CN106038300A - Drying and granulating integrated equipment and application thereof - Google Patents
Drying and granulating integrated equipment and application thereof Download PDFInfo
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- CN106038300A CN106038300A CN201610185437.6A CN201610185437A CN106038300A CN 106038300 A CN106038300 A CN 106038300A CN 201610185437 A CN201610185437 A CN 201610185437A CN 106038300 A CN106038300 A CN 106038300A
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- drying
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- granulating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
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Abstract
The invention provides drying and granulating integrated equipment. The equipment is implemented by virtue of a method comprising the following steps: adding materials to a feed tank 1, uniformly stirring the materials, conveying the stirred materials onto a material conveying device 4 which is arranged in a vacuum drier 3 under the action of a screw pump 2, separately drying the materials by virtue of a steam heating section 5 and a hot water heating section 6 on the conveying device, crushing the materials in a crushing device 7 on the basis of self-gravity of the materials, and conveying the materials into a granulating device 8 for granulation until the materials are crushed to a certain degree, wherein finally obtained granules can be applied to a next process of producing a traditional Chinese medicinal preparation. The invention also provides an application of the equipment in preparing compound tablets of radix salviae miltiorrhizae, or compound granules of radix salviae miltiorrhizae or compound capsules of radix salviae miltiorrhizae. The equipment has the characteristics of being low in energy consumption, low in loss of effective ingredients and simple to operate.
Description
Technical field
The invention belongs to pharmaceutical production apparatus field, be specifically related to a kind of drying and granulating equipment integrating and application thereof.
Background technology
In conventional Chinese medicine preparation preparation process, due to big to the demand of Chinese medicine extractum and half extractum,
So generally requiring, extractum being dried, pelletizing again after pulverizing, then complete next step production process.For containing temperature-sensitive
Property composition kind Chinese medicine preparation preparation process in, often use vacuum drying leaching to reduce the loss of heat-sensitive ingredients
Cream, then pulverizes granulation, then is dried, then carries out next step production process.
Although conventional Chinese medicine preparation preparation technology have employed vacuum drying reduce the loss of heat-sensitive ingredients, the most at present
Be dried for equipment required in the preparation technology of conventional Chinese medicine preparation and facility for granulating be separate, thus being dried and
More exchange device is needed, to ensure being smoothed out of production process in the step pelletized.It is tired to there is pulverizing in the most dried extractum
Difficulty, is easily heated in crushing process, the moisture absorption softens, and often changes primary equipment and just strengthen the loss of heat-sensitive ingredients once, and
Formulation process also needs to through twice dry run, the heat brought except replacing equipment during being dried at twice
The loss of sensitive ingredient, can cause the loss of heat-sensitive ingredients too in twice dry run.
In order to solve above-mentioned deficiency of the prior art, the present invention proposes a kind of new solution.
Summary of the invention
For solving above-mentioned technical problem, the invention provides a kind of drying and granulating equipment integrating.
Drying and granulating equipment integrating of the present invention, it is possible to the effective Chinese medical concrete reduced containing heat-sensitive ingredients and
The loss of heat-sensitive ingredients in being prepared as Finished product processThe of half extractum solid preparation, shortens technique prepared by Chinese medicine preparation simultaneously
Process, simple to operate, decrease the labor time of workman.
Drying and granulating equipment integrating of the present invention, including feed pot, screw pump, vacuum desiccator, reducing mechanism, system
Grain device, described feed pot is connected with screw pump by pipeline, and screw pump is connected with one end of vacuum desiccator, reducing mechanism
Being connected with the other end of vacuum desiccator, granulation device is connected with reducing mechanism.
Described vacuum desiccator is provided with material conveying device, described material conveying device is provided with 2 and adds
Hot arc is respectively steam heating segment and hot water heating section, wherein, steam heating segment front, hot water heating Duan Hou.
The condensation water that the hot water source of described hot water heating section produces in the steam consumed.
Drying and granulating equipment integrating of the present invention is achieved through the following technical solutions:
Material is joined in feed pot, after stirring, by the effect of screw pump, the material being stirred is transported to vacuum
On the material conveying device arranged in exsiccator, the material two sections of bringing-up sections on transporter are dried, by from heavy sensation of the body
Power enters in reducing mechanism and pulverizes, and is crushed to enter into the most afterwards in granulation device granulation, the granule finally obtained
Mixture of powders can be used for next step production process of Chinese medicine preparation, i.e. direct compression or fill capsule or be prepared as granule.
Wherein, the described vacuum in vacuum desiccator is 0～0.08MPa, preferably 0.04MPa.
Wherein, the heating-up temperature of described bringing-up section is 35～120 DEG C, preferably 55 DEG C.
Wherein, described device for transporting objects transporting velocity is 0.001～5m/min, preferably 1.2m/min.
Wherein, the pulverizing mesh number of reducing mechanism is below 200 mesh, preferably 20 mesh.
Present invention also offers the application of a kind of described drying and granulating equipment integrating.
Described drying and granulating equipment integrating may be used for FUFANG DANSHEN PIAN, compound Salviae Miltiorrhizae granule or FUFANG DANSHEN JIAONANG
Prepared by technique.
Drying and granulating equipment integrating of the present invention is used to contain the Chinese medicine preparation of heat-sensitive ingredients in preparation, with routine
Technique is compared, and the extent of damage of effective ingredient substantially reduces, and simultaneously compared with common vacuum drying, is consuming same steam
In the case of, the rate of drying of drying and granulating equipment integrating of the present invention improves 3～5 times.So it is of the present invention dry
Dry granulation equipment integrating can effectively reduce energy consumption and reduce the loss of effective ingredient.
Accompanying drawing explanation
Fig. 1 is the structural representation of drying and granulating equipment integrating of the present invention.
Wherein, 1 is feed pot, and 2 is screw pump, and 3 is vacuum desiccator, and 4 is device for transporting objects, and 5 is steam heating segment,
6 is hot water heating section, and 7 is reducing mechanism, and 8 is granulation device.
Detailed description of the invention
The embodiment of the present invention, by providing a kind of drying and granulating equipment integrating, solves in prior art to containing temperature-sensitive
Property composition Chinese medicine be prepared as heat-sensitive ingredients during preparation and easily cause the problem of quadratic loss, of the present invention dry
Dry granulation equipment integrating decreases secondary and pelletizes and dry run, reduces the quadratic loss of heat-sensitive ingredients, simple to operate.
Below in conjunction with accompanying drawing and specific embodiment, technique scheme is described in detail.
Embodiment 1
As it is shown in figure 1, this drying and granulating equipment integrating includes feed pot 1, screw pump 2, vacuum desiccator 3, device for transporting objects
4, steam heating segment 5, hot water heating section 6, reducing mechanism 7, granulation device 8, described feed pot 1 passes through pipeline with screw pump 2
Connect, after material is stirred mixing in feed pot 1, be transported to the material in vacuum desiccator 3 by the effect of screw pump 2
On conveyer device 4, then it is dried respectively through steam heating segment 5 and hot water heating section 6, the last material weight by self
Power enters the granularity (mesh number) being ground into needs in reducing mechanism 7, enters back into the granule being prepared as process requirements in granulation device 8
Mixture of powders.
Following two embodiment is as a example by the preparation of FUFANG DANSHEN PIAN.
Embodiment 2
Use drying and granulating equipment integrating of the present invention that the supplementary material of FUFANG DANSHEN PIAN carries out preparation of pelletizing.
The prescription of FUFANG DANSHEN PIAN: Radix Salviae Miltiorrhizae 450g, Radix Notoginseng 141g, Borneolum Syntheticum 8g
The process of prescription medical material: with reference to the method in Chinese Pharmacopoeia 2,015 first page 1214 to the Radix Salviae Miltiorrhizae of 10 recipe quantities,
Radix Notoginseng, Borneolum Syntheticum process.
Preparation method: the Salvia mitiorrhiza liquid handled well, Radix Notoginseng powder, Borneolum Syntheticum are joined in feed pot 1, after stirring,
Add appropriate starch, after mix homogeneously, by the effect of screw pump, the material mixed is transported in vacuum desiccator 3
Device for transporting objects 4 on, the vacuum in regulation vacuum desiccator 3 is 0.04MPa simultaneously, defeated on device for transporting objects 4
Sending speed is 1.2m/min, and the temperature of steam heating segment 5 and hot water heating section 6 is 55 DEG C, and dried material is by self gravitation
Enter in reducing mechanism 7, be crushed to 20 mesh, pelletize subsequently in granulation device 8, in the granule prepared, add total amount
The magnesium stearate of 1%, tabletting after mix homogeneously, coating, obtain FUFANG DANSHEN PIAN, every tablet weight 0.32g.
Record according to the detection method of tanshinone IIA and salvianolic acid B in 2015 editions first page 1215 of pharmacopeia China
Stating the content of tanshinone IIA in FUFANG DANSHEN PIAN is 0.53mg/ sheet, and content of danshinolic acid B is 8.76mg/ sheet.
Embodiment 3
The prescription of FUFANG DANSHEN PIAN: Radix Salviae Miltiorrhizae 450g, Radix Notoginseng 141g, Borneolum Syntheticum 8g
With reference to the method in Chinese Pharmacopoeia 2,015 first page 1214～1215 to 10 recipe quantity Radix Salviae Miltiorrhizaes, fine powder will be ground into
Radix Notoginseng, finely ground Borneolum Syntheticum and appropriate amount of starch mix with Salvia mitiorrhiza liquid, dry in the vacuum desiccator that vacuum is 0.04MPa
After dry, pulverize, pelletize, by the granule that makes in vacuum is 0.04MPa vacuum desiccator dried, add the hard of total amount 1%
Fatty acid magnesium, tabletting after mix homogeneously, coating, obtain FUFANG DANSHEN PIAN, every tablet weight 0.32g.
Record according to the detection method of tanshinone IIA and salvianolic acid B in 2015 editions first page 1215 of pharmacopeia China
The content stating the tanshinone IIA in FUFANG DANSHEN PIAN is 0.35mg/ sheet, and content of danshinolic acid B is 5.63mg/ sheet.
Above-described embodiment 2 applies drying and granulating equipment integrating of the present invention to prepare FUFANG DANSHEN PIAN, implement
Example 3 uses the preparation technology of routine and prepares described in FUFANG DANSHEN PIAN, the FUFANG DANSHEN PIAN described in embodiment 2 and embodiment 3
FUFANG DANSHEN PIAN compare, the FUFANG DANSHEN PIAN described in embodiment 2 is tanshinone IIA and salvianolic acid B in formulation process
Content substantially ratio high (P < 0.01) of embodiment 3, the method described in embodiment 2 is prepared FUFANG DANSHEN PIAN and can be effectively reduced
Tanshinone IIA and salvianolic acid B loss in preparing production process.Meanwhile, inventor is by described in embodiment 2 and embodiment 3
Rate of drying compare, in the case of consuming same steam, the rate of drying described in embodiment 2 is than described in embodiment 3
Rate of drying improve 3～5 times.
In above-described embodiment 2, the hot water source in hot water heating section 6 is in extracting the condensation water that the steam consumed in workshop produces,
Such design can reduce energy consumption.
To sum up, containing the preparation technology of the FUFANG DANSHEN PIAN of heat-sensitive ingredients uses drying and granulating one of the present invention
Body equipment is dried granulation, the loss in formulation process of the effective ingredient in the FUFANG DANSHEN PIAN finally prepared
Substantially reduce.Use drying and granulating equipment integrating of the present invention have reduction energy consumption, simple to operate, decrease thermal sensitivity become
The advantage of the quadratic loss divided.
Claims (7)
1. a drying and granulating equipment integrating, it is characterised in that described equipment is realized by the following method: added by material
Enter in feed pot 1, after stirring, be transported in vacuum desiccator 3 set by the material being stirred by the effect of screw pump 2
On the material conveying device 4 put, material is dried respectively through the steam heating segment 5 on transporter and hot water heating section 6, logical
Cross in self gravitation entrance reducing mechanism 7 and pulverize, be crushed to enter into the most afterwards in granulation device 8 granulation, finally
The granule obtained can be used for next step production process of Chinese medicine preparation.
Drying and granulating equipment integrating the most according to claim 1, it is characterised in that true in described vacuum desiccator 3
Reciprocal of duty cycle is 0～0.08MPa, is further selected as 0.04MPa.
Drying and granulating equipment integrating the most according to claim 1, it is characterised in that described steam heating segment 5 and hot water
The heating-up temperature of bringing-up section 6 is 35～120 DEG C, is further selected as 55 DEG C.
Drying and granulating equipment integrating the most according to claim 1, it is characterised in that described device for transporting objects 4 carries
Speed is 0～5m/min, is further selected as 1.2m/min.
Drying and granulating equipment integrating the most according to claim 1, it is characterised in that the pulverizing mesh of described reducing mechanism 7
Number is below 200 mesh, is further selected as 20 mesh.
6. the application of a kind of drying and granulating equipment integrating as described in Claims 1 to 5 any one claim.
Application the most according to claim 6, it is characterised in that it is red that described drying and granulating equipment integrating may be used for compound recipe
Prepared by the technique of ginseng sheet or compound Salviae Miltiorrhizae granule or FUFANG DANSHEN JIAONANG.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610185437.6A CN106038300A (en) | 2016-03-29 | 2016-03-29 | Drying and granulating integrated equipment and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610185437.6A CN106038300A (en) | 2016-03-29 | 2016-03-29 | Drying and granulating integrated equipment and application thereof |
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| Publication Number | Publication Date |
|---|---|
| CN106038300A true CN106038300A (en) | 2016-10-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610185437.6A Pending CN106038300A (en) | 2016-03-29 | 2016-03-29 | Drying and granulating integrated equipment and application thereof |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2469927Y (en) * | 2001-04-12 | 2002-01-09 | 沈善明 | Chinese-medicinal-extract vacuum drying granulator |
| CN2754629Y (en) * | 2004-09-04 | 2006-02-01 | 常州市范群干燥设备有限公司 | Host computer of cream material vacuum drier |
| CN101015577A (en) * | 2006-11-30 | 2007-08-15 | 浙江大学 | Preparing method of fleabane extract dry matter |
| CN101332217A (en) * | 2008-07-11 | 2008-12-31 | 天津红日药业股份有限公司 | Drying method of compound traditional Chinese medicine Xuebijin monarch drug extract |
| CN203493924U (en) * | 2013-09-27 | 2014-03-26 | 宜春万申制药机械有限公司 | Totally-closed integrated pharmaceutical equipment |
| CN204115430U (en) * | 2014-07-18 | 2015-01-21 | 陈长清 | A kind of high-efficiency and continuous vacuum microwave drier |
| CN204268816U (en) * | 2014-11-10 | 2015-04-15 | 江苏宇通干燥工程有限公司 | Multi-functional, environment-friendly and energy-efficient vacuum belt drier group |
-
2016
- 2016-03-29 CN CN201610185437.6A patent/CN106038300A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2469927Y (en) * | 2001-04-12 | 2002-01-09 | 沈善明 | Chinese-medicinal-extract vacuum drying granulator |
| CN2754629Y (en) * | 2004-09-04 | 2006-02-01 | 常州市范群干燥设备有限公司 | Host computer of cream material vacuum drier |
| CN101015577A (en) * | 2006-11-30 | 2007-08-15 | 浙江大学 | Preparing method of fleabane extract dry matter |
| CN101332217A (en) * | 2008-07-11 | 2008-12-31 | 天津红日药业股份有限公司 | Drying method of compound traditional Chinese medicine Xuebijin monarch drug extract |
| CN203493924U (en) * | 2013-09-27 | 2014-03-26 | 宜春万申制药机械有限公司 | Totally-closed integrated pharmaceutical equipment |
| CN204115430U (en) * | 2014-07-18 | 2015-01-21 | 陈长清 | A kind of high-efficiency and continuous vacuum microwave drier |
| CN204268816U (en) * | 2014-11-10 | 2015-04-15 | 江苏宇通干燥工程有限公司 | Multi-functional, environment-friendly and energy-efficient vacuum belt drier group |
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Application publication date: 20161026 |