CN106083942A - A kind of method improving stability of trichlorosucrose - Google Patents
A kind of method improving stability of trichlorosucrose Download PDFInfo
- Publication number
- CN106083942A CN106083942A CN201610525035.6A CN201610525035A CN106083942A CN 106083942 A CN106083942 A CN 106083942A CN 201610525035 A CN201610525035 A CN 201610525035A CN 106083942 A CN106083942 A CN 106083942A
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- China
- Prior art keywords
- sucralose
- weight portion
- trichlorosucrose
- room temperature
- aqueous phase
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A kind of method improving stability of trichlorosucrose, key step is as follows: (1) weighs sucralose, adds water and is stirred dissolving, after standing, is filtered to remove insoluble impurities；Continuously add extractant ethyl acetate, after stirring, stratification, collect aqueous phase, repeat to extract organic facies 23 times, finally all aqueous phases are merged；(2) aqueous phase in step 1 is carried out decompression distillation, collect the concentrated solution of sucralose, add buffer agent sodium acetate, ethanol, it is heated to 50 DEG C, then after naturally cooling to room temperature, is transferred in ultrasonic crystallization apparatus crystallize, with the hydrochloric acid that concentration is 0.1mol/L and the pH of isocyatic sodium hydrate regulator solution in crystallization process, it is ensured that pH value maintains neutrality.The product present invention prepared does blank with the sample being not added with buffer agent, do not regulate pH, it was found that the stability of the said goods improves 15% compared with matched group, extends the shelf-life of sucralose.
Description
Technical field
The present invention relates to the stability of sucralose, be specifically related to a kind of method improving stability of trichlorosucrose.
Background technology
The chemical name of sucralose (Sucralose) is Isosorbide-5-Nitrae, 6 one sucralose, is three hydroxyl quilts in sucrose molecule
The high-intensity sweeteners that chlorine atoms ground replaces and obtains, within 1991, first Canada ratify for food, and it highlights
Feature is: (l) Heat stability is good, temperature and pH value on it almost without impact, more more stable than alitame in baking technology, be suitable for
High temperature sterilize in food processing, be spray-dried, bake, the technique such as extruding；(2) pH wide adaptability, it is adaptable to acid in
Property food, covers effect to the unpleasant taste such as puckery, bitter；(3) soluble in water, it is not easy to produce foaming phenomena during dissolving, suitable
High speed bottling line for soda pop；(4) sweet taste is pure, sweet sense presentation speed, maximum the impression intensity of sweet taste, sweet taste
The most closely sucrose such as persistent period, aftertaste, is the ideal intense sweetener of a kind of combination property.
The synthesis mother liquid of sucralose can become acid along with the increase of cycle-index, reduces the trichlorine sugarcane produced
The storage life of sugar, and the accumulation of impurity can also interfere with the crystallization of sucralose, causes needing the some cycles will be
Mother solution abandons, thus causes the increase of waste and cost.
Summary of the invention
For problems of the prior art, the present invention provides a kind of method improving stability of trichlorosucrose.
The present invention can be achieved through the following technical solutions:
A kind of method improving stability of trichlorosucrose, it is characterised in that key step is as follows:
(1) weighing the sucralose of 1 weight portion under room temperature, the water adding 5 weight portions is stirred dissolving, and stands
After 10min, it is filtered to remove insoluble impurities；Continuously add the extractant ethyl acetate of 1 weight portion, after stirring, stand and divide
Layer, collects aqueous phase, repeats to extract organic facies 2-3 time, is finally merged by all aqueous phases；
(2) aqueous phase in step 1 is carried out decompression distillation, collects the concentrated solution of sucralose, add 0.2-0.4 weight
Part buffer agent sodium acetate, the ethanol of 1 weight portion, it is heated to 50 DEG C, stirs after it all dissolves, then naturally cool to room temperature
After, it is transferred in ultrasonic crystallization apparatus crystallize, with the hydrochloric acid that concentration is 0.1mol/L and isocyatic hydrogen in crystallization process
The pH of sodium oxide regulation solution, it is ensured that pH value maintains neutrality.
The invention have the benefit that 1) by ethyl acetate as extractant, the pure of sucralose after extraction can be improved
Degree；2) add buffer agent sodium acetate, sucralose can be avoided to go bad because turning sour during preserving；3) ethanol is added permissible
Significantly improve the stability of product, increase the yield after product crystallization simultaneously.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated.
Embodiment
A kind of method improving stability of trichlorosucrose, it is characterised in that key step is as follows: weigh 1 weight under (1) room temperature
The sucralose of amount part, the water adding 5 weight portions is stirred dissolving, and after standing 10min, is filtered to remove insoluble impurities；
Continuously add the extractant ethyl acetate of 1 weight portion, after stirring, stratification, collect aqueous phase, repeat to extract organic facies 2-
3 times, finally all aqueous phases are merged；(2) aqueous phase in step 1 is carried out decompression distillation, collects the concentrated solution of sucralose, then
Add 0.2 weight portion buffer agent sodium acetate, the ethanol of 1 weight portion, be heated to 50 DEG C, stir after it all dissolves, then from
After being so cooled to room temperature, it is transferred in ultrasonic crystallization apparatus crystallize, crystallization process is the hydrochloric acid of 0.1mol/L by concentration
PH with isocyatic sodium hydrate regulator solution, it is ensured that pH value maintains neutrality.
The product prepared by said method does blank with the sample being not added with buffer agent, do not regulate pH, and experimental result is sent out
Existing, the stability of the said goods improves 15% compared with matched group, extends the shelf-life of sucralose.
The foregoing is only the section Example of the present invention, not in order to limit the present invention, all essences in the present invention
Any amendment, equivalent and the improvement etc. made within god and principle, should be included within the scope of the present invention.
Claims (1)
1. the method improving stability of trichlorosucrose, it is characterised in that key step is as follows:
(1) weighing the sucralose of 1 weight portion under room temperature, the water adding 5 weight portions is stirred dissolving, after standing 10min,
It is filtered to remove insoluble impurities；Continuously add the extractant ethyl acetate of 1 weight portion, after stirring, stratification, collect water
Phase, repeats to extract organic facies 2-3 time, is finally merged by all aqueous phases；
(2) aqueous phase in step 1 is carried out decompression distillation, collects the concentrated solution of sucralose, add 0.2-0.4 weight portion and delay
Electuary sodium acetate, the ethanol of 1 weight portion, it is heated to 50 DEG C, stirs after it all dissolves, then after naturally cooling to room temperature,
It is transferred in ultrasonic crystallization apparatus crystallize, by the hydrochloric acid that concentration is 0.1mol/L and isocyatic hydroxide in crystallization process
The pH of sodium regulation solution, it is ensured that pH value maintains neutrality.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610525035.6A CN106083942A (en) | 2016-07-02 | 2016-07-02 | A kind of method improving stability of trichlorosucrose |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610525035.6A CN106083942A (en) | 2016-07-02 | 2016-07-02 | A kind of method improving stability of trichlorosucrose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106083942A true CN106083942A (en) | 2016-11-09 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610525035.6A Pending CN106083942A (en) | 2016-07-02 | 2016-07-02 | A kind of method improving stability of trichlorosucrose |
Country Status (1)
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| CN (1) | CN106083942A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106474766A (en) * | 2016-11-30 | 2017-03-08 | 广东技术师范学院 | A kind of sucralose low energy consumption extraction equipment |
| CN111138502A (en) * | 2019-12-31 | 2020-05-12 | 山东三和维信生物科技有限公司 | Crystallization process of large-particle sucralose |
| CN112961201A (en) * | 2021-03-29 | 2021-06-15 | 福州大学 | Crystallization method of spherical sucralose |
| WO2022067621A1 (en) * | 2020-09-30 | 2022-04-07 | 安徽金禾实业股份有限公司 | Sucralose purification method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101429220A (en) * | 2008-12-10 | 2009-05-13 | 吴洪元 | Separation and purification process for sucrose trichloride |
-
2016
- 2016-07-02 CN CN201610525035.6A patent/CN106083942A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101429220A (en) * | 2008-12-10 | 2009-05-13 | 吴洪元 | Separation and purification process for sucrose trichloride |
Non-Patent Citations (3)
| Title |
|---|
| 曹敢星等，: "改善三氯蔗糖稳定性的研究.", 《食品工业科技》 * |
| 王国宇，: "三氯蔗糖的分离提纯与稳定性研究.", 《中国优秀硕士学位论文全文数据库 工程科技I辑》 * |
| 蔡基智，: "一种提高三氯蔗糖稳定性的工艺研究.", 《中国食品添加剂》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106474766A (en) * | 2016-11-30 | 2017-03-08 | 广东技术师范学院 | A kind of sucralose low energy consumption extraction equipment |
| CN111138502A (en) * | 2019-12-31 | 2020-05-12 | 山东三和维信生物科技有限公司 | Crystallization process of large-particle sucralose |
| CN111138502B (en) * | 2019-12-31 | 2022-01-11 | 山东三和维信生物科技有限公司 | Crystallization process of large-particle sucralose |
| WO2022067621A1 (en) * | 2020-09-30 | 2022-04-07 | 安徽金禾实业股份有限公司 | Sucralose purification method |
| CN112961201A (en) * | 2021-03-29 | 2021-06-15 | 福州大学 | Crystallization method of spherical sucralose |
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Application publication date: 20161109 |
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| RJ01 | Rejection of invention patent application after publication |