CN106075726A - Stimulation state adjustment method in sacral nerve stimulator - Google Patents

Stimulation state adjustment method in sacral nerve stimulator Download PDF

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Publication number
CN106075726A
CN106075726A CN201610536972.1A CN201610536972A CN106075726A CN 106075726 A CN106075726 A CN 106075726A CN 201610536972 A CN201610536972 A CN 201610536972A CN 106075726 A CN106075726 A CN 106075726A
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difference
value
stimulation
current
sacral nerve
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CN201610536972.1A
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CN106075726B (en
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王克明
孙增军
刘新东
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Lishengte Medical Science & Tech Co Ltd
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Lishengte Medical Science & Tech Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36007Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0507Electrodes for the digestive system
    • A61N1/0514Electrodes for the urinary tract
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system

Abstract

The present invention provides the stimulation state adjustment method in a kind of sacral nerve stimulator, and sacral nerve stimulator uses automatic mode to realize the adjustment of stimulation state, specifically includes following steps: 1) obtain initial impulse parameter and desired stimulation Effect value;2) start sacral nerve stimulator to start to stimulate;3) in stimulating course, after often stimulating N number of pulse, obtain the nerves reaction magnitude of voltage v measured on electrode and measure interelectrode resistance value r, current nerves reaction Effect value nr is calculated according to nerves reaction magnitude of voltage v and resistance value r, the nerves reaction Effect value calculating gained is compared with desired stimulation Effect value, if calculating the nerves reaction Effect value of gained less than desired stimulation Effect value, then add strong stimulation, if the nerves reaction Effect value calculating gained is more than desired stimulation Effect value, then weaken stimulation.Present invention achieves being automatically adjusted of sacral nerve stimulator, to reach more preferable using effect.

Description

Stimulation state adjustment method in sacral nerve stimulator
Technical field
The present invention relates to sacral nerve stimulator, particularly relate to the stimulation state adjustment side in a kind of sacral nerve stimulator Method.
Background technology
The bladder such as urinary incontinence, frequent micturition system disease generally causes because of nervous system spinal cord injury, and medical research and practice are Confirmed, it is a kind of effective Therapeutic Method to relevant neural applying electricity irritation.Many studies have shown that, stimulate sacral nerves S2 S3 Before S4, root can affect the action of detrusor of bladder and EUS, thus utilizes suitable stimulus signal can suppress wing Guang detrusor overactivity, reaches to alleviate the purpose of urinary incontinence;Specific stimulating pulsatile series can also be used, excite bladder Detrusor and EUS coordination are to realize controlled urinating.
Current existing sacral nerve stimulation product or technology, be all to stimulate according to the stimulus parameter set, stimulation Actual effect cannot the most directly be weighed.If able to effect of stimulation is monitored in real time, and adjust stimulation accordingly Parameter, will can reach the therapeutic effect determined, accordingly, it would be desirable to a kind of energy real-time monitoring stimulates the sacral nerve stimulator of state.
Summary of the invention
The shortcoming of prior art in view of the above, it is an object of the invention to provide the thorn in a kind of sacral nerve stimulator Swash state adjustment method, can only stimulate by the stimulus parameter set for solving sacral nerve stimulator in prior art, it is impossible to from The dynamic problem adjusted.
For achieving the above object and other relevant purposes, the present invention provides the stimulation state in a kind of sacral nerve stimulator to adjust Adjusting method, described sacral nerve stimulator uses automatic mode to realize the adjustment of stimulation state, specifically includes following steps:
1) obtaining initial impulse parameter and desired stimulation Effect value, initial impulse parameter includes boost pulse amplitude, stimulation Pulse width and stimulus frequency, and specify two electrodes as working electrode, it is intended that two electrodes are as measuring electrode;
2) starting described sacral nerve stimulator to start to stimulate, sacral nerve stimulator starts to stimulate according to initial impulse parameter;
3) in stimulating course, after often stimulating N number of pulse, N is preset value, obtains the nerves reaction electricity on described measurement electrode Pressure value v and measure interelectrode resistance value r, calculates current nerve according to described nerves reaction magnitude of voltage v and resistance value r Reaction effect value nr, computing formula is nr=v/r;Nerves reaction Effect value and the step 1 of gained will be calculated) described in expectation thorn Sharp Effect value compares, if the nerves reaction Effect value calculating gained is less than desired stimulation Effect value, then adds strong stimulation, as Fruit calculates the nerves reaction Effect value of gained and is more than desired stimulation Effect value, then weaken stimulation.
Preferably, in described automatic mode, specifically adjustment to stimulating state also includes: calculate described current neural anti- Answer the difference between Effect value nr and described desired stimulation Effect value, adjust current stimulation ginseng according to the size of described difference Number, realizes adding strong stimulation or weakening stimulation with this;Described current stimulus parameter is current boost pulse amplitude, currently stimulates One or several combination in pulse width and current stimulus frequency.
Preferably, each stimulus parameter used in described sacral nerve stimulator in the range of: boost pulse amplitude is divided into 100 Shelves, gear difference is 0-0.2V;Boost pulse width is divided into 13 grades, and gear difference is 30us;Stimulus frequency scope 44 grades, gear difference is 0-30Hz。
Preferably, when described current stimulus parameter is current boost pulse amplitude, current boost pulse amplitude adjusts Method particularly includes: when described difference be on the occasion of time, current boost pulse amplitude is adjusted upward, when described difference is negative value, Current boost pulse amplitude being adjusted downwards, the gear number adjusted up or down is regulated by the order of magnitude of difference, specifically For: when the absolute value of difference is more than 10, adjust 3 grades;When the absolute value of difference is more than 5 less than 10, adjust 2 grades;Difference absolute When value is more than 1 less than 5, adjust 1 grade, when the absolute value of difference is less than 1, do not adjust.
Preferably, when described current stimulus parameter is current boost pulse width, current boost pulse width adjustment Method particularly includes: when described difference be on the occasion of time, current boost pulse width is adjusted upward, when described difference is negative value, Being adjusted downwards by current boost pulse width, the gear number adjusted up or down is regulated by the order of magnitude of difference, specifically For: when the absolute value of difference is more than 10, adjust 3 grades;When the absolute value of difference is more than 5 less than 10, adjust 2 grades;Difference absolute When value is more than 1 less than 5, adjust 1 grade, when the absolute value of difference is less than 1, do not adjust.
Preferably, when described current stimulus parameter is current stimulus frequency, the concrete grammar that current stimulus frequency adjusts For: when described difference be on the occasion of time, current stimulus frequency is adjusted upward, when described difference is negative value, will currently stimulate frequency Rate adjusts downwards, and the gear number adjusted up or down is regulated by the order of magnitude of difference, particularly as follows: the absolute value of difference is big In 10 time, adjust 3 grades;When the absolute value of difference is more than 5 less than 10, adjust 2 grades;When the absolute value of difference is more than 1 less than 5, adjust Whole 1 grade, when the absolute value of difference is less than 1, do not adjust.
Preferably, described sacral nerve stimulator also includes using fixed model to stimulate, and fixed model refers to: sacral nerves The constant stimulus parameter that stimulator is sent to sacral nerve stimulator according to external controller persistently stimulates, constant stimulus parameter bag Include the boost pulse amplitude of setting, boost pulse width and stimulus frequency.
As it has been described above, the stimulation state adjustment method in the sacral nerve stimulator of the present invention, have the advantages that this The sacral nerve stimulator of invention has automatic mode and can automatically adjust, and it can be by obtaining the nerves reaction measured on electrode Magnitude of voltage and the interelectrode resistance value of measurement, calculate current nerves reaction effect by nerves reaction magnitude of voltage and resistance value Value, and current nerves reaction Effect value is compared with desired stimulation Effect value, regulate in real time according to comparative result Effect of stimulation, adds strong stimulation or weakens stimulation, therefore, present invention achieves being automatically adjusted of sacral nerve stimulator, to reach Preferably using effect.
Accompanying drawing explanation
The schematic flow sheet stimulating state adjustment method that Fig. 1 is shown as in the sacral nerve stimulator of the present invention.
Fig. 2 is shown as the structured flowchart of the sacral nerve stimulator of the present invention.
Fig. 3 is shown as the stimulating electrode schematic diagram used by the sacral nerve stimulator of the present invention.
Element numbers explanation
1 single-chip microcomputer
2 first selectors
3 adjustable current sources
4 analog-digital converters
5 electrode bundles
51 first electrodes
52 second electrodes
53 the 3rd electrodes
54 the 4th electrodes
6 amplifiers
7 second selectors
Detailed description of the invention
By particular specific embodiment, embodiments of the present invention being described below, those skilled in the art can be by this explanation Content disclosed by book understands other advantages and effect of the present invention easily.
Refer to Fig. 1 to Fig. 3.It should be clear that structure depicted in this specification institute accompanying drawing, ratio, size etc., the most only in order to Coordinating the content disclosed in description, understand for those skilled in the art and read, being not limited to the present invention can be real The qualifications executed, therefore do not have technical essential meaning, the modification of any structure, the change of proportionate relationship or the tune of size Whole, under not affecting effect that the present invention can be generated by and the purpose that can reach, all should still fall in disclosed skill In the range of art content can contain.Meanwhile, in this specification cited as " on ", D score, "left", "right", " middle " and The term of " one " etc., is merely convenient to understanding of narration, and is not used to limit the enforceable scope of the present invention, its relativeness It is altered or modified, is changing under technology contents without essence, when being also considered as the enforceable category of the present invention.
As it is shown in figure 1, the present invention provides the stimulation state adjustment method in a kind of sacral nerve stimulator, the sacrum god of the present invention Having two kinds of stimulus modelities through stimulator may select, one is exactly fixed model, stimulates according to fixed model, then sacrum The constant stimulus parameter being sent to sacral nerve stimulator according to external controller is persistently stimulated by nerve stimulator, constant stimulus Parameter includes boost pulse amplitude, boost pulse width and the stimulus frequency set.One is automatic mode, according to automatic mold Formula realizes the adjustment of stimulation state, specifically includes following steps:
1) obtaining initial impulse parameter and desired stimulation Effect value nr0, initial impulse parameter includes boost pulse amplitude, thorn Swash pulse width and stimulus frequency, and specify two electrodes as working electrode, it is intended that two electrodes are as measuring electrode;See Shown in Fig. 3, specifying the first electrode 51 and the 3rd electrode 53 in the present embodiment is working electrode, the second electrode 52 and the 4th electrode 54 For measuring electrode;
2) starting sacral nerve stimulator to start to stimulate, sacral nerve stimulator starts to stimulate according to initial impulse parameter;
3) in stimulating course, after often stimulating N number of pulse, N is preset value, obtains the nerves reaction magnitude of voltage measured on electrode V and measure interelectrode resistance value r, calculates current nerves reaction effect according to nerves reaction magnitude of voltage v and resistance value r Value nr, computing formula is nr=v/r;Nerves reaction Effect value and the step 1 of gained will be calculated) described in desired stimulation Effect value Nr0 compares, if the nerves reaction Effect value calculating gained is less than desired stimulation Effect value, then adds strong stimulation, if meter The nerves reaction Effect value calculating gained is more than desired stimulation Effect value, then weaken stimulation.
The sacral nerve stimulator of the present invention has automatic mode and can automatically adjust, and it can be measured on electrode by obtaining Nerves reaction magnitude of voltage v and measure interelectrode resistance value r, calculated currently by nerves reaction magnitude of voltage v and resistance value r Nerves reaction Effect value nr, and current nerves reaction Effect value nr is compared with desired stimulation Effect value nr0, root Regulate effect of stimulation according to comparative result in real time, add strong stimulation or weaken stimulation, therefore, present invention achieves sacral nerve stimulation Being automatically adjusted of device, to reach more preferable using effect.
For preferably regulating, above-mentioned N can be the natural number between 15-25, and optimum just carries out one for 20 pulses of stimulation Secondary measurement.
For realize preferably regulation stimulation degree, in above-mentioned automatic mode specifically to stimulate state adjustment also include: meter Difference between current nerves reaction Effect value nr and desired stimulation Effect value nr0, Δ=nr-nr0, big according to difference Little adjust current stimulus parameter, realize adding strong stimulation or weakening stimulation with this;Described current stimulus parameter is current One or several combination in boost pulse amplitude, current boost pulse width and current stimulus frequency.
Separately below using boost pulse amplitude, boost pulse width (i.e. pulsewidth) and stimulus frequency as current stimulus parameter Adjust.
In the present embodiment each stimulus parameter used in sacral nerve stimulator in the range of: boost pulse amplitude is divided into 100 Shelves, gear difference is 0-0.2V;Boost pulse width is divided into 13 grades, and gear difference is 30us;Stimulus frequency scope 44 grades, gear difference is 0-30Hz;The division of above-mentioned gear number human body the most preferably adapts and divides.
When current stimulus parameter is current boost pulse amplitude, current boost pulse amplitude adjusts method particularly includes: When difference be on the occasion of time, current boost pulse amplitude is adjusted upward, when described difference is negative value, by current boost pulse width Degree adjusts downwards, and the gear number adjusted up or down is regulated by the order of magnitude of difference, particularly as follows: the absolute value of difference is big In 10 time, adjust 3 grades;When the absolute value of difference is more than 5 less than 10, adjust 2 grades;When the absolute value of difference is more than 1 less than 5, adjust Whole 1 grade, when the absolute value of difference is less than 1, do not adjust.Such as patient selects the initial impulse parameter to be: boost pulse amplitude is 906uA, stimulus frequency is 65Hz, and boost pulse width is 240us, and under automatic mode, the practical stimulation pulse amplitude of acquisition is 900uA, Δ=6, illustrate that stimulation degree is too strong, and when the absolute value of difference is more than 5 less than 10, then lower 2 grades.
When current stimulus parameter is current boost pulse width, current boost pulse width adjustment method particularly includes: When described difference be on the occasion of time, current boost pulse width is adjusted upward, when described difference is negative value, will currently stimulate arteries and veins Rushing width to adjust downwards, the gear number adjusted up or down is regulated by the order of magnitude of difference, particularly as follows: difference is absolute When value is more than 10, adjust 3 grades;When the absolute value of difference is more than 5 less than 10, adjust 2 grades;The absolute value of difference is more than 1 less than 5 Time, adjust 1 grade, when the absolute value of difference is less than 1, do not adjust.
When current stimulus parameter is current stimulus frequency, current stimulus frequency adjusts method particularly includes: when described difference Value on the occasion of time, current stimulus frequency is adjusted upward, when described difference is negative value, current stimulus frequency is adjusted downwards, The gear number adjusted up or down is regulated by the order of magnitude of difference, during particularly as follows: the absolute value of difference is more than 10, adjusts 3 grades;When the absolute value of difference is more than 5 less than 10, adjust 2 grades;When the absolute value of difference is more than 1 less than 5, adjust 1 grade, difference When absolute value is less than 1, do not adjust.
Form is made in the adjustment of above-mentioned stimulus parameter, in order to the more specific adjustment understanding automatic mode, see table 1.
Table 1
The concrete structure of the sacral nerve stimulator of the present invention is: sacral nerve stimulator includes for receiving body outer controller institute Transmission circuit, single-chip microcomputer, boost pulse generation module and the electrode bundle signaled, electrode bundle includes four electrodes, every electrode End all have the stimulation point for contacting with sacral nerves, according to reality implant situation, chosen position suitable two from which Root electrode, exports boost pulse as working electrode;And other two electrodes are as measuring electrode, it is used for measuring nerves reaction electricity Pressure signal and tissue impedance, for understanding the automatic adjustment of the actual physiological situation within patient body and stimulus parameter.Work Choosing of electrode is configured by external controller.
The first circuit of neural voltage between electrode is measured as in figure 2 it is shown, be provided with in above-mentioned boost pulse generation module Module and complete to measure the second circuit module of tissue impedance between electrode, two circuit modules are all connected with single-chip microcomputer 1, are used to Understand the automatic adjustment of the actual physiological situation within patient body and stimulus parameter;Above-mentioned first circuit module includes and electrode The first selectors 2 that bundle 5 is connected, and the amplifier 6 of voltage and amplification and analog-digital converter 4, the first circuit between acquisition electrode Module is controlled by the single-chip microcomputer 1 in implant stimulator, completes the measurement of neural voltage between electrode in the moment required;Second electricity Road module includes the second selector 7 being connected with described electrode bundle 5, and the adjustable current source 3 being connected with second selector 7, And above-mentioned first circuit module, second circuit module is controlled by single-chip microcomputer 1, completes tissue impedance between electrode in the moment required Measurement, for understanding automatically adjusting of actual physiological situation patient body within and stimulus parameter.
When measuring interelectrode nerves reaction voltage, as shown in Figure 2, single-chip microcomputer 1 sends control signals to first Selector 2, connects two electrodes specifying as measuring electrode, then these two voltages measured between electrodes are exaggerated device 6 and adopt Collecting and amplify, the signal after amplification is converted to digital signal by analog-digital converter 4, sends single-chip microcomputer 1 to.
When measuring interelectrode tissue impedance, as shown in Figure 2, single-chip microcomputer 1 sends control signals to the second selection Device 7 and adjustable current source 3, to send two measurement electrodes that the electric current determining amplitude flows to specify.Then single-chip microcomputer 1 is sent out again Go out control signal and measure the voltage signal on electrode to first selector 2, amplifier 6, analog-digital converter 4, collection.By this voltage Value, divided by aforementioned currents value, just obtains tissue impedance values.
Single-chip microcomputer 1 calculates nerves reaction Effect value nr, nr=v/r subsequently.This value is characterized under current stimulus parameter, suffers from The nerves reaction intensity of person.During controller sends automatic mode setting command in vitro, specify the expectation of nerves reaction intensity Value nr0.If this value is less than expected value, then show that stimulation degree is inadequate, it should add strong stimulation;If this value is more than expected value, Then show that stimulation degree is the strongest, it should weaken stimulation.
In sum, the stimulation state adjustment method in the sacral nerve stimulator of the present invention, it can be measured by acquisition Nerves reaction magnitude of voltage on electrode and the interelectrode resistance value of measurement, calculated by nerves reaction magnitude of voltage and resistance value and work as Before nerves reaction Effect value, and current nerves reaction Effect value is compared with desired stimulation Effect value, according to than Relatively result regulates effect of stimulation in real time, adds strong stimulation or weakens stimulation, therefore, present invention achieves sacral nerve stimulator It is automatically adjusted, to reach more preferable using effect.So, the present invention effectively overcomes various shortcoming of the prior art and has height Degree industrial utilization.
The principle of above-described embodiment only illustrative present invention and effect thereof, not for limiting the present invention.Any ripe Above-described embodiment all can be modified under the spirit and the scope of the present invention or change by the personage knowing this technology.Cause This, have usually intellectual such as complete with institute under technological thought without departing from disclosed spirit in art All equivalences become are modified or change, and must be contained by the claim of the present invention.

Claims (7)

1. the stimulation state adjustment method in a sacral nerve stimulator, it is characterised in that described sacral nerve stimulator uses certainly Dynamic model formula realizes the adjustment of stimulation state, specifically includes following steps:
1) obtaining initial impulse parameter and desired stimulation Effect value, initial impulse parameter includes boost pulse amplitude, boost pulse Width and stimulus frequency, and specify two electrodes as working electrode, it is intended that two electrodes are as measuring electrode;
2) starting described sacral nerve stimulator to start to stimulate, sacral nerve stimulator starts to stimulate according to described initial impulse parameter;
3) in stimulating course, after often stimulating N number of pulse, N is preset value, obtains the nerves reaction magnitude of voltage on described measurement electrode V and measure interelectrode resistance value r, calculates current nerves reaction according to described nerves reaction magnitude of voltage v and resistance value r Effect value nr, computing formula is nr=v/r;Nerves reaction Effect value and the step 1 of gained will be calculated) described in desired stimulation effect Fruit value compares, if the nerves reaction Effect value calculating gained is less than desired stimulation Effect value, then adds strong stimulation, if meter The nerves reaction Effect value calculating gained is more than desired stimulation Effect value, then weaken stimulation.
Stimulation state adjustment method in sacral nerve stimulator the most according to claim 1, it is characterised in that: described automatically In pattern, specifically adjustment to stimulating state also includes: calculate described current nerves reaction Effect value nr and described desired stimulation Difference between Effect value, adjusts current stimulus parameter according to the size of described difference, with this realize adding strong stimulation or Weaken stimulation;Described current stimulus parameter is current boost pulse amplitude, current boost pulse width and current stimulus frequency In one or several combination.
Stimulation state adjustment method in sacral nerve stimulator the most according to claim 2, it is characterised in that: described sacrum god Through each stimulus parameter used in stimulator in the range of: boost pulse amplitude is divided into 100 grades, and gear difference is 0-0.2V;Stimulate Pulse width is divided into 13 grades, and gear difference is 30us;Stimulus frequency scope 44 grades, gear difference is 0-30Hz.
Stimulation state adjustment method in sacral nerve stimulator the most according to claim 3, it is characterised in that: described currently Stimulus parameter when being current boost pulse amplitude, current boost pulse amplitude adjusts method particularly includes: when described difference is On the occasion of time, current boost pulse amplitude is adjusted upward, when described difference is negative value, by current boost pulse amplitude to downward Whole, the gear number adjusted up or down is regulated by the order of magnitude of difference, during particularly as follows: the absolute value of difference is more than 10, Adjust 3 grades;When the absolute value of difference is more than 5 less than 10, adjust 2 grades;When the absolute value of difference is more than 1 less than 5, adjust 1 grade, poor When the absolute value of value is less than 1, do not adjust.
Stimulation state adjustment method in sacral nerve stimulator the most according to claim 3, it is characterised in that: described currently Stimulus parameter when being current boost pulse width, current boost pulse width adjustment method particularly includes: when described difference is On the occasion of time, current boost pulse width is adjusted upward, when described difference is negative value, by current boost pulse width to downward Whole, the gear number adjusted up or down is regulated by the order of magnitude of difference, during particularly as follows: the absolute value of difference is more than 10, Adjust 3 grades;When the absolute value of difference is more than 5 less than 10, adjust 2 grades;When the absolute value of difference is more than 1 less than 5, adjust 1 grade, poor When the absolute value of value is less than 1, do not adjust.
Stimulation state adjustment method in sacral nerve stimulator the most according to claim 3, it is characterised in that: described currently Stimulus parameter when being current stimulus frequency, current stimulus frequency adjusts method particularly includes: when described difference be on the occasion of time, general Current stimulus frequency adjusts upward, and when described difference is negative value, is adjusted downwards by current stimulus frequency, adjusts up or down Gear number regulate by the order of magnitude of difference, particularly as follows: the absolute value of difference more than 10 time, adjust 3 grades;Difference absolute When value is more than 5 less than 10, adjust 2 grades;When the absolute value of difference is more than 1 less than 5, adjust 1 grade, when the absolute value of difference is less than 1, Do not adjust.
Stimulation state adjustment method in sacral nerve stimulator the most according to claim 1, it is characterised in that: described sacrum god Also including using fixed model to stimulate through stimulator, fixed model refers to: sacral nerve stimulator is sent out according to external controller The constant stimulus parameter giving sacral nerve stimulator persistently stimulates, constant stimulus parameter include set boost pulse amplitude, Boost pulse width and stimulus frequency.
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107789733A (en) * 2017-11-23 2018-03-13 清华大学 Electric pulse stimulation system and control method, the control method of electric pulse stimulation signal
CN109865200A (en) * 2019-01-28 2019-06-11 廖旺才 Parameters of electrical stimulation adjusting method, system, electrical stimulation device, computer equipment
CN109982742A (en) * 2016-11-18 2019-07-05 欧姆龙健康医疗事业株式会社 Electric therapeutic apparatus and treatment system
CN113491827A (en) * 2020-04-07 2021-10-12 浙江迈达佩思医疗科技有限公司 Sacral nerve stimulation system and method for determining configuration parameters of sacral nerve stimulation system

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120172742A1 (en) * 2010-12-29 2012-07-05 Shantha Arcot-Krishnamurthy Systems and methods for using electrical impedance for neuro cardiac therapy
US20120245656A1 (en) * 2006-08-29 2012-09-27 Brockway Marina V Controlled titration of neurostimulation therapy
CN102716549A (en) * 2012-07-11 2012-10-10 江苏中普科技有限公司 Self-adaptive device and method for controlling load of nerve and muscle stimulator
CN103079636A (en) * 2010-06-18 2013-05-01 心脏起搏器公司 Neurostimulation system with control using evoked responses
CN103845793A (en) * 2012-12-07 2014-06-11 苏州景昱医疗器械有限公司 Implantable nerve stimulator, system and method for combining multiple sets of stimulus parameters
CN105363127A (en) * 2015-12-01 2016-03-02 杭州承诺医疗科技有限公司 Sacral nerve stimulation generator
CN205268832U (en) * 2015-12-01 2016-06-01 杭州承诺医疗科技有限公司 Implanted sacrum neural stimulator
CN106714896A (en) * 2014-07-25 2017-05-24 萨鲁达医疗有限公司 Neural stimulation dosing

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120245656A1 (en) * 2006-08-29 2012-09-27 Brockway Marina V Controlled titration of neurostimulation therapy
CN103079636A (en) * 2010-06-18 2013-05-01 心脏起搏器公司 Neurostimulation system with control using evoked responses
US20120172742A1 (en) * 2010-12-29 2012-07-05 Shantha Arcot-Krishnamurthy Systems and methods for using electrical impedance for neuro cardiac therapy
CN102716549A (en) * 2012-07-11 2012-10-10 江苏中普科技有限公司 Self-adaptive device and method for controlling load of nerve and muscle stimulator
CN103845793A (en) * 2012-12-07 2014-06-11 苏州景昱医疗器械有限公司 Implantable nerve stimulator, system and method for combining multiple sets of stimulus parameters
CN106714896A (en) * 2014-07-25 2017-05-24 萨鲁达医疗有限公司 Neural stimulation dosing
CN105363127A (en) * 2015-12-01 2016-03-02 杭州承诺医疗科技有限公司 Sacral nerve stimulation generator
CN205268832U (en) * 2015-12-01 2016-06-01 杭州承诺医疗科技有限公司 Implanted sacrum neural stimulator

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109982742A (en) * 2016-11-18 2019-07-05 欧姆龙健康医疗事业株式会社 Electric therapeutic apparatus and treatment system
CN107789733A (en) * 2017-11-23 2018-03-13 清华大学 Electric pulse stimulation system and control method, the control method of electric pulse stimulation signal
CN109865200A (en) * 2019-01-28 2019-06-11 廖旺才 Parameters of electrical stimulation adjusting method, system, electrical stimulation device, computer equipment
CN109865200B (en) * 2019-01-28 2023-05-26 曾乐朋 Electrical stimulation parameter adjusting method, system, electrical stimulation device and computer equipment
CN113491827A (en) * 2020-04-07 2021-10-12 浙江迈达佩思医疗科技有限公司 Sacral nerve stimulation system and method for determining configuration parameters of sacral nerve stimulation system
CN113491827B (en) * 2020-04-07 2023-12-29 浙江迈达佩思医疗科技有限公司 Sacral nerve stimulation system and method for determining configuration parameters of sacral nerve stimulation system

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