CN106075726B - Stimulation state adjustment method in sacral nerve stimulator - Google Patents

Stimulation state adjustment method in sacral nerve stimulator Download PDF

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Publication number
CN106075726B
CN106075726B CN201610536972.1A CN201610536972A CN106075726B CN 106075726 B CN106075726 B CN 106075726B CN 201610536972 A CN201610536972 A CN 201610536972A CN 106075726 B CN106075726 B CN 106075726B
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stimulation
value
difference
current
sacral nerve
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CN106075726A (en
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王克明
孙增军
刘新东
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Lishengte Medical Science & Tech Co Ltd
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Lishengte Medical Science & Tech Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36007Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0507Electrodes for the digestive system
    • A61N1/0514Electrodes for the urinary tract
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system

Abstract

The present invention provides the stimulation state adjustment method in a kind of sacral nerve stimulator, and sacral nerve stimulator is realized the adjustment of stimulation state using automatic mode, specifically includes following steps:1)Obtain initial impulse parameter and desired stimulation Effect value;2)Start sacral nerve stimulator to start to stimulate;3)In stimulating course, after often stimulating N number of pulse, obtain the nerves reaction voltage value v in the measuring electrode and impedance value r between measuring electrode, current nerves reaction Effect value nr is calculated according to nerves reaction voltage value v and impedance value r, the nerves reaction Effect value for calculating gained is compared with desired stimulation Effect value, if the nerves reaction Effect value for calculating gained is less than desired stimulation Effect value, then reinforce stimulating, if the nerves reaction Effect value for calculating gained is more than desired stimulation Effect value, weaken stimulation.The present invention realizes the automatic adjustment of sacral nerve stimulator, to reach better using effect.

Description

Stimulation state adjustment method in sacral nerve stimulator
Technical field
The present invention relates to sacral nerve stimulators, more particularly to the stimulation state adjustment side in a kind of sacral nerve stimulator Method.
Background technology
The bladders such as the urinary incontinence, frequent micturition system disease usually causes because of nervous system spinal cord injury, and medical research and practice are Confirmed, it is a kind of effective therapy to apply electro photoluminescence to related nerve.Many studies have shown that stimulation sacral nerve S2 S3 Root can influence the action of detrusor urinae of bladder and external urethral sphincter before S4, to inhibit wing using suitable stimulus signal Guang detrusor overactivity achievees the purpose that alleviate the urinary incontinence;Specific stimulating pulsatile series can also be used, to excite bladder Detrusor is with external urethral sphincter coordination to realize controlled urination.
Current existing sacral nerve stimulation product or technology, are stimulated according to the stimulation parameter of setting, stimulation Actual effect can not be weighed directly in a short time.If can in real time be monitored to effect of stimulation, and adjustment stimulation accordingly Parameter will can reach determining therapeutic effect, and therefore, it is necessary to the sacral nerve stimulators that a kind of energy real-time monitoring stimulates state.
Invention content
In view of the foregoing deficiencies of prior art, the purpose of the present invention is to provide the thorns in a kind of sacral nerve stimulator Swash state adjustment method, can only be stimulated by the stimulation parameter of setting for solving sacral nerve stimulator in the prior art, it cannot be certainly The problem of dynamic adjustment.
In order to achieve the above objects and other related objects, the present invention provides the stimulation state tune in a kind of sacral nerve stimulator Adjusting method, the sacral nerve stimulator are realized the adjustment of stimulation state using automatic mode, specifically include following steps:
1) initial impulse parameter and desired stimulation Effect value are obtained, initial impulse parameter includes boost pulse amplitude, stimulation Pulse width and frequency of stimulation, and specify two electrodes as working electrode, specify two electrodes as measuring electrode;
2) start the sacral nerve stimulator to start to stimulate, sacral nerve stimulator starts to stimulate according to initial impulse parameter;
3) in stimulating course, after often stimulating N number of pulse, N is preset value, obtains the nerves reaction electricity in the measuring electrode Impedance value r between pressure value v and measuring electrode calculates current nerve according to the nerves reaction voltage value v and impedance value r Reaction effect value nr, calculation formula nr=v/r;The nerves reaction Effect value for calculating gained is pierced with expectation described in step 1) Sharp Effect value is compared, if the nerves reaction Effect value for calculating gained is less than desired stimulation Effect value, reinforces stimulating, such as The nerves reaction Effect value that fruit calculates gained is more than desired stimulation Effect value, then weakens stimulation.
Preferably, further include to the adjustment for stimulating state specifically in the automatic mode:It is anti-to calculate the current nerve The difference between Effect value nr and the desired stimulation Effect value is answered, current stimulation ginseng is adjusted according to the size of the difference Number reinforces stimulation or weakens to stimulate with this to realize;The current stimulation parameter is current boost pulse amplitude, current stimulation One or several combinations in pulse width and current frequency of stimulation.
Preferably, each stimulation parameter used in the sacral nerve stimulator is ranging from:Boost pulse amplitude is divided into 100 Shelves, gear difference are 0-0.2V;Boost pulse width is divided into 13 grades, and gear difference is 30us;44 grades of frequency of stimulation range, gear difference are 0-30Hz。
Preferably, when the current stimulation parameter is current boost pulse amplitude, current boost pulse amplitude adjustment Specific method is:When the difference is positive value, current boost pulse amplitude is adjusted upward, when the difference is negative value, Current boost pulse amplitude is adjusted downwards, the gear number adjusted upward or downward is adjusted by the order of magnitude of difference, specifically For:When the absolute value of difference is more than 10,3 grades are adjusted;When the absolute value of difference is less than 10 more than 5,2 grades are adjusted;Difference it is absolute When value is less than 5 more than 1,1 grade is adjusted, when the absolute value of difference is less than 1, is not adjusted.
Preferably, when the current stimulation parameter is current boost pulse width, current boost pulse width adjustment Specific method is:When the difference is positive value, current boost pulse width is adjusted upward, when the difference is negative value, Current boost pulse width is adjusted downwards, the gear number adjusted upward or downward is adjusted by the order of magnitude of difference, specifically For:When the absolute value of difference is more than 10,3 grades are adjusted;When the absolute value of difference is less than 10 more than 5,2 grades are adjusted;Difference it is absolute When value is less than 5 more than 1,1 grade is adjusted, when the absolute value of difference is less than 1, is not adjusted.
Preferably, when the current stimulation parameter is current frequency of stimulation, the specific method of current frequency of stimulation adjustment For:When the difference is positive value, current frequency of stimulation is adjusted upward, when the difference is negative value, will currently stimulate frequency Rate adjusts downwards, and the gear number adjusted upward or downward is adjusted by the order of magnitude of difference, specially:The absolute value of difference is big When 10,3 grades are adjusted;When the absolute value of difference is less than 10 more than 5,2 grades are adjusted;When the absolute value of difference is less than 5 more than 1, adjust It whole 1 grade, when the absolute value of difference is less than 1, does not adjust.
Preferably, the sacral nerve stimulator further includes being stimulated using fixed mode, and fixed mode refers to:Sacral nerve Stimulator is sent to the constant stimulus parameter of sacral nerve stimulator to continue stimulation, constant stimulus parameter packet according to external controller Include boost pulse amplitude, boost pulse width and the frequency of stimulation of setting.
As described above, the stimulation state adjustment method in the sacral nerve stimulator of the present invention, has the advantages that:This The sacral nerve stimulator of invention has automatic mode can be with adjust automatically, can be by obtaining the nerves reaction in measuring electrode Impedance value between voltage value and measuring electrode calculates current nerves reaction effect by nerves reaction voltage value and impedance value Value, and current nerves reaction Effect value is compared with desired stimulation Effect value, it is adjusted in real time according to comparison result Effect of stimulation reinforces stimulation or weakens stimulation, and therefore, the present invention realizes the automatic adjustment of sacral nerve stimulator, to reach Better using effect.
Description of the drawings
Fig. 1 is shown as the flow diagram of the stimulation state adjustment method in the sacral nerve stimulator of the present invention.
Fig. 2 is shown as the structure diagram of the sacral nerve stimulator of the present invention.
Fig. 3 is shown as the stimulating electrode schematic diagram used in the sacral nerve stimulator of the present invention.
Component label instructions
1 microcontroller
2 first selectors
3 adjustable current sources
4 analog-digital converters
5 electrode bundles
51 first electrodes
52 second electrodes
53 third electrodes
54 the 4th electrodes
6 amplifiers
7 second selectors
Specific implementation mode
Illustrate that embodiments of the present invention, those skilled in the art can be by this explanations by particular specific embodiment below Content disclosed by book understands other advantages and effect of the present invention easily.
It please refers to Fig.1 to Fig.3.It should be clear that structure, ratio, size etc. depicted in this specification institute attached drawing, only to Coordinate the revealed content of specification, so that those skilled in the art understands and reads, being not limited to the present invention can be real The qualifications applied, therefore do not have technical essential meaning, the tune of the modification of any structure, the change of proportionate relationship or size It is whole, in the case where not influencing the effect of present invention can be generated and the purpose that can reach, should all still fall in disclosed skill In the range of art content can cover.Meanwhile in this specification it is cited as "upper", "lower", "left", "right", " centre " and The term of " one " etc. is merely convenient to being illustrated for narration, rather than to limit the scope of the invention, relativeness It is altered or modified, in the case where changing technology contents without essence, when being also considered as the enforceable scope of the present invention.
As shown in Figure 1, the present invention provides the stimulation state adjustment method in a kind of sacral nerve stimulator, sacrum of the invention god Through stimulator tool, there are two types of stimulus modalities may be selected, and one kind is exactly fixed mode, is stimulated according to fixed mode, then sacrum The constant stimulus parameter that sacral nerve stimulator is sent to according to external controller is continued stimulation, constant stimulus by nerve stimulator Parameter includes boost pulse amplitude, boost pulse width and the frequency of stimulation of setting.One is automatic modes, according to automatic mold Formula realizes the adjustment of stimulation state, specifically includes following steps:
1) initial impulse parameter and desired stimulation Effect value nr0 are obtained, initial impulse parameter includes boost pulse amplitude, thorn Swash pulse width and frequency of stimulation, and specify two electrodes as working electrode, specifies two electrodes as measuring electrode;See It is working electrode, second electrode 52 and the 4th electrode 54 that first electrode 51 and third electrode 53 are specified shown in Fig. 3, in the present embodiment For measuring electrode;
2) start sacral nerve stimulator to start to stimulate, sacral nerve stimulator starts to stimulate according to initial impulse parameter;
3) in stimulating course, after often stimulating N number of pulse, N is preset value, obtains the nerves reaction voltage value in measuring electrode Impedance value r between v and measuring electrode calculates current nerves reaction effect according to nerves reaction voltage value v and impedance value r Value nr, calculation formula nr=v/r;By the nerves reaction Effect value for calculating gained and desired stimulation Effect value described in step 1) Nr0 is compared, if the nerves reaction Effect value for calculating gained is less than desired stimulation Effect value, reinforces stimulating, if meter The nerves reaction Effect value for calculating gained is more than desired stimulation Effect value, then weakens stimulation.
The sacral nerve stimulator of the present invention has automatic mode can be with adjust automatically, can be by obtaining in measuring electrode Nerves reaction voltage value v and measuring electrode between impedance value r, calculated by nerves reaction voltage value v and impedance value r current Nerves reaction Effect value nr, and current nerves reaction Effect value nr is compared with desired stimulation Effect value nr0, root Come to adjust effect of stimulation in real time according to comparison result, reinforce stimulation or weaken stimulation, therefore, the present invention realizes sacral nerve stimulation The automatic adjustment of device, to reach better using effect.
Preferably to adjust, the natural number that above-mentioned N can be between 15-25 is optimal just to carry out one for 20 pulses of stimulation Secondary measurement.
Stimulation degree is preferably adjusted to realize, further includes to the adjustment for stimulating state specifically in above-mentioned automatic mode:Meter Difference between current nerves reaction Effect value nr and desired stimulation Effect value nr0, Δ=nr-nr0, according to the big of difference It is small to adjust current stimulation parameter, reinforce stimulation or weaken to stimulate to realize with this;The current stimulation parameter is current One or several combinations in boost pulse amplitude, current boost pulse width and current frequency of stimulation.
Separately below using boost pulse amplitude, boost pulse width (i.e. pulsewidth) and frequency of stimulation as current stimulation parameter To adjust.
Each stimulation parameter in the present embodiment used in sacral nerve stimulator is ranging from:Boost pulse amplitude is divided into 100 Shelves, gear difference are 0-0.2V;Boost pulse width is divided into 13 grades, and gear difference is 30us;44 grades of frequency of stimulation range, gear difference are 0-30Hz;Human body has preferably been adapted to divide for the division of above-mentioned gear number.
When current stimulation parameter is current boost pulse amplitude, the specific method of current boost pulse amplitude adjustment is: When difference is positive value, current boost pulse amplitude is adjusted upward, when the difference is negative value, by current boost pulse width Adjustment, the gear number adjusted upward or downward are adjusted degree by the order of magnitude of difference downwards, specially:The absolute value of difference is big When 10,3 grades are adjusted;When the absolute value of difference is less than 10 more than 5,2 grades are adjusted;When the absolute value of difference is less than 5 more than 1, adjust It whole 1 grade, when the absolute value of difference is less than 1, does not adjust.Such as patient select initial impulse parameter for:Boost pulse amplitude is 906uA, frequency of stimulation 65Hz, boost pulse width is 240us, and under automatic mode, the practical stimulation impulse amplitude of acquisition is 900uA, Δ=6 illustrate that stimulation degree is too strong, and the absolute value of difference be less than 10 be more than 5 when, then lower 2 grades.
When current stimulation parameter is current boost pulse width, the specific method of current boost pulse width adjustment is: When the difference is positive value, current boost pulse width is adjusted upward, when the difference is negative value, will currently stimulate arteries and veins It rushes width to adjust downwards, the gear number adjusted upward or downward is adjusted by the order of magnitude of difference, specially:Difference it is absolute When value is more than 10,3 grades are adjusted;When the absolute value of difference is less than 10 more than 5,2 grades are adjusted;The absolute value of difference is less than 5 and is more than 1 When, 1 grade is adjusted, when the absolute value of difference is less than 1, is not adjusted.
When current stimulation parameter is current frequency of stimulation, the specific method of current frequency of stimulation adjustment is:When the difference When value is positive value, current frequency of stimulation is adjusted upward, when the difference is negative value, current frequency of stimulation is adjusted downwards, The gear number adjusted upward or downward is adjusted by the order of magnitude of difference, specially:When the absolute value of difference is more than 10, adjustment 3 grades;When the absolute value of difference is less than 10 more than 5,2 grades are adjusted;When the absolute value of difference is less than 5 more than 1,1 grade is adjusted, difference When absolute value is less than 1, do not adjust.
Table is made into the adjustment of above-mentioned stimulation parameter, so as to the more specific adjustment for understanding automatic mode, see the table below 1.
Table 1
The concrete structure of sacral nerve stimulator of the present invention is:Sacral nerve stimulator includes for receiving external controller institute Module and electrode bundle occur for transmission circuit, microcontroller, the boost pulse of signalling, and electrode bundle includes four electrodes, every electrode End be useful for the stimulation point contacted with sacral nerve, according to practical the case where being implanted into, from wherein chosen position suitable two Root electrode exports boost pulse as working electrode;And other two electrodes are as measuring electrode, it is electric for measuring nerves reaction Press signal and tissue impedance, the adjust automatically for understanding practical physiological status and stimulation parameter inside patient body.Work The selection of electrode is configured by external controller.
As shown in Fig. 2, the first circuit equipped with neural voltage between completion measuring electrode in module occurs for above-mentioned boost pulse Module and the second circuit module for completing tissue impedance between measuring electrode, two circuit modules are connected with microcontroller 1, are used to Understand the adjust automatically of the practical physiological status and stimulation parameter inside patient body;Above-mentioned first circuit module includes and electrode Voltage and the amplifier of amplification 6 and analog-digital converter 4 between beam 5 connected first selector 2 and acquisition electrode, the first circuit Module is controlled by the microcontroller 1 in implant stimulator, and the measurement of neural voltage between electrode is completed at the time of requiring;Second electricity Road module includes the second selector 7 being connected with the electrode bundle 5, and the adjustable current source 3 being connected with second selector 7, And above-mentioned first circuit module, second circuit module are controlled by microcontroller 1, and tissue impedance between electrode is completed at the time of requiring Measurement, the adjust automatically for understanding practical physiological status and stimulation parameter inside patient body.
In the nerves reaction voltage between measuring measuring electrode, as shown in Figure 2, microcontroller 1 sends control signals to first Selector 2 connects two specified electrodes as measuring electrode, then the voltage between this two measuring electrodes is amplified device 6 and adopts Collect and amplify, amplified signal is converted to digital signal by analog-digital converter 4, sends microcontroller 1 to.
In the tissue impedance between measuring measuring electrode, as shown in Figure 2, microcontroller 1 sends control signals to the second selection Device 7 and adjustable current source 3, to send out the current transmission of determining amplitude to two specified measuring electrodes.Then microcontroller 1 is sent out again Go out to control signal to first selector 2, amplifier 6, analog-digital converter 4, acquires the voltage signal in measuring electrode.By this voltage Value divided by aforementioned currents value, just obtain tissue impedance values.
Microcontroller 1 then calculates nerves reaction Effect value nr, nr=v/r.This value is characterized under current stimulation parameter, is suffered from The nerves reaction intensity of person.Controller is sent in automatic mode setting command in vitro, has specified the expectation of nerves reaction intensity Value nr0.If the value is less than desired value, show that stimulation degree is inadequate, it should reinforce stimulation;If the value is more than desired value, Then show that stimulation degree is too strong, it should weaken stimulation.
In conclusion the stimulation state adjustment method in the sacral nerve stimulator of the present invention, can be measured by obtaining Nerves reaction voltage value on electrode and the impedance value between measuring electrode, are worked as by nerves reaction voltage value and impedance value to calculate Preceding nerves reaction Effect value, and current nerves reaction Effect value is compared with desired stimulation Effect value, according to than Relatively result to adjust effect of stimulation in real time, reinforces stimulation or weakens stimulation, therefore, the present invention realizes sacral nerve stimulator Automatic adjustment, to reach better using effect.So the present invention effectively overcomes various shortcoming in the prior art and has height Spend industrial utilization.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe The personage for knowing this technology can all carry out modifications and changes to above-described embodiment without violating the spirit and scope of the present invention.Cause This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as At all equivalent modifications or change, should by the present invention claim be covered.

Claims (7)

1. the stimulation state adjustment method in a kind of sacral nerve stimulator, which is characterized in that the sacral nerve stimulator uses certainly Dynamic model formula realizes the adjustment of stimulation state, specifically includes following steps:
1) it includes boost pulse amplitude, boost pulse to obtain initial impulse parameter and desired stimulation Effect value, initial impulse parameter Width and frequency of stimulation, and specify two electrodes as working electrode, specify two electrodes as measuring electrode;
2) start the sacral nerve stimulator to start to stimulate, sacral nerve stimulator starts to stimulate according to the initial impulse parameter;
3) in stimulating course, after often stimulating N number of pulse, N is preset value, obtains the nerves reaction voltage value in the measuring electrode Impedance value r between v and measuring electrode calculates current nerves reaction according to the nerves reaction voltage value v and impedance value r Effect value nr, calculation formula nr=v/r;The nerves reaction Effect value for calculating gained is imitated with desired stimulation described in step 1) Fruit value is compared, if the nerves reaction Effect value for calculating gained is less than desired stimulation Effect value, reinforces stimulating, if meter The nerves reaction Effect value for calculating gained is more than desired stimulation Effect value, then weakens stimulation.
2. the stimulation state adjustment method in sacral nerve stimulator according to claim 1, it is characterised in that:It is described automatic Further include to the adjustment for stimulating state specifically in pattern:Calculate the current nerves reaction Effect value nr and the desired stimulation Difference between Effect value adjusts current stimulation parameter according to the size of the difference, with this come realize reinforce stimulation or Weaken stimulation;The current stimulation parameter is current boost pulse amplitude, current boost pulse width and current frequency of stimulation In one or several combinations.
3. the stimulation state adjustment method in sacral nerve stimulator according to claim 2, it is characterised in that:The sacrum god Ranging from through each stimulation parameter used in stimulator:Boost pulse amplitude is divided into 100 grades, and gear difference is 0-0.2V;Stimulation Pulse width is divided into 13 grades, and gear difference is 30us;44 grades of frequency of stimulation range, gear difference are 0-30Hz.
4. the stimulation state adjustment method in sacral nerve stimulator according to claim 3, it is characterised in that:It is described current Stimulation parameter when being current boost pulse amplitude, the specific method of current boost pulse amplitude adjustment is:When the difference is When positive value, current boost pulse amplitude is adjusted upward, when the difference is negative value, by current boost pulse amplitude to downward Whole, the gear number adjusted upward or downward is adjusted by the order of magnitude of difference, specially:When the absolute value of difference is more than 10, 3 grades of adjustment;When the absolute value of difference is less than 10 more than 5,2 grades are adjusted;When the absolute value of difference is less than 5 more than 1,1 grade of adjustment is poor When the absolute value of value is less than 1, do not adjust.
5. the stimulation state adjustment method in sacral nerve stimulator according to claim 3, it is characterised in that:It is described current Stimulation parameter be current boost pulse width when, the specific method of current boost pulse width adjustment is:When the difference is When positive value, current boost pulse width is adjusted upward, when the difference is negative value, by current boost pulse width to downward Whole, the gear number adjusted upward or downward is adjusted by the order of magnitude of difference, specially:When the absolute value of difference is more than 10, 3 grades of adjustment;When the absolute value of difference is less than 10 more than 5,2 grades are adjusted;When the absolute value of difference is less than 5 more than 1,1 grade of adjustment is poor When the absolute value of value is less than 1, do not adjust.
6. the stimulation state adjustment method in sacral nerve stimulator according to claim 3, it is characterised in that:It is described current Stimulation parameter when being current frequency of stimulation, the specific method of current frequency of stimulation adjustment is:It, will when the difference is positive value Current frequency of stimulation adjusts upward, and when the difference is negative value, current frequency of stimulation is adjusted downwards, is adjusted upward or downward Gear number adjusted by the order of magnitude of difference, specially:When the absolute value of difference is more than 10,3 grades are adjusted;Difference it is absolute When value is less than 10 more than 5,2 grades are adjusted;When the absolute value of difference is less than 5 more than 1,1 grade, when the absolute value of difference is less than 1 is adjusted, It does not adjust.
7. the stimulation state adjustment method in sacral nerve stimulator according to claim 1, it is characterised in that:The sacrum god Further include being stimulated using fixed mode through stimulator, fixed mode refers to:Sacral nerve stimulator is sent out according to external controller The constant stimulus parameter of sacral nerve stimulator is given to continue stimulation, constant stimulus parameter include setting boost pulse amplitude, Boost pulse width and frequency of stimulation.
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