CN106040008A - Cleaning method of purification ultrafilter - Google Patents
Cleaning method of purification ultrafilter Download PDFInfo
- Publication number
- CN106040008A CN106040008A CN201610623019.0A CN201610623019A CN106040008A CN 106040008 A CN106040008 A CN 106040008A CN 201610623019 A CN201610623019 A CN 201610623019A CN 106040008 A CN106040008 A CN 106040008A
- Authority
- CN
- China
- Prior art keywords
- purification
- cleaning
- cleaning method
- ultrafilter
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
- B01D65/02—Membrane cleaning or sterilisation ; Membrane regeneration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/20—Accessories; Auxiliary operations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
- B01D2321/16—Use of chemical agents
- B01D2321/164—Use of bases
Abstract
The invention discloses a cleaning method of a purification ultrafilter. The cleaning method comprises the following steps: S1, circularly cleaning the purification ultrafilter for 20-40 minutes by utilizing a sodium hydroxide solution; S2, flushing the cleaned purification ultrafilter for 23-27 minutes by utilizing purified water; S3, cleaning the flushed purification ultrafilter for three times by using concentrated injection water, wherein once cleaning is finished after injection water of 1.2-1.4 tons is concentrated to be 0.18-0.22 ton at each time. According to the cleaning method of the purification ultrafilter, (1), concentration cleaning is utilized to ensure the pressure before and after film package, and a film package cleaning effect is better; and (2), the amount of low-temperature injection water for cleaning at each time is reduced about 10-15 tons.
Description
Technical field
The present invention relates to a kind of purification ultrafiltration machine cleaning method.
Background technology
Purification ultrafiltration machine uses relatively broad during bio-pharmaceuticals, needs periodically to clean flushing during use, with full
Requirement in foot pharmacy procedure, extends the life-span of film simultaneously, and water for injection large usage quantity in conventional flush process is wasted the tightest
Weight, the cleaning performance of film bag has much room for improvement simultaneously.
Summary of the invention
For the deficiency in the presence of prior art, the invention provides a kind of purification ultrafiltration machine cleaning method, purpose exists
In saving the water for injection water yield in cleaning process, improve the cleaning performance to film bag simultaneously.
For achieving the above object, present invention employs following technical scheme: a kind of purification ultrafiltration machine cleaning method, including
Following steps:
S1, employing sodium hydroxide solution wash cycles 20-40 minute；
S2, employing purified water are rinsed 23-27 minute；
S3, employing water for injection concentrate and clean 3 times, and each 1.2-1.4 ton water for injection is concentrated into 0.18-0.22 ton and is once
Clean complete.
As preferably, in step S1, the concentration of sodium hydroxide solution is 0.2～0.5mol/L.
As preferably, in step S2, purified water consumption is 10-20 ton.
As preferably, in step S2, washing time is 25 ± 2 minutes.
As preferably, in step S3 each 1.3 tons of waters for injection be concentrated into 0.2 ton be once clean complete.
Compared to prior art, there is advantages that (1) present invention uses concentration to clean, it is ensured that
Pressure before and after film bag, more preferable to film bag cleaning performance.(2) present invention cleans saving low-temperature injection water amount about 10-15 every time
Ton.
Detailed description of the invention
1, purification ultrafiltration machine equipment model:
The present invention is used in SartoriusSF-160 ultrafiltration system, it is adaptable to ultrafilter film envelope amasss 84-112.
2, the treatment fluid of purification ultrafiltration machine:
Purified water, 2.0～8.0 DEG C of water for injection, 0.2～the sodium hydroxide solution of 0.5mol/L.
In a preferred embodiment, a kind of purification ultrafiltration machine cleaning method, comprise the steps:
S1, employing sodium hydroxide solution wash cycles 20-40 minute；
S2, employing purified water are rinsed 23-27 minute；
S3, employing water for injection concentrate and clean 3 times, and each 1.2-1.4 ton water for injection is concentrated into 0.18-0.22 ton and is once
Clean complete.
In the present embodiment, in step S1, the concentration of sodium hydroxide solution is 0.2～0.5mol/L.
In the present embodiment, in step S2, purified water consumption is 10-20 ton.
In the present embodiment, in step S2, washing time is 25 minutes.
In the present embodiment, in step S3 each 1.3 tons of waters for injection be concentrated into 0.2 ton be once clean complete.
The former cleaning method of this ultrafilter is as follows:
1,0.2～0.5mol/L sodium hydroxide solution circulates 20-40 minute.
2, purified water rinses 25 minutes (water consumption about 20 tons).
3, water for injection rinses about needs to rinse about 30 minutes to electrical conductivity 10mS/cm(, water consumption about 20 tons).
It follows that compared with former cleaning way, the present invention uses concentration to clean, it is ensured that pressure before and after film bag, right
Film bag cleaning performance is more preferable.The present invention cleans saving low-temperature injection water amount about 10-15 ton every time, and water-saving result is excellent, with
Time reduce production cost.
Finally illustrating, above example is only in order to illustrate technical scheme and unrestricted, although with reference to relatively
The present invention has been described in detail by good embodiment, it will be understood by those within the art that, can be to the skill of the present invention
Art scheme is modified or equivalent, and without deviating from objective and the scope of technical solution of the present invention, it all should be contained at this
In the middle of the right of invention.
Claims (5)
1. a purification ultrafiltration machine cleaning method, it is characterised in that comprise the steps:
S1, employing sodium hydroxide solution wash cycles 20-40 minute；
S2, employing purified water are rinsed 23-27 minute；
S3, employing water for injection concentrate and clean 3 times, and each 1.2-1.4 ton water for injection is concentrated into 0.18-0.22 ton and is once
Clean complete.
Purification ultrafiltration machine cleaning method the most according to claim 1, it is characterised in that sodium hydroxide solution in step S1
Concentration is 0.2～0.5mol/L.
Purification ultrafiltration machine cleaning method the most according to claim 1, it is characterised in that in step S2, purified water consumption is
10-20 ton.
Purification ultrafiltration machine cleaning method the most according to claim 1, it is characterised in that in step S2 washing time be 25 ±
2 minutes.
Purification ultrafiltration machine cleaning method the most according to claim 1, it is characterised in that each 1.3 tons of injections in step S3
With water be concentrated into 0.2 ton be once clean complete.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610623019.0A CN106040008A (en) | 2016-08-02 | 2016-08-02 | Cleaning method of purification ultrafilter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610623019.0A CN106040008A (en) | 2016-08-02 | 2016-08-02 | Cleaning method of purification ultrafilter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106040008A true CN106040008A (en) | 2016-10-26 |
Family
ID=57197114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610623019.0A Pending CN106040008A (en) | 2016-08-02 | 2016-08-02 | Cleaning method of purification ultrafilter |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106040008A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11156166A (en) * | 1997-11-28 | 1999-06-15 | Mitsubishi Heavy Ind Ltd | Cleaning method for hollow fiber membrane module |
| CN2533123Y (en) * | 2002-03-01 | 2003-01-29 | 长春安特涂装技术工程有限公司 | Ultrafiltering and reverse osmosis combined enclosed cleaning recovery device |
| CN101392402A (en) * | 2008-10-16 | 2009-03-25 | 海宁市海整整流器有限公司 | Electroplating washing water zero discharge method |
| CN201768694U (en) * | 2010-01-08 | 2011-03-23 | 李正安 | Intelligent mildew picking machine for grain seeds |
| JP2011147880A (en) * | 2010-01-21 | 2011-08-04 | Nomura Micro Sci Co Ltd | Method and apparatus for production of purified water for medicine |
| CN104829694A (en) * | 2015-04-30 | 2015-08-12 | 上海上药第一生化药业有限公司 | Purifying method for hypophysin |
-
2016
- 2016-08-02 CN CN201610623019.0A patent/CN106040008A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11156166A (en) * | 1997-11-28 | 1999-06-15 | Mitsubishi Heavy Ind Ltd | Cleaning method for hollow fiber membrane module |
| CN2533123Y (en) * | 2002-03-01 | 2003-01-29 | 长春安特涂装技术工程有限公司 | Ultrafiltering and reverse osmosis combined enclosed cleaning recovery device |
| CN101392402A (en) * | 2008-10-16 | 2009-03-25 | 海宁市海整整流器有限公司 | Electroplating washing water zero discharge method |
| CN201768694U (en) * | 2010-01-08 | 2011-03-23 | 李正安 | Intelligent mildew picking machine for grain seeds |
| JP2011147880A (en) * | 2010-01-21 | 2011-08-04 | Nomura Micro Sci Co Ltd | Method and apparatus for production of purified water for medicine |
| CN104829694A (en) * | 2015-04-30 | 2015-08-12 | 上海上药第一生化药业有限公司 | Purifying method for hypophysin |
Non-Patent Citations (1)
| Title |
|---|
| 《中国博士学位论文全文数据库 农业科技辑》 * |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161026 |
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| RJ01 | Rejection of invention patent application after publication |