CN106000486B - A kind of inverted Y-shaped miniflow selector valve and sample separation method for laboratory CD disks - Google Patents
A kind of inverted Y-shaped miniflow selector valve and sample separation method for laboratory CD disks Download PDFInfo
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- CN106000486B CN106000486B CN201610323421.7A CN201610323421A CN106000486B CN 106000486 B CN106000486 B CN 106000486B CN 201610323421 A CN201610323421 A CN 201610323421A CN 106000486 B CN106000486 B CN 106000486B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
- B01L2400/0412—Moving fluids with specific forces or mechanical means specific forces centrifugal forces using additionally coriolis forces
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- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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Abstract
The invention discloses a kind of inverted Y-shaped miniflow selector valve and sample separation method for laboratory CD disks, belong to micro-fluidic technologies field.Including a circular cavity A for being provided with passage, circular cavity A lower section is provided with a blood capillary pipe valve with cavity insertion, the fluidic generator that blood capillary pipe valve is more than its duct width with width is connected, a Y type microchannels branch is communicated with below fluidic generator, circular cavity B and circular cavity C provided with passage are connected in Y type microchannels branch.The valve overcomes the influence of Euler force convection body and the influence of Coanda effect convection body, in the presence of without any applied force, just with coriolis force caused by the rotating of Lab on CD centrifugal platforms, a kind of sample separation that can control any one branch of controlling flow direction Y shape microchannel is realized.Present invention design is simple, rational in infrastructure, it is easy to accomplish.
Description
Technical field
The invention belongs to micro-fluidic technologies field, and in particular to one kind is used for the Y that falls of Lab-on-CD disks (laboratory CD disks)
Type miniflow selector valve and sample separation method.
Background technology
Micro-fluidic (Microfluidics) be using MEMS processing platform as technical foundation, be directed to analytical instrument,
Chemistry, biochemistry, it is clinical medical miniaturization with it is integrated.(size is to be tens of to hundreds of using microchannel for microflow control technique
Micron) processing or the system that manipulates minute fluid (volume for nanoliter arrive A Sheng).It is related to numerous subjects：Chemistry, fluid physics,
The cross disciplines such as microelectronics, new material and biomedical engineering.One of micro-fluidic key character is that have under micro-scale environments
Unique fluid properties, such as laminar flow and drop.It is micro-fluidic to realize a series of routines by these unique fluid phenomenons
Method is difficult to the micro Process completed and microoperation.At present, it is micro-fluidic to have been had breakthrough in biomedical research, it is believed that meeting
Have and be more widely applied prospect.
In the research of current microfluid valve, the design of various valves emerges in an endless stream, wax valve (wax be animal, plant or
It is oily caused by mineral, be solid-state under normal temperature, melt after heating) due to needing to add wax in microfluidic channel in advance, and
And need additional lasing light emitter heating to undergo phase transition wax, can just valve be opened, microchannel can so be polluted, so as to
The accuracy of detection to sample is influenceed, and can not be closed after cooling down；Such as hydrophilic valve of other valves, hydrophobic valve are required for miniflow
Body pipe surface is handled, and adds the manufacture difficulty and technological requirement of valve；In addition, point of micro-example is realized at present
From, it is necessary to by syringe pump and microfluidic valve (such as：Pneumatic operated valve, mechanical valve) etc. device realize the Quantitative Separation of sample so that it is overall
Structure is more complicated, and cost is higher.
The content of the invention
To solve drawbacks described above present in prior art, it is an object of the invention to provide one kind to be used for Lab-on-CD
Inverted Y-shaped the miniflow selector valve and its sample separation method of disk, the design structure is simple, easily realizes；The design does not need any outer
Reinforcing is acted on, and without too many servicing unit, the flowing to sample flow is can be achieved with just with the rotating of Lab-on-CD platforms
Direction controlling.
The present invention is realized by following technical proposals.
A kind of inverted Y-shaped miniflow selector valve for laboratory CD disks, including a circular cavity A for being provided with passage, circle
Shape cavity A lower section is provided with a blood capillary pipe valve with cavity insertion, and blood capillary pipe valve is more than its duct width with width
Fluidic generator is connected, and a Y type microchannels branch is communicated with below fluidic generator, is divided in Y type microchannels branch
Circular cavity B and circular cavity C provided with passage are not connected with.
Further, the width of the blood capillary pipe valve is 400 μm, is highly 1.5mm；The width of fluidic generator is
4.8mm；Highly it is 6.6mm.
Further, described circular chamber A, B and C diameter are 6mm.
Further, the bottom of the fluidic generator is provided with reversed cone angle, and the angle with horizontal direction is 65~75 °.
Further, the angle between the inverted Y-shaped microchannel branch is 75~85 °；The left and right branch of Y type microchannels
Physical dimension it is consistent.
Correspondingly, The present invention gives a kind of experimental rig of the inverted Y-shaped miniflow selector valve for laboratory CD disks, including
The motor being connected with computer, motor output shaft are vertically connected by bearing and experimental bench, and making is connected with motor output shaft
There are the laboratory CD disks of inverted Y-shaped miniflow selector valve, the wireless camera being connected with computer is corresponding with above the CD disks of laboratory, can
So that real-time liquid flowing picture is transferred back into computer.
Further, the laboratory CD disks for having inverted Y-shaped miniflow selector valve that make are provided with two along laboratory CD disks
The inverted Y-shaped miniflow selector valve that pivot is symmetrically distributed, the passages of two inverted Y-shaped miniflow selector valves is along laboratory CD disks
Pivot both sides distribution.
Further, the inverted Y-shaped miniflow selector valve on the laboratory CD disks through traditional glass etching, sputtering technology or
PDMS overmoldeds obtain, and inverted Y-shaped miniflow selector valve is 700 μm in the glass etching depth of laboratory CD disks.
The present invention so give a kind of sample separation method of the inverted Y-shaped miniflow selector valve for laboratory CD disks, bag
Include following step：
1) sample is injected separately into the circular cavity A of two symmetrical inverted Y-shaped miniflow selector valves from passage, computer
Controlled motor starts, and drives laboratory CD disc spins；
2) sample is subject to centrifugal forces enters in blood capillary pipe valve；
3) rotary speed of motor is brought up to rapidly more than critical value, sample overcomes resistance to be flowed from blood capillary pipe valve
Go out, after sample enters fluidic generator, form jet；
4) jet flow direction in the presence of coriolis force changes, and passes through the positive and negative of computer controlled motor (102)
Turn to, rotation time and rotating speed control sample selectively to enter Y-piece road left branch or Y-piece road right branch and and then entered
Enter circular cavity B or circular cavity C sample size；
5) simultaneously, the corresponding wireless camera above the CD disks of laboratory is by two symmetrical inverted Y-shaped miniflow selector valves
Sample forms jet and the process record into circular cavity B or circular cavity C gets off and inputted into computer, in real time control
Sample, which flows into, specifies in cavity, realizes the Quantitative Separation of sample.
Further, the motor speed critical value is 1000rpm.
The present invention has technique effect beneficial below：
The present invention designs for Lab-on-CD inverted Y-shaped miniflow selector valve, in the end of blood capillary pipe valve, increase suddenly
The width of capillary, i.e. fluidic generator, during sample outwards flowing subject to centrifugal forces, drop due to speed compared with
Greatly, the inertia to travel forward is remain, departs from the absorption (i.e. Coanda effect) of left and right pipeline, and forms jet.Fluidic generator
The influence in Coanda effect fluid flow direction can effectively be avoided.Because platform can produce Euler force in accelerator,
Euler force can produce interference to the flow direction of jet, in order to avoid the influence of Euler force, pass through blood capillary pipe valve in sample
During, instrument rotating speed is brought up to more than critical value rapidly, and the rotation that remains a constant speed.
The present invention designs the influence that a blood capillary pipe valve is used to overcome Euler force convection body, and a fluidic generator is used for
Overcome the influence of Coanda effect convection body, two Y type microchannels branches are used to receive the microfluid that direction changes.This hair
It is bright without in the presence of any applied force, just with coriolis force caused by the rotating of Lab-on-CD disks, realizing one kind
The new design of any one branch of controlling flow direction Y shape microchannel can be controlled, that is, controls stream of the liquid in microfluidic channel
Dynamic direction.The present invention can effectively control the flow direction of fluid in the CD disks of laboratory, solve Euler force, Coanda effect pair
The interference problem of fluid motion.The present invention will not cause any pollution to sample, not interfere with last testing result；Its structure
Design is simple, easily manufactured, easily realizes, it is not necessary to uses expensive external equipment.
Brief description of the drawings
Fig. 1 is the pipeline configuration schematic diagram of the present invention；
Fig. 2 positions sample is injected into schematic diagram in A chambers；
Fig. 3 be sample by blood capillary pipe valve, into fluidic generator after form jet schematic diagram；
Fig. 4 is that jet is acted on by coriolis force to the right, and jet deflects schematic diagram；
Fig. 5 is that jet flows into Y type microchannel right branch schematic diagrames；
Fig. 6 is that liquid enters schematic diagram in cavity C；
Fig. 7 is that liquid is fully entered in cavity C, and whole experiment process completes schematic diagram；
Fig. 8 is after platform operates counterclockwise, and remaining liq enters schematic diagram in cavity B；
Fig. 9 is schematic view of the mounting position of the laboratory CD disks in Lab-on-CD.
In figure：1- blood capillary pipe valves；2- fluidic generators；3-Y type microchannel left branch；Right point of 4-Y types microchannel
Branch；5- circular cavities A；6- circular cavities B；7- circular cavities C；8- passages；The pivot of 9- laboratories CD disks；101- is counted
Calculation machine；102- motors；103- experimental benches；104- laboratories CD；105- wireless cameras.
Embodiment
The invention will be described in further detail with reference to the accompanying drawings and examples, but is not intended as doing any limit to invention
The foundation of system.
As shown in figure 1, the inverted Y-shaped miniflow selector valve for Lab-on-CD disks of the present invention, including one be provided with passage
8 circular cavity A5, circular cavity A5 lower section are provided with a blood capillary pipe valve 1 with cavity insertion, blood capillary pipe valve 1 and width
Degree is connected more than the fluidic generator 2 of its duct width, and the lower section of fluidic generator 2 is communicated with a Y type microchannels branch
(Y type microchannels left branch 3, Y type microchannels right branch 4), it is connected to provided with passage in Y type microchannels branch
Circular cavity B6 and circular cavity C7.
Circular chamber A5, B6 and C7 diameter are 6mm, and the width of blood capillary pipe valve 1 is 400 μm, is highly 1.5mm,
The width of fluidic generator 2 is 4.8mm, is highly 6.6mm.There is a reversed cone angle in the bottom of fluidic generator 2, with level
The angle in direction is 65~75 °, and the angle between two Y type microchannels branches is 75~85 °.Left and right point of Y type microchannels
The physical dimension of branch is consistent.
As shown in figure 9, a kind of experimental rig of the inverted Y-shaped miniflow selector valve for Lab-on-CD disks is illustrated, including with
The connected motor 102 of computer 101, the output shaft of motor 102 is vertically connected by bearing and experimental bench 103, on motor output shaft
The laboratory CD disks 104 for making and having inverted Y-shaped miniflow selector valve are connected with, the top of laboratory CD disks 104 is corresponding with and computer 101
Connected wireless camera 105.The laboratory CD disks 104 that making has inverted Y-shaped miniflow selector valve are provided with two along laboratory CD
The inverted Y-shaped miniflow selector valve that the pivot 9 of disk is symmetrically distributed, the passages 8 of two inverted Y-shaped miniflow selector valves is along experiment
The both sides of pivot 9 distribution of room CD disks.
Inverted Y-shaped miniflow selector valve on laboratory CD disks 104 is through traditional glass etching, sputtering or PDMS overmolded techniques
Obtain, and inverted Y-shaped miniflow selector valve is 700 μm in the glass etching depth of laboratory CD disks 104.
The present invention utilizes the sample separation method of the above-mentioned inverted Y-shaped miniflow selector valve for Lab-on-CD disks, including following
Step：
1) sample is injected separately into the circular cavity A5 of two symmetrical inverted Y-shaped miniflow selector valves from passage 8, sees figure
Shown in 2, the controlled motor 102 of computer 101 starts clockwise, drives the rotation (as shown in Figure 9) of laboratory CD disks 104；
2) sample is subject to centrifugal forces enters in blood capillary pipe valve 1, due to the inhibition of blood capillary pipe valve, sample
It is difficult to flow out, the rotary speed of motor 102 is brought up to more than critical value 1000rpm rapidly, i.e., centrifugal force suffered by sample is more than
Resistance of the capillary to sample；
3) sample overcomes resistance to be flowed out from blood capillary pipe valve 1, and capillary can effectively avoid Euler force, jet hair
Raw device can effectively avoid Coanda effect, make full use of centrifugal force and coriolis force caused by platform rotation to control sample flow
The direction of motion；The process can avoid the influence of caused Euler force to sample flow in accelerator of laboratory CD disks 104,
Due to centrifugal force caused by the high speed rotary motion of laboratory CD disks 104 so that sample is after by blood capillary pipe valve 1, sample
Into after fluidic generator 2, jet is formed, as shown in Figure 3；
4) jet flow direction in the presence of coriolis force changes, and as shown in Figure 4, jet can selectively enter Y types
In pipeline right branch 4 (or Y-piece road left branch 3), as shown in Figure 5；When being rotated due to 104 positive hour hands of laboratory CD disks, jet
Entered by coriolis force to the right among circular cavity C7, controlled motor rotating speed critical (1000rpm) rotation time, i.e.,
The amount of liquid that controllable liquid enters in circular cavity C7, as shown in Fig. 6, Fig. 7；When again by platform rotate counterclockwise, jet
Entered by coriolis force to the left among circular cavity B6, as shown in Figure 8；Passage 8 can ensure the freedom of cavity air-flow
Into, prevent inside cavity formed negative pressure, influence the flowing of liquid；
5) simultaneously, the corresponding wireless camera 105 above laboratory CD disks 104 selects two symmetrical inverted Y-shaped miniflows
Select sample formation jet in valve and the process record into circular cavity B6 or circular cavity C7 gets off and inputted to computer 101
In, control sample to flow into real time and specify in cavity, realize the Quantitative Separation of sample.
Concrete principle of the present invention is as follows：Liquid, due to receiving the constraint of blood capillary pipe valve, only works as rotation in A chambers
When speed reaches certain critical value (when centrifugal force suffered by drop is more than blood capillary pipe valve to its resistance), could smoothly it lead to
Cross.We can make full use of the obstruction feature of blood capillary pipe valve convection body, within period of the liquid by blood capillary pipe valve,
Rotary speed is rapidly increased to more than critical value, then at the uniform velocity rotated, to eliminate influence of the Euler force to jet.Although jet
Have while into the trend of B, C chamber, but effect of the coriolis force to jet caused by instrument turns clockwise to the right,
So that jet processed changes direction, C chambers are finally entered.Similarly, in order to control jet to enter B chambers, as long as making instrument rotate counterclockwise
.
The invention is not limited in above-described embodiment, on the basis of technical scheme disclosed by the invention, the skill of this area
Art personnel are according to disclosed technology contents, it is not necessary to which performing creative labour can makes one to some of which technical characteristic
A little to replace and deform, these are replaced and deformation is within the scope of the present invention.
Claims (10)
1. a kind of inverted Y-shaped miniflow selector valve for laboratory CD disks, it is characterised in that be provided with passage (8) including one
Circular cavity A (5), circular cavity A (5) lower section are provided with a blood capillary pipe valve (1) with cavity insertion, blood capillary pipe valve
(1) fluidic generator (2) for being more than its duct width with width is connected, and it is micro- to be communicated with a Y type below fluidic generator (2)
Pipe branch is flowed, circular cavity B (6) and circular cavity C (7) provided with passage are connected in Y type microchannels branch.
2. a kind of inverted Y-shaped miniflow selector valve for laboratory CD disks according to claim 1, it is characterised in that described
The width of blood capillary pipe valve (1) is 400 μm, is highly 1.5mm；The width of fluidic generator (2) is 4.8mm, is highly
6.6mm。
3. a kind of inverted Y-shaped miniflow selector valve for laboratory CD disks according to claim 1, it is characterised in that described
Circular chamber A (5), circular chamber B (6) and circular chamber C (7) diameter are 6mm.
4. a kind of inverted Y-shaped miniflow selector valve for laboratory CD disks according to claim 1, it is characterised in that described
The bottom of fluidic generator (2) is provided with reversed cone angle, and the angle with horizontal direction is 65~75 °.
5. a kind of inverted Y-shaped miniflow selector valve for laboratory CD disks according to claim 1, it is characterised in that described
Angle between inverted Y-shaped microchannel branch is 75~85 °；The physical dimension of the left and right branch of Y type microchannels is consistent.
6. a kind of experimental rig of the inverted Y-shaped miniflow selector valve for laboratory CD disks described in claim 1, its feature exist
In, including the motor (102) being connected with computer (101), motor (102) output shaft be vertical with experimental bench (103) by bearing
It is connected, the laboratory CD disks (104) for making and having inverted Y-shaped miniflow selector valve, laboratory CD disks (104) is connected with motor output shaft
Top is corresponding with the wireless camera (105) being connected with computer (101).
7. device according to claim 6, it is characterised in that described to make the laboratory CD for having inverted Y-shaped miniflow selector valve
The inverted Y-shaped miniflow selector valve that disk (104) is symmetrically distributed provided with two pivots (9) along laboratory CD disks, two
Pivot (9) both sides distribution of the passage (8) of inverted Y-shaped miniflow selector valve along laboratory CD disks.
8. device according to claim 6, it is characterised in that the inverted Y-shaped miniflow selection on the laboratory CD disks (104)
Valve obtains through traditional glass etching, sputtering or PDMS overmolded techniques, and inverted Y-shaped miniflow selector valve is in laboratory CD disks (104)
Glass etching depth is 700 μm.
A kind of 9. sample of the experimental rig of inverted Y-shaped miniflow selector valve for laboratory CD disks using described in claim 6
Separation method, it is characterised in that comprise the steps：
1) sample is injected separately into the circular cavity A (5) of two symmetrical inverted Y-shaped miniflow selector valves from passage (8), calculated
Machine (101) controlled motor (102) starts, and drives laboratory CD disks (104) rotation；
2) sample is subject to centrifugal forces enters in blood capillary pipe valve (1)；
3) rotary speed of motor (102) is brought up to rapidly more than critical value, sample overcomes resistance from blood capillary pipe valve (1)
Outflow, after sample enters fluidic generator (2), form jet；
4) jet flow direction in the presence of coriolis force changes, and passes through the positive and negative of computer (101) controlled motor (102)
Turn to, rotation time and rotating speed control the sample jet selectively to enter Y-piece road left branch (3) or Y-piece road right branch
(4) and and then enter circular cavity B (6) or circular cavity C (7) sample size；
5) simultaneously, the corresponding wireless camera (105) above laboratory CD disks (104) selects two symmetrical inverted Y-shaped miniflows
Select sample formation jet in valve and the process record into circular cavity B (6) or circular cavity C (7) gets off and inputted to calculating
In machine (101), control sample to flow into real time and specify in cavity, realize the Quantitative Separation of sample.
10. according to the method for claim 9, it is characterised in that motor (102) the rotary speed critical value is
1000rpm。
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| CN201610323421.7A CN106000486B (en) | 2016-05-16 | 2016-05-16 | A kind of inverted Y-shaped miniflow selector valve and sample separation method for laboratory CD disks |
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| CN201610323421.7A CN106000486B (en) | 2016-05-16 | 2016-05-16 | A kind of inverted Y-shaped miniflow selector valve and sample separation method for laboratory CD disks |
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| US7951333B2 (en) * | 2006-09-05 | 2011-05-31 | Samsung Electronics Co., Ltd. | Centrifugal force-based microfluidic device for protein detection and microfluidic system including the same |
| WO2009099512A2 (en) * | 2008-02-04 | 2009-08-13 | Micropoint Biosciences, Inc. | Centrifugal fluid analyzer rotor |
| GB2491813A (en) * | 2011-06-03 | 2012-12-19 | Univ Dublin City | A microfluidic device with sacrificial valve |
| KR20130029277A (en) * | 2011-09-14 | 2013-03-22 | 삼성전자주식회사 | Microfluidic device and control method thereof |
| EP2781263A3 (en) * | 2013-03-19 | 2017-11-22 | Samsung Electronics Co., Ltd. | Microfluidic Device and Control Method Thereof |
| KR101636120B1 (en) * | 2014-04-11 | 2016-07-04 | 한국과학기술원 | Integrated rotary pcr method and microchip for the same |
| CN104148125B (en) * | 2014-08-27 | 2015-12-30 | 南京发艾博光电科技有限公司 | Polymorphic actuation means on a kind of micro-fluidic chip |
| CN104155464B (en) * | 2014-08-27 | 2016-05-25 | 南京发艾博光电科技有限公司 | Drop logic control device on a kind of micro-fluidic chip |
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