CN106039599A - Prediction method for organs at risk average dosage in intensity modulated radiation therapy and application thereof - Google Patents
Prediction method for organs at risk average dosage in intensity modulated radiation therapy and application thereof Download PDFInfo
- Publication number
- CN106039599A CN106039599A CN201610527428.0A CN201610527428A CN106039599A CN 106039599 A CN106039599 A CN 106039599A CN 201610527428 A CN201610527428 A CN 201610527428A CN 106039599 A CN106039599 A CN 106039599A
- Authority
- CN
- China
- Prior art keywords
- organ
- dmx
- vox
- volume
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
- A61N5/1031—Treatment planning systems using a specific method of dose optimization
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
The invention discloses a prediction method for organs at risk average dosage in an intensity modulated radiation therapy. The prediction method comprises the following steps of 1), obtaining a functional relation formula between Vox/Vx and Dmx/Dp, wherein Vx is organs at risk volume, Vox is crossed volume between the organs at risk and planning target volume, Dp is prescribed dose, and Dmx is organs at risk average dose; and 2), predicting the organs at risk average dosage through the functional relation formula. The application of the prediction method particularly comprises the following steps of A), determining Dp; B), according to the functional relation formula between Vox/Vx and Dmx/Dp in the prediction method, obtaining the organs at risk average dosage Dmx1; C), performing simulated intensity modulation optimization, thereby obtaining an average dosage Dmx2; D), comparing Dma1 with Dmx2; and E), when Dmx2<=Dmx1, determining a fact that the organs at risk average dosage reaches the standard; and when Dmx2>Dmx1, continuing intensity modulation optimization. The prediction method has advantages of easy data acquisition, convenient establishment for an organs-at-risk prediction model which is suitable for corresponding department treatment plan systems and equipment, and effective reduction of influence caused by subjective factors in a plan optimization process.
Description
Technical field
The present invention relates to medical radiotherapy technical field, specifically refer to intensity modulated radiation therapy jeopardizes the pre-of organ mean dose
Survey method and the concrete application of this Forecasting Methodology.
Background technology
At present, the topmost treatment means of malignant tumor includes that the treatment of surgical operation therapy, chemical classes and radiation class are controlled
Treat, especially to middle and terminal cancer patient, radiation class treatment proportion bigger；And in radiation class treatment means, nearly 20
Year domestic and international application most commonly used one Therapeutic Method is intensity modulated radiation therapy.
Intensity modulated radiation therapy i.e. strength regulated shape-adapted radiation therapeutic is the one of three dimensional conformal radiation therapy, it is desirable in radiation field size, dose intensity is pressed
Certain requirement is adjusted, and is called for short intensity modulated radiation therapy.It is under conditions of radiation field size is consistent with target area profile throughout, for target area
Beam intensity is adjusted by 3D shape and critical organ with the concrete anatomy relationship of target area, and in single radiation field size, dose distribution is
In uneven still whole Gross Target Volume, dose distribution is treated evenly than three-dimensional conformal.
Through clinical practice for many years, lot of documents report result display intensity modulated radiation therapy technology not only increases the treatment of patient
Effect, and effectively improve the quality of life after patient treatment.Make target dose height as far as possible, jeopardize organ dose the lowest,
It it is the cardinal principle of radiotherapy.But actual adjust strong optimization during, affected, greatly by optimization method, means and the factor such as artificial
Although most radiotherapy center jeopardize organ and control in the range of limiting, but owing to lacking effective predicting means, jeopardize organ
Final absorbed dose rely more heavily on the experience of each radiotherapy center, and therefore subjective factors optimizes process very to radiotherapy planning
Greatly.
Existing Forecasting Methodology, is by extracting the dosage information jeopardizing each sampled point of organ in treatment plan, sets up
The forecast model of intensity modulated radiation therapy, crosses the prediction before making intensity modulated radiation therapy planning premise of this model and jeopardizes the dose volume song of organ
Line, to ensure to adjust the quality of strong plan, but this Forecasting Methodology is complex, requires higher to related equipment, puts by force adjusting
Treatment plan is difficult to obtain the most concrete application in making.
Summary of the invention
It is an object of the invention to provide one and be prone to gather data, convenient foundation is suitable for corresponding section office treatment planning systems
With equipment jeopardize organ forecast model, reduce in the intensity modulated radiation therapy that subjective factors during radiotherapy planning optimization impacts and endanger
And the Forecasting Methodology of organ mean dose.
Further object is that the concrete application that this Forecasting Methodology is provided.
The present invention is achieved through the following technical solutions: jeopardize the Forecasting Methodology of organ mean dose in intensity modulated radiation therapy, including
Following steps:
(1) obtain the functional relationship formula between Vox/Vx and Dmx/Dp, wherein, Vx be jeopardize the volume of organ, Vox is
Jeopardize organ and plan field intersect volume, Dp is prescribed dose, Dmx is the mean dose jeopardizing organ；
(2) the volume Vx that jeopardizes organ known, jeopardize organ and plan field intersect volume Vox and place's prescription
In the case of amount Dp, jeopardized the mean dose Dmx of organ by the functional relationship formula predictions between Vox/Vx and Dmx/Dp.
The operation principle of this Forecasting Methodology is, finds to jeopardize the organ phase with plan field by the research of a large amount of clinical datas
Volume Vox and jeopardizing is handed over to also exist between the ratio of organ mass Vx and its mean dose Dmx and prescribed dose D p ratio notable
Positive correlation.
This Forecasting Methodology simulates when not losing target area prescribed dose Dp respectively, difference jeopardize organ Vox/Vx and
Functional relationship formula between Dmx/Dp.By calculating Vox/Vx under conditions of given prescribed dose D p, just can be daily excellent
Chemoradiotherapy calculates difference by the functional relationship formula between Vox/Vx and Dmx/Dp before adjusting strong plan and jeopardizes the average of organ
Dosage Dmx, the standard checked and accepted as the strong plan of tune using this mean dose Dmx jeopardizing organ, thus reduce radiotherapy planning optimization
During the impact that causes of subjective factors.
For the method that the present invention is better achieved, further, in described step (1), it is thus achieved that Vox/Vx and Dmx/Dp
Between the method for functional relationship formula comprise the following steps:
(2.1) with the case history of least one set tumor patient as template, the case history of same group of tumor patient all shows same class
Type tumor；
(2.2) the same volume Vx data jeopardizing organ in the case history of same group of tumor patient are collected；And same group swell
What in the case history of tumor patient, this jeopardized organ and plan field intersects volume Vox data；
(2.3) according to intensity modulated radiation therapy plan, it is thus achieved that the mean dose Dmx in every part of case history and the data of prescribed dose D p；
(2.4) building rectangular coordinate system, with the data of Vox/Vx as abscissa, the data of Dmx/Dp are vertical coordinate, with often
Based on data in part case history, mark coordinate points in a coordinate system, it is thus achieved that the discrete point diagram of all patient datas；
(2.5) carry out the matching of equation according to each discrete point, i.e. obtain the functional relationship between Vox/Vx and Dmx/Dp public
Formula.
For the method that the present invention is better achieved, further, in described step (2.2), in the case history of tumor patient
Jeopardize the volume Vx of organ, and the volume Vox that intersects jeopardizing organ and plan field is all to be entered by radiotherapy planning software
OK.
For the method that the present invention is better achieved, further, described radiotherapy planning software is Pinnacle, passes through
Pinnacle radiotherapy planning software obtains and jeopardizes the volume Vx of organ, and jeopardize organ and plan field intersect volume Vox
Detailed process comprise the following steps:
(2.2.1) cross-sectional image of patient's corresponding site is scanned by CT machine；
(2.2.2) by Pinnacle radiotherapy planning software sketch out on each CT cross-sectional image each jeopardize organ with
Plan field；
(2.2.3) Pinnacle radiotherapy planning software jeopardizes organ and plan field according to each sketched out, and automatically gives birth to
Become to jeopardize the 3-D view of organ and plan field, and directly calculate this volume size jeopardizing organ and plan field, i.e.
The volume Vx of organ must be jeopardized；
(2.2.4) last, created jeopardizing organ with the volume that intersects of plan field by Pinnacle radiotherapy planning software
Build a new organ, and calculate the size intersecting volume jeopardizing organ with plan field, organ and plan must be jeopardized
The crossing volume Vox of target area.
For the method that the present invention is better achieved, further, in described step (2.5), each discrete point is the most logical
Cross business mathematics software and carry out equation model.
For the method that the present invention is better achieved, further, described business mathematics software is matlab software, passes through
The process of the smoothed curve that each discrete point of matlab software matching is constituted, comprises the following steps:
(2.5.1) using the data of Vox/Vx as the data of abscissa x, Dmx/Dp as vertical coordinate y, matlab is soft in input
Part；
(2.5.2) select the fit type in matlab software, just can obtain different fit type by matlab software
Fitting formula；
(2.5.3) according to the relation between curve and each discrete point of fitting formula generation, select to overlap with discrete point
The equation of many curves is as the functional relationship formula between Vox/Vx and Dmx/Dp.
For the method that the present invention is better achieved, further, described VOX/VXAnd the functional relationship public affairs between Dmx/Dp
Formula is:
Y=p1*x3+p2*x2+p3*x+p4；
Wherein, p1、p2、p3、p4Difference for dissimilar tumor jeopardizes the weight coefficient parameter of organ；
Y=Dmx/Dp, x=Vox/Vx；
Vox tumor plan field with jeopardize organ intersect volume；
Vx jeopardizes organ mass；
Dmx jeopardizes the mean dose of organ；
The prescribed dose of Dp tumor plan field.
Above-mentioned intensity modulated radiation therapy jeopardizes the concrete application of organ mean dose Forecasting Methodology, comprises the following steps:
(A) given prescribed dose D p determined；
(B) the functional relationship formula between relevant Vox/Vx and Dmx/Dp jeopardizing organ is obtained by Forecasting Methodology, and
According to known prescribed dose D p, tumor plan field and jeopardize organ intersect volume Vox, jeopardize organ mass Vx, calculate
Obtain the relevant mean dose Dmx jeopardizing organ1；
(C) it is simulated adjusting strong optimization, optimizes and draw the relevant mean dose Dmx jeopardizing organ2；
(D) by Dmx1Dmx2Compare；
(E) Dmx is worked as2≤Dmx1Time, conformance with standard, then this simulation adjusts strong optimization up to standard；Work as Dmx2＞ Dmx1Time, then continue
It is simulated adjusting strong optimization, until conformance with standard.
The present invention compared with prior art, has the following advantages and beneficial effect:
(1) present invention is by finding the functional relationship formula between Vox/Vx and Dmx/Dp, it is possible to carrying out radiotherapy planning
Before, it was predicted that go out the mean dose of relevant crisis organ, the standard checked and accepted as the strong plan of tune using the mean dose of prediction, thus
The impact that during minimizing radiotherapy planning optimization, subjective factors causes；
(2) the inventive method is simple, and data are prone to gather, and most radiotherapy centers can be at existing treatment planning systems
On the basis of utilize the method to set up to be suitable for oneself section office's treatment planning systems and jeopardize the forecast model of organ, the most extensively pushing away
Wide application.
Accompanying drawing explanation
By the detailed description non-limiting example made with reference to the following drawings of reading, other features of the present invention,
Purpose and advantage will become apparent:
Fig. 1 be the crossing volume Voe and internal ear volume Ve of Middle inner ear of the present invention and tumor plan field ratio with interior
The mean dose Dme of ear and the scatterplot of prescribed dose D p ratio；
Fig. 2 is ratio and the oral cavity of the crossing volume Voo and oral cavity volume Vo of oral cavity and tumor plan field in the present invention
Mean dose Dmo and the scatterplot of prescribed dose D p ratio；
Fig. 3 is the ratio of the crossing volume Vop and Parotid volume Ve of the parotid gland and tumor plan field and and the cheek in the present invention
The mean dose Dme of gland and the scatterplot of prescribed dose D p ratio；
Fig. 4 be in the present invention ratio of the crossing volume Vol of glottis larynx and tumor plan field and glottis larynx volume Vl with
Mean dose Dml and the scatterplot of prescribed dose D p ratio with glottis larynx；
Fig. 5 is that in the present invention, the crossing volume Voph of postcricoid area pharynx and tumor plan field swallows volume Vph with postcricoid area
Ratio and the mean dose Dmph and the scatterplot of prescribed dose D p ratio with postcricoid area pharynx；
Fig. 6 be in the present invention ratio of the crossing volume Voes and esophagus volume Ves of esophagus and tumor plan field with
The mean dose Dmes of esophagus and the scatterplot of prescribed dose D p ratio；
Fig. 7 is the ratio of the crossing volume Vob and bladder volume Vb of bladder and tumor plan field and and wing in the present invention
The mean dose Dmb of Guang and the scatterplot of prescribed dose D p ratio；
Fig. 8 be in the present invention ratio of the crossing volume Vor and rectum volume Vr of rectum and tumor plan field with directly
The mean dose Dmr of intestinal and the scatterplot of prescribed dose D p ratio；
Fig. 9 is present invention flow chart when using.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention is not limited to this,
Without departing from the idea case in the present invention described above, according to ordinary skill knowledge and customary means, make various replacing
Change and change, all should be included within the scope of the invention.
Embodiment 1:
The present embodiment is chosen two groups of nasopharyngeal carcinoma and adjusts case history and the case history of cervical cancer patient of strong patient, often organize each 50 parts,
And select nasopharyngeal carcinoma to adjust the internal ear of strong patient, oral cavity, the parotid gland, glottis larynx, postcricoid area pharynx, six crisis organs of esophagus respectively, with
And the bladder of cervical cancer patient, two, rectum jeopardize organ as template.
First, collect the selected volume jeopardizing organ, and jeopardize organ and intersect the data of volume with plan field, have
It is as follows that body collects process:
The cross-sectional image of patient's corresponding site is scanned by CT machine；By the CT image transmitting that scans to Pinnacle
Radiotherapy planning software；Utilize and Pinnacle software delineates instrument, each CT cross-sectional image sketches out each and jeopardizes device
Official and plan field；Now Pinnacle software automatically generates by jeopardizing the two dimensional image of organ and plan field on transverse section
Certain jeopardizes the 3-D view of organ and plan field, clicks on Volume instrument, directly calculates this and jeopardize organ and plan field
Volume size；By the ROIExpansion/Contraction instrument in Pinnacle software, choosing plan field is
Source, the organ that jeopardizes studied is AvoidExterior, clicks on Expand, creates a new organ, and now this is new
Organ be exactly plan field and this jeopardizes the intersecting area of organ, then click on Volume instrument, calculate plan field with should
Jeopardize the volume size of organ intersecting area.
Secondly, analyze the intensity modulated therapy plan in case history, collect every part of medical record data, as follows:
A. from Nasopharyngeal Carcinoma Patients intensity modulated therapy draw the most respectively the crossing volume Voe of internal ear and tumor plan field with
The ratio of internal ear volume Ve and the mean dose Dme of internal ear and Dp ratio, and using the data of Vox/Vx as abscissa x, Dmx/
The data of Dp are as vertical coordinate y, with every patient medical record situation, build discrete point diagram, as shown in Figure 1；
B. from Nasopharyngeal Carcinoma Patients intensity modulated therapy the most respectively outlet plenum and tumor plan field crossing volume Voo with
The ratio of oral cavity volume Vo and the mean dose Dmo in oral cavity and Dp ratio, and using the data of Vox/Vx as abscissa x, Dmx/
The data of Dp are as vertical coordinate y, with every patient medical record situation, build discrete point diagram, as shown in Figure 2；
C. from Nasopharyngeal Carcinoma Patients intensity modulated therapy draw the most respectively the crossing volume Vop of the parotid gland and tumor plan field with
The mean dose Dmp of the ratio of Parotid volume Vp and the parotid gland and Dp ratio, and using the data of Vox/Vx as abscissa x, Dmx/
The data of Dp are as vertical coordinate y, with every patient medical record situation, build discrete point diagram, as shown in Figure 3；
D. the crossing volume Vol of glottis larynx and tumor plan field is drawn the most respectively from Nasopharyngeal Carcinoma Patients intensity modulated therapy
With the ratio of glottis larynx Vl and the mean dose Dml of glottis larynx and Dp ratio, and using the data of Vox/Vx as abscissa x,
The data of Dmx/Dp are as vertical coordinate y, with every patient medical record situation, build discrete point diagram, as shown in Figure 4；
E. postcricoid area pharynx and the crossing volume of tumor plan field are drawn the most respectively from Nasopharyngeal Carcinoma Patients intensity modulated therapy
Voph and the ratio of postcricoid area pharynx volume Vph and the mean dose Dmph of postcricoid area pharynx and Dp ratio, and with the data of Vox/Vx
As the data of abscissa x, Dmx/Dp as vertical coordinate y, with every patient medical record situation, build discrete point diagram, such as Fig. 5 institute
Show；
F. the crossing volume Voes of esophagus and tumor plan field is drawn the most respectively from Nasopharyngeal Carcinoma Patients intensity modulated therapy
With the ratio of esophagus volume Ves and the mean dose Dmes of esophagus and Dp ratio, and using the data of Vox/Vx as abscissa x,
The data of Dmx/Dp are as vertical coordinate y, with every patient medical record situation, build discrete point diagram, as shown in Figure 6；
G. from cervical cancer patient intensity modulated therapy draw the most respectively the crossing volume Vob of bladder and tumor plan field with
The ratio of bladder volume Vb and the mean dose Dmb of bladder and Dp ratio, and using the data of Vox/Vx as abscissa x, Dmx/
The data of Dp are as vertical coordinate y, with every patient medical record situation, build discrete point diagram, as shown in Figure 7；
H. from cervical cancer patient intensity modulated therapy draw the most respectively the crossing volume Vor of rectum and tumor plan field with
The ratio of rectum volume Vr and the mean dose Dmr of rectum and Dp ratio, and using the data of Vox/Vx as abscissa x, Dmx/
The data of Dp are as vertical coordinate y, with every patient medical record situation, build discrete point diagram, as shown in Figure 8.
Again, constitute data according to a～g, and shown in Fig. 1～Fig. 8, set up the tables of data of Vox/Vx, Dmx/Dp, such as table
Shown in 1.
Table 1VOX/VX, the tables of data of Dmx/Dp
| y | x |
| Dme/Dp | Voe/Ve |
| Dmo/Dp | Voo/Vo |
| Dmp/Dp | Vop/Vp |
| Dml/Dp | Vol/Vl |
| Dmph/Dp | Voph/Vph |
| Dmes/Dp | Voes/Ves |
| Dmb/Dp | Vob/Vb |
| Dmr/Dp | Vor/Vr |
The concrete value of y and x is inputted matlab software, click on the Start → Toolboxes in matlab software →
Curve Fitting → Curve Fitting Tool (cftool) → Data → X Data selects step 1) the x value that inputs,
Y Data selects step 1) the y value that inputs, Weights chooses (none) → arrange x, y data → click Fitting → choose
Fit type (linear fit, fitting of a polynomial, Power matching etc.) → click Apply, just can draw the plan of different fit type
Close formula.
Finally, repeatedly use different formulas to be fitted Fig. 1～Fig. 8 data by matlab software, finally use system
The 3 order polynomial formula of one, draw following fitting formula:
Y=p1*x3+p2*x2+p3*x+p4；
Wherein, p1、p2、p3、p4Difference for dissimilar tumor jeopardizes the weight coefficient parameter of organ；
Y=Dmx/Dp, x=Vox/Vx；
Vox tumor plan field with jeopardize organ intersect volume；
Vx jeopardizes organ mass；
Dmx jeopardizes the mean dose of organ；
The prescribed dose of Dp tumor plan field.
p1、p2、p3、p4Weight coefficient parameter list, as shown in table 2:
Table 2 weight coefficient parameter list
As seen in Table 2, by Nasopharyngeal Carcinoma Patients jeopardize organ internal ear as a example by, and the letter between Vox/Vx and Dmx/Dp
Number relation formula is:
Y=2.391x3-3.649x2+2.051x+0.5207；
When the patient suffering from nasopharyngeal carcinoma is carried out intensity modulated radiation therapy plan it is, according to patient internal ear volume Ve, internal ear and plan
Intersect volume Voe in target area, and prescribed dose D p of given plan field, just can jeopardize device by what above formula drew Nasopharyngeal Carcinoma Patients
The mean dose Dme of official's internal ear, the mean dose Dme of this internal ear are the mean dose jeopardizing organ of prediction.
The method is all used to find respective Vox/Vx with respective for remaining different types of tumor and the neighbouring organ that jeopardizes
Functional relationship formula between Dmx/Dp, and the mean dose Dmx of organ is jeopardized accordingly by this functional relationship formula predictions.
Embodiment 2:
Based on the present embodiment jeopardizes organ mean dose Forecasting Methodology in the intensity modulated radiation therapy described in above-described embodiment, carry
Supply the concrete application process of this Forecasting Methodology, it was predicted that gained is correlated with the draw dosage jeopardizing organ as the examination adjusting strong plan
Standard, adjusts the mean dose of strong calculated optimization gained no more than prediction averaging of income dosage, therefore reduces radiotherapy planning
The impact that during optimization, subjective factors causes.
Concrete steps are as it is shown in figure 9, comprise the following steps:
(A) given prescribed dose D p determined；
(B) the functional relationship formula between relevant Vox/Vx and Dmx/Dp jeopardizing organ is obtained by Forecasting Methodology, and
According to known prescribed dose D p, tumor plan field and jeopardize organ intersect volume Vox, jeopardize organ mass Vx, calculate
Obtain the relevant mean dose Dmx1 jeopardizing organ；
(C) it is simulated adjusting strong optimization, optimizes and draw the relevant mean dose Dmx2 jeopardizing organ；
(D) Dmx1's and Dmx2 are compared；
(E) as Dmx2≤Dmx1, conformance with standard, then this simulation adjusts strong optimization up to standard, if during Dmx2 ＞ Dmx1, then continued
Continuous simulation adjusts strong optimization, until conformance with standard.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that: not
Depart from and these embodiments can be carried out multiple change under the principle of the present invention and objective, revise, replace and modification, the present invention's
Scope is limited by claim and equivalent thereof.
Claims (8)
1. intensity modulated radiation therapy jeopardizes the Forecasting Methodology of organ mean dose, it is characterised in that comprise the following steps:
(1) obtaining the functional relationship formula between Vox/Vx and Dmx/Dp, wherein, Vx is to jeopardize the volume of organ, Vox for jeopardizing
Organ and plan field intersect volume, Dp is prescribed dose, Dmx is the mean dose jeopardizing organ；
(2) at the known volume V jeopardizing organX, jeopardize organ and plan field intersect volume VOX, and prescribed dose D p
In the case of, the mean dose Dmx of organ is jeopardized by the functional relationship formula predictions between Vox/Vx and Dmx/Dp.
Intensity modulated radiation therapy the most according to claim 1 jeopardizes the Forecasting Methodology of organ mean dose, it is characterised in that described
In step (1), it is thus achieved that the method for the functional relationship formula between Vox/Vx and Dmx/Dp comprises the following steps:
(2.1) with the case history of least one set tumor patient as template, the case history of same group of tumor patient all shows that same type swells
Tumor；
(2.2) the same volume Vx data jeopardizing organ in the case history of same group of tumor patient are collected；And same group of tumor trouble
What in the case history of person, this jeopardized organ and plan field intersects volume Vox data；
(2.3) according to intensity modulated radiation therapy plan, it is thus achieved that the mean dose Dmx in every part of case history and the data of prescribed dose D p；
(2.4) building rectangular coordinate system, with the data of Vox/Vx as abscissa, the data of Dmx/Dp are vertical coordinate, with every part of disease
Based on the data gone through, mark coordinate points in a coordinate system, it is thus achieved that the discrete point diagram of all patient datas；
(2.5) carry out the matching of equation according to each discrete point, i.e. obtain the functional relationship formula between Vox/Vx and Dmx/Dp.
Intensity modulated radiation therapy the most according to claim 2 jeopardizes the Forecasting Methodology of organ mean dose, it is characterised in that described
In step (2.2), the case history of tumor patient jeopardizes the volume Vx of organ, and jeopardize organ and plan field intersect volume
Vox is all to be carried out by radiotherapy planning software.
Intensity modulated radiation therapy the most according to claim 3 jeopardizes the Forecasting Methodology of organ mean dose, it is characterised in that described
Radiotherapy planning software is Pinnacle, is obtained the volume Vx jeopardizing organ by Pinnacle radiotherapy planning software, and jeopardizes
Organ comprises the following steps with the detailed process intersecting volume Vox of plan field:
(2.2.1) cross-sectional image of patient's corresponding site is scanned by CT machine；
(2.2.2) on each CT cross-sectional image, sketch out each by Pinnacle radiotherapy planning software and jeopardize organ and plan
Target area；
(2.2.3) Pinnacle radiotherapy planning software jeopardizes organ and plan field according to each sketched out, and automatically generates danger
And the 3-D view of organ and plan field, and directly calculate this volume size jeopardizing organ and plan field, obtain danger
And the volume Vx of organ；
(2.2.4) last, create one by jeopardizing organ with the volume that intersects of plan field by Pinnacle radiotherapy planning software
Individual new organ, and calculate the size intersecting volume jeopardizing organ with plan field, organ and plan field must be jeopardized
Crossing volume Vox.
5. according to the intensity modulated radiation therapy described in any one of claim 2～4 jeopardizes the Forecasting Methodology of organ mean dose, its feature
Being, in described step (2.5), each discrete point mainly carries out equation model by business mathematics software.
Intensity modulated radiation therapy the most according to claim 5 jeopardizes the Forecasting Methodology of organ mean dose, it is characterised in that described
Business mathematics software is matlab software, the process of smoothed curve consisted of the matlab each discrete point of software matching, including
Following steps:
(2.5.1) using the data of Vox/Vx as the data of abscissa x, Dmx/Dp as vertical coordinate y, input matlab software；
(2.5.2) select the fit type in matlab software, i.e. obtained the matching of different fit type by matlab software
Formula；
(2.5.3) according to the relation between curve and each discrete point of fitting formula generation, selection overlaps most with discrete point
The equation of curve is as the functional relationship formula between Vox/Vx and Dmx/Dp.
Intensity modulated radiation therapy the most according to claim 6 jeopardizes the Forecasting Methodology of organ mean dose, it is characterised in that described
Functional relationship formula between Vox/Vx and Dmx/Dp is:
Y=p1*x3+p2*x2+p3*x+p4；
Wherein, p1、p2、p3、p4Difference for dissimilar tumor jeopardizes the weight coefficient parameter of organ；
Y=Dmx/Dp, x=Vox/Vx；
Vox tumor plan field with jeopardize organ intersect volume；
Vx jeopardizes organ mass；
Dmx mean dose；
Dp prescribed dose.
8., according to jeopardizing the application of organ mean dose Forecasting Methodology in the intensity modulated radiation therapy described in the claims, its feature exists
In, comprise the following steps:
(A) given prescribed dose D p determined；
(B) the functional relationship formula between Vox/Vx and Dmx/Dp jeopardizing organ that be correlated with is obtained by Forecasting Methodology, and according to
Known prescribed dose D p, tumor plan field and jeopardize organ intersect volume Vox, jeopardize organ mass Vx, calculate and obtain
The relevant mean dose Dmx jeopardizing organ1；
(C) it is simulated adjusting strong optimization, optimizes and draw the relevant mean dose Dmx jeopardizing organ2；
(D) by Dmx1And Dmx2Compare；
(E) Dmx is worked as2≤Dmx1Time, conformance with standard, then this simulation adjusts strong optimization up to standard；Work as Dmx2＞ Dmx1Time, then proceed mould
Intend adjusting strong optimization, until conformance with standard.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610527428.0A CN106039599A (en) | 2016-07-05 | 2016-07-05 | Prediction method for organs at risk average dosage in intensity modulated radiation therapy and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610527428.0A CN106039599A (en) | 2016-07-05 | 2016-07-05 | Prediction method for organs at risk average dosage in intensity modulated radiation therapy and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106039599A true CN106039599A (en) | 2016-10-26 |
Family
ID=57201131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610527428.0A Pending CN106039599A (en) | 2016-07-05 | 2016-07-05 | Prediction method for organs at risk average dosage in intensity modulated radiation therapy and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106039599A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108364678A (en) * | 2018-02-10 | 2018-08-03 | 福建省肿瘤医院（福建省肿瘤研究所、福建省癌症防治中心） | A kind of nasopharyngeal carcinoma radiotherapy plan the Automation Design method based on machine learning |
| CN108899093A (en) * | 2018-05-11 | 2018-11-27 | 南方医科大学 | Intensity modulated radiation therapy intended dose indication item prediction technique based on intelligence learning |
| CN111863203A (en) * | 2020-07-20 | 2020-10-30 | 上海联影医疗科技有限公司 | Method, device, equipment and storage medium for classifying radiotherapy data |
| CN113440153A (en) * | 2020-03-25 | 2021-09-28 | 西门子医疗有限公司 | Method and device for controlling a medical device |
| CN113633897A (en) * | 2021-07-05 | 2021-11-12 | 四川大学华西医院 | Method for setting tolerance limit value of monitoring intensity modulated radiotherapy dose verification process |
| CN113679962A (en) * | 2021-08-25 | 2021-11-23 | 上海联影医疗科技股份有限公司 | System for optimizing dose line conformality |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101422640A (en) * | 2008-11-25 | 2009-05-06 | 中国科学院等离子体物理研究所 | Multiple-objective optimization method and system capable of optimizing radiotherapy beam intensity distribution |
| CN102184330A (en) * | 2011-05-09 | 2011-09-14 | 周寅 | Image feature and smart regressive model-based method for optimizing intensity modulated radiotherapy plan |
-
2016
- 2016-07-05 CN CN201610527428.0A patent/CN106039599A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101422640A (en) * | 2008-11-25 | 2009-05-06 | 中国科学院等离子体物理研究所 | Multiple-objective optimization method and system capable of optimizing radiotherapy beam intensity distribution |
| CN102184330A (en) * | 2011-05-09 | 2011-09-14 | 周寅 | Image feature and smart regressive model-based method for optimizing intensity modulated radiotherapy plan |
Non-Patent Citations (1)
| Title |
|---|
| 庞皓文等: "《宫颈癌根治性调强放疗器件膀胱直肠体积与其吸收剂量的关系》", 《肿瘤防治研究》 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108364678A (en) * | 2018-02-10 | 2018-08-03 | 福建省肿瘤医院（福建省肿瘤研究所、福建省癌症防治中心） | A kind of nasopharyngeal carcinoma radiotherapy plan the Automation Design method based on machine learning |
| CN108364678B (en) * | 2018-02-10 | 2022-02-01 | 福建省肿瘤医院（福建省肿瘤研究所、福建省癌症防治中心） | Nasopharyngeal carcinoma radiotherapy plan automatic design method based on machine learning |
| CN108899093A (en) * | 2018-05-11 | 2018-11-27 | 南方医科大学 | Intensity modulated radiation therapy intended dose indication item prediction technique based on intelligence learning |
| CN113440153A (en) * | 2020-03-25 | 2021-09-28 | 西门子医疗有限公司 | Method and device for controlling a medical device |
| CN111863203A (en) * | 2020-07-20 | 2020-10-30 | 上海联影医疗科技有限公司 | Method, device, equipment and storage medium for classifying radiotherapy data |
| CN113633897A (en) * | 2021-07-05 | 2021-11-12 | 四川大学华西医院 | Method for setting tolerance limit value of monitoring intensity modulated radiotherapy dose verification process |
| CN113633897B (en) * | 2021-07-05 | 2023-05-23 | 四川大学华西医院 | Method for setting tolerance limit value of monitoring intensity modulated radiation therapy dose verification process |
| CN113679962A (en) * | 2021-08-25 | 2021-11-23 | 上海联影医疗科技股份有限公司 | System for optimizing dose line conformality |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106039599A (en) | Prediction method for organs at risk average dosage in intensity modulated radiation therapy and application thereof | |
| CN107441637B (en) | Intensity modulated radiation therapy 3-dimensional dose is distributed in the works prediction technique and its application | |
| CN102306239B (en) | Method for evaluating and optimizing radiotherapy dose based on cone beam CT (Computer Tomography) image CT value correction technology | |
| Seddon et al. | Target volume definition in conformal radiotherapy for prostate cancer: quality assurance in the MRC RT-01 trial | |
| Nassef et al. | Quantification of dose uncertainties in cumulated dose estimation compared to planned dose in prostate IMRT | |
| US10076673B2 (en) | Interactive dose gradient based optimization technique to control IMRT delivery complexity | |
| CN112546463B (en) | Radiotherapy dose automatic prediction method based on deep neural network | |
| CN110124214A (en) | Intensity modulated radiation therapy plan optimization method and application based on predicted dose distribution guidance | |
| CN114681813A (en) | Automatic planning system, automatic planning method and computer program product for radiation therapy | |
| JP7076380B2 (en) | Robust Broadbeam Optimization for Proton Treatment | |
| WO2009118020A1 (en) | 3d medical image segmentation | |
| CN106169028B (en) | System for constructing prediction of absorption dose of organs at risk in intensity modulated radiotherapy | |
| CN104636618B (en) | Radiotherapy planning system | |
| CN110349665A (en) | Carcinoma of the rectum radiotherapy planning the Automation Design method based on deep learning | |
| CN107480445A (en) | Method for calculating probability is invaded in clinical tumor target area based on hidden Markov model | |
| Baron et al. | Estimation of daily interfractional larynx residual setup error after isocentric alignment for head and neck radiotherapy: quality assurance implications for target volume and organs‐at‐risk margination using daily CT on‐rails imaging | |
| CN110706779B (en) | Automatic generation method of accurate target function of radiotherapy plan | |
| CN105477789A (en) | Dynamic intensity-modulated radiotherapy method based on quadratic programming model suppressing total beam-out time | |
| CN116570848B (en) | Radiotherapy clinical auxiliary decision-making system based on automatic sketching | |
| US10835759B2 (en) | Methods, apparatuses, and systems for creating a patient-specific soft bolus for radiotherapy treatment | |
| CN112635023B (en) | Method for generating dose prediction model of nasopharyngeal carcinoma, dose prediction method and device | |
| Wang et al. | An individualized strategy to estimate the effect of deformable registration uncertainty on accumulated dose in the upper abdomen | |
| CN107437249A (en) | The automatic delineation method in primary lesion of nasopharyngeal carcinoma clinic target area based on GrowCut | |
| CN112635024A (en) | Automatic planning and designing system for radiotherapy and construction method thereof | |
| Simon et al. | Is Dose Deformation–Invariance Hypothesis Verified in Prostate IGRT? |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161026 |