CN106083608A - A kind of synthetic method of 3 aminobphenyls - Google Patents
A kind of synthetic method of 3 aminobphenyls Download PDFInfo
- Publication number
- CN106083608A CN106083608A CN201610436976.2A CN201610436976A CN106083608A CN 106083608 A CN106083608 A CN 106083608A CN 201610436976 A CN201610436976 A CN 201610436976A CN 106083608 A CN106083608 A CN 106083608A
- Authority
- CN
- China
- Prior art keywords
- synthetic method
- reaction vessel
- methanol
- aminobphenyls
- nitro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
- C07C209/36—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention discloses the synthetic method of a kind of 3 aminobphenyls, it relates to the synthesis technical field of compound；Its synthetic method is: parazon being dissolved in methyl tertiary butyl ether(MTBE), mixing and stirring, instills nitric acid in gained mixed solution, continue stirring 1 3h after dripping off, whole process temperature controls at 20 40 DEG C；Obtain solid chemical compound 3 nitro；Joining in reaction vessel by 3 nitros, with methanol as solvent, Raney's nickel is catalyst, pressurizes to reaction vessel, and pressure is 2 3MPa, under the conditions of temperature is 80 90 DEG C, reacts 2 3h, then removes methanol by rotary evaporation in vacuo, obtain 3 aminobphenyls；The present invention can realize Fast back-projection algorithm, and synthesis technique is simple, quick, time-consuming.
Description
Technical field
The present invention relates to compou nd synthesis technical field, be specifically related to the synthetic method of a kind of 3-aminobphenyl.
Background technology
Biphenyl is important Organic Ingredients, is widely used in the fields such as medicine, pesticide, dyestuff, liquid crystal material；Can be used to close
Become plasticizer, preservative, it is also possible to be used for manufacturing fuel, engineering plastics and high-energy fuel etc.；Biphenyl is present in coal tar, crude oil
With in natural gas；The preparation method of biphenyl has the chemical synthesis by benzene pyrolysis biphenyl processed etc. and by various coal tar fractions
The separation and Extraction method of biphenyl processed；Biphenyl mass fraction in coal tar is 0.20%-0.40%, current coal tar extraction and change
Learn synthetic method and deposit；The synthetic method of existing 3-aminobphenyl is slow, and loses time and cost, operation complexity.
Summary of the invention
Present invention aims to defect and the deficiency of prior art, it is provided that the synthesis side of a kind of 3-aminobphenyl
Method.
In order to solve the problem existing for background technology, the synthetic method of a kind of 3-aminobphenyl of the present invention, its conjunction
One-tenth method is: parazon is dissolved in methyl tertiary butyl ether(MTBE), mixing and stirring, instills nitric acid in gained mixed solution,
Continuing stirring 1-3h after dripping off, whole process temperature controls at 20-40 DEG C；Obtain solid chemical compound 3-nitro；3-nitro is added
Entering in reaction vessel, with methanol as solvent, Raney's nickel is catalyst, pressurizes to reaction vessel, and pressure is 2-3MPa, and temperature is
Under the conditions of 80-90 DEG C, react 2-3h, then remove methanol by rotary evaporation in vacuo, obtain 3-aminobphenyl.
Present invention have the beneficial effect that and can realize Fast back-projection algorithm, and synthesis technique is simple, quick, time-consuming.
Detailed description of the invention
This detailed description of the invention adopts the following technical scheme that its synthetic method is: parazon is dissolved in methyl-tert
Butyl ether, mixing and stirring, in gained mixed solution, instill nitric acid, after dripping off, continue stirring 1-3h, whole process temperature
Control at 20-40 DEG C；Obtain solid chemical compound 3-nitro；3-nitro is joined in reaction vessel, with methanol as solvent, thunder
Buddhist nun's nickel is catalyst, pressurizes to reaction vessel, and pressure is 2-3MPa, under the conditions of temperature is 80-90 DEG C, reacts 2-3h, then leads to
Cross rotary evaporation in vacuo and remove methanol, obtain 3-aminobphenyl.
The above, only in order to technical scheme to be described and unrestricted, those of ordinary skill in the art are to this
Other amendment or equivalent that bright technical scheme is made, without departing from the spirit and scope of technical solution of the present invention,
All should contain in the middle of scope of the presently claimed invention.
Claims (1)
1. the synthetic method of a 3-aminobphenyl, it is characterised in that: its synthetic method is: parazon is dissolved in methyl
Tertbutyl ether, mixing and stirring, in gained mixed solution, instill nitric acid, after dripping off, continue stirring 1-3h, whole process temperature
Degree controls at 20-40 DEG C；Obtain solid chemical compound 3-nitro；3-nitro is joined in reaction vessel, with methanol as solvent, thunder
Buddhist nun's nickel is catalyst, pressurizes to reaction vessel, and pressure is 2-3MPa, under the conditions of temperature is 80-90 DEG C, reacts 2-3h, then leads to
Cross rotary evaporation in vacuo and remove methanol, obtain 3-aminobphenyl.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610436976.2A CN106083608A (en) | 2016-06-20 | 2016-06-20 | A kind of synthetic method of 3 aminobphenyls |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610436976.2A CN106083608A (en) | 2016-06-20 | 2016-06-20 | A kind of synthetic method of 3 aminobphenyls |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106083608A true CN106083608A (en) | 2016-11-09 |
Family
ID=57236725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610436976.2A Pending CN106083608A (en) | 2016-06-20 | 2016-06-20 | A kind of synthetic method of 3 aminobphenyls |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106083608A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06239856A (en) * | 1993-02-15 | 1994-08-30 | Shin Nippon Yakuhin Kk | 1,3-benzoxathiol-2-thione derivative |
-
2016
- 2016-06-20 CN CN201610436976.2A patent/CN106083608A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06239856A (en) * | 1993-02-15 | 1994-08-30 | Shin Nippon Yakuhin Kk | 1,3-benzoxathiol-2-thione derivative |
Non-Patent Citations (2)
| Title |
|---|
| RAIFORD, L. CHAS.ETAL: "3-Nitro-4-hydroxydiphenyl and some of its derivatives", 《JOURNAL OF THE AMERICAN CHEMICAL SOCIETY》 * |
| VOROZHTSOV, N. N., JR.ETAL: "Derivatives of 2- and 4-hydroxybiphenyls. II. Nitrohydroxybiphenyls and aminohydroxybiphenyls and their derivatives. Azo dyes from hydroxybiphenyls", 《ZHURNAL OBSHCHEI KHIMII》 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161109 |
|
| RJ01 | Rejection of invention patent application after publication |