CN106075303A - A kind of Chinese medicine treating the postoperative emboli syndrome of hepatocarcinoma TACE - Google Patents

Abstract

The invention belongs to pharmaceutical technology field, be specifically related to a kind of Chinese medicine treating the postoperative emboli syndrome of hepatocarcinoma TACE.This Chinese medicine is made up of the raw material of Chinese medicine medicine of following weight portion: 48 parts of Radix Glycyrrhizae, the Rhizoma Pinelliae 5 13 parts, 5 13 parts of Poria, 5 13 parts of Semen Armeniacae Amarum, Radix Paeoniae Rubra 48 parts, Pericarpium Citri Reticulatae 48 parts, Fructus Schisandrae Chinensis 48 parts, Bulbus Fritillariae Thunbergii 48 parts, Radix Curcumae 8 16 parts, Rhizoma Corydalis 8 16 parts, Herba Scutellariae Barbatae 8 16 parts, Herba Hedyotidis Diffusae 8 16 parts, Fructus Amomi 5 13 parts, Radix Salviae Miltiorrhizae 11 19 parts, peninjau gardenia 26 parts.All medicines and conjunction, play invigorating the spleen and relieving depression of liver-QI, clear fall lung stomach, upper and lower, the merit of blood circulation promoting and blood stasis dispelling, dispelling phlegm and alleviating pain that is in harmonious proportion altogether.The postoperative emboli syndrome of Hepatic cancer can be improved.

Description

A kind of Chinese medicine treating the postoperative emboli syndrome of hepatocarcinoma TACE

Technical field

The invention belongs to pharmaceutical technology field, be specifically related to a kind of Chinese medicine treating the postoperative emboli syndrome of hepatocarcinoma TACE.

Background technology

China is the country that whole world onset of liver cancer rate is the highest and death toll is most, during most of patients finds during hepatocarcinoma to be In late period, be the first-selected treatment of current late primary liver cancer patient's non-operative treatment through conduit hepatic intraarterial chemotherapy Embolization (TACE) Method, but the postoperative thromboembolism Post-operative syndrome having 93.4% patient's generation in various degree of TACE, show as heating, hepatalgia, vomit Tell, the symptom such as gastrointestinal reaction.Western medicine gives symptomatic treatment, and several drugs is used simultaneously, and symptom is difficult to full relief sometimes, no Only affect the quality of life of patient, also have influence on next step TACE.

Summary of the invention

In order to solve above-mentioned technical problem, the invention provides a kind for the treatment of in the postoperative emboli syndrome of hepatocarcinoma TACE Medicine.

The present invention is to be realized by following technical scheme:

A kind of Chinese medicine treating the postoperative emboli syndrome of hepatocarcinoma TACE, is made up of the raw material of Chinese medicine medicine of following weight portion:

Radix Glycyrrhizae 4-8 part, Rhizoma Pinelliae 5-13 part, Poria 5-13 part, Semen Armeniacae Amarum 5-13 part, Radix Paeoniae Rubra 4-8 part, Pericarpium Citri Reticulatae 4-8 part, Fructus Schisandrae Chinensis 4-8 Part, Bulbus Fritillariae Thunbergii 4-8 part, Radix Curcumae 8-16 part, Rhizoma Corydalis 8-16 part, Herba Scutellariae Barbatae 8-16 part, Herba Hedyotidis Diffusae 8-16 part, Fructus Amomi 5-13 Part, Radix Salviae Miltiorrhizae 11-19 part, peninjau gardenia 2-6 part.

Preferably, the Chinese medicine of the above-mentioned postoperative emboli syndrome for the treatment of hepatocarcinoma TACE, by the raw material of Chinese medicine of following weight portion Medicine forms:

Radix Glycyrrhizae 5-7 part, Rhizoma Pinelliae 7-11 part, Poria 7-11 part, Semen Armeniacae Amarum 7-11 part, Radix Paeoniae Rubra 5-7 part, Pericarpium Citri Reticulatae 5-7 part, Fructus Schisandrae Chinensis 5-7 Part, Bulbus Fritillariae Thunbergii 5-7 part, Radix Curcumae 10-14 part, Rhizoma Corydalis 10-14 part, Herba Scutellariae Barbatae 10-14 part, Herba Hedyotidis Diffusae 10-14 part, Fructus Amomi 7-11 part, Radix Salviae Miltiorrhizae 13-17 part, peninjau gardenia 3-5 part.

It is furthermore preferred that the Chinese medicine of the above-mentioned postoperative emboli syndrome for the treatment of hepatocarcinoma TACE, the Chinese medicine by following weight portion is former Material medicine composition:

6 parts of Radix Glycyrrhizae, the Rhizoma Pinelliae 9 parts, 9 parts of Poria, 9 parts of Semen Armeniacae Amarum, Radix Paeoniae Rubra 6 parts, Pericarpium Citri Reticulatae 6 parts, Fructus Schisandrae Chinensis 6 parts, Bulbus Fritillariae Thunbergii 6 parts, Radix Curcumae 12 parts, Rhizoma Corydalis 12 parts, Herba Scutellariae Barbatae 12 parts, Herba Hedyotidis Diffusae l2 part, Fructus Amomi 9 parts, Radix Salviae Miltiorrhizae 15 parts, peninjau gardenia 4 parts.

In Basic Theories of Chinese Medicine, liver controlling conveyance and dispersion, liver and peripheral region thereof are caused pathology row to damage, more affect by TACE operation The function of liver controlling conveyance and dispersion.Thus the syndromes such as heating, nausea and vomiting, hepatalgia, abdominal distention, appetite difference occur.The present invention's Treatment the postoperative emboli syndrome of hepatocarcinoma TACE Chinese medicine in, Radix Glycyrrhizae and in, control at taste, help it to lift.Rhizoma Pinelliae regulating the stomach and sending down the abnormal ascending QI, controls Help it to drop at stomach.Poria spleen invigorating eliminating dampness by diuresis, Fructus Amomi removing dampness is amusing, and controls and helps at spleen it to rise.Four tastes and conjunction and nurse one's health the taste day after tomorrow, Help its source of generating QI and blood, evil with Fuzheng Yiliu.Pericarpium Citri Reticulatae, Semen Armeniacae Amarum, Bulbus Fritillariae Thunbergii, enter edema caused by disorder of QI, and lung heat clearing is regulated the flow of vital energy, eliminating phlegm and lowering adverse QI.Radix Paeoniae Rubra, five Taste, Radix Curcumae, Rhizoma Corydalis, enter Liver Channel blood system, removing heat from the liver, and soothing the liver liter falls into, and holds concurrently with flat gallbladder.Herba Scutellariae Barbatae enters lung, liver, kidney channel, heat clearing away Removing toxic substances, blood stasis dispelling diuresis, Herba Hedyotidis Diffusae heat-clearing and toxic substances removing.Herba Hedyotidis Diffusae is sweet, light, cool, enters stomach, large intestine, small intestine meridian, heat clearing away solution Poison, inducing diuresis to remove edema, promoting blood circulation and stopping pain.Radix Salviae Miltiorrhizae GUIXIN, Liver Channel, stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness；GUIXIN, lung, tri-jiao channel. Peninjau gardenia GUIXIN, lung, tri-jiao channel, pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Why parching to brown, is to strengthen its burnt bitter in taste acting on the heart Effect, lets out effect of heart-fire.Because of emboli syndrome simulataneous insufficiency and excessive after TACE surgery, stagnation of QI-blood, for its domination of pathogen part, need Its son is rushed down dirty by mother child relation, the raw heart-fire of edema with the liver involved, liver is female, and the heart is son, and liver has excess-fire, not only wants eliminating pathogen in the liver, eliminating heart-fire of also should holding concurrently, Then liver-fire is easily clear, therefore takes peninjau gardenia and comes down in torrents heart-fire with thorough removing heat from the liver.All medicines and conjunction, play invigorating the spleen and relieving depression of liver-QI, clear fall lung stomach, tune altogether With upper and lower, blood circulation promoting and blood stasis dispelling, the merit of dispelling phlegm and alleviating pain, making stomach fall and kind receive, spleen rises and kind mill, and liver rises and blood is the most strongly fragrant, and lung fall and gas are not Stagnant, heart kidney therefore hands over Thailand's (regulation between water and fire), the mechanism of qi of all internal organs disorders, thus its lifting multiple is often, and disease can be to the most also.

Clinical test results shows, the Chinese medicine of the postoperative emboli syndrome for the treatment of hepatocarcinoma TACE of the present invention, the abdomen for the treatment of group Bitterly, generate heat, vomit the persistent period and be all shorter than matched group (P ＜ 0.05), the quality of life improvement coefficient of stabilization relatively matched group for the treatment of group Significantly improve (P ＜ 0.01), postoperative 7th day glutamate pyruvate transaminase (ALT) for the treatment of group, glutamic oxaloacetic transaminase, GOT (AST) and total bilirubin (TBIL) within more postoperative 2nd day, significantly improving (P ＜ 0.01), ALT, AST improve curative effect and are better than matched group (P ＜ 0.05).Invention The Chinese medicine of the postoperative emboli syndrome for the treatment of hepatocarcinoma TACE can improve the postoperative emboli syndrome of Hepatic cancer.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about The present invention, but and it is not so limited the present invention.

Embodiment 1

A kind of Chinese medicine treating the postoperative emboli syndrome of hepatocarcinoma TACE, is made up of following raw material of Chinese medicine medicine:

6 parts of Radix Glycyrrhizae, the Rhizoma Pinelliae 9 parts, 9 parts of Poria, 9 parts of Semen Armeniacae Amarum, Radix Paeoniae Rubra 6 parts, Pericarpium Citri Reticulatae 6 parts, Fructus Schisandrae Chinensis 6 parts, Bulbus Fritillariae Thunbergii 6 parts, Radix Curcumae 12 parts, Rhizoma Corydalis 12 parts, Herba Scutellariae Barbatae 12 parts, Herba Hedyotidis Diffusae l2 part, Fructus Amomi 9 parts, Radix Salviae Miltiorrhizae 15 parts, peninjau gardenia 4 parts.

Embodiment 2

A kind of Chinese medicine treating the postoperative emboli syndrome of hepatocarcinoma TACE, is made up of following raw material of Chinese medicine medicine:

5 parts of Radix Glycyrrhizae, the Rhizoma Pinelliae 11 parts, 7 parts of Poria, 11 parts of Semen Armeniacae Amarum, Radix Paeoniae Rubra 5 parts, Pericarpium Citri Reticulatae 7 parts, Fructus Schisandrae Chinensis 5 parts, Bulbus Fritillariae Thunbergii 7 parts, strongly fragrant Gold 10 parts, Rhizoma Corydalis 14 parts, Herba Scutellariae Barbatae 10 parts, Herba Hedyotidis Diffusae 14 parts, Fructus Amomi 7 parts, Radix Salviae Miltiorrhizae 17 parts, peninjau gardenia 5 parts.

Embodiment 3

A kind of Chinese medicine treating the postoperative emboli syndrome of hepatocarcinoma TACE, is made up of following raw material of Chinese medicine medicine:

7 parts of Radix Glycyrrhizae, the Rhizoma Pinelliae 7 parts, 11 parts of Poria, 7 parts of Semen Armeniacae Amarum, Radix Paeoniae Rubra 7 parts, Pericarpium Citri Reticulatae 5 parts, Fructus Schisandrae Chinensis 7 parts, Bulbus Fritillariae Thunbergii 5 parts, Radix Curcumae 14 parts, Rhizoma Corydalis 10 parts, Herba Scutellariae Barbatae 14 parts, Herba Hedyotidis Diffusae 10 parts, Fructus Amomi 11 parts, Radix Salviae Miltiorrhizae 13 parts, peninjau gardenia 3 parts.

Embodiment 4

A kind of Chinese medicine treating the postoperative emboli syndrome of hepatocarcinoma TACE, is made up of following raw material of Chinese medicine medicine:

4 parts of Radix Glycyrrhizae, the Rhizoma Pinelliae 13 parts, 5 parts of Poria, 13 parts of Semen Armeniacae Amarum, Radix Paeoniae Rubra 4 parts, Pericarpium Citri Reticulatae 8 parts, Fructus Schisandrae Chinensis 4 parts, Bulbus Fritillariae Thunbergii 8 parts, strongly fragrant Gold 8 parts, Rhizoma Corydalis 16 parts, Herba Scutellariae Barbatae 8 parts, Herba Hedyotidis Diffusae 16 parts, Fructus Amomi 5 parts, Radix Salviae Miltiorrhizae 19 parts, peninjau gardenia 6 parts.

Embodiment 5

A kind of Chinese medicine treating the postoperative emboli syndrome of hepatocarcinoma TACE, is made up of following raw material of Chinese medicine medicine:

8 parts of Radix Glycyrrhizae, the Rhizoma Pinelliae 5 parts, 13 parts of Poria, 5 parts of Semen Armeniacae Amarum, Radix Paeoniae Rubra 8 parts, Pericarpium Citri Reticulatae 4 parts, Fructus Schisandrae Chinensis 8 parts, Bulbus Fritillariae Thunbergii 4 parts, Radix Curcumae 16 parts, Rhizoma Corydalis 8 parts, Herba Scutellariae Barbatae 16 parts, Herba Hedyotidis Diffusae 8 parts, Fructus Amomi 13 parts, Radix Salviae Miltiorrhizae 11 parts, peninjau gardenia 2 parts.

The Chinese medicine of the embodiment of the present invention 1 has been carried out clinical pharrnacokinetics test, and concrete condition is as follows:

1 data and method

1.1 physical data

Select Patients with Primary 160 example, be primary hepatocarcinoma (HCC) patient without operative treatment indication, age 29-85 Year, the median age 62 years old, wherein treatment group and each 80 examples of matched group.Treatment group female 15 example, male 45 examples；Matched group female 20 example, man 40 examples, two groups of Ka Shi mark all more than 60 points, and Child-Pugh classification is in A level or B level.Two groups of patients the age, sex, Child-Pugh classification, Ka Shi scoring aspect comparing difference not statistically significant (P > 0.05), have comparability.

1.2 diagnosis and exclusion standards

Meet clinical diagnosis and the staging scale of hepatocarcinoma Professional Committee of Chinese Anti-Cancer Association primary hepatocarcinoma；Meet the suitable of TACE Should demonstrate,prove；Anticipated life cycle >=3 month；Patient's muscle power situation is fair, and Karnofsky marks >=60 points.Exclusion standard: have TACE to prohibit Avoid card；Research process merges and uses other Chinese medicines, affect observation index and judge；Through informed consent not by regulation medication, or The congruent judgement person that affects the treatment of data.

1.3 method

1.3.1 TACE method patient lies supine DSA bed, selects right common femoral artery after bilateral inguinal district routine disinfection, drape, local anaesthesia Puncture approach, inserts 5F-catheter sheath after puncturing successfully, select 5F-RH conduit selectivity to be inserted to coeliac trunk, common hepatic artery radiography. Observe tumor feeding situation.Microtubular super-selective is inserted to blood supply of tumor, radiography display tumor staining sign.Clearly lead Behind pipe position, with iodized oil (LP) 10mL, add lobaplatin 50mg, Perarubicin (THP) 30mg, add polidocanol 5mL and blend together emulsifying agent, Take 10mL emulsifying agent row chemoembolization, give appropriate PVA particulate embolization, parallel postoperative radiography.Art finishes tube drawing, at right femoral artery puncture Sterilizing bandaging after hemostasis by compression.

1.3.2 the administrated method chemoembolization postoperative same day, two groups are all supplemented glucose and normal saline, the secondary class of cephalo Antibiotic prophylaxis infects and conventional liver protection treatment.The postoperative three degree of vomiter intramuscular injection metoclopramide 20mg of TACE, four degree of vomiters Intravenous injection ondansetron 8mg；Generate heat less than 39 DEG C persons, and ice compress is brought down a fever, more than 39 DEG C persons, and oral indomethacin 25mg, after 4h Body temperature fall person not yet, intramuscular injection compound aminophenazone 2mL or intravenous injection dexamethasone 5～10mg；Abdominal part moderate pain person Oral indomethacin 25mg, severe pain person applies dolantin pain relieving.Treatment group on the basis for the treatment of of control group, the postoperative 1st It adds with the Chinese medicine of the embodiment of the present invention 1, decocting extracting juice 150mL, 2 sub-services every day, is total to 7d the course for the treatment of.

1.4 observation item

Acute and the subacute reaction grade scale by WHO anticarcinogen, observes and records chemoembolization postoperative two groups of patients heating, liver District's pain, nausea and vomiting symptom variation.Judge its degree and duration.Liver function grade: glutamic oxaloacetic transaminase, GOT (AST), paddy third Transaminase (ALT), total bilirubin (TBil) utilize full automatic biochemical apparatus to detect in the 2nd day after surgery and the 7th day.

1.5 quality of life efficacy assessment standards

China has worked out a draft in nineteen ninety with reference to external index, according to appetite, spirit, sleep, tired, pain, family Front yard understand with coordinate, the understanding worked together with coordinate, self is to the understanding of cancer, the attitude to treating, daily life, the pair for the treatment of The scoring of the project such as effect, facial expression, quality of life full marks are 60 points, quality of life extreme difference be < 20 points, differ from for 20-30 Point, generally 31-40 divides, and preferably divides for 41-50, and good divides for 51-60.Improve after treatment: after treatment, scoring is than treatment Front increase >=10 point；Decline: after treatment, scoring reduces >=10 points than before treatment；Stable: scoring increase and decrease person within 10 points.Stable Rate=(raising number of cases+stablize number of cases)/total number of cases × 100%.

1.6 statistical method

Using statistic software SPSS 13.0 to process data, measurement data uses mean ± standard deviation (x ± s) to represent, group Between compare employing t inspection, enumeration data adopts and is expressed as a percentage, and between group, contrast uses chi-square criterion.System is had for difference with P < 0.05 Meaning learned by meter.

2 results

After 2.1 liang of group patient TACE, clinical symptoms and sign persistent period and quality of life compare

The stomachache for the treatment of group, generate heat, persistent period of vomitting all is shorter than matched group, two groups of statistically significant (P ＜ of comparing difference 0.05).Quality of life comparitive study after two groups of treatments, treatment group is respectively with matched group quality of life improvement coefficient of stabilization 93.75%, 56.25%, two groups of comparing differences statistically significant (P ＜ 0.01).It is shown in Table 1.

Before and after 2.2 liang of group treatments, liver function compares

Treatment group and postoperative 2nd day liver function comparing difference not statistically significant (P > 0.05) of matched group；Treatment group and matched group In each group, postoperative 7th day ALT, AST and TBIL value has height statistical significance (P ＜ with postoperative 2nd day comparing difference respectively 0.01)；Treatment group ALT, AST relatively matched group substantially reduces (P ＜ < 0.05).Two groups of total bilirubin comparing differences are anticipated without statistics Justice (P ＞ 0.05).It is shown in Table 2.

Claims (3)

1. treat a Chinese medicine for the postoperative emboli syndrome of hepatocarcinoma TACE, be made up of the raw material of Chinese medicine medicine of following weight portion:

Radix Glycyrrhizae 4-8 part, Rhizoma Pinelliae 5-13 part, Poria 5-13 part, Semen Armeniacae Amarum 5-13 part, Radix Paeoniae Rubra 4-8 part, Pericarpium Citri Reticulatae 4-8 part, Fructus Schisandrae Chinensis 4-8 Part, Bulbus Fritillariae Thunbergii 4-8 part, Radix Curcumae 8-16 part, Rhizoma Corydalis 8-16 part, Herba Scutellariae Barbatae 8-16 part, Herba Hedyotidis Diffusae 8-16 part, Fructus Amomi 5-13 Part, Radix Salviae Miltiorrhizae 11-19 part, peninjau gardenia 2-6 part.

The Chinese medicine of the postoperative emboli syndrome for the treatment of hepatocarcinoma TACE the most according to claim 1, it is characterised in that by weighing as follows The raw material of Chinese medicine medicine composition of amount part:

Radix Glycyrrhizae 5-7 part, Rhizoma Pinelliae 7-11 part, Poria 7-11 part, Semen Armeniacae Amarum 7-11 part, Radix Paeoniae Rubra 5-7 part, Pericarpium Citri Reticulatae 5-7 part, Fructus Schisandrae Chinensis 5-7 Part, Bulbus Fritillariae Thunbergii 5-7 part, Radix Curcumae 10-14 part, Rhizoma Corydalis 10-14 part, Herba Scutellariae Barbatae 10-14 part, Herba Hedyotidis Diffusae 10-14 part, Fructus Amomi 7-11 part, Radix Salviae Miltiorrhizae 13-17 part, peninjau gardenia 3-5 part.

The Chinese medicine of the postoperative emboli syndrome for the treatment of hepatocarcinoma TACE the most according to claim 2, it is characterised in that by weighing as follows The raw material of Chinese medicine medicine composition of amount part:

6 parts of Radix Glycyrrhizae, the Rhizoma Pinelliae 9 parts, 9 parts of Poria, 9 parts of Semen Armeniacae Amarum, Radix Paeoniae Rubra 6 parts, Pericarpium Citri Reticulatae 6 parts, Fructus Schisandrae Chinensis 6 parts, Bulbus Fritillariae Thunbergii 6 parts, Radix Curcumae 12 parts, Rhizoma Corydalis 12 parts, Herba Scutellariae Barbatae 12 parts, Herba Hedyotidis Diffusae l2 part, Fructus Amomi 9 parts, Radix Salviae Miltiorrhizae 15 parts, peninjau gardenia 4 parts.