CN105999265A - Application of photodynamic combination of photosensitive molecules in acne treating medicine - Google Patents
Application of photodynamic combination of photosensitive molecules in acne treating medicine Download PDFInfo
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- CN105999265A CN105999265A CN201610297266.6A CN201610297266A CN105999265A CN 105999265 A CN105999265 A CN 105999265A CN 201610297266 A CN201610297266 A CN 201610297266A CN 105999265 A CN105999265 A CN 105999265A
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- photosensitive molecular
- power combination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
Abstract
The invention relates to application of a photodynamic combination of photosensitive molecules in acne treating medicine. The combination comprises the photosensitive molecules and a light source. The light source in the combination provides energy for activating the photosensitive molecules, photons with special energy activate photosensitizer molecules of photosensitive molecules, the photosensitive molecules transfer energy to oxygen molecules in the human body to form high-energy-state oxygen, and then high-energy oxygen molecules kill adjacent target germ propionibacterium acnes and staphylococcus aureus. The photodynamic combination of the photosensitive molecules is applied in preparation of acne treating medicine, the photosensitive molecules and the light source are effectively combined to form the photodynamic combination, and the new application of the photodynamic combination of the photosensitive molecules in the field of acne treating medicine is developed.
Description
Technical field
The invention provides the light power combination of a kind of photosensitive molecular, relate generally to the application in abundance type acne treatment drug of the light power combination of photosensitive molecular.
Background technology
Existing acne treatment method, mainly includes chemical medicinal treatment, Chinese herbal medicine anti-acne therapy and photodynamic therapy.
Wherein chemical medicinal treatment includes following several:
One, glucocorticoid method: glucocorticoid itself can induce acne, life-time service will make immunity of organisms reduce, cause other side effect.
Two, antibiotic method: antibiotic can antibacterial anti-acne, but reuse antibiotic and may result in drug resistance and skin injury.And the drug resistance of pathogenic bacterium will make associated antibiotic lose curative effect.
Three, salicylic acid (fruit acid) method: the excessive concentration of salicylic acid (fruit acid), pH value are little, use overlong time, all can cause damage and other side effect of skin.Salicylic acid (fruit acid) the product needed physician guidance of high concentration uses.
Four, the cycle of the physical therapy of Chinese herbal medicine anti-acne therapy is long, takes effect slow.
Antibacterial is the key of anti-acne, is badly in need of the antibacterial anti-acne method of the highly effective and safe of a kind of non-antibiotic.
Over nearly 10 years, photodynamic therapy (Photodynamic Therapy, PDT) is the method for emerging a kind of antibacterial therapy acne, energy high-efficiency antimicrobial anti-acne, and does not produce drug resistance.Along with the development of the research of photosensitive molecular, photosensitizer is had the requirement of related parameter also to differ by different fields, and different clinical applications requires that different photosensitizer matches.Preferably novel photosensitive agent needs to meet following requirement: 1. component is single, and structure is clear and definite；2. convenient administration, shortens the time being administered into treatment；3. excretion is fast, toxicity, side effect is little, and the lucifuge time is short；4. there is higher functioning efficiency, produce the oxygen (ROS) of enough upper state；5. absorbed by selectivity on pathological tissues, health tissues should not be absorbed or few absorption；6. there is the effect wavelength of coupling with corresponding treatment disease, etc..
CN201380020826 patent discloses a kind of bio-photon compositions, test kit and method, use the compositions of photosensitive molecular of several chromophore for photon delicate skin, this compositions comprises three class chromophores, solves the general toxicity directly contacted due to photosensitizer and tissue or localized toxic.The weak picked-up of photosensitizer is in target tissue, and this type of existing scheme generally confirms low therapeutic efficiency.
CN200880117950 discloses a kind of compositions for photodynamic skin treatment, this combination includes CHLOROPHYLLINE and aminolevulinic acid, 5-aminolevulinic acid (the aminolevulinic acid that compositions uses, and derivant itself is not photosensitive molecular ALA), but can synthesize the photosensitive molecular of macro ring for human skin, during use, amount ratio is bigger.This quasi-molecule of 5-ALA has the strongest side effect to skin simultaneously, and red swelling of the skin often occurs in patient, bubbles, also needs to lucifuge a few hours after treatment.To this end, the method can only control to use under department of dermatologry medical practitioner instructs.
At present, be badly in need of developing a kind of uncomplicated smooth dynamical system of composition that can be applicable to photodynamic therapy acne, simultaneously little to skin side-effects, without lucifuge, photosensitive molecular light trans-utilization rate is high simultaneously, is conducive to efficiently treating acne.
Summary of the invention
It is an object of the present invention to provide the light power combination of a kind of photosensitive molecular, by choosing light power combination, it is achieved photosensitive molecular acne-removing, it is to avoid the phototoxicity of photosensitive molecular.
It is a still further object of the present invention to provide the application in abundance type acne treatment drug of the light power combination of a kind of photosensitive molecular, it, by utilizing photodynamic therapy technology effectively to suppress propionibacterium acnes and staphylococcus aureus, is finally reached the purpose of anti-acne.
Two principal characters according to the present invention, described light power combination comprises (1) chlorophyll；(2) red-light source；
Further saying, described photosensitive molecular is sodium copper chlorophllin and derivant, tartrazines, curcumin, riboflavin 5'-monophosphate sodium salt, lures red AC, new coccine, Chromotrope FB, indigo carmine, erioglaucine disodium salt, fast green FCF, Lissamine green B, naphthol green or acid green, alkermes, Xylene Red azorubine, amaranth, brilliant scarlet G 4R, chlorophyll and copper complex, brilliant black BN (PN), chocolate brown HT, β-carotene, bixin, lycopene, betanin, riboflavin, algae red B sodium salt and mixture thereof.Photosensitive molecular is as the high food additive of safety and light-sensitive coloring agent, and safety is high.
Further say, described photosensitive molecular is sodium copper chlorophllin and derivant, indigo carmine, erioglaucine disodium salt, fast green FCF, Lissamine green B, chlorophyll and copper complex, high with light source joint efficiency, kill and cause propionibacterium acnes, staphylococcus aureus efficiency high.
Light source can use any suitable light.Such as, low power sources or diode laser light source can be used.Any suitable light, such as visible or iraser can be used.Also high-energy black light, such as tungsten halogen or xenon arc light source can be used.Also LED light source can be used.The advantage using LED light source is that it will reduce the probability producing uncomfortable heat, therefore causes the discomfort reducing experimenter.Whole involved area can be implemented illumination procedure.The most preferably face, the whole internal implementation of back are irradiated.Such as, can be operable to light source irradiate accessible inner surface.Or, only irradiate some regions.Such as, can indivedual acnes of irradiation area.Light source may be suitable for all regions of face, including underthe nose, forehead, face cheek and surface thereof everywhere.
Can use any device of the light being suitable to launch wavelength described above, energy dose and luminous power, including pocket lamp, chargeable flashlight or desk lamp device, alternative light source includes the most luminotherapeutic device that can irradiate acne spots at once.
Further saying, the light source irradiation acne spots time is 0.5-30 minute, preferably 2-10 minute, it is ensured that photosensitive molecular, by the light source activation time, can guarantee that again simultaneously and will not irradiate the skin discomfort that cause treated acne personnel because of the time.
Described red-light source can be applied on skin, and expection utilizes wavelength between 400nm and 700nm, between preferably 400-500nm and 600-700nm, causes the activation of described photosensitive molecular (photosensitive molecular).The light source using this wavelength makes it possible to the (infiltration of about 5-8mm rank under the gratifying infiltration of described photosensitive molecular, the i.e. level of corium) work, photosensitization molecule is irradiated by the light source of specific wavelength simultaneously, produce upper state oxygen, kill propionibacterium acnes and staphylococcus aureus.
The light power combination of the present invention, the light power combination of described photosensitive molecular uses with liquid, semisolid, solid or aerosol form.The forms such as such as water solublity or insoluble muddy suspension, solution, curry, Emulsion (including cream), ointment, gel, serosity, suppository, tablet, capsule or fine spray agent are used.
The light power combination of photosensitive molecular of the present invention is mainly used in the treatment of propionibacterium, the particularly treatment of propionibacterium acnes, including that occurred and potential.According to character, the order of severity and/or position, acne can be categorized into multi-form, such as blackhead, Whiteheads, pimple, pustule and/or cyst.Including homeliness type acne, acne erythematosa, spherical acne, acne papulosa and the acne before menstrual period according to the medicable representative acne type of the present invention, the present invention is preferentially used for acne vulgaris, and acne may alternatively appear in back, chest, upper arm and/or face；The Therapeutic Method that the present invention provides can be used for treating any of above body position, particularly face.
The beneficial effects of the present invention is:
1, photosensitive molecular and light source are combined and are used for acne treatment by the present invention, and its therapeutic effect is good, and without antibiotic, without hormone, do not produce that drug resistance, side effect be little, safety non-toxic and economical and practical, the photosensitive molecular structure of employing is single, and safety is high.
2, the present invention can the most quickly kill propionibacterium and the staphylococcus aureus that induction acne occurs, green pus bacterium, treats acne, but does not damage normal cell.
3, active drug consumption of the present invention is little, and the effect killing acne pathogenic bacterium is strong.
4. the present invention takes photosensitive molecular as anti-acne system, and the light source in conjunction with different-waveband uses, and can effectively strengthen system bactericidal effect, hence it is evident that reduce anti-acne course for the treatment of.
5. the photosensitive molecular in the present invention is the composition of food additive, higher than phthalocyanines photosensitive molecular safety, and water solublity is strong.
Detailed description of the invention
Photosensitive molecular alternatively water solublity is also scattered in pearl, bar or the small container in whole face or topical acne medicine.The wavelength to the light used and optics dosage can be used and to the stable ingredient of photosensitizer.Other compositions are not the most by the wavelength absorption of light.It addition, germ killing drugs can be containing more than one photosensitive molecular to give the different acceptable colors of consumer.Photosensitive molecular absorbing wavelength for the common low toxicity of the present invention is shown in Table 1.
Table
1
Photosensitive molecular maximum absorption wavelength
Following example illustrate the present invention, but are not limiting as its scope.In these embodiments, unless otherwise noted, parts and percentages are given based on weight, and the photosensitive molecular be given in embodiment is the photosensitive molecular material in claim.
Table
2
The embodiment of the light power combination of photosensitive molecular
Embodiment 1
Weigh up each constituent content according to table 2,0.0001% photosensitive molecular solution is mixed with moisture, after fully dissolving, supply excess water, regulate pH to 5, at 0.1J/cm2Under light intensity, under 400nm wavelength, propionibacterium acnes, the antibacterial efficiency of staphylococcus aureus reaching 99%, matched group variable light source uses nature light, and other conditions are constant, and experimental group is apparently higher than the antibacterial efficiency of matched group (being specifically shown in Table 3).
Embodiment 2
Weigh up each constituent content according to table 2,0.0001% photosensitive molecular solution is mixed with moisture, after fully dissolving, supply excess water, regulate pH to 7, at 100J/cm2Under light intensity, under 600nm wavelength, propionibacterium acnes, the antibacterial efficiency of staphylococcus aureus reaching 99%, matched group variable light source uses nature light, and other conditions are constant, and experimental group is apparently higher than the antibacterial efficiency of matched group (being specifically shown in Table 3).
Embodiment 3
Weigh up each constituent content according to table 2,0.0001% photosensitive molecular solution is mixed with moisture, after fully dissolving, supply excess water, regulate pH to 9, at 1000J/cm2Under light intensity, under 600nm wavelength, propionibacterium acnes, the antibacterial efficiency of staphylococcus aureus reaching 99%, matched group variable light source uses nature light, and other conditions are constant, and experimental group is apparently higher than the antibacterial efficiency of matched group (being specifically shown in Table 3).
Embodiment 4
Weigh up each constituent content according to table 2,10% photosensitive molecular solution is mixed with moisture, after fully dissolving, supply excess water, regulate pH to 5, at 0.1J/cm2Under light intensity, under 400nm wavelength, propionibacterium acnes, the antibacterial efficiency of staphylococcus aureus reaching 99%, matched group variable light source uses nature light, and other conditions are constant, and experimental group is apparently higher than the antibacterial efficiency of matched group (being specifically shown in Table 3).
Embodiment 5
Weigh up each constituent content according to table 2,10% photosensitive molecular solution is mixed with moisture, after fully dissolving, supply excess water, regulate pH to 7, at 100J/cm2Under light intensity, under 600nm wavelength, propionibacterium acnes, the antibacterial efficiency of staphylococcus aureus reaching 99%, matched group variable light source uses nature light, and other conditions are constant, and experimental group is apparently higher than the antibacterial efficiency of matched group (being specifically shown in Table 3).
Embodiment 6
Weigh up each constituent content according to table 2,10% photosensitive molecular solution is mixed with moisture, after fully dissolving, supply excess water, regulate pH to 9, at 1000J/cm2Under light intensity, under 600nm wavelength, propionibacterium acnes, the antibacterial efficiency of staphylococcus aureus reaching 99%, matched group variable light source uses nature light, and other conditions are constant, and experimental group is apparently higher than the antibacterial efficiency of matched group (being specifically shown in Table 3).
Embodiment 7
Weigh up each constituent content according to table 2,50% photosensitive molecular solution is mixed with moisture, after fully dissolving, supply excess water, regulate pH to 5, at 0.1J/cm2Under light intensity, under 400nm wavelength, propionibacterium acnes, the antibacterial efficiency of staphylococcus aureus reaching 99%, matched group variable light source uses nature light, and other conditions are constant, and experimental group is apparently higher than the antibacterial efficiency of matched group (being specifically shown in Table 3).
Embodiment 8
Weigh up each constituent content according to table 2,50% photosensitive molecular solution is mixed with moisture, after fully dissolving, supply excess water, regulate pH to 7, at 100J/cm2Under light intensity, under 600nm wavelength, propionibacterium acnes, the antibacterial efficiency of staphylococcus aureus reaching 99%, matched group variable light source uses nature light, and other conditions are constant, and experimental group is apparently higher than the antibacterial efficiency of matched group (being specifically shown in Table 3).
Embodiment 9
Weigh up each constituent content according to table 2,50% photosensitive molecular solution is mixed with moisture, after fully dissolving, supply excess water, regulate pH to 9, at 1000J/cm2Under light intensity, under 600nm wavelength, propionibacterium acnes, the antibacterial efficiency of staphylococcus aureus reaching 99%, matched group variable light source uses nature light, and other conditions are constant, and experimental group is apparently higher than the antibacterial efficiency of matched group (being specifically shown in Table 3).
Table
3
The antimicrobial efficiency of photosensitive molecular light power combination under different light sources
Table
4
The antimicrobial efficiency of the photosensitive molecular light power combination of different component content
Embodiment 1-9 demonstrates the intensity of light source, light application time, pH for the impact of system, determine the optimum range being applicable to system, the present invention will be described for 1-9 in conjunction with specific embodiments, for the pH condition of light power combination, the intensity of illumination (0.1-1000J/CM of photosensitizer illumination of photosensitive molecular within the scope of the claims2), pH condition (5-9) and light irradiation time (2min-10min) be suitable for this system, system antibacterial effect efficiency reaches 99% (being specifically shown in Table 4), and system antibacterial tests meets stripping property bacteriostatic test standard during Ministry of Public Health (2002) disinfection technology standard requires.
Embodiment 10
There is the light power combination of the photosensitive molecular therapeutic effect to acne.
Clinical investigation phase is entered by the light power combination of the photosensitive molecular in embodiment 1-9, the patient implementing treatment has 50 examples, wherein there are 20 male and 30 women (18 years old age or more than), face side is not smeared and is combined containing photosensitizer photosensitive molecular, and opposite side is smeared and combined without photosensitizer photosensitive molecular.This research evaluation after having smeared photosensitive molecular, the effectiveness carried out after using up irradiation and safety evaluation.Have rated the most further photosensitive molecular smear with illumination be utilized in conjunction with treat acne effect.Patient's situation before the treatment: acne is red and swollen, indivedual abscess, and wash one's face pain, patient has smeared the photosensitive molecular solution in embodiment 1-9 for the first time at half side face acne spots, irradiates 2min through LED light；Next day, the photosensitive molecular solution in embodiment 1-9 is smeared rear small pox and is significantly reduced, and continues to smear embodiment 1-9 photosensitive molecular solution, irradiates 2min through LED light.Third time is observed small pox great majority by fanaticism and is disappeared, and continues to smear embodiment 1-9 photosensitive molecular solution, irradiates 2min through LED light.Being observed by fanaticism for 4th time, pox is the most flat, continues the photosensitive molecular solution smearing in embodiment 1-9, irradiates 2min through LED light.Through 6 physical therapys, pox is the most flat.Being for 6 times a course for the treatment of, severe acne can suitably increase the course for the treatment of.Matched group is smeared through same, but does not use LED light source to irradiate, and small pox does not significantly reduce, and the epidermal structure cicatrix being damaged does not significantly reduces.
Although the embodiment that disclosed herein is as above, but described content only readily appreciates the present invention and the embodiment that uses, is not limited to the present invention.Technical staff in any art of the present invention; on the premise of without departing from the spirit and scope that disclosed herein; any amendment and change can be carried out in the form implemented and details, but the scope of patent protection of the present invention, still must be defined in the range of standard with appending claims.
Claims (8)
1. a light power combination for photosensitive molecular, is mainly formed light power combination by (1) photosensitive molecular (2) light source.
The light power combination of photosensitive molecular the most according to claim 1, it is characterized in that, described photosensitive molecular is selected from: sodium copper chlorophllin and derivant, tartrazines, curcumin, riboflavin 5'-monophosphate sodium salt, lure red AC, new coccine, Chromotrope FB, indigo carmine, erioglaucine disodium salt, fast green FCF, Lissamine green B, naphthol green or acid green, alkermes, Xylene Red azorubine, amaranth, brilliant scarlet G 4R, chlorophyll and copper complex, brilliant black BN
(PN), chocolate brown HT, β-carotene, bixin, lycopene, betanin, riboflavin, algae red B sodium salt and mixture thereof.
The light power combination of photosensitive molecular the most according to claim 1, it is characterised in that described photosensitive molecular is selected from: sodium copper chlorophllin and derivant, indigo carmine, erioglaucine disodium salt, fast green FCF, Lissamine green B, chlorophyll and copper complex.
The light power combination of photosensitive molecular the most according to claim 1, it is characterised in that the wave-length coverage of light source is 400-700nm.
The light power combination of photosensitive molecular the most according to claim 1, it is characterised in that the irradiation time of light source is 0.5-30 minute.
The light power combination of photosensitive molecular the most according to claim 1, it is characterised in that the intensity of light source is 0.1-1000J/cm2。
7. the light power combination of the photosensitive molecular described in any one of claim 1-6, the application in medicine of the light power combination of wherein said photosensitive molecular.
8. the light power combination of the photosensitive molecular described in any one of claim 1-6, the application in abundance type acne treatment drug of the light power combination of wherein said photosensitive molecular.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102725026A (en) * | 2009-12-21 | 2012-10-10 | 高露洁-棕榄公司 | Method of treating and/or preventing conditions caused by microorganisms using an oral light device |
| CN105163759A (en) * | 2013-03-14 | 2015-12-16 | 克洛克斯科技公司 | Biophotonic materials and uses thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102725026A (en) * | 2009-12-21 | 2012-10-10 | 高露洁-棕榄公司 | Method of treating and/or preventing conditions caused by microorganisms using an oral light device |
| CN105163759A (en) * | 2013-03-14 | 2015-12-16 | 克洛克斯科技公司 | Biophotonic materials and uses thereof |
Non-Patent Citations (1)
| Title |
|---|
| 施建新等: "光动力疗法治疗痤疮的光敏剂研究进展", 《临床皮肤科杂志》 * |
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Application publication date: 20161012 |