CN106072628A - A kind of preparation method of the health food with antioxidation activity - Google Patents

A kind of preparation method of the health food with antioxidation activity Download PDF

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Publication number
CN106072628A
CN106072628A CN201610399807.6A CN201610399807A CN106072628A CN 106072628 A CN106072628 A CN 106072628A CN 201610399807 A CN201610399807 A CN 201610399807A CN 106072628 A CN106072628 A CN 106072628A
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CN
China
Prior art keywords
extract
asiatic plantain
panacis japonici
folium panacis
japonici cum
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CN201610399807.6A
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Chinese (zh)
Inventor
刘春明
张语迟
李赛男
唐英
李森林
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Changchun Normal University
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Changchun Normal University
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Priority to CN201610399807.6A priority Critical patent/CN106072628A/en
Publication of CN106072628A publication Critical patent/CN106072628A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/68—Plantaginaceae (Plantain Family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The preparation method of a kind of health food with antioxidation activity, belongs to field of health care food.It is an object of the invention to provide the preparation method of a kind of health food with antioxidation activity as primary raw material with folium panacis japonici cum caule and Asiatic plantain.The present invention pulverizes after processing Chinese medicine folium panacis japonici cum caule and Asiatic plantain, mixing loads capsule.Advantage of the present invention is embodied in: 1. raw materials used cheap and easy to get.2. folium panacis japonici cum caule and Asiatic plantain are the article in " can be used for the article list of health food ", and the antioxidant functional food of exploitation folium panacis japonici cum caule and Asiatic plantain has legitimacy.3., owing to being mainly composed of ginsenoside in folium panacis japonici cum caule, ginsenoside has antifatigue effect, and this health food proves also have antifatigue effect through zoopery, to the elderly's particularly matters.4. owing to Asiatic plantain has diuresis, and this health food has Herba Plantaginis extract, be likely to be of the latent effect of diuresis.

Description

A kind of preparation method of the health food with antioxidation activity
Technical field
The invention belongs to field of health care food.
Background technology
Chinese medicine Asiatic plantain be Araliaceae ginseng (Panax ginseng C. A. Mey) dry leaf.Autumn Gather, dry or dry.Chinese medicine Asiatic plantain has tonifying Qi, benefit lung, drives away summer heat, the function promoted the production of body fluid.Being usually used in qi-asthenia cough, hot summer weather is tired of Hot-tempered, Tianjin wound is thirsty, and the head is unclear, the tired weary grade disease of four limbs.Ginsenoside is the chemical composition that in Asiatic plantain, a class is important, and pharmacology is real Testing result to show, Asiatic plantain ethanol extract can significantly reduce MDA and Prot content, has certain increasing action to GSH content, but Without obvious significant difference, on T-SOD vigor without impact.Before Asiatic plantain is Plantaginaceae plant car (Plantago asiaticaL.) or ordinary building (Plantago depressaWilld.) drying or fresh herb.Its taste Sweet, cold in nature, there is heat-clearing, diuresis, eliminate the phlegm, cool blood, removing toxic substances etc. acts on.Being usually used in for oedema oliguria, heat drenches puckery pain, and summer-heat and damp is rushed down Dysentery, phlegm-heat cough, hematemesis and epistaxis, carbuncle sore tumefacting virus.Polyphenol is most important material in Asiatic plantain, and the pharmacological results shows, car Front grass ethanol extract is remarkably improved GSH and T-SOD content, has a certain effect for the reduction of MDA and Prot, but nothing Significant difference.Require in antioxidant functional food exploitation, it is desirable to LPO, protein carbonyl group, anti-oxidant Enzymatic activity, reductive glutathione are as evaluation index, and evaluating requirement is: given the test agent group compares with model control group, peroxide Change lipid and the content of protein carbonyl group reduces；The vigor of antioxidase and GSH raises.This four indices has three indexs in The positive then can be determined that health food has drug effect.
Owing to being used alone Asiatic plantain and part index number all can only be played beneficial effect by Asiatic plantain, and can not to three and Above inspection target plays beneficial effect, individually then can not reach to develop antioxidant functional food to Asiatic plantain and Asiatic plantain Require.And the two be used in combination the defect that can make up each other.Therefore, Asiatic plantain and Asiatic plantain are used in combination, can reach Exploitation requirement to antioxidant functional food.
In the exploitation of natural products antioxidant functional food, scholar is had to be studied.Wherein Wang Yulan is special in China Profit (application number: 201510367412.3) proposes Composition, develops antioxidant functional food.This health food is embodied in protection male sex prostatitis at oxidation resistant functionally emphasis Gland.Yan Guangli proposes with plant physalis pubescens as raw material in Chinese patent (application number: 201310424431.6), the extraction of preparation Thing can significantly reduce the content of MDA in rat blood serum (MDA), improves superoxide dismutase (SOD) and glutathione peroxide The activity of compound enzyme (GSH-Px).Bao Xiaping propose in the Chinese patent (application number: 201310420317.6) with astaxanthin and Grape pip is raw material, and health food is prepared in exploitation, every Ageing Index in can significantly improving animal body.Li Qing is special in China Proposing with lycopene, grape seed extract and vitamin E as raw material in profit (application number: 201310584032.6), exploitation is anti- Oxidation health food.Shang little Yu proposes with astaxanthin, Fructus Canrii Albi extract in Chinese patent (application number: 201010602921.7) Cherry powder is the antioxidant functional food that raw material preparation has prophylaxis of chronic.Song Yunfei Chinese patent (application number: 200410081447.2) propose with OPC, isoflavones, vitamin C and vitamin E as composition in, prepare antioxygen Change health food.
Content of the invention
It is an object of the invention to provide a kind of with Asiatic plantain and Asiatic plantain the guarantor with antioxidation activity as primary raw material The preparation method of health food.
Chinese medicine Asiatic plantain is pulverized by the present invention, puts in extractor, is 30 ~ 80% ethanol waters as carrying using volume ratio Take solution, folium panacis japonici cum caule's mass: extract liquor capacity=1:10 1:20；Extracting temperature is 110 oC ~ 200oC, each extraction time It is 20 ~ 60 minutes, extract and after terminating, take out extract, extract 2 ~ 4 times with method, merge extract, be evaporated to substance Long-pending 1/3 to 1/5；Extremely dry with spray drying or oven drying, prepare extract of Radix Ginseng leaf powder；Again by Chinese medicine folium panacis japonici cum caule's powder Broken, put in extractor, be that 30 ~ 80% ethanol waters are as extraction solution, Asiatic plantain quality: extract solution body using volume ratio Long-pending=1:10 1:20, Extracting temperature is 110 oC ~ 200oC, each extraction time is 20 ~ 60 minutes, extracts and takes out after terminating Extract, extracts 2 ~ 4 times with method, merges extract, is evaporated to the 1/3 to 1/5 of original volume；With spray drying or baking Case is dried, and prepares Herba Plantaginis extract powder；Taking Asiatic plantain and Plantain Herb respectively, the mass ratio of the two is 3:1 to 1:3, Load in hard shell capsules.
Advantage of the present invention is embodied in: 1. raw materials used cheap and easy to get.2. Asiatic plantain and Asiatic plantain are and " can be used for keeping healthy The article list of food " in article, exploitation Asiatic plantain and the antioxidant functional food of Asiatic plantain have legitimacy.3. due to car Being mainly composed of ginsenoside in front grass, ginsenoside has antifatigue effect, and this health food proves through zoopery Also there is antifatigue effect, to the elderly's particularly matters.4. owing to Asiatic plantain has diuresis, and this health food has There is Herba Plantaginis extract, be likely to be of the latent effect of diuresis.
Detailed description of the invention
Chinese medicine Asiatic plantain is pulverized by the present invention, puts in extractor, is 30 ~ 80% ethanol waters as carrying using volume ratio Take solution, folium panacis japonici cum caule's mass (g): extract liquor capacity (mL)=1:10 1:20.Extracting temperature is 110 oC ~ 200oC, every time Extraction time is 20 ~ 60 minutes, extracts and takes out extract after terminating, extract 2 ~ 4 times with method, merges extract, reduce pressure dense It is reduced to the 1/3 to 1/5 of original volume.Extremely dry with spray drying or oven drying, prepare extract of Radix Ginseng leaf powder.Again by Chinese medicine Asiatic plantain is pulverized, and puts in extractor, is 30 ~ 80% ethanol waters as extracting solution using volume ratio, Asiatic plantain quality (g): Extract liquor capacity (mL)=1:10 1:20.Extracting temperature is 110 oC ~ 200oC, each extraction time is 20 ~ 60 minutes, Extraction takes out extract after terminating, and extracts 2 ~ 4 times with method, merges extract, is evaporated to the 1/3 to 1/5 of original volume.With It is spray-dried or oven drying is to dry, prepare Herba Plantaginis extract powder.Take folium panacis japonici cum caule and Plantain Herb respectively, the two Mass ratio is 3:1 to 1:3, loads in hard shell capsules, is prepared as the health food with anti-oxidation function.
Anti-oxidant experiment: take 180 ICR male mices, after cleaning agent observation ward adapts to three days, is divided into 12 at random Group, often organizes 15, and first group is Vehicle controls group, second group be model control group, the 3rd group be Ascorbyl C pill group, the 4th, 5th, six groups are respectively Asiatic plantain high dose group 1g/kg, middle dosage group 0.5g/kg and low dose group 0.25g/kg, and the 7th, the 8th, nine Group is respectively Asiatic plantain high dose group 1g/kg, middle dosage group 0.5g/kg and low dose group 0.25g/kg, and the tenth, 11,12 Group is respectively Asiatic plantain and Asiatic plantain mixing group high dose group 1g/kg(Asiatic plantain and each 0.5g of Asiatic plantain), middle dosage group 0.5g/ Kg(Asiatic plantain and each 0.25g of Asiatic plantain) and low dose group 0.25g/kg(Asiatic plantain and each 0.125g of Asiatic plantain).Gastric infusion, Every day 1 time, successive administration 30 days, volume is 10 mL/kg, and Vehicle controls group gives 0.5 % CMCNa of same volume.End After secondary gavage, except Vehicle controls group does not processes, non-fasting frame venous blood sampling, remaining respectively organizes equal fasting 16 hours, then once Property gavage give 50% ethanol 12mL/kg BW, 6 hours after-frame venous blood samplings, 2% anticoagulant heparin, prepare blood plasma, survey fat in blood plasma Matter oxidation product MDA (MDA), protein carbonyl group (Prot), reductive glutathione (GSH) content and superoxide dismutase Enzyme (T-SOD) content.
Antifatigue is tested: take 60 ICR male mices, after cleaning agent observation ward adapts to three days, is divided into 4 groups at random, Often organize 15, if 3 dosage groups and 1 control group.With human body recommend dose the 20th, the 10th, 5 times (matched doses is respectively 1.0th, the 0.5th, 0.25 g/kg) it is bundled in mouse root of the tail as experiment with the sheet lead of own body weight 5%, put 25oC water went swimming, note Record mouse starts swimming to the death time.If dosage group mouse swimming time is considerably longer than control group, then it is believed that this sample can To strengthen mice burden swimming ability.
Beneficial effect: the invention provides the preparation method of a kind of health food with antioxidation activity, through filling, Obtain the hard capsule that content is powder Chinese medical extract.This extract proves through zoopery, can significantly improve Superoxide dismutase (T-SOD) and reductive glutathione (GSH) content, reduction animal in animal model blood and hepatic tissue In hepatic tissue, lipid oxidation products MDA (MDA) and protein carbonyl group (Prot) content, have interior antioxidation action, possess The exploitation of antioxidant functional food requires.Additionally, this health food has auxiliary antifatigue effect.
Table 1 be folium panacis japonici cum caule, Asiatic plantain and composition successive administration after 30 days in blood plasma Antioxidant Indexes affect result. Table 1 result shows, in model control group hepatic tissue, T-SOD vigor, GSH content substantially reduce, and Prot, MDA content significantly rises Height, shows oxidation of ethanol damage model modeling success.Folium panacis japonici cum caule's group can with the content of significantly raised GSH and T-SOD, to MDA and Prot has certain effect, but without statistical result.Asiatic plantain group can reduce MDA and Prot content, to GSH by necessarily Increasing action, but without obvious significant difference.And folium panacis japonici cum caule and Asiatic plantain mixing group can containing with significantly raised GSH and T-SOD Measure and reduce MDA and Prot content.
The impact on Antioxidant Indexes in blood plasma after 30 days of table 1 folium panacis japonici cum caule, Asiatic plantain and composition successive administration
Note: compare with Vehicle controls group: ▲ P < 0.05；▲▲P<0.01；▲▲▲P<0.001
Compare with model control group: * P < 0.05；**P<0.01；***P<0.001.
Table 2 is folium panacis japonici cum caule and Asiatic plantain and composition walking weight load result, and result shows, high dose and middle dosage The mice burden swimming time is had and significantly affects by this health food.Show that this health food has antifatigue effect.
Table 2 folium panacis japonici cum caule and Asiatic plantain and composition walking weight load result (± s, n=15)
Note: compare with Vehicle controls group, * P < 0.05, * * P < 0.01；；***P<0.001.
Embodiment 1
Chinese medicine folium panacis japonici cum caule is pulverized, puts in extractor, be that 40 % ethanol waters are as extraction solution, the ginseng food value of leaf using volume ratio Amount (g): extract liquor capacity (mL)=1:10.Extracting temperature is 110oC, each extraction time is 20 minutes, extracts and takes after terminating Go out extract, extract 2 times with method, merge extract, be evaporated to the 1/5 of original volume.With spray drying or oven drying To dry, prepare extract of Radix Ginseng leaf powder.Again Chinese medicine Asiatic plantain is pulverized, put in extractor, be that 30% ethanol is water-soluble with volume ratio Liquid is as extraction solution, Asiatic plantain quality (g): extract liquor capacity (mL)=1:10.Extracting temperature is 110 oC, when extracting every time Between be 20 minutes, extract terminate after take out extract, with method extract 2 times, merge extract, be evaporated to the 1/5 of original volume. Extremely dry with spray drying or oven drying, prepare Herba Plantaginis extract powder.Take folium panacis japonici cum caule and Plantain Herb respectively, the two Mass ratio be 3:1, load in hard shell capsules, be prepared as the health food with anti-oxidation function and auxiliary anti-fatigue effect.
Embodiment 2
Chinese medicine folium panacis japonici cum caule is pulverized, puts in extractor, be that 50% ethanol water is as extraction solution, the ginseng food value of leaf using volume ratio Amount (g): extract liquor capacity (mL)=1:15.Extracting temperature is 120 oC, each extraction time is 30 minutes, extracts and takes after terminating Go out extract, extract 3 times with method, merge extract, be evaporated to the 1/4 of original volume.With spray drying or oven drying To dry, prepare extract of Radix Ginseng leaf powder.Again Chinese medicine Asiatic plantain is pulverized, put in extractor, be that 50% ethanol is water-soluble with volume ratio Liquid is as extraction solution, Asiatic plantain quality (g): extract liquor capacity (mL)=1:15.Extracting temperature is 120 oC, when extracting every time Between be 30 minutes, extract terminate after take out extract, with method extract 3 times, merge extract, be evaporated to the 1/4 of original volume. With being spray-dried to dry, prepare Herba Plantaginis extract powder.Taking folium panacis japonici cum caule and Plantain Herb respectively, the mass ratio of the two is 1: 1, load in hard shell capsules, be prepared as the health food with anti-oxidation function and auxiliary anti-fatigue effect.
Embodiment 3
Chinese medicine folium panacis japonici cum caule is pulverized, puts in extractor, be that 60% ethanol water is as extraction solution, the ginseng food value of leaf using volume ratio Amount (g): extract liquor capacity (mL)=1:20.Extracting temperature is 140oC, each extraction time is 60 minutes, extracts after terminating Take out extract, extract 4 times with method, merge extract, be evaporated to the 1/3 of original volume.Done by spray drying or baking oven Dry to dry, prepare extract of Radix Ginseng leaf powder.Again Chinese medicine Asiatic plantain is pulverized, put in extractor, be 60% ethanol water with volume ratio Solution is as extraction solution, Asiatic plantain quality (g): extract liquor capacity (mL)=1:20.Extracting temperature is 140 oC, extract every time Time is 60 minutes, extracts and takes out extract after terminating, extract 4 times with method, merges extract, be evaporated to the 1/ of original volume 3.With being spray-dried to dry, prepare Herba Plantaginis extract powder.Taking folium panacis japonici cum caule and Plantain Herb respectively, the mass ratio of the two is 1:3, loads in hard shell capsules, is prepared as the health food with anti-oxidation function and auxiliary anti-fatigue effect.
Embodiment 4
Chinese medicine folium panacis japonici cum caule is pulverized, puts in extractor, be that 40% ethanol water is as extraction solution, the ginseng food value of leaf using volume ratio Amount (g): extract liquor capacity (mL)=1:10.Extracting temperature is 200oC, each extraction time is 20 minutes, extracts after terminating Take out extract, extract 2 times with method, merge extract, be evaporated to the 1/5 of original volume.Done by spray drying or baking oven Dry to dry, prepare extract of Radix Ginseng leaf powder.Again Chinese medicine Asiatic plantain is pulverized, put in extractor, be 60% ethanol water with volume ratio Solution is as extraction solution, Asiatic plantain quality (g): extract liquor capacity (mL)=1:20.Extracting temperature is 120 oC, extract every time Time is 60 minutes, extracts and takes out extract after terminating, extract 3 times with method, merges extract, be evaporated to the 1/ of original volume 4.With oven drying to dry, prepare Herba Plantaginis extract powder.Taking folium panacis japonici cum caule and Plantain Herb respectively, the mass ratio of the two is 1:1, loads in hard shell capsules, is prepared as the health food with anti-oxidation function and auxiliary anti-fatigue effect.

Claims (1)

1. the preparation method of a health food with antioxidation activity, it is characterised in that: Chinese medicine folium panacis japonici cum caule is pulverized, puts and carry Take in tank, be that 30 ~ 80% ethanol waters are as extraction solution, folium panacis japonici cum caule's mass: extract liquor capacity=1:10 using volume ratio 1:20；Extracting temperature is 110 oC ~ 200oC, each extraction time is 20 ~ 60 minutes, extracts and takes out extract after terminating, Extract 2 ~ 4 times with method, merge extract, be evaporated to the 1/3 to 1/5 of original volume；With spray drying or oven drying To dry, prepare extract of Radix Ginseng leaf powder；Again Chinese medicine Asiatic plantain is pulverized, put in extractor, be 30 ~ 80% second with volume ratio Alcohol solution is as extraction solution, Asiatic plantain quality: extracting liquor capacity=1:10 1:20, Extracting temperature is 110 oC ~ 200oC, each extraction time is 20 ~ 60 minutes, extracts and takes out extract after terminating, extract 2 ~ 4 times with method, merges and extract Liquid, is evaporated to the 1/3 to 1/5 of original volume；With spray drying or oven drying, prepare Herba Plantaginis extract powder；Point Not taking folium panacis japonici cum caule and Plantain Herb, the mass ratio of the two is 3:1 to 1:3, loads in hard shell capsules.
CN201610399807.6A 2016-06-08 2016-06-08 A kind of preparation method of the health food with antioxidation activity Pending CN106072628A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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CN1456092A (en) * 2002-05-06 2003-11-19 李永进 Chinese leaves concentrates
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CN103734427A (en) * 2013-12-31 2014-04-23 广州神农生物技术有限公司 Method of preparing plant bag beverage by taking natural raw materials as adsorptive carrier
CN105267268A (en) * 2014-07-03 2016-01-27 株式会社韩国化妆品制造 Ginseng leaf extractive manufacturing method and cosmetic composition comprising ginseng leaf extractive serving as effective ingredient
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