CN106075724A - Implanted vagus nerve dual pathways stimulating apparatus - Google Patents

Implanted vagus nerve dual pathways stimulating apparatus Download PDF

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Publication number
CN106075724A
CN106075724A CN201610406252.3A CN201610406252A CN106075724A CN 106075724 A CN106075724 A CN 106075724A CN 201610406252 A CN201610406252 A CN 201610406252A CN 106075724 A CN106075724 A CN 106075724A
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Prior art keywords
wound form
stimulation pulse
electric stimulation
electrode
unit
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CN201610406252.3A
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Chinese (zh)
Inventor
肖波
文志林
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Individual
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Priority to CN201610406252.3A priority Critical patent/CN106075724A/en
Publication of CN106075724A publication Critical patent/CN106075724A/en
Priority to PCT/CN2017/000380 priority patent/WO2017215256A1/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36053—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for vagal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A61N1/0558—Anchoring or fixation means therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Electrotherapy Devices (AREA)

Abstract

A kind of implanted vagus nerve dual pathways stimulating apparatus, relates to technical field of medical equipment, and solved is to improve effect of stimulation, safety and reduce the technical problem of operation easier.This device includes electric stimulation pulse generator, connects the sign detection module of electric stimulation pulse generator, and two are implanted unit；Described implantation unit includes wound form location anchor, flexible electrode big envelope, and the wound form electrode that two polarity is different, wound form therein location anchor is fixed on electrode big envelope by the cross structure of a flexibility, two wound form electrodes are placed in the both sides of wound form location anchor, and the electrical lead wire of two wound form electrodes is each passed through electrode big envelope affixed with electrode big envelope；The electrical lead wire of two wound form electrodes implanted in unit is coupled with two boost pulse output ports of electric stimulation pulse generator.The device that the present invention provides, it is adaptable to vagus nerve is implemented electricity irritation.

Description

Implanted vagus nerve dual pathways stimulating apparatus
Technical field
The present invention relates to armarium technology, particularly relate to the skill of a kind of implanted vagus nerve dual pathways stimulating apparatus Art.
Background technology
Implanted vns device is to stimulate vagal armarium by output electrical stimulation signal.Existing Some implanted vns device are mainly different by electric stimulation pulse generator, wound form location anchor and two polarity Wound form electrode forms, and wound form positions during use anchor and two wound form electrodes are wrapped on target vagus nerve, is wound around Formula location anchor is for two the wound form electrodes in location, and electric stimulation pulse generator is used for exporting electrical stimulation signal and controls two and twine Wound electrode works, thus realizes stimulation vagal to target.
Existing implanted vns device all only has two wound form electrodes, can only be to one side in the same time Vagus nerve stimulates, and its field stimulation is narrower, and effect of stimulation is the most poor, and existing implanted vns device Use open stimulus modelity, not for the monitoring of vital sign parameter, there is potential stimulation risk, thus give By nerve electric stimulation, person brings potential safety hazard.Potential safety hazard, existing implanted fan is there is just because of open stimulus modelity When walking nerve stimulation device use, within the same time, all only unilateral vagus nerve is carried out nerve electric stimulation, the most only It is equipped with two wound form electrodes.
Further, in existing implanted vns device, wound form location anchor and two wound form electrodes be according to The sequencing arrangement of operation technique, i.e. two wound form electrodes are all laid in the same side of wound form location anchor, in operation During operation, doctor positions anchor, proximal wind formula electrode (i.e. proximal wind formula electricity close to the anchor of wound form location according to wound form Pole), wound form positions the order of far-end wound form electrode anchor and two wound form electrodes are sequentially wrapped in target vagus nerve On, but when being wound around proximal wind formula electrode, far-end wound form electrode is also in free state, and due to far-end wound form Farther out, travelling amplitude also can be relatively large for electrode distance wound form location anchor, easily interference doctor operation, thus adds doctor Operation easier.
Summary of the invention
For defect present in above-mentioned prior art, the technical problem to be solved is to provide and a kind of stimulates effect The best, safety is high, and the implanted vagus nerve dual pathways stimulating apparatus that operation easier is low.
In order to solve above-mentioned technical problem, a kind of implanted vagus nerve dual pathways stimulating apparatus provided by the present invention, Including implanting unit, electric stimulation pulse generator, it is characterised in that: this device also includes for detecting the heart rate of human body, breathing The sign detection module of the sign situation such as frequency, blood oxygen saturation；Described sign detection module is with radio communication or wire communication Mode connects electric stimulation pulse generator；
Described implantation unit includes wound form location anchor, flexible electrode big envelope, and the wound form electrode that two polarity is different, its In wound form location anchor be fixed on electrode big envelope by the cross structure of a flexibility, two wound form electrodes are placed in wound form The both sides of location anchor, the electrical lead wire of two wound form electrodes is each passed through electrode big envelope affixed with electrode big envelope；
Described implantation unit has two, and one of them implants unit is the first implantation unit, and another implants unit is second Implant unit；
Described electric stimulation pulse generator is provided with for exporting the first boost pulse output port of electric stimulation pulse, the second stimulation Pulse output end mouth, the first electrical lead wire implanting two wound form electrodes in unit receives the of electric stimulation pulse generator One boost pulse output port, the second electrical lead wire implanting two wound form electrodes in unit is received electric stimulation pulse and is occurred Second boost pulse output port of device.
Further, also include for electric stimulation pulse generator input control signal manually stimulate control module, Control module is manually stimulated to connect electric stimulation pulse generator with radio communication or wire communication mode.
Further, described wound form electrode is by spiral base load circle, and the electrode strip composition being fixed on base load circle, Base load circle has elasticity and flexibility, and the two ends of base load circle are all fixed with the boost line of flexibility.
Further, described wound form location anchor is the spiral type anchor with elasticity and flexibility, the two of wound form location anchor End is all fixed with the boost line of flexibility.
The implanted vagus nerve dual pathways stimulating apparatus that the present invention provides, uses closed type stimulus modelity, is implementing electricity In stimulating course, it is possible to use sign detection module detects human body physical sign situation in real time, thus reduces stimulation risk, has peace The feature of Quan Xinggao, the most therefore can utilize two to implant unit and both sides vagus nerve be implemented electricity irritation simultaneously, improve thorn Swashing effect, and implanting in unit, two wound form electrodes are placed in the both sides of wound form location anchor, two wound form electrodes With distance all relative close of wound form location anchor, travelling amplitude is the most relatively small, and the impact on doctor's operation is the least, thus Reduce the operation easier of doctor.
Accompanying drawing explanation
Fig. 1 is the structural representation of the implanted vagus nerve dual pathways stimulating apparatus of the embodiment of the present invention.
Detailed description of the invention
Illustrate embodiments of the invention are described in further detail below in conjunction with accompanying drawing, but the present embodiment is not used to limit The present invention processed, the analog structure of every employing present invention and similar change thereof, protection scope of the present invention, the present invention all should be listed in In pause mark all represent the relation of sum.
As it is shown in figure 1, a kind of implanted vagus nerve dual pathways stimulating apparatus that the embodiment of the present invention is provided, including planting Enter unit, electric stimulation pulse generator U1, it is characterised in that: this device also include for detect the heart rate of human body, respiratory frequency, The sign detection module U2 of the sign situations such as blood oxygen saturation；Described sign detection module U2 is with radio communication or wire communication side Formula connects electric stimulation pulse generator U1；
Described implantation unit includes wound form location anchor M1, flexible electrode big envelope T1, and the wound form electricity that two polarity is different Pole J1, J2, wound form therein location anchor M1 is fixed on electrode big envelope T1 by the cross structure B1 of a flexibility, two wound forms Electrode J1, J2 be placed in wound form location anchor M1 both sides, the electrical lead wire of two wound forms electrode J1, J2 is each passed through electrode Big envelope T1 is the most affixed with electrode big envelope；
Described implantation unit has two, and one of them implants unit is the first implantation unit, and another implants unit is second Implant unit；
Described electric stimulation pulse generator U1 is provided with for exporting the first boost pulse output port of electric stimulation pulse, the second thorn Swashing pulse output end mouth, the first electrical lead wire implanting two wound forms electrode J1, J2 in unit is received electric stimulation pulse and is sent out The first boost pulse output port of raw device U1, the second electrical lead wire implanting two wound forms electrode J1, J2 in unit connects The second boost pulse output port to electric stimulation pulse generator U1.
The embodiment of the present invention also include for electric stimulation pulse generator U1 input control signal manually stimulate control Module U3, manually stimulates control module U3 to connect electric stimulation pulse generator U1 with radio communication or wire communication mode.
In the embodiment of the present invention, described wound form electrode is by spiral base load circle, and is fixed on the electrode on base load circle Bar forms, and base load circle has elasticity and flexibility, and the spiral internal diameter of base load circle is 1.5～1.8mm, and the coil number of base load circle is 2.5 Individual circumference, the length of run of base load circle is 18～25mm, and the two ends of base load circle are all fixed with the boost line of flexibility, and boost line is can Implant surgery silk thread, the line length of boost line is 8～10mm, can help to winding operation in operation；Electrode strip is width 1mm's Metal silver strip, the outer surface platinum plating of electrode strip, electrode strip is embedded in the middle part of the medial surface of base load circle in the partly mode of burying.
In the embodiment of the present invention, described wound form location anchor is the spiral type anchor with elasticity and flexibility, and wound form positions The spiral internal diameter of anchor is 1.5～1.8mm, and the coil number of wound form location anchor is 3 circumference, the length of run of wound form location anchor Being 24～30mm, the two ends of wound form location anchor are all fixed with the boost line of flexibility, and boost line is implantable operation silk thread, auxiliary The line length of index contour is 8～10mm, can help to winding operation in operation.
In the embodiment of the present invention, the external diameter of described electrode big envelope is 2.7～3mm, a length of the 5 of cross structure～7mm, connects The width of bridge is 2.9～3.1mm, and the electrical lead wire of wound form electrode can be played a protective role by electrode big envelope, and electrode Big envelope is connected by cross structure with wound form location anchor, positions coordinating of anchor by electrode big envelope with wound form, can be to winding Formula electrode plays positioning action.
In the embodiment of the present invention, described electric stimulation pulse generator, sign detection module, manually stimulation control module are Prior art.
The stimulating method of the implanted vagus nerve dual pathways stimulating apparatus that the embodiment of the present invention is provided is as follows:
Two wound forms implanted in unit position anchor, wound form electrode implantation within a patient respectively, and each implantation unit exists When implanting wound form location anchor, wound form electrode, first wound form is positioned anchor and is wrapped on target vagus nerve, the most again by two Individual wound form electrode is successively wrapped on target vagus nerve, and electric stimulation pulse generator is detected in real time by sign detection module The sign situation of patient；
If the sign condition monitor data that electric stimulation pulse generator receives is in safety range set in advance, electricity irritation arteries and veins Rush generator and i.e. control rule output electric stimulation pulse according to set in advance stimulation so that two wound forms implanted in unit Electrode carries out electricity irritation according to corresponding stimulation rules to the target vagus nerve of patient；
If the sign condition monitor data that electric stimulation pulse generator receives exceeds in safety range set in advance, electricity irritation Pulse generator, i.e. according to security control set in advance rule, stops output side or bilateral electric stimulation pulse or to electricity irritation The stimulus parameter of pulse is adjusted, and the stimulus parameter of electric stimulation pulse includes electricity irritation pulsewidth, electricity irritation duration, electricity irritation frequency The exchange of rate, electricity irritation single-phase two-phase, stimulating current intensity etc.；
Doctor can manually stimulate control module to input corresponding manual control signal to electric stimulation pulse generator, thus Implement electric stimulation pulse generator manually to intervene.

Claims (4)

1. an implanted vagus nerve dual pathways stimulating apparatus, including implanting unit, electric stimulation pulse generator, its feature exists In: this device also includes the sign detection mould for detecting the sign situations such as the heart rate of human body, respiratory frequency, blood oxygen saturation Block；Described sign detection module connects electric stimulation pulse generator with radio communication or wire communication mode；
Described implantation unit includes wound form location anchor, flexible electrode big envelope, and the wound form electrode that two polarity is different, its In wound form location anchor be fixed on electrode big envelope by the cross structure of a flexibility, two wound form electrodes are placed in wound form The both sides of location anchor, the electrical lead wire of two wound form electrodes is each passed through electrode big envelope affixed with electrode big envelope；
Described implantation unit has two, and one of them implants unit is the first implantation unit, and another implants unit is second Implant unit；
Described electric stimulation pulse generator is provided with for exporting the first boost pulse output port of electric stimulation pulse, the second stimulation Pulse output end mouth, the first electrical lead wire implanting two wound form electrodes in unit receives the of electric stimulation pulse generator One boost pulse output port, the second electrical lead wire implanting two wound form electrodes in unit is received electric stimulation pulse and is occurred Second boost pulse output port of device.
Implanted vagus nerve dual pathways stimulating apparatus the most according to claim 1, it is characterised in that: also include for Electric stimulation pulse generator input control signal manually stimulate control module, manually stimulate control module with radio communication or to have Line communication mode connects electric stimulation pulse generator.
Implanted vagus nerve dual pathways stimulating apparatus the most according to claim 1, it is characterised in that: described wound form electricity Pole is by spiral base load circle, and the electrode strip composition being fixed on base load circle, and base load circle has elasticity and flexibility, base load circle Two ends are all fixed with the boost line of flexibility.
Implanted vagus nerve dual pathways stimulating apparatus the most according to claim 1, it is characterised in that: described wound form is fixed Position anchor is the spiral type anchor with elasticity and flexibility, and the two ends of wound form location anchor are all fixed with the boost line of flexibility.
CN201610406252.3A 2016-06-12 2016-06-12 Implanted vagus nerve dual pathways stimulating apparatus Pending CN106075724A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201610406252.3A CN106075724A (en) 2016-06-12 2016-06-12 Implanted vagus nerve dual pathways stimulating apparatus
PCT/CN2017/000380 WO2017215256A1 (en) 2016-06-12 2017-06-06 Implantable double-channel vagus nerve stimulation device

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Application Number Priority Date Filing Date Title
CN201610406252.3A CN106075724A (en) 2016-06-12 2016-06-12 Implanted vagus nerve dual pathways stimulating apparatus

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017215256A1 (en) * 2016-06-12 2017-12-21 上海市儿童医院 Implantable double-channel vagus nerve stimulation device
CN113713259A (en) * 2021-11-02 2021-11-30 上海神奕医疗科技有限公司 Implanted electrode and implanted electrical stimulation system
CN114177517A (en) * 2022-02-15 2022-03-15 杭州神络医疗科技有限公司 Nerve stimulation electrode and nerve stimulation device
CN114522072A (en) * 2022-01-27 2022-05-24 南京鼓楼医院 Peak locking pulse interaction vagus nerve stimulation device for arrhythmia patients

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111939482B (en) * 2020-08-10 2022-02-25 中国科学院上海微系统与信息技术研究所 Optical device of flexible implanted nerve photoelectric electrode and design and preparation method thereof

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CN101107040A (en) * 2005-01-26 2008-01-16 策尔伯米德有限公司 Device for the transdermal stimulation of a nerve of the human body
CN101648053A (en) * 2009-09-03 2010-02-17 清华大学 Double-channel embedded nerve stimulator
CN201871123U (en) * 2010-10-25 2011-06-22 鼎迈医疗科技(苏州)有限公司 Two-channel pulse generator and implantable electrical stimulation system
CN204106842U (en) * 2014-08-29 2015-01-21 常州瑞神安医疗器械有限公司 Vagus nerve stimulator electrode cable end construction
CN206007802U (en) * 2016-06-12 2017-03-15 肖波 Implanted vagus nerve dual pathways stimulating apparatus

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CN102457252B (en) * 2010-10-25 2015-01-21 苏州景昱医疗器械有限公司 Dual channel pulse generator and implantable electrical stimulation system
CN106075724A (en) * 2016-06-12 2016-11-09 肖波 Implanted vagus nerve dual pathways stimulating apparatus

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1583191A (en) * 2004-06-11 2005-02-23 文贵华 Biological affinitic electrode stimulating device
CN101107040A (en) * 2005-01-26 2008-01-16 策尔伯米德有限公司 Device for the transdermal stimulation of a nerve of the human body
CN101648053A (en) * 2009-09-03 2010-02-17 清华大学 Double-channel embedded nerve stimulator
CN201871123U (en) * 2010-10-25 2011-06-22 鼎迈医疗科技(苏州)有限公司 Two-channel pulse generator and implantable electrical stimulation system
CN204106842U (en) * 2014-08-29 2015-01-21 常州瑞神安医疗器械有限公司 Vagus nerve stimulator electrode cable end construction
CN206007802U (en) * 2016-06-12 2017-03-15 肖波 Implanted vagus nerve dual pathways stimulating apparatus

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017215256A1 (en) * 2016-06-12 2017-12-21 上海市儿童医院 Implantable double-channel vagus nerve stimulation device
CN113713259A (en) * 2021-11-02 2021-11-30 上海神奕医疗科技有限公司 Implanted electrode and implanted electrical stimulation system
CN114522072A (en) * 2022-01-27 2022-05-24 南京鼓楼医院 Peak locking pulse interaction vagus nerve stimulation device for arrhythmia patients
CN114177517A (en) * 2022-02-15 2022-03-15 杭州神络医疗科技有限公司 Nerve stimulation electrode and nerve stimulation device

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