CN106063740A - A kind of brain temperature regulating device and temperature-controlled process - Google Patents
A kind of brain temperature regulating device and temperature-controlled process Download PDFInfo
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- CN106063740A CN106063740A CN201610236008.7A CN201610236008A CN106063740A CN 106063740 A CN106063740 A CN 106063740A CN 201610236008 A CN201610236008 A CN 201610236008A CN 106063740 A CN106063740 A CN 106063740A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0002—Head or parts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0054—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
- A61F2007/0056—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water for cooling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0093—Heating or cooling appliances for medical or therapeutic treatment of the human body programmed
Abstract
The invention discloses a kind of brain temperature regulating device and temperature-controlled process, its device includes casing, ice cap, refrigeration system and control system, described refrigeration system includes that cooling water tank, semiconductor chilling plate, fin, cooling water pump and effusion meter, described control system comprise single chip circuit, control panel and several temperature probes；The outfan of cooling water tank connects the input of ice cap by conduit, the input of cooling water tank connects the outfan of ice cap by conduit, cooling water pump and effusion meter are all connected on conduit, and the cold end of semiconductor chilling plate is close to cooling water tank, and hot junction is close to fin.Change cooling water temperature by adjusting the power that heats of semiconductor chilling plate, and then control patient's brain temperature.This programme is applicable to medical science cranium brain cooling field.
Description
Technical field
The present invention relates to patient temperature control field, especially relate to a kind of for patients head's fall
The brain temperature regulating device of temperature and temperature-controlled process.
Background technology
Semiconductor cooler is a kind of refrigerating plant utilizing peltier effect, because its miniaturization,
Noiseless, and need not use cold-producing medium and the feature of length in service life, at Space Experiments
Technology, medical skill, Aero-Space and biotechnology equitemperature control field obtain
It is widely applied.
Mild hypothermia therapy be a kind of with physical method by the hypothermia of patient to expection level
The method reaching to treat disease purpose.The application of clinical profound hypothermia treatment and study long-standing,
Low temperature is widely used in Cardiac Surgery and neurosurgery, and obtains good brain guarantor
Protect effect, but when body temperature is less than 28 DEG C, often induce arrhythmia, disturbances of blood coagulation etc. serious
Complication.Therefore from the eighties, profound hypothermia is seldom applied, the end of the eighties, and research is sent out
Existing brain temperature declines 2-3 DEG C of (Mild Hypothermal) effect the most protected to ischemic brain injury, and without deep
Various complication caused by low temperature, make low temperature therapy again arouse people's interest.In recent years,
Abroad take the lead in beginning to use Mild Hypothermal (30-35 DEG C) treatment cerebral ischemia, cerebral anoxia and cerebral hemorrhage
Patient, achieves the achievement in research attracted people's attention.
Now, market occurs in that the sub-low-temperature therapeutic equipment of some employing semiconductor refrigeratings,
But its cooling strategy predominantly carries out total body hypothermia by ice blanket, then by changing human body core
Heart temperature reduces the purpose of brain temperature, may cause multiple complications；The most also have and pass through ice
Cap carries out the cooling of selectivity cranium brain, but to there is volume and weight big for ice cap used by it, mobile and
Dress difficulty, it is difficult to carry out the distinct disadvantage such as accurate temperature control, be suitable only in ward etc. fixing
Place uses.
Summary of the invention
The temperature control precision that the present invention mainly solves existing for prior art is not high enough, easy
Cause that complication, ice cap volume are relatively big, dress difficulty, be difficult to accurate temperature control etc.
Technical problem, it is provided that one can with precise control of temperature, directly lower the temperature for cranium brain, ice cap body
Long-pending little, dress convenient, be difficult to cause the cranium mild hypothermia therapeutic instrument of complication and temperature controlling party
Method.
The present invention is directed to what above-mentioned technical problem was mainly addressed by following technical proposals:
A kind of brain temperature regulating device, including casing, ice cap, refrigeration system and control system, described system
Cooling system includes cooling water tank, semiconductor chilling plate, fin, cooling water pump and effusion meter,
Described control system comprises single chip circuit, control panel and several temperature probes；Cooling
The outfan of water tank connects the input of ice cap by conduit, and the input of cooling water tank is by leading
Pipe connects the outfan of ice cap, and cooling water pump and effusion meter are all connected on conduit, quasiconductor system
The cold end of cold is close to cooling water tank, and hot junction is close to fin, and a temperature probe is fixed
Inside cooling water tank, another cochlea type temperature probe inserts patient cochlea and represents patient's brain temperature,
Semiconductor chilling plate, temperature probe, cooling water pump and control panel are all electrically connected with single chip circuit
Connect；Cooling water tank and cooling water pump are arranged on box house, and control panel is arranged on casing appearance
Face.
Under the pumping of cooling water pump, in cooling water tank through semiconductor chilling plate cool down cold
But the cooled water pump of water constantly circulates to ice cap, the order then returning cooling water tank, will refrigeration
The cold of sheet is constantly delivered in ice cap；Meanwhile, the hot side of semiconductor chilling plate passes through fin
Distribute heat in external environment, it is achieved that the balance of refrigeration radiating, thus ensure that and partly lead
The normal work of body cooling piece.
As preferably, described cooling water tank is aluminum cooling water tank, the temperature within cooling water tank
Probe is for measuring the water temperature of cooling water, and the cold end of semiconductor chilling plate passes through heat-conducting silicone grease with cold
But water tank fits tightly, and the hot junction of semiconductor chilling plate is closely pasted with fin by heat-conducting silicone grease
Close heat radiation；Cooling water inputs from the bottom of cooling water tank, and top exports.
As preferably, described ice cap is by TPU (Thermoplastic polyurethanes, warm
Plastic polyurethane elastomer rubber) material makes, ice cap medial surface and patient's scalp and cervical region patch
Closing, ice cap both sides are fixed by velcro, and cooling water flows through the stream within ice cap and realizes fall
Temperature, ice cap is shaped as soil font.
Flowmeter survey flows into the cooling water flow of ice cap, when actual flow is higher than setting value,
Limit cooling water flow, keep flow to maintain near setting value.
As preferably, brain temperature regulating device also includes three-way valve, the wherein two-way of described three-way valve
Being connected in the input stream of ice cap cooling water, another road communicates with ice cap cooling water output stream,
Can control to flow into the cooling water flow of ice cap by regulating three-way valve thus regulate ice cap
Degrees of expansion, the biggest then cooling water that three-way valve is opened to the path of ice cap is the most, and ice cap expands journey
Spending the biggest, the space that ice cap is wrapped up is the least, is achieved in the tight patch to patients head
Close, and ice cap tension will not be made to affect patient safety.
The mode of operation of the cranium mild hypothermia therapeutic instrument of this programme is: set patient's brain temperature or cooling
Water temperature, cooling piece works, and this brain temperature or coolant water temperature setting value can be selected in future
Constant or slow rise/fall extremely a certain temperature is kept, by control system in 0-96 hour
Corresponding control output makes akrencephalon temperature or cooling water temperature reach design temperature.Can be by setting
Determine change curve, make akrencephalon temperature or cooling water temperature change according to change curve.
In this programme, control system includes single chip circuit and control panel, single chip circuit bag
Including Industry Control chip, and corresponding ADC, PWM output module, single chip circuit is by defeated
According to temperature-controlled process, the temperature signal, the design temperature that enter show that corresponding control signal exports,
Single chip circuit electrically connects with control panel and other devices.Control panel can show the coldest
But water temperature and patient's brain temperature.
As preferably, single chip circuit and control panel are arranged on the top of casing, cooling water tank,
Semiconductor chilling plate and cooling water pump are arranged on the bottom of casing, are provided with division board in the middle of casing.
A kind of brain temperature regulating device temperature-controlled process, based on fuzzy-adaptation PID control, including following
Step:
S11, setting expectation brain temperature or coolant water temperature, with the real-time brain temperature collected or cooling water
Temperature compares, and obtains actual error E and error rate Ec and inputs as fuzzy quantity；
S12, according to fuzzy reasoning table, obtain proportional control factor Kp, integral adjustment COEFFICIENT K i
With differential adjustment factor Kd, then use centroid method to carry out defuzzification process, obscured
Output signal u of PID controller；
S13, according to control signal u export corresponding pwm ripple, by change duty cycle adjustment
The refrigeration work consumption of cooling piece, it is achieved to brain temperature or the control of coolant water temperature.
A kind of brain temperature regulating device temperature-controlled process, based on fuzzy neural network, including following
Step:
S21, set the initial value of one group of fuzzy neural network controller FNNC, including Vague language
Speech variable number, each Fuzzy Linguistic Variable center b, scope m and the connection of neutral net
Weights ω；
S22, set desired brain temperature or coolant water temperature, with actually measured brain temperature or cooling water
Temperature comparison, obtains the rate of change Ec of error E and error, as Fuzzy Neural-network Control
The input of device FNNC；
S23, E and Ec according to input, the output of fuzzy neural network controller FNNC is corresponding
Semiconductor chilling plate control signal u；
S24, according to control signal u export corresponding pwm ripple, by change duty cycle adjustment
The refrigeration work consumption of cooling piece, it is achieved to brain temperature or the control of coolant water temperature；
S25, according to error E regulate fuzzy neural network controller FNNC parameters, until
Fuzzy neural network controller FNNC is mated with plant characteristic.
As preferably, control system carries out override control for cooling water pump, desired when setting
Brain temperature or coolant water temperature, when being less than 5 DEG C with actually measured brain temperature or coolant water temperature error, cold
But the 50%-80% of the power of water pump and the 0-100% of cooling piece refrigeration work consumption constitutes the most corresponding
Relation；When temperature difference is more than 6 DEG C, cooling water pump power keeps the state of 100%, cools down water
Pump and effusion meter form redundant flow and control, and strengthen the safety of system.
This programme uses fuzzy and fuzzy Neural Network Control Method, because the master of instrument
Wanting controlled variable temperature is the parameter that a dead time delay is bigger, and system also presents the most uncertain
Property and nonlinear characteristic.This kind of system be typically difficult to accurately to describe the transmission function of control object or
State equation, and the PID of routine controls to be difficult to obtain good control effect.It addition,
Though single fuzzy control need not accurate mathematical model, but easily near equilibrium point
Produce small amplitude oscillation, so that whole control system can not have good dynamic quality.And
Fuzzy and fuzzy neural network then can be good at overcoming problem above, obtain one good
Good control effect.
The substantial effect that the present invention brings is, accurately can control ice cap temperature by fast and stable,
Reduce ice cap volume, directly lower the temperature for cranium brain, be difficult to cause complication, it is possible to adapt to difference
Environment, refrigerating efficiency is high, good reliability, safety and save the energy.
Accompanying drawing explanation
Fig. 1 is a kind of structural representation of the present invention；
Fig. 2 is a kind of fuzzy control flow chart of the present invention；
Fig. 3 is a kind of structure of fuzzy neural network figure of the present invention；
Fig. 4 is a kind of fuzzy Neural Network Control System block chart of the present invention；
Fig. 5 is a kind of ice cap figure of the present invention；
In figure: 1: casing, 2: cooling water tank, 3: semiconductor chilling plate, 4: fin,
5: cooling water pump, 6: cooling water temperature is popped one's head in, 7: control panel and single chip circuit, 8:
Conduit, 9: three-way valve, 10: ice cap, 11: cochlea temperature probe, 12 effusion meters.
Detailed description of the invention
Below by embodiment, and combine accompanying drawing, technical scheme is made tool further
The explanation of body.
Embodiment: a kind of brain temperature regulating device of the present embodiment, as it is shown in figure 1, include casing
1, refrigeration system, control system, ice cap 10 and three-way valve 9, refrigeration system includes quasiconductor
Cooling piece 3, fin 4, cooling water tank 2, cooling water pump 5 and effusion meter 12, control system
System includes control panel and single chip circuit 7 and cooling water temperature probe 6, cochlea temperature probe
11, the outfan of cooling water tank connects the input of ice cap by conduit 8, cooling water tank defeated
Entering end and connected the outfan of ice cap by conduit, cooling water pump is connected on conduit, quasiconductor system
The cold end of cold is close to cooling water tank, and hot junction is close to fin, semiconductor chilling plate, temperature
Degree probe, cooling water pump and control panel all electrically connect with single chip circuit.Cooling water tank and cold
But water pump is arranged on box house, and control panel is arranged on box outer surface.
The huyashi-chuuka (cold chinese-style noodles) that produces of semiconductor chilling plate passes through one layer of heat-conducting silicone grease with high-termal conductivity and aluminum
Cooling water tank processed be in close contact, under the pumping of cooling water pump, through cooling piece cool down cold
But the order that the external ice cap of the cooled water pump of water then returns constantly circulates, cold by cooling piece
Amount is constantly delivered in ice cap, and meanwhile, the hot side of semiconductor chilling plate passes through fin by heat
It is dispersed in external environment, it is achieved that the balance of refrigeration radiating, thus ensure that semiconductor refrigerating
The normal work of sheet, cooling water inputs from the bottom of cooling water tank, and top exports.
Described ice cap is by TPU (Thermoplastic polyurethanes, thermoplastic polyurethane
Elastomer rubber) material makes, ice cap medial surface and patient's scalp and cervical region laminating, ice cap two
Side is fixed by velcro, and cooling water flows through the stream within ice cap and realizes cooling, ice cap shape
Shape is soil font, and ice cap wraps the head of patient.
Described flowmeter survey flows into the cooling water flow of ice cap, when actual flow is higher than a certain
During setting value, limit cooling water flow, keep flow to maintain near setting value.
Described control system carries out override control for cooling water pump, when setting desired brain temperature
Or coolant water temperature, when being less than 5 DEG C with actually measured brain temperature or coolant water temperature error, cool down water
Pump power is determined by controller one, the 50%-80% of its power and cooling piece refrigeration work consumption
0-100% constitutes linear corresponding relation；When temperature difference is more than 6 DEG C, cooling water pump power is by controlling
Device two processed determines, its power keeps the state of 100%, total power fast cooling, thus realizes
Balance between cooling water pump heat production and patient are freezed.Cooling water pump and effusion meter are formed superfluous
Remaining flow-control, strengthens the safety of system.
Described brain temperature regulating device also includes three-way valve, and the wherein two-way of described three-way valve is connected to
In the input stream of ice cap cooling water, another road communicates with ice cap cooling water output stream, permissible
Control to flow into the cooling water flow of ice cap by regulating three-way valve thus regulate the expansion of ice cap
Degree, the biggest then cooling water that three-way valve is opened to the path of ice cap is the most, and ice cap degrees of expansion is also
The biggest, the space that ice cap is wrapped up is the least, is achieved in fitting tightly patients head.
Described brain temperature regulating device, sets patient's brain temperature or coolant water temperature, and cooling piece works, and
And this brain temperature or coolant water temperature setting value can be selected to keep constant in following 0-96 hour
Or slowly rise/fall, to a certain temperature, is made by the corresponding control output of control system
Akrencephalon temperature or coolant water temperature reach design temperature.
Described brain temperature regulating device, control system and corresponding circuit part are arranged on device
Top, refrigeration system is arranged on the bottom of device, and both are mutually isolated.
A kind of brain temperature regulating device temperature-controlled process of the present embodiment, based on fuzzy-adaptation PID control,
Comprise the following steps:
S11, setting expectation brain temperature or coolant water temperature, with the real-time brain temperature collected or cooling water
Temperature compares, and obtains actual error E and error rate Ec and inputs as fuzzy quantity；
S12, according to fuzzy reasoning table, obtain proportional control factor Kp, integral adjustment COEFFICIENT K i
With differential adjustment factor Kd, then use centroid method to carry out defuzzification process, obscured
Output signal u of PID controller；
S13, according to control signal u export corresponding pwm ripple, by change duty cycle adjustment
The refrigeration work consumption of cooling piece, it is achieved to brain temperature or the control of coolant water temperature.
The computing formula of actual error E and error rate Ec is as follows:
E (k)=T (k)-Tc (k)
Ec (k)=E (k)-E (k-1) (1.1)；
Wherein: T (k) is the design temperature value in the k moment, Tc (k) is the reality gathered in the k moment
Shi Wendu.
Table 1 is fuzzy reasoning table, and in two wherein corresponding for E with Ec row, NB represents negative big,
NM represents negative medium, and NS represents negative little, and ZO represents zero, and PS represents the least, and PM represents
The most medium, PB represents honest；Output signal U part, PB represents honest, and PM is just representing
Medium, PS represents the least, and ZO represents zero, and NS represents negative little, and NM represents negative medium, NB
Represent negative big.
Table 1
In step S12, the basic domain of E and EC is [-6 ,+6], is separated into 13
Grade is i.e. [-6 ,-5 ,-4 ,-3 ,-2 ,-1,0 ,+1 ,+2 ,+3 ,+4 ,+5 ,+6]；Will [-6,
+ 6] be divided into negative big [NB], negative in [NM], negative little [NS], zero [ZO], the least [PS], center [PM]
With honest [PB] 7 linguistic variables, then drawn according to maximum value process by E and Ec membership function
Corresponding fuzzy variable；
As in figure 2 it is shown, select to set brain temperature or coolant water temperature, and when forebrain temperature or coolant water temperature
Difference E and the rate of change Ec of difference be input in fuzzy controller, according to set
Fuzzy rule output control signal controls semiconductor chilling plate and realizes coolant water temperature or patient
The control of brain temperature.
When setting desired brain temperature or coolant water temperature, miss with actually measured brain temperature or coolant water temperature
When difference is less than 5 DEG C, the 50%-80% of the power of cooling water pump and the 0-100% of cooling piece refrigeration work consumption
Constitute linear corresponding relation；When temperature difference is more than 6 DEG C, cooling water pump power keeps 100%
State, cooling water pump and effusion meter form redundant flow and control.
Embodiment 2: a kind of brain temperature regulating device of the present embodiment, structure is same as in Example 1.
A kind of brain temperature regulating device temperature-controlled process of the present embodiment, based on fuzzy neural network
Control, comprise the following steps:
S21, set the initial value of one group of fuzzy neural network controller FNNC, including Vague language
Speech variable number, each Fuzzy Linguistic Variable center b, scope m and the connection of neutral net
Weights ω；
S22, set desired brain temperature or coolant water temperature, with actually measured brain temperature or cooling water
Temperature comparison, obtains the rate of change Ec of error E and error, as Fuzzy Neural-network Control
The input of device FNNC；
S23, E and Ec according to input, the output of fuzzy neural network controller FNNC is corresponding
Semiconductor chilling plate control signal u；
S24, according to control signal u export corresponding pwm ripple, by change duty cycle adjustment
The refrigeration work consumption of cooling piece, it is achieved to brain temperature or the control of coolant water temperature；
S25, according to error E regulate fuzzy neural network controller FNNC parameters, until
Fuzzy neural network controller FNNC is mated with plant characteristic.
As it is shown on figure 3, fuzzy neural network is constituted by five layers, particularly as follows: ground floor input layer,
Play the effect of data transmission, input two variable x1 (corresponding error E), x2 (corresponding mistake
Difference rate of change Ec)；Second layer linguistic variable layer, is made up of several nodes, each node generation
One linguistic variable of table, belongs to each linguistic variable value fuzzy set for calculating each input component
Membership function μ, and have(i=2 herein, j are the nodes 5 set),
Wherein b is Blur center, and m is fuzzy ranges；Third layer fuzzy rule layer, each node
Represent a fuzzy rule, make expenditure for calculate every ruleThe
Four layers of normalization layer, it is achieved the normalization computing of variable, between data normalization to 0-1,
Obtain normalized valueLayer 5 output layer, neutral net link weight coefficients ω realizes sharpening
Computing, exports result y, the wherein number of Fuzzy Linguistic Variable, each Fuzzy Linguistic Variable
The connection weights ω of center b, scope m, and neutral net can be with arbitrary initial.
Being illustrated in figure 4 fuzzy Neural Network Control System block chart, wherein FNNC is one
Fuzzy neural network controller, according to setting value and the error E of output valve the change obtaining error
Rate Ec, is input in fuzzy neural network controller FNNC, defeated according to control signal u
Go out corresponding pwm ripple, by changing the refrigeration work consumption of duty cycle adjustment cooling piece, it is achieved to brain
Temperature or the control of water temperature, wherein setting value is reverse also by steepest descent method with the error of output valve
In transmission regulation fuzzy neural network controller, neutral net connects weights ω and blurred portions
Central value of parameter b, scope m, finally realize mating of control system and controlled device, strengthens
Control effect.
When setting desired brain temperature or coolant water temperature, miss with actually measured brain temperature or coolant water temperature
When difference is less than 5 DEG C, the 50%-80% of the power of cooling water pump and the 0-100% of cooling piece refrigeration work consumption
Constitute linear corresponding relation；When temperature difference is more than 6 DEG C, cooling water pump power keeps 100%
State, cooling water pump and effusion meter form redundant flow and control.
Specific embodiment described herein is only to present invention spirit explanation for example.This
The technical staff of technical field that the present invention belongs to described specific embodiment can be done various respectively
Amendment or supplementary or that employing the is similar mode of sample substitute, but without departing from the spirit of the present invention
Or surmount scope defined in appended claims.
Although the most more employing the terms such as semiconductor chilling plate, ice cap, fuzzy control,
But it is not precluded from using the probability of other term.These terms are used to be only used to more convenient
Describe and explain the essence of the present invention；Being construed as any additional restriction is all
Contrary with spirit of the present invention.
Claims (9)
1. a brain temperature regulating device, it is characterised in that include casing, ice cap, refrigeration system
And control system, described refrigeration system include cooling water tank, semiconductor chilling plate, fin,
Cooling water pump and effusion meter, if described control system comprise single chip circuit, control panel and
Dry temperature probe；The outfan of cooling water tank connects the input of ice cap, cooling by conduit
The input of water tank connects the outfan of ice cap by conduit, and cooling water pump and effusion meter are all connected
On conduit, the cold end of semiconductor chilling plate is close to cooling water tank, and hot junction is close to fin,
One temperature probe is fixed on inside cooling water tank, and another cochlea type temperature probe inserts patient
Cochlea represents patient's brain temperature, semiconductor chilling plate, temperature probe, cooling water pump and control panel
All electrically connect with single chip circuit；Cooling water tank and cooling water pump are arranged on box house, control
Panel is arranged on box outer surface.
A kind of brain temperature regulating device the most according to claim 1, it is characterised in that described
Cooling water tank is aluminum cooling water tank, and the cold end of semiconductor chilling plate passes through heat-conducting silicone grease and cooling
Water tank fits tightly, and the hot junction of semiconductor chilling plate is fitted tightly with fin by heat-conducting silicone grease
Heat radiation；Cooling water inputs from the bottom of cooling water tank, and top exports.
A kind of brain temperature regulating device the most according to claim 1 and 2, it is characterised in that
Described ice cap is made up of TPU material, ice cap medial surface and patient's scalp and cervical region laminating, ice cap
Both sides are fixed by velcro, and cooling water flows through the stream within ice cap and realizes cooling, ice cap
It is shaped as soil font.
A kind of brain temperature regulating device the most according to claim 1, it is characterised in that also wrap
Including three-way valve, the wherein two-way of described three-way valve is connected in the input stream of ice cap cooling water,
Another road communicates with ice cap cooling water output stream.
A kind of brain temperature regulating device the most according to claim 1, it is characterised in that single
Sheet electromechanics road and control panel are arranged on the top of casing, cooling water tank, semiconductor chilling plate and
Cooling water pump is arranged on the bottom of casing, is provided with division board in the middle of casing.
6. a brain temperature regulating device temperature-controlled process, it is characterised in that: include following step
Suddenly,
S11, setting expectation brain temperature or coolant water temperature, with the real-time brain temperature brain temperature or cold collected
But water temperature compares, and obtains actual error E and error rate Ec and inputs as fuzzy quantity；
S12, according to fuzzy reasoning table, obtain proportional control factor Kp, integral adjustment COEFFICIENT K i
With differential adjustment factor Kd, then use centroid method to carry out defuzzification process, obscured
Output signal u of PID controller；
S13, according to control signal u export corresponding pwm ripple, by change duty cycle adjustment
The refrigeration work consumption of cooling piece, it is achieved to brain temperature or the control of coolant water temperature.
A kind of brain temperature regulating device the most according to claim 6, it is characterised in that control
System processed carries out override control for cooling water pump, when setting desired brain temperature or coolant water temperature,
When being less than 5 DEG C with actually measured brain temperature or coolant water temperature error, the power of cooling water pump
50%-80% constitutes linear corresponding relation with the 0-100% of cooling piece refrigeration work consumption；When temperature difference is big
In 6 DEG C time, cooling water pump power keeps the state of 100%, and cooling water pump and effusion meter are formed superfluous
Remaining flow-control.
8. a brain temperature regulating device temperature-controlled process, it is characterised in that include following step
Rapid:
S21, set the initial value of one group of fuzzy neural network controller FNNC, including Vague language
Speech variable number, each Fuzzy Linguistic Variable center b, scope m and the connection of neutral net
Weights ω；
S22, set desired brain temperature or coolant water temperature, with actually measured brain temperature or cooling water
Temperature comparison, obtains the rate of change Ec of error E and error, as Fuzzy Neural-network Control
The input of device FNNC；
S23, E and Ec according to input, the output of fuzzy neural network controller FNNC is corresponding
Semiconductor chilling plate control signal u；
S24, according to control signal u export corresponding pwm ripple, by change duty cycle adjustment
The refrigeration work consumption of cooling piece, it is achieved to brain temperature or the control of coolant water temperature；
S25, according to error E regulate fuzzy neural network controller FNNC parameters, until
Fuzzy neural network controller FNNC is mated with plant characteristic.
A kind of brain temperature regulating device the most according to claim 8, it is characterised in that its
Being characterised by, control system carries out override control for cooling water pump, when setting desired brain temperature
Or coolant water temperature, when being less than 5 DEG C with actually measured brain temperature or coolant water temperature error, cool down water
The 50%-80% of the power of pump constitutes linear corresponding relation with the 0-100% of cooling piece refrigeration work consumption；
When temperature difference is more than 6 DEG C, cooling water pump power keeps the state of 100%, cooling water pump and stream
Gauge forms redundant flow and controls.
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| CN201610236008.7A CN106063740A (en) | 2016-04-15 | 2016-04-15 | A kind of brain temperature regulating device and temperature-controlled process |
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| CN201610236008.7A CN106063740A (en) | 2016-04-15 | 2016-04-15 | A kind of brain temperature regulating device and temperature-controlled process |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107647963A (en) * | 2017-10-26 | 2018-02-02 | 兰州汶河医疗器械研制开发有限公司 | A kind of dual-purpose release dressing device of water circulation hot and cold and its method |
| CN108489179A (en) * | 2018-03-27 | 2018-09-04 | 北京华信佳音医疗科技发展有限责任公司 | A kind of human body temperature-controlling system and device |
| CN108880113A (en) * | 2018-08-20 | 2018-11-23 | 宿迁海沁节能科技有限公司 | A kind of heat dissipating method of electric vehicle motor |
| CN109099561A (en) * | 2018-08-13 | 2018-12-28 | 广州致远电子有限公司 | Temprature control method, apparatus and system |
| CN109394415A (en) * | 2018-12-07 | 2019-03-01 | 张玉婷 | A kind of intravascular sub-low-temperature therapeutic equipment of severe medicine section |
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| CN110801338A (en) * | 2019-11-14 | 2020-02-18 | 华中科技大学同济医学院附属协和医院 | Water circulation cooling blanket and control method thereof |
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| CN111474968A (en) * | 2020-04-30 | 2020-07-31 | 厦门中翎易优创科技有限公司 | Temperature control method and system of temperature therapeutic apparatus |
| CN111481335A (en) * | 2019-01-28 | 2020-08-04 | 深圳市科曼医疗设备有限公司 | Human body temperature adjusting method and device and sub-hypothermia treatment equipment |
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| CN111966138A (en) * | 2020-06-30 | 2020-11-20 | 厦门大学 | High-precision temperature control method and system for medical equipment |
| CN112197487A (en) * | 2020-09-29 | 2021-01-08 | 成都利尼科医学技术发展有限公司 | Special liquid cooling circulating equipment of medical treatment |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2624862Y (en) * | 2003-05-23 | 2004-07-14 | 天津市塑料研究所 | Special body surface cooling cap for treating SARS |
| CN202177456U (en) * | 2011-07-08 | 2012-03-28 | 深圳市东迪欣科技有限公司 | Temperature sensing head and ear temperature thermometer |
| CN103052366A (en) * | 2010-08-13 | 2013-04-17 | 帕克斯曼冷却器有限公司 | Body part temperature regulating apparatus |
| CN103190981A (en) * | 2013-02-27 | 2013-07-10 | 河南省华氏实业有限公司 | Low temperature therapeutic apparatus |
| CN103522526A (en) * | 2013-09-30 | 2014-01-22 | 西安交通大学 | Multi-layer co-extrusion die head intelligent temperature control system and control method thereof |
| CN204468404U (en) * | 2014-12-17 | 2015-07-15 | 咸阳职业技术学院 | Small-sized household human body physical hypothermal device |
| CN204890323U (en) * | 2015-08-22 | 2015-12-23 | 夏宝宝 | Emergency call nursing head heat sink |
-
2016
- 2016-04-15 CN CN201610236008.7A patent/CN106063740A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2624862Y (en) * | 2003-05-23 | 2004-07-14 | 天津市塑料研究所 | Special body surface cooling cap for treating SARS |
| CN103052366A (en) * | 2010-08-13 | 2013-04-17 | 帕克斯曼冷却器有限公司 | Body part temperature regulating apparatus |
| CN202177456U (en) * | 2011-07-08 | 2012-03-28 | 深圳市东迪欣科技有限公司 | Temperature sensing head and ear temperature thermometer |
| CN103190981A (en) * | 2013-02-27 | 2013-07-10 | 河南省华氏实业有限公司 | Low temperature therapeutic apparatus |
| CN103522526A (en) * | 2013-09-30 | 2014-01-22 | 西安交通大学 | Multi-layer co-extrusion die head intelligent temperature control system and control method thereof |
| CN204468404U (en) * | 2014-12-17 | 2015-07-15 | 咸阳职业技术学院 | Small-sized household human body physical hypothermal device |
| CN204890323U (en) * | 2015-08-22 | 2015-12-23 | 夏宝宝 | Emergency call nursing head heat sink |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107647963A (en) * | 2017-10-26 | 2018-02-02 | 兰州汶河医疗器械研制开发有限公司 | A kind of dual-purpose release dressing device of water circulation hot and cold and its method |
| CN108489179A (en) * | 2018-03-27 | 2018-09-04 | 北京华信佳音医疗科技发展有限责任公司 | A kind of human body temperature-controlling system and device |
| CN109099561A (en) * | 2018-08-13 | 2018-12-28 | 广州致远电子有限公司 | Temprature control method, apparatus and system |
| CN108880113A (en) * | 2018-08-20 | 2018-11-23 | 宿迁海沁节能科技有限公司 | A kind of heat dissipating method of electric vehicle motor |
| CN109394415B (en) * | 2018-12-07 | 2021-08-06 | 张玉婷 | Intravascular sub-low temperature therapeutic instrument for severe medical science |
| CN109394415A (en) * | 2018-12-07 | 2019-03-01 | 张玉婷 | A kind of intravascular sub-low-temperature therapeutic equipment of severe medicine section |
| CN111481335A (en) * | 2019-01-28 | 2020-08-04 | 深圳市科曼医疗设备有限公司 | Human body temperature adjusting method and device and sub-hypothermia treatment equipment |
| CN110676680A (en) * | 2019-09-03 | 2020-01-10 | 南京理工大学 | Device for controlling output wavelength of microchip laser pumping source |
| CN110801338A (en) * | 2019-11-14 | 2020-02-18 | 华中科技大学同济医学院附属协和医院 | Water circulation cooling blanket and control method thereof |
| CN111249061A (en) * | 2020-03-05 | 2020-06-09 | 广安市人民医院 | Intelligent temperature control water tank for cooling human body and temperature control method |
| CN111474968A (en) * | 2020-04-30 | 2020-07-31 | 厦门中翎易优创科技有限公司 | Temperature control method and system of temperature therapeutic apparatus |
| CN111474968B (en) * | 2020-04-30 | 2021-09-07 | 厦门中翎易优创科技有限公司 | Temperature control method and system of temperature therapeutic apparatus |
| CN111714274A (en) * | 2020-05-29 | 2020-09-29 | 汤聿修 | Head-mounted equipment for fever and cooling of children |
| CN111966138A (en) * | 2020-06-30 | 2020-11-20 | 厦门大学 | High-precision temperature control method and system for medical equipment |
| CN112197487A (en) * | 2020-09-29 | 2021-01-08 | 成都利尼科医学技术发展有限公司 | Special liquid cooling circulating equipment of medical treatment |
| CN112747498A (en) * | 2021-01-29 | 2021-05-04 | 江苏大学 | Personal thermal management method based on Peltier effect |
| CN112747498B (en) * | 2021-01-29 | 2022-04-26 | 江苏大学 | Personal thermal management method based on Peltier effect |
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