obtains cocoa powder；Weigh 100g above-mentioned cacao bean powder, add
320mL normal hexane, keeps temperature 40 DEG C, stirs 4h with agitator, stands 30min, separates upper strata yellow liquid, repeats above-mentioned behaviour
Make, to supernatant liquid to colourless, to filter, filtering residue is inserted 15 DEG C of cold drying casees are dried 6h, obtain degreased cocoa powder；Weigh 60g
Above-mentioned degreased cocoa powder, adding 600mL mass concentration is 60% ethanol solution, is placed in 50 DEG C of shaking baths, after ultrasonic 2h, puts
Enter centrifuge, be centrifuged 15min with 8000r/min, filter, take supernatant, obtain cocoa polyphenol extracting solution；Above-mentioned cocoa polyphenol is carried
Take liquid Rotary Evaporators and be evaporated to the 40% of original volume, pour evaporating dish into and be placed in 95 DEG C of drying baker, be dried 3h, will
Dried solid adds pulverizer and pulverizes, and crosses 100 mesh sieves, obtains cocoa polyphenol powder；Weigh 6g sucrose, 3g lactose, 6g respectively
Mannitol, 0.3g citric acid, mix homogeneously, mixture pulverizer is pulverized, crosses 100 mesh sieves, obtain mix powder, add respectively
Entering 5g above-mentioned cocoa polyphenol powder, 18g mass concentration is 12% starch slurry, and 0.3g magnesium stearate stirs, uses squeezing and pressing method mistake
20 mesh sieves, the granule after sieving is inserted in 65 DEG C of drying baker, after being dried 40min, then with singly filling tabletting machine, does at 65 DEG C
Dry case is dried 35min, obtains cocoa polyphenol chewable tablet.
The application process of the present invention: swallow, chew containing sucking or take after water-dispersible, every day one after each meal 2, entrance nozzle
Chewing 15s or containing sucking 50s, after taking one month, rate and blood-lipid decreased 5%, passive protective physical fitness improves 8%, and morbidity rate declines 12%, the present invention
In the cocoa polyphenol chewable tablet of preparation, polyphenol content is 180mg/g.
Claims (1)
1. the preparation method of a cocoa polyphenol chewable tablet, it is characterised in that concrete preparation process is:
(1) weigh 500 ~ 800g cocoa fresh fruit, shell and process to obtain cacao bean, with 85 ~ 100 DEG C of deionized waters soak cacao beans 10 ~
15min, takes out cacao bean and is placed in 40 ~ 50 DEG C of baking ovens and is dried 2 ~ 3h, dried cacao bean is added baking machine, 125 ~
After baking and banking up with earth 1 ~ 2h at 130 DEG C, it is put into skinning machine peeling, then inserts pulverizer pulverizing, cross 100 mesh sieves, obtain cocoa powder；
(2) weigh 80 ~ 100g above-mentioned cacao bean powder, add 300 ~ 320mL normal hexane, keep temperature 37 ~ 40 DEG C, use agitator
Stirring 3 ~ 4h, stands 20 ~ 30min, separates upper strata yellow liquid, repeats aforesaid operations the most colourless to supernatant liquid, filters, will filter
Slag is inserted and is dried 5 ~ 6h in 10 ~ 15 DEG C of cold drying casees, obtains degreased cocoa powder；
(3) weighing the above-mentioned degreased cocoa powder of 50 ~ 60g, adding 500 ~ 600mL mass concentration is 60% ethanol solution, is placed in 45 ~ 50
In DEG C shaking bath, after ultrasonic 1 ~ 2h, insert centrifuge, be centrifuged 10 ~ 15min with 6000 ~ 8000r/min, filter, take supernatant
Liquid, obtains cocoa polyphenol extracting solution；
(4) above-mentioned cocoa polyphenol extracting solution Rotary Evaporators is evaporated to the 30 ~ 40% of original volume, pours evaporating dish into also
It is placed in 90 ~ 95 DEG C of drying baker, is dried 1 ~ 3h, dried solid is added pulverizer and pulverizes, cross 100 mesh sieves, obtain cocoa many
Phenol powder；
(5) weighing 5 ~ 6g sucrose respectively, 2 ~ 3g lactose, 5 ~ 6g mannitol, 0.2 ~ 0.3g citric acid, mix homogeneously, by mixture
Pulverizing with pulverizer, cross 100 mesh sieves, obtain mix powder, be separately added into 4 ~ 5g above-mentioned cocoa polyphenol powder, 16 ~ 18g mass is dense
Degree is 10 ~ 12% starch slurries, and 0.2 ~ 0.3g magnesium stearate stirs, and crosses 20 mesh sieves by squeezing and pressing method, and the granule after sieving is put
Enter in 60 ~ 65 DEG C of drying baker, be dried after 30 ~ 40min, then with singly filling tabletting machine, dry 30 in 60 ~ 65 DEG C of drying baker ~
35min, obtains cocoa polyphenol chewable tablet.
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| CN201610477188.8A CN106109512A (en) | 2016-06-27 | 2016-06-27 | A kind of preparation method of cocoa polyphenol chewable tablet |
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| CN201610477188.8A CN106109512A (en) | 2016-06-27 | 2016-06-27 | A kind of preparation method of cocoa polyphenol chewable tablet |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022243214A1 (en) * | 2021-05-19 | 2022-11-24 | Dsm Ip Assets B.V. | Non-effervescent fast dissolvable tablets comprising cocoa powder |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1168632A (en) * | 1994-10-03 | 1997-12-24 | 火星有限公司 | Antineoplastic cocoa extracts, method for making, using |
| CN102414312A (en) * | 2009-04-03 | 2012-04-11 | 戴安娜植物科学有限公司 | Production and extraction of procyanidins from plant cell cultures |
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2016
- 2016-06-27 CN CN201610477188.8A patent/CN106109512A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1168632A (en) * | 1994-10-03 | 1997-12-24 | 火星有限公司 | Antineoplastic cocoa extracts, method for making, using |
| CN102414312A (en) * | 2009-04-03 | 2012-04-11 | 戴安娜植物科学有限公司 | Production and extraction of procyanidins from plant cell cultures |
Non-Patent Citations (1)
| Title |
|---|
| 易桥宾等: "发酵和焙烤对可可豆多酚、黄酮和风味品质的影响", 《食品科学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022243214A1 (en) * | 2021-05-19 | 2022-11-24 | Dsm Ip Assets B.V. | Non-effervescent fast dissolvable tablets comprising cocoa powder |
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Application publication date: 20161116 |