CN106039601A - Magnetic-compatibility ultrasonic stimulation system - Google Patents
Magnetic-compatibility ultrasonic stimulation system Download PDFInfo
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- CN106039601A CN106039601A CN201610374699.7A CN201610374699A CN106039601A CN 106039601 A CN106039601 A CN 106039601A CN 201610374699 A CN201610374699 A CN 201610374699A CN 106039601 A CN106039601 A CN 106039601A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0043—Ultrasound therapy intra-cavitary
Abstract
The invention provides a magnetic-compatibility ultrasonic stimulation system, which comprises an ultrasonic probe module, a magnetic resonance coil module, a magnetic resonance module and a supporting module, wherein the ultrasonic probe module and the magnetic resonance coil module are arranged on the supporting module; the ultrasonic probe module is used for sending ultrasonic waves to stimulate a to-be-treated animal brain deep cerebral nuclei; the magnetic resonance coil module is connected with the ultrasonic probe module and the magnetic resonance module respectively for monitoring stimulation effects of the to-be-treated animal stimulated by the ultrasonic waves and the stimulation position and displaying and outputting the monitoring result via an external magnetic resonance system; and the supporting module is used for limiting the activity of the to-be-treated animal and fixing the to-be-treated animal in a predetermined area.
Description
Technical field
The present invention relates to field of medical device, espespecially a kind of magnetic compatibility ultrasound stimulation system.
Background technology
Along with depression, the patient of the brain diseasess such as parkinson disease gradually increases, and the treatment of brain diseases is increasingly becoming existing
For the focus of medical research, brain treatment now also proposed many in addition to oral drugs and utilizes external condition to stimulate brainpan
Core group reaches the scheme of therapeutic effect, and its stimulating method mainly used is photostimulation, electricity irritation, Neural stem cell and ultrasound stimulation.
Ultrasound stimulation obtains paying close attention to the most widely due to its safety, non-invasive and effectiveness.There are many experiments the most in the world
Room is carrying out the research of ultrasound stimulation treatment brain diseases, and it is next to start to carry out ultrasound stimulation experiment with animal (monkey)
Explore and verify the therapeutic effect of the ultrasonic brain diseases to primate.
Ultrasonic as a kind of mechanical wave, it is to be produced by object (sound source) vibration, and causes it by compressing and expand medium
Propagating, medical ultrasonic typically refers to frequency sound wave in 20kHz to 10MHz interval.The ultrasonic general property except having ripple,
Also having an important feature, its decay in the tissue such as water, muscle is the least, can arrive at deeper tissue.Doctor
Learn ultrasound wave to interact with tissue, mainly apply the Basic Physical Properties of sound wave and matter interaction, there is ripple
The three big acoustic effects such as dynamic effect, mechanics effect and heat effect, these effects have important application or weight in biomedicine
Big potentiality.Traditional ultrasonic based on fluctuation effect with heat effect, have been developed as that there is imaging diagnosis and thermal ablation therapy two
Big basic function.Fluctuation effect can be used for B ultrasonic, color ultrasound, radiography etc. and has the ultra sonic imaging diagnosis of quite varied application in clinic
Technology；Heat effect can be used for heating ablation and nerve nucleus damage treatment, the such as high intensity focused ultrasound (HIFU) of tumor.Ultrasonic
Nerve stimulation is its non-intruding character with the advantage of regulation and control.The ultrasonic neuromodulation in molecule, cell, animal and human brain level is
New science evidence demonstrate effectively ultrasonic can through people skull noinvasive, effectively regulate synaptic plasticity, neuron regulation and control and
Brain district, deep nerve nucleus.
Although it is preferable that ultrasonic nerve stimulation is proved to therapeutic effect, but because intracranial environment is complex, related work people
Member cannot intuitively obtain treatment position and whether effect reaches expection, and set parameter is the most suitable, hence in so that ultrasonic nerve
Stimulation cannot effectively be promoted.
Summary of the invention
The present invention relates to a kind of magnetic compatibility ultrasound stimulation system that may be used for brain stimulation, use this stimulating system, then
It is aided with supporting ultrasound electronics system and magnetic resonance system and animal brain pathogenic cell core group can be carried out accurate ultrasound stimulation,
And use magnetic resonance system that stimulation sites, dynamics and effect are monitored, thus explore and verify ultrasonic to primate
The therapeutic effect of brain diseases, simple to operate, easy to use.
For reaching above-mentioned purpose, the magnetic compatibility ultrasound stimulation system that the present invention is specifically provided, specifically comprise ultrasonic probe mould
Block, magnetic resonance coil module, magnetic resonance module and support module；Described ultrasonic probe module and described magnetic resonance coil module set
Put in described support module；Wherein, described ultrasonic probe module is used for sending the ultrasonic stimulation deep brain of animal brain to be treated
Core group；Described magnetic resonance coil module is connected with described ultrasonic probe module and described magnetic resonance module respectively, for being surpassed
Effect of stimulation and the stimulation sites of sound stimulation tested animal animal to be treated are monitored, and are shown by outside magnetic resonance system
Show output；Described support module is used for limiting animal activity to be treated, and animal to be treated is fixed on presumptive area.
In above-mentioned magnetic compatibility ultrasound stimulation system, it is preferred that described system also comprises hollow connecting rod, described hollow company
Extension bar is for providing the passage connecting cable of described ultrasonic probe module and described magnetic resonance coil module.
In above-mentioned magnetic compatibility ultrasound stimulation system, it is preferred that described system also comprises control module, described control module
It is connected with described ultrasonic probe module, for referring to according to the monitoring situation output control of described outside magnetic resonance system display output
Order adjusts stimulus intensity and the stimulation sites of described ultrasonic probe module output ultrasonic wave
In above-mentioned magnetic compatibility ultrasound stimulation system, it is preferred that described ultrasonic probe module comprise two-dimensional array transducer,
Transducer fixed frame and transducer socket；Described two-dimensional array transducer is for sending ultrasonic stimulation brain according to control instruction
Brain core group deeply；Described transducer socket receives the data-interface of control instruction for providing described two-dimensional array transducer；Described
Transducer fixed frame is for being fixed on described support module by described two-dimensional array transducer.
In above-mentioned magnetic compatibility ultrasound stimulation system, it is preferred that the supersonic frequency of described two-dimensional array transducer is 0.2M
To 5M, and described two-dimensional array transducer comprises multiple ultrasound wave array element, and the plurality of ultrasound wave array element composition is dynamic with to be treated
The globoidal structure that the head-bent degree of thing is consistent.
In above-mentioned magnetic compatibility ultrasound stimulation system, it is preferred that described magnetic resonance coil module comprises coil unit and puts
Big device unit；Described coil unit comprises magnetic resonance coil, coil upper cover and coil lower cover；Wherein said magnetic resonance coil is used for
Output radiofrequency signal；Described coil upper cover and described coil lower cover are used for combining the described magnetic resonance coil of protection；Described amplifier
Unit comprises amplifier and amplifier lid；Wherein said amplifier is used for amplifying described radiofrequency signal；Described amplifier lid is used for
Protect described amplifier.
In above-mentioned magnetic compatibility ultrasound stimulation system, it is preferred that described transducer fixed frame is fixed with described coil lower cover
Connecting, described amplifier is connected by rotary shaft under described coil, and described transducer socket is fixing with described support module even
Connect.
In above-mentioned magnetic compatibility ultrasound stimulation system, it is preferred that described support module comprises the spacing module of body, cervical region limit
Position module, the spacing module of ear and the spacing module of face；The spacing module of described body is used for limiting animal body action to be treated；
The spacing module of described cervical region is used for limiting animal neck to be treated and rocks；The spacing module of described ear is used for limiting animal to be treated
Head rocks；The spacing module of described face, for against animal head to be treated, limits animal head action to be treated.
In above-mentioned magnetic compatibility ultrasound stimulation system, it is preferred that the spacing module of described body comprises base, at least two is propped up
Support crossbeam and at least four bracing frame；Support frame as described above one end is vertical with described base to be connected, described support crossbeam and described
The support other end vertically connects；It is respectively arranged with lacing hole, the spacing module of described body on described base and described support crossbeam
By described lacing hole and rope, animal to be treated is fixed on described support crossbeam；Described base is additionally provided with balance adjustment spiral shell
Nail, described balance adjustment screws is used for regulating the spacing module balancing of described body.
In above-mentioned magnetic compatibility ultrasound stimulation system, it is preferred that the spacing module of described cervical region comprises cervical region connector and neck
Portion's locating part；Described cervical region connector one end is vertical along described support crossbeam parallel direction and is movably installed on described base；
Described cervical region locating part comprises upper semi-circle position limiting structure and lower half circle position limiting structure, described upper semi-circle position limiting structure and described cervical region
The connector other end is fixing to be connected, and described lower half circle position limiting structure is flexibly connected with described upper semi-circle position limiting structure.
In above-mentioned magnetic compatibility ultrasound stimulation system, it is preferred that the spacing module of described ear comprises ear acupuncture, ear acupuncture props up bracer
With ear acupuncture connector；Described ear acupuncture connector is flexibly connected with described support crossbeam；Described ear acupuncture props up bracer with described ear acupuncture even
Fitting active link, described ear acupuncture is fixed on described ear acupuncture and props up on bracer；Wherein said ear acupuncture is used for inserting animal ear to be treated
Portion, moves left and right limiting animal head；Described ear acupuncture props up bracer and is used for fixing described ear acupuncture and regulating described ear acupuncture position；Institute
State ear acupuncture connector for providing described ear acupuncture to prop up bracer movable passageway on described support crossbeam.
In above-mentioned magnetic compatibility ultrasound stimulation system, it is preferred that the spacing module of described face comprises tongue block, face supports sheet and props up
Support unit；Described support unit comprises support upper plate, supports back plate and two pieces of support side plate；Described tongue block is parallel to described support
The outer surface of upper plate is arranged, and is used for inserting in animal oral cavity to be treated, limits animal oral cavity to be treated and move；Described face supports sheet and lives
Move and be arranged on described support upper plate, be used for limiting animal head and move forward and backward；Described support side plate is fixedly installed on described
Between support crossbeam and described base；Described support back plate is connected with two pieces of support side plate and described support crossbeam respectively；Described
Support upper plate be arranged between described support side plate and described support back plate, and with described support side plate and described support back plate activity
Connect.
In above-mentioned magnetic compatibility ultrasound stimulation system, it is preferred that described support module is by bakelite or epoxy resin or polysulfones
(psu, Polysulfone) is constituted.
The Advantageous Effects of the present invention is: by using this stimulating system, then be aided with supporting ultrasound electronics system
Animal brain pathogenic cell core group can be carried out accurate ultrasound stimulation with magnetic resonance system, and use magnetic resonance system to stimulation
Position, dynamics and effect are monitored, thus explore and verify the therapeutic effect of the ultrasonic brain diseases to primate, behaviour
Make simple, easy to use.
Accompanying drawing explanation
Accompanying drawing described herein is used for providing a further understanding of the present invention, constitutes the part of the application, not
Constitute limitation of the invention.In the accompanying drawings:
Fig. 1 is the overall structure schematic diagram of magnetic compatibility ultrasound stimulation system provided by the present invention；
Fig. 2 is the overall exploded perspective view of magnetic compatibility ultrasound stimulation system provided by the present invention；
Fig. 3 is ultrasonic probe module and magnetic resonance coil module knot in magnetic compatibility ultrasound stimulation system provided by the present invention
Structure schematic diagram；
Fig. 4 is cervical region spacing modular structure schematic diagram in magnetic compatibility ultrasound stimulation system provided by the present invention；
Fig. 5 is ear's spacing modular structure schematic diagram in magnetic compatibility ultrasound stimulation system provided by the present invention；
Fig. 6 is magnetic compatibility ultrasound stimulation system septum reset spacing modular structure schematic diagram provided by the present invention.
Drawing reference numeral
100, ultrasonic probe module；200, magnetic resonance coil module；300, module is supported；400, support member；500, even
Extension bar；110, two-dimensional array transducer；120, transducer fixed frame；130, transducer socket；210, coil upper cover；220, coil
Lower cover；230, amplifier unit；240, amplifier lid；311, base；312, bracing frame；313, crossbeam is supported；314, lacing hole；
315, balance adjustment screws；321, upper semi-circle position limiting structure；322, lower half circle position limiting structure；323, cervical region connector；331, ear
Pin；332, ear acupuncture props up bracer；333, ear acupuncture connector；341, tongue block；342, face supports sheet；343, upper plate is supported；344, support-side
Plate；345, back plate is supported；
Detailed description of the invention
For making the purpose of the embodiment of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment and attached
Figure, is described in further details the present invention.Here, the schematic description and description of the present invention is used for explaining the present invention,
But it is not as a limitation of the invention.
Refer to shown in Fig. 1 and Fig. 2, the invention provides a kind of magnetic compatibility ultrasound stimulation system, specifically comprise ultrasonic spy
Head module 100, magnetic resonance coil module 200, magnetic resonance module (not shown) and support module 300；Described ultrasonic probe module
100 and described magnetic resonance coil module 200 be arranged in described support module 300；Wherein, described ultrasonic probe module 100 is used
In sending ultrasonic stimulation animal brain to be treated deep brain core group；Described magnetic resonance coil module 200 respectively with described ultrasonic spy
Head module 100 is connected with described magnetic resonance module, for by the effect of stimulation of ultrasonic stimulation animal to be treated and stimulation position
Put and be monitored；Described magnetic resonance module is for adjusting described ultrasonic spy according to monitoring situation by described magnetic resonance coil module
The stimulus intensity of head module 100 output ultrasonic wave and stimulation sites；Described support module 300 is used for limiting animal to be treated and lives
Dynamic, animal to be treated is fixed on presumptive area.Wherein, described ultrasonic probe module 100 and described magnetic resonance coil module 200
Can be secured in described support module 300 by support member 400, this support member 400 is described in detail following.
In the above-described embodiments, described system also comprises hollow connecting rod 500 and control module (the most graphic), described hollow
Connecting rod 500 is for providing the passage connecting cable of described ultrasonic probe module 100 and described magnetic resonance coil module 200；
Described control module is connected with described ultrasonic probe module 100 and described magnetic resonance coil module 200 respectively, for according to described
Magnetic resonance coil module 200 output control instruction adjust described ultrasonic probe module 100 output ultrasonic wave stimulus intensity and
Stimulation sites.
Concrete, magnetic compatibility ultrasound stimulation system provided by the present invention includes: ultrasonic probe module 100, magnetic resonance line
Circle module 200 and support structure module 300；Wherein ultrasonic probe module 100 and magnetic resonance coil module 200 pass through support member
400 and connecting rod 500 be connected with support structure module 300, connecting rod 500 can be hollow connecting rod 500 so that ultrasonic probe
The cable of module 100 and magnetic resonance coil module 200 can be drawn from hollow connecting rod 500.
Refer to shown in Fig. 1 to Fig. 3, in the present invention one preferred embodiment, described ultrasonic probe module 100 comprises two
Dimension face array transducer 110, transducer fixed frame 120 and transducer socket 130；Described two-dimensional array transducer 110 is for basis
Control instruction sends ultrasonic stimulation brain deep brain core group；Described transducer socket 130 is used for inserting described two-dimensional array transducing
Device 110, and provide described two-dimensional array transducer 110 to receive the data-interface of control instruction；Described transducer fixed frame 120 is used
In described two-dimensional array transducer 110 is fixed on described transducer socket 130；Wherein, described two-dimensional array transducer 110
Supersonic frequency be 0.2M to 5M, and described two-dimensional array transducer 110 comprises multiple ultrasound wave array element, the plurality of ultrasound wave
The globoidal structure that array element composition is consistent with the head-bent degree of animal to be treated.
Refer to shown in Fig. 1 to Fig. 3, described magnetic resonance coil module 200 comprises coil unit (not shown) again
With amplifier unit 230；Described coil unit comprises magnetic resonance coil, coil upper cover 210 and coil lower cover 220；Wherein said
Magnetic resonance coil is used for exporting radiofrequency signal；Described coil upper cover 210 and described coil lower cover 220 are used for combining the described magnetic of protection
Resonance coil；Described amplifier unit 230 comprises amplifier and amplifier lid 240；Wherein said amplifier is used for amplifying described
Radiofrequency signal；Described amplifier lid 240 is used for protecting described amplifier；Described transducer fixed frame 120 and described coil lower cover
220 fixing connections, described amplifier is connected by rotary shaft under described coil, described transducer socket 130 and described support
Module 300 is fixing to be connected.
In the above-described embodiments, magnetic resonance coil module 200 is used for coordinating magnetic resonance system to effect of stimulation and to stimulate position
Put and carry out imaging, successive step stimulus intensity and a position of going forward side by side.Amplifier unit 230 is for magnetic resonance coil module
The radiofrequency signal of 200 is amplified；Two-dimensional array transducer 110 is placed in transducer fixed frame 120, transducer fixed frame 120
Fixing with coil lower cover 220 and be connected, coil is placed between coil upper cover 210 and coil lower cover 220；Under amplifier 230 and coil
Lid 220 is connected by rotary shaft, and amplifier 230 can rotate with rotary shaft for axle center；Transducer socket 130 is solid with holding components
Fixed connection, and be electrically connected with two-dimensional array transducer 110.Transducer socket 130 is for two-dimensional array transducer 110 and ultrasonic electronic
System is attached.Two-dimensional array transducer 110 supersonic frequency is 0.2M～5M, and array number is 1～4096.Used herein
Two-dimensional array transducer 110 bends to the cambered surface consistent with animal skull degree of crook, in order to sound wave from skull vertical incidence,
Reduce the sound wave decay caused because of refraction in communication process.
Refer to shown in Fig. 1 and Fig. 2, support module 300 provided by the present invention comprises the spacing module of body 310, cervical region
Spacing module 320, the spacing module of ear 330 and the spacing module of face 340；The spacing module of described body 310 is used for limiting to be waited to control
Treat animal body action；The spacing module of described cervical region 320 is used for limiting animal neck to be treated and rocks；The spacing module of described ear
330 are used for limiting animal head to be treated rocks；The spacing module of described face 340, for against animal head to be treated, limits
Animal head action to be treated.
For clearer explanation above-mentioned support module 300, individually below its each parts are elaborated:
Refer to shown in Fig. 1 and Fig. 2 in the above-described embodiments, the spacing module of described body 310 comprises base 311, at least
Two support crossbeam 313 and at least four bracing frame 312；Support frame as described above 312 one end is vertical with described base 311 to be connected, institute
Stating support, crossbeam 313 is vertical with support frame as described above 312 other end is connected；Described base 311 and difference on described support crossbeam 313
Being provided with lacing hole, animal to be treated is fixed on described by described lacing hole with rope by the spacing module of described body 310
On support crossbeam 313；Described base 311 is additionally provided with balance adjustment screws, and described balance adjustment screws is used for regulating described body limit
Position module 310 balances.The number of wherein said support crossbeam and the data of bracing frame can be arranged according to actual needs, and purpose only exists
In keeping the balance of magnetic compatibility ultrasound stimulation system and helping fixing animal to be treated, the present invention does not do particular number of at this
Limit.
Refer to shown in Fig. 4, in the above-described embodiments, the spacing module of described cervical region 320 comprises cervical region connector 323 and neck
Portion's locating part；Described cervical region connector 323 one end is vertical along described support crossbeam 313 parallel direction and is movably installed in the described end
On seat 311；Described cervical region locating part comprises upper semi-circle position limiting structure 321 and lower half circle position limiting structure 322, and described upper semi-circle is spacing
Structure 321 is fixing with described cervical region connector 323 other end to be connected, and described lower half circle position limiting structure 322 limits with described upper semi-circle
Bit architecture 321 is flexibly connected, concrete, and the spacing module of this cervical region 320 is movably arranged on base 311, and can be at base 311
On move up in the side parallel with crossbeam, the spacing module of cervical region 320 includes the spacing knot of upper semi-circle position limiting structure 321, lower half circle
Structure 322 and cervical region connector 323, upper semi-circle position limiting structure 321 and lower half circle position limiting structure 322 are flexibly connected so that two and half
Circle can the cervical region size of compatible different animals；Lower half circle position limiting structure 322 is flexibly connected with cervical region connector 323, lower half
Circle position limiting structure 322 can move up and down so that the spacing module of cervical region 320 can the cervical region height of compatible different animals.
Refer to shown in Fig. 5, in the above-described embodiments, the spacing module of described ear 330 comprises ear acupuncture 331, ear acupuncture supports
Block 332 and ear acupuncture connector 333；Described ear acupuncture connector 333 is flexibly connected with described support crossbeam 313；Described ear acupuncture supports
Block 332 and described ear acupuncture connector 333 active link, described ear acupuncture 331 is fixed on described ear acupuncture and props up on bracer 332；Wherein institute
State ear acupuncture 331 for inserting animal ear to be treated, move left and right limiting animal head；Described ear acupuncture props up bracer 332 and is used for
Fixing described ear acupuncture 331 and described ear acupuncture 331 position of regulation；Described ear acupuncture connector 333 is used for providing described ear acupuncture to prop up bracer
332 movable passageways on described support crossbeam 313；In actually used, the spacing module of this ear 330 has two, left and right, all wraps
Include ear acupuncture 331, ear acupuncture props up bracer 332 and ear acupuncture connector 333, and ear acupuncture 331 is used for inserting animal ear, to limit animal head
Side-to-side movement.The spacing module of ear 330 is connected with supporting crossbeam 313 by ear acupuncture connector 333, and ear acupuncture connector 333 can
The spacing module of ear 330 is driven to move on support crossbeam 313；Ear acupuncture 331 is movably arranged on ear acupuncture and props up on bracer 332, two
Ear acupuncture 331 is movable to be arranged, and is shortened by its relative distance animal with compatible different brain sizes；Ear acupuncture prop up bracer 332 with
Ear acupuncture connector 333 is flexibly connected, in order to regulate the height of ear acupuncture 331.
Refer to shown in Fig. 6, in the above-described embodiments, the spacing module of described face 340 comprises tongue block 341, face supports sheet 342
And support unit；Described support unit comprises support upper plate 343, supports back plate 345 and two pieces of support side plate 344；Described tongue block
341 outer surfaces being parallel to described support upper plate 343 are arranged, and are used for inserting in animal oral cavity to be treated, limit animal to be treated
Oral cavity is moved；Described face supports sheet 342 and is movably arranged on described support upper plate 343, is used for limiting animal head and moves forward and backward；Institute
State support side plate 344 to be fixedly installed between described support crossbeam 313 and described base 311；Described support back plate 345 respectively with
Two pieces of support side plate 344 are connected with described support crossbeam 313；Described support upper plate 343 is arranged at described support side plate 344 and institute
State between support back plate 345, and be flexibly connected with described support side plate 344 and described support back plate 345.Specifically, in reality
The border work spacing module of septum reset 340 can include that 341, two faces of tongue block support sheet 342, support 343, two support side plate of upper plate
344 and support back plate 345, tongue block 341 can be put in the oral cavity of animal, face supports sheet 342 and can prop up the face of animal, limits
The motion of animal head.Tongue block 341 is parallel to support the upper surface of upper plate 343 and arranges, and face supports sheet 342 and is movably arranged in support
On plate 343, face supports the distance of sheet 342 scalable and animal face, with the size of compatible different animals head.Support side plate 344
Be fixedly installed on support crossbeam 313 and base plate between, support back plate 345 respectively with support side plate 344 and support crossbeam 313 end
Point is fixing to be connected, support upper plate 343 respectively with support side plate 344 and support back plate 345 and be flexibly connected, support upper plate 343 can be
Vertical Square moves up so that tongue block 341 and face support the height adjustable of sheet 342.
Refer to again shown in Fig. 1 and Fig. 6, the support member 400 in magnetic compatibility ultrasound stimulation system provided by the present invention
Mainly include vertical bracer and the support bar of level, a vertical bracer and the support back plate 345 of the spacing module of face 340
Connect；Support bar one end of level is connected with a vertical bracer, and the other end is connected with supporting linkage 500, the support of level
The middle part of bar is additionally provided with rotating shaft, ultrasonic probe module 100 and magnetic resonance coil module 200 can carry out level by this rotating shaft
Rotation on direction.
In real work, based on environmental protection and the consideration of magnetic flux, described support module 300 can be by bakelite or epoxy resin
Or polysulfones (psu, Polysulfone) equimagnetic compatible material is constituted.
By using this stimulating system, then it is aided with supporting ultrasound electronics system and magnetic resonance system can be to animal brain
Pathogenic cell core group carries out accurate ultrasound stimulation, and uses magnetic resonance system to be monitored stimulation sites, dynamics and effect, from
And explore and verify the therapeutic effect of the ultrasonic brain diseases to primate, and simple to operate, easy to use.
Particular embodiments described above, has been carried out the purpose of the present invention, technical scheme and beneficial effect the most in detail
Describe in detail bright, be it should be understood that the specific embodiment that the foregoing is only the present invention, the guarantor being not intended to limit the present invention
Protect scope, all within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. done, should be included in this
Within the protection domain of invention.
Claims (13)
1. a magnetic compatibility ultrasound stimulation system, it is characterised in that described system comprises ultrasonic probe module, magnetic resonance coil mould
Block and support module；
Described ultrasonic probe module and described magnetic resonance coil module are arranged in described support module；
Wherein, described ultrasonic probe module is used for sending ultrasonic stimulation animal brain to be treated deep brain core group；
Described magnetic resonance coil module is connected with described ultrasonic probe module, for the thorn by ultrasonic stimulation animal to be treated
Swash effect and stimulation sites is monitored, and by outside magnetic resonance system display output；
Described support module is used for limiting animal activity to be treated, and animal to be treated is fixed on presumptive area.
Magnetic compatibility ultrasound stimulation system the most according to claim 1, it is characterised in that described system also comprises hollow connection
Bar, described hollow connecting rod is for providing the logical of the connection cable of described ultrasonic probe module and described magnetic resonance coil module
Road.
Magnetic compatibility ultrasound stimulation system the most according to claim 1, it is characterised in that described system also comprises control mould
Block, described control module is connected with described ultrasonic probe module, for the prison according to described outside magnetic resonance system display output
Control situation output control instruction adjusts stimulus intensity and the stimulation sites of described ultrasonic probe module output ultrasonic wave.
Magnetic compatibility ultrasound stimulation system the most according to claim 1, it is characterised in that described ultrasonic probe module comprises two
Dimension face array transducer, transducer fixed frame and transducer socket；
Described two-dimensional array transducer is for sending ultrasonic stimulation brain deep brain core group according to control instruction；
Described transducer socket receives the data-interface of control instruction for providing described two-dimensional array transducer；
Described transducer fixed frame is for being fixed on described support module by described two-dimensional array transducer.
Magnetic compatibility ultrasound stimulation system the most according to claim 4, it is characterised in that surpassing of described two-dimensional array transducer
Acoustic frequency is 0.2M to 5M, and described two-dimensional array transducer comprises multiple ultrasound wave array element, the plurality of ultrasound wave array element group
Become the globoidal structure consistent with the head-bent degree of animal to be treated.
Magnetic compatibility ultrasound stimulation system the most according to claim 4, it is characterised in that described magnetic resonance coil module comprises
Coil unit and amplifier unit；
Described coil unit comprises magnetic resonance coil, coil upper cover and coil lower cover；
Wherein said magnetic resonance coil is used for exporting radiofrequency signal；Described coil upper cover and described coil lower cover are used for combining protection
Described magnetic resonance coil；
Described amplifier unit comprises amplifier and amplifier lid；
Wherein said amplifier is used for amplifying described radiofrequency signal；Described amplifier lid is used for protecting described amplifier.
Magnetic compatibility ultrasound stimulation system the most according to claim 6, it is characterised in that described transducer fixed frame is with described
Coil lower cover is fixing to be connected, and described amplifier is connected by rotary shaft under described coil, described transducer socket and described
Hold mode block is fixing to be connected.
Magnetic compatibility ultrasound stimulation system the most according to claim 1, it is characterised in that described support module comprises body limit
Position module, the spacing module of cervical region, the spacing module of ear and the spacing module of face；
The spacing module of described body is used for limiting animal body action to be treated；
The spacing module of described cervical region is used for limiting animal neck to be treated and rocks；
The spacing module of described ear is used for limiting animal head to be treated and rocks；
The spacing module of described face, for against animal head to be treated, limits animal head action to be treated.
Magnetic compatibility ultrasound stimulation system the most according to claim 8, it is characterised in that the spacing module of described body comprises the end
Seat, at least two support crossbeam and at least four bracing frame；
Support frame as described above one end is vertical with described base to be connected, and described support crossbeam is vertical with the support frame as described above other end to be connected；
Be respectively arranged with lacing hole on described base and described support crossbeam, the spacing module of described body by described lacing hole with
Animal to be treated is fixed on described support crossbeam by rope；
Described base is additionally provided with balance adjustment screws, and described balance adjustment screws is used for regulating the spacing module balancing of described body.
Magnetic compatibility ultrasound stimulation system the most according to claim 9, it is characterised in that the spacing module of described cervical region comprises
Cervical region connector and cervical region locating part；
Described cervical region connector one end is vertical along described support crossbeam parallel direction and is movably installed on described base；
Described cervical region locating part comprises upper semi-circle position limiting structure and lower half circle position limiting structure, and described upper semi-circle position limiting structure is with described
The cervical region connector other end is fixing to be connected, and described lower half circle position limiting structure is flexibly connected with described upper semi-circle position limiting structure.
11. magnetic compatibility ultrasound stimulation systems according to claim 9, it is characterised in that the spacing module of described ear comprises
Ear acupuncture, ear acupuncture prop up bracer and ear acupuncture connector；
Described ear acupuncture connector is flexibly connected with described support crossbeam；Described ear acupuncture props up bracer and described ear acupuncture connector activity chain
Connecing, described ear acupuncture is fixed on described ear acupuncture and props up on bracer；
Wherein said ear acupuncture is used for inserting animal ear to be treated, moves left and right limiting animal head；
Described ear acupuncture props up bracer and is used for fixing described ear acupuncture and regulating described ear acupuncture position；
Described ear acupuncture connector is for providing described ear acupuncture to prop up bracer movable passageway on described support crossbeam.
12. magnetic compatibility ultrasound stimulation systems according to claim 9, it is characterised in that the spacing module of described face comprises
Tongue block, face support sheet and support unit；
Described support unit comprises support upper plate, supports back plate and two pieces of support side plate；
Described tongue block is parallel to the outer surface of described support upper plate and arranges, and is used for inserting in animal oral cavity to be treated, limits and wait to control
Treatment animal oral cavity moves；
Described face supports sheet and is movably arranged on described support upper plate, is used for limiting animal head and moves forward and backward；
Described support side plate is fixedly installed between described support crossbeam and described base；Described support back plate is propped up with two pieces respectively
Support side plate is connected with described support crossbeam；Described support upper plate is arranged between described support side plate and described support back plate, and
It is flexibly connected with described support side plate and described support back plate.
13. according to the magnetic compatibility ultrasound stimulation system described in any one in claim 1 to 12, it is characterised in that described
Support module to be made up of bakelite or epoxy resin or polysulfones.
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