CN106038593A - Potassium permanganate tablets for external use and production process thereof - Google Patents

Potassium permanganate tablets for external use and production process thereof Download PDF

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Publication number
CN106038593A
CN106038593A CN201610606624.7A CN201610606624A CN106038593A CN 106038593 A CN106038593 A CN 106038593A CN 201610606624 A CN201610606624 A CN 201610606624A CN 106038593 A CN106038593 A CN 106038593A
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Prior art keywords
potassium permanganate
external sheet
production technology
tablet
tablets
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CN201610606624.7A
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Chinese (zh)
Inventor
米金国
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Ji'nan Kangfusheng Pharmaceutical Co Ltd
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Ji'nan Kangfusheng Pharmaceutical Co Ltd
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Priority to CN201610606624.7A priority Critical patent/CN106038593A/en
Publication of CN106038593A publication Critical patent/CN106038593A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/32Manganese; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Inorganic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention provides potassium permanganate tablets for external use and a production process thereof. The production process comprises the following steps: treating raw materials, granulating, tabletting, packaging, checking and storing in a warehouse. The potassium permanganate tablets for external use and the production process thereof have the following beneficial effects that potassium permanganate raw materials are treated to obtain higher purity, and the purity of the prepared potassium permanganate tablets for external use is also improved; according to the production process of the potassium permanganate tablets for external use, the raw materials and auxiliary materials are sufficiently mixed, then grains are prepared in certain moisture content, and the bonding force of the raw materials and the auxiliary materials is increased, so that the molding rate is improved and fragments are reduced, wherein the molding rate can be improved by 30 percent or more; the production efficiency of potassium permanganate is improved, and abrasion caused by the fact that the fragments are repeatedly prepared by a machine is reduced, so that the service life of the machine is prolonged and the production cost is reduced.

Description

A kind of potassium permanganate external sheet and production technology thereof
Technical field
The present invention relates to the production method of a kind of disinfectant, more specifically, refer to a kind of potassium permanganate external sheet And production technology.
Background technology
Potassium permanganate is a kind of inorganic compound, and for reddish violet, granular or acicular crystal, has metallic luster.
Potassium permanganate external sheet, for black purple tablet.Potassium permanganate external sheet is strong oxidizer, to various antibacterials, fungus Killing action is had Deng pathogenic microorganism.For acute dermatitis or the soak of acute eczema, clean burst skin ulcer and hemorrhoid demibain.Also May be used for the urinary tract infection etc. of women.Women uses the potassium permanganate should be prudent, preferably uses under doctor instructs, and not one Find pudendum or vagina inflammation, use potassium permanganate solution demibain the most at once, but should make a definite diagnosis and belong to which type of vagina Scorching.Additionally, also do not want life-time service potassium permanganate, in order to avoid the Flora Disturbance in vagina.Use potassium permanganate it shall yet further be noted that due to The speed that potassium permanganate releases oxygen is slow, and soak time must reach 5 minutes just to kill antibacterial.
Some women thinks that potassium permanganate sterilization is strong, is just often used in cleaning pudendum.In fact, do so is to strong Health is the most unfavorable.Under normal circumstances, the bacterium vaginae the most useful to people of surviving in woman vagina, can be by thin for intravaginal epidermis In born of the same parents, the glycogenolysis of storage becomes lactic acid, and to keep intravaginal acidity, it is numerous in road the moon that formation is prevented from pathogenic bacterium together The natural cover for defense grown.If commonly used potassium permanganate washing vagina, substantial amounts of bacterium vaginae can be made to be killed.Lactic acid is raw therewith Becoming to reduce, intravaginal sour environment is also the most destroyed, and various pathogenic bacterium will be taken advantage of a weak point, and at intravaginal amount reproduction, draws Play multiple gynecological illness.Especially after postmenopausal women, due to hypo-ovaria, vaginal mucosa is thinning, bacterium vaginae phase To minimizing, abuse potassium permanganate is easier to induction senile vaginitis.
Potassium permanganate external sheet is more suitable for acute dermatitis or acute eczema, particularly accompanies the soak of secondary infection, cleans Little area ulcer.When acute dermatitis and acute eczema, prepared before use becomes 1:4000 solution (take 1 and add water 400 milliliters), After Disinfectant absorbent cotton or gauze moistening, spread on affected part, when transudate is many, directly affected part can be immersed solution Chinese herb bath.For cleaning During little area ulcer, prepared before use becomes 1:1000 solution (take 1 and add water 100 milliliters), after dipping with Disinfectant absorbent cotton or cotton swab Clean.
The pathogenic microorganism such as various antibacterials, fungus are had killing action to make it apply very because of it by potassium permanganate external sheet Extensively.But the preparation method of potassium permanganate external sheet is at present: after potassium permanganate solid material mixes with various solid adjuvant materials Directly pelletizing, the external sheet that the method produces is frangible, and ratio of briquetting is low, so that the cost producing potassium permanganate external sheet is high, Production efficiency is low.
Summary of the invention
In view of the problems referred to above present in existing method, present invention is primarily targeted at a kind of potassium permanganate external of offer Sheet and production technology thereof, can improve the ratio of briquetting of potassium permanganate external sheet by this production technology, reduces its production cost, carries Its production efficiency high.
In order to reach above-mentioned purpose, the present invention provides the production technology of a kind of potassium permanganate external sheet, including walking as follows Rapid:
The process of S1: raw material:
A1: the ratio being (1:20)~(1:14) with the volume ratio of the quality of potassium permanganate with distilled water by raw material potassium permanganate Example is completely dissolved in this distilled water, is sufficiently stirred for, and makes potassium permanganate be completely dissolved to form solution;
B1: be centrifuged by the solution obtained in step A1,8000rpm, 10min, removes insoluble matter, obtains potassium permanganate Solution;
C1: the potassium permanganate solution obtained in step B1 is dried until its water content drops to 2%~5%;
S2: pelletize:
A2, weigh various adjuvant, join it in step C1, be sufficiently mixed and be formed uniformly mixture;
B2, the mixture obtained in step A2 is sieved after put in granulator pelletize, obtain granule;
S3: tabletting: be placed in tablet machine by granule obtained above, regulates tablet weight, tabletting, obtains tablet;
S4: pack, check, put in storage.
According in one embodiment of the invention, the wherein quality of the described potassium permanganate in step A1 and distilled water Volume ratio be 1:16.
According in one embodiment of the invention, wherein the described potassium permanganate solution in step C1 be dried until its Water content drops to 3%.
According in one embodiment of the invention, wherein the adjuvant in step A2 includes boric acid and hydroxy propyl cellulose Element, described boric acid is 1:1 with the mass ratio of hydroxypropyl cellulose.
According in one embodiment of the invention, wherein the adjuvant in step A2 also includes quick-dissolving agent.
According to the quality in one embodiment of the invention, between described boric acid, hydroxypropyl cellulose and quick-dissolving agent Ratio is 2:2:1.
According in one embodiment of the invention, sieve described in wherein in step B2 the sieve into crossing 24 mesh.
According in one embodiment of the invention, wherein the described tablet weight in step S3 is 0.125g ± 7.5%.
According in one embodiment of the invention, wherein in the described tablet in step S3, the content of potassium permanganate is 0.1g ± 7.5%.
The present invention also provides for a kind of potassium permanganate external sheet prepared according to the production technology of above-mentioned potassium permanganate external sheet.
The method have the advantages that
1. potassium permanganate raw material is processed by the present invention so that it is purity is higher so that it is the potassium permanganate external made The purity of sheet also improves;
2. the production technology of the potassium permanganate external sheet that the present invention provides, after raw material and adjuvant being sufficiently mixed, one In fixed water content, it is prepared granule, adds the adhesion of raw material and adjuvant, thus improve its ratio of briquetting, decrease broken Sheet, ratio of briquetting therein can improve more than 30%;
3. the present invention improves the efficiency that potassium permanganate produces, and reduces the mill that machine brings because fragment repeats preparation Damage, extend machine service life, reduce production cost.
Detailed description of the invention
Below the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment It is a part of embodiment of the present invention rather than whole embodiments.The detailed description of embodiments of the invention presented below is also It is not intended to be limiting the scope of claimed invention, but is merely representative of the selected embodiment of the present invention.Based in the present invention Embodiment, the every other embodiment that this area commonsense method personnel are obtained under not making creative work premise, Broadly fall into the scope of protection of the invention.
The production technology of a kind of potassium permanganate external sheet, comprises the steps:
The process of S1: raw material:
A1: by raw material potassium permanganate with the quality of potassium permanganate and the volume ratio of distilled water as 1:14~20 ratio complete Soluble in water, preferred ratio is 1:16, is sufficiently stirred for, and makes potassium permanganate be completely dissolved formation solution;
B1: be centrifuged by the solution in step A1,8000rpm, 10min, removes insoluble matter, obtains potassium permanganate molten Liquid;
C1: being dried by potassium permanganate solution until its water content drops to 2%~5%, preferred water content is 3%;
S2: pelletize:
A2, weigh boric acid and hydroxypropyl cellulose, add it to, in step C1, be sufficiently mixed and be formed uniformly mixture;
B2, the mixture in step A2 is crossed 24 mesh sieves after put in granulator pelletize, obtain granule;
S3: tabletting: granule B is put tablet machine regulation tablet weight, tabletting, obtains tablet;
S4: pack, check, put in storage.
As the preferred embodiment of above-mentioned embodiment, wherein the adjuvant in step A2 also includes quick-dissolving agent, and quick-dissolving agent can For carrageenan or maltodextrin etc..Mass ratio between boric acid, hydroxypropyl cellulose and quick-dissolving agent is 2:2:1.
The potassium permanganate external sheet prepared by production technology according to above-mentioned potassium permanganate external sheet, the tablet weight of external sheet is 0.125g ± 7.5%.Wherein, in tablet, the content of potassium permanganate is 0.1g ± 7.5%.
Embodiment 1
The production technology of a kind of potassium permanganate external sheet, comprises the steps:
The process of S1: raw material:
A1: the ratio as 1:20 is completely dissolved in the quality of potassium permanganate and the volume ratio of distilled water by raw material potassium permanganate In water, it is sufficiently stirred for, makes potassium permanganate be completely dissolved formation solution;
B1: be centrifuged by the solution in step A1,8000rpm, 10min, removes insoluble matter, obtains potassium permanganate molten Liquid;
C1: potassium permanganate solution is dried until its water content drops to 5%;
S2: pelletize:
A2, weigh boric acid and hydroxypropyl cellulose according to the mass ratio of 1:1, add it in step C1, the most mixed Conjunction is formed uniformly mixture;
B2, the mixture in step A2 is crossed 24 mesh sieves after put in granulator pelletize, obtain granule;
S3: tabletting: granule step B2 obtained is placed in tabletting on tablet machine, obtains tablet;
S4: pack, check, put in storage.
Embodiment 2
The production technology of a kind of potassium permanganate external sheet, comprises the steps:
The process of S1: raw material:
A1: the ratio as 1:16 is completely dissolved in the quality of potassium permanganate and the volume ratio of distilled water by raw material potassium permanganate In water, it is sufficiently stirred for, makes potassium permanganate be completely dissolved formation solution;
B1: be centrifuged by the solution in step A1,8000rpm, 10min, removes insoluble matter, obtains potassium permanganate solution;
C1: potassium permanganate solution is dried until its water content drops to 3%;
S2: pelletize:
A2, weigh boric acid, hydroxypropyl cellulose and quick-dissolving agent according to the mass ratio of 2:2:1, add it to step C1 In, it is sufficiently mixed and is formed uniformly mixture;
B2, the mixture in step A2 is crossed 24 mesh sieves after put in granulator pelletize, obtain granule;
S3: tabletting: granule step B2 obtained is placed in tabletting machine, obtains tablet;
S4: pack, check, put in storage.
Embodiment 3
The production technology of a kind of potassium permanganate external sheet, comprises the steps:
The process of S1: raw material:
A1: the ratio as 1:14 is completely dissolved in the quality of potassium permanganate and the volume ratio of distilled water by raw material potassium permanganate In water, it is sufficiently stirred for, makes potassium permanganate be completely dissolved formation solution;
B1: be centrifuged by the solution in step A1,8000rpm, 10min, removes insoluble matter, obtains potassium permanganate solution;
C1: potassium permanganate solution is dried until its water content drops to 2%;
S2: pelletize:
A2, weigh boric acid, hydroxypropyl cellulose and quick-dissolving agent according to the mass ratio of 2:2:1, add it to step C1 In, it is sufficiently mixed and is formed uniformly mixture;
B2, the mixture in step A2 is crossed 24 mesh sieves after put in granulator pelletize, obtain granule;
S3: tabletting: granule step B2 obtained is placed in tabletting on tablet machine, obtains tablet;
S4: pack, check, put in storage.
Embodiment 4
The process of S1: raw material:
A1: the ratio as 1:16 is completely dissolved in the quality of potassium permanganate and the volume ratio of distilled water by raw material potassium permanganate In water, it is sufficiently stirred for, makes potassium permanganate be completely dissolved formation solution;
B1: be centrifuged by the solution in step A1,8000rpm, 10min, removes insoluble matter, obtains potassium permanganate solution;
C1: potassium permanganate solution is dried until its water content drops to 3%;
S2: pelletize:
A2, weigh boric acid and hydroxypropyl cellulose according to the mass ratio of 1:1, add it in step C1, the most mixed Conjunction is formed uniformly mixture;
B2, the mixture in step A2 is crossed 24 mesh sieves after put in granulator pelletize, obtain granule;
S3: tabletting: granule step B2 obtained is placed in tabletting on tablet machine, obtains tablet;
S4: pack, check, put in storage.
Embodiment 5
The process of S1: raw material:
A1: the ratio as 1:18 is completely dissolved in the quality of potassium permanganate and the volume ratio of distilled water by raw material potassium permanganate In water, it is sufficiently stirred for, makes potassium permanganate be completely dissolved formation solution;
B1: be centrifuged by the solution in step A1,8000rpm, 10min, removes insoluble matter, obtains potassium permanganate molten Liquid;
C1: potassium permanganate solution is dried until its water content drops to 4%;
S2: pelletize:
A2, weigh boric acid, hydroxypropyl cellulose and quick-dissolving agent according to the mass ratio of 2:2:1, add it to step C1 In, it is sufficiently mixed and is formed uniformly mixture;
B2, the mixture in step A2 is crossed 24 mesh sieves after put in granulator pelletize, obtain granule;
S3: tabletting: granule step B2 obtained is placed in tabletting on tablet machine, obtains tablet;
S4: pack, check, put in storage.
In embodiment 1-5, the tablet weight of finally prepd potassium permanganate external sheet is 0.125g ± 7.5%, wherein, effectively becomes The content dividing potassium permanganate is 0.1g ± 7.5%.The compression molding rate of potassium permanganate external sheet and the test of dissolution velocity
Wider with at present application: according to the final content of effective ingredient potassium permanganate in final tablet as 0.1g ± 7.5% weighs potassium permanganate raw material and adjuvant (boric acid is 1:1 with the mass ratio of hydroxypropyl cellulose), direct mistake after mix homogeneously 24 mesh sieves are pelletized, and tabletting, with the potassium permanganate external sheet of preparation for comparison, tests the Gao Meng that embodiment 1-5 in the present invention produces The compression molding rate of acid potassium external sheet and dissolution velocity thereof, all tests all use to be repeated several times and average and draw final Result.
1. the experimental result of potassium permanganate external sheet compression molding rate see table 1.
The experimental result of the potassium permanganate external sheet compression molding rate produced in table 1 embodiment of the present invention 1-5
Compression molding rate
Matched group 73.64%
Embodiment 1 98.52%
Embodiment 2 99.23%
Embodiment 3 98.74%
Embodiment 4 99.08%
Embodiment 5 98.57
From table 1 it follows that the compression molding rate of the potassium permanganate external sheet produced in embodiment of the present invention 1-5 all exists More than 98.5%.Compared with the control, ratio of briquetting at least improves more than 33.8%.Therefore, the present invention improves outside potassium permanganate With the ratio of briquetting of sheet, save technique, reduce cost.
It addition, the present invention can also increase the adhesion between raw material potassium permanganate and adjuvant so that tablet weight is easier to control System, reduces the error of each tablet weight.
2. potassium permanganate external sheet rate of dissolution: use the warm water of equivalent isothermal to dissolve in matched group and the present invention and implement The potassium permanganate external sheet that example 1-5 provides, records each potassium permanganate external sheet and is completely dissolved required time record.Gao Meng The experimental result of acid potassium external sheet rate of dissolution see table 2.
The experimental result of the potassium permanganate external sheet rate of dissolution produced in table 2 embodiment of the present invention 1-5
Matched group 9 points 38 seconds
Embodiment 1 9 points 37 seconds
Embodiment 2 9 points 26 seconds
Embodiment 3 5 points 44 seconds
Embodiment 4 5 points 28 seconds
Embodiment 5 9 points 35 seconds
From Table 2, it can be seen that after addition quick-dissolving agent, the rate of dissolution of potassium permanganate external sheet is substantially accelerated, reduce The time that user waits, reduce contact during potassium permanganate external sheet dissolves extraneous and occur oxidation etc. existing simultaneously As.
The above, the only present invention preferably detailed description of the invention, but protection scope of the present invention is not limited thereto, Any those skilled in the art in the technical scope that the invention discloses, the change that can readily occur in or replacement, All should contain within protection scope of the present invention.Therefore, protection scope of the present invention should be with the protection model of claims Enclose and be as the criterion.

Claims (10)

1. the production technology of a potassium permanganate external sheet, it is characterised in that comprise the steps:
The process of S1: raw material:
A1: by raw material potassium permanganate with the quality of potassium permanganate and the volume ratio of distilled water as 1:14~20 ratio be completely dissolved in In this distilled water, it is sufficiently stirred for, makes potassium permanganate be completely dissolved to form solution;
B1: be centrifuged by the solution obtained in step A1,8000rpm, 10min, removes insoluble matter, obtains potassium permanganate molten Liquid;
C1: the potassium permanganate solution obtained in step B1 is dried until its water content drops to 2%~5%;
S2: pelletize:
A2, weigh various adjuvant, join it in step C1, be sufficiently mixed and be formed uniformly mixture;
B2, the mixture obtained in step A2 is sieved after put in granulator pelletize, obtain granule;
S3: tabletting: be placed in tablet machine by granule obtained above, regulates tablet weight, tabletting, obtains tablet;
S4: pack, check, put in storage.
The production technology of potassium permanganate external sheet the most according to claim 1, it is characterised in that the wherein institute in step A1 The volume ratio of the quality and distilled water of stating potassium permanganate is 1:16.
The production technology of potassium permanganate external sheet the most according to claim 1, it is characterised in that the wherein institute in step C1 State potassium permanganate solution to be dried until its water content drops to 3%.
The production technology of potassium permanganate external sheet the most according to claim 1, it is characterised in that wherein auxiliary in step A2 Material includes that boric acid and hydroxypropyl cellulose, described boric acid are 1:1 with the mass ratio of hydroxypropyl cellulose.
The production technology of potassium permanganate external sheet the most according to claim 4, it is characterised in that wherein auxiliary in step A2 Material also includes quick-dissolving agent.
The production technology of potassium permanganate external sheet the most according to claim 5, it is characterised in that described boric acid, hydroxypropyl Mass ratio between cellulose and quick-dissolving agent is 2:2:1.
The production technology of potassium permanganate external sheet the most according to claim 1, it is characterised in that the wherein institute in step B2 State the sieve sieved as crossing 24 mesh.
The production technology of potassium permanganate external sheet the most according to claim 1, it is characterised in that the wherein institute in step S3 Stating tablet weight is 0.125g ± 7.5%.
The production technology of potassium permanganate external sheet the most according to claim 1, it is characterised in that the wherein institute in step S3 Stating the content of potassium permanganate in tablet is 0.1g ± 7.5%.
10. the permanganic acid prepared according to the production technology of the potassium permanganate external sheet according to any one of claim 1-9 Potassium external sheet.
CN201610606624.7A 2016-07-28 2016-07-28 Potassium permanganate tablets for external use and production process thereof Pending CN106038593A (en)

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN107982224A (en) * 2017-11-29 2018-05-04 重庆昌元化工集团有限公司 A kind of method for producing tablet potassium permanganate

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107982224A (en) * 2017-11-29 2018-05-04 重庆昌元化工集团有限公司 A kind of method for producing tablet potassium permanganate

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Application publication date: 20161026