CN105999020A - Facial neuritis treating pharmaceutical composition and preparation method thereof - Google Patents
Facial neuritis treating pharmaceutical composition and preparation method thereof Download PDFInfo
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- CN105999020A CN105999020A CN201610338500.5A CN201610338500A CN105999020A CN 105999020 A CN105999020 A CN 105999020A CN 201610338500 A CN201610338500 A CN 201610338500A CN 105999020 A CN105999020 A CN 105999020A
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- pharmaceutical composition
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Abstract
The invention relates to a facial neuritis treating pharmaceutical composition and a preparation method thereof. The pharmaceutical composition is prepared from, by weight, 40-60 parts of androsace umbellata, 20-40 parts of radix scutellariae, 10-40 parts of flos chrysanthemi, 10-40 parts of the rhizome of cyrtomium, 5-25 parts of daphne genkwa, 20-50 parts of Chinese yam, 10-50 parts of radix angelicae sinensis, 10-40 parts of dried tangerine peel, 10-30 parts of areca-nut, 10-30 parts of fructus amomi and 10-30 parts of fructus cnidii, by the steps of decocting in water and alcohol leaching. As the total effective rate reaches 93.7% according to 270 facial neuritis treating examples, the facial neuritis treating pharmaceutical composition has remarkable efficacy, is free of adverse reaction, toxic and side effects, and has high promotion value.
Description
Technical field
The present invention relates to field of medicine invention, be specifically related to a kind of pharmaceutical composition treating facial neuritis
And preparation method thereof.
Background technology
Facial neuritis refers to acute non-suppuration facial neuritis, causes a kind of face of infranuclear facial palsy
Portion's pathological changes, primary disease any age all can fall ill, with 20-40 year the most common, male is more than women, many
Falling ill in side, bilateral sends out that patient is less to be seen simultaneously.Its cause of disease and pathogenesis are the most fully aware of, and one
As think owing to nervus facialis is positioned at the facial canal confined space, Different types of etiopathogenises such as catch cold catch a cold, virus
Property or nonspecific infection cause nervus facialis edema swelling, are limited by neurocele and are oppressed.The lighter god
Through pressurized, myelin damage；Severe one causes nerve injury in various degree, axonal degeneration, and regeneration function is poor,
Then cause functional rehabilitation incomplete, leave serious sequela.More primary disease morbidity suddenly, has face to catch a cold and is subject to
Wind history.Rising and have face uncomfortable after being ill, some patients has pain after ear, inconvenience of speaking, and face is stiff,
Distortion of commissure, volume stricture of vagina disappearance etc..Patient's nasolabial fold flattens smooth, leaks gas during air-blowing, widening of palpebral fissure, stream
Tear, hypophasis, 2/3rds hypogeusia before tongue, or have hypercacusis, mastoid process tenderness,
External auditory meatus or tympanum herpes etc..Primary disease belongs to the categories such as " facial paralysis ", " facial paralysis " of Chinese medicine.Face
Bed is dialectical is divided into wind-cold channel blocking network, expectorant stasis of blood internal resistance, wind heat resistance three pattern of syndrome of network.
The at present treatment for facial neuritis uses acupuncture, Western medicine therapy more, and relapse rate is the highest, can not
Cure, and face nerve damage is serious, brings great misery to patient, need to improve, pure west
Medicine therapeutic effect is bad.
The present inventor, in order to solve the problems referred to above, have developed a kind of new drug.
Summary of the invention
It is an object of the invention to provide a kind of pharmaceutical composition treating facial neuritis.
It is a further object of the present invention to provide the preparation method of a kind of pharmaceutical composition treating facial neuritis.
The present invention provides a kind of pharmaceutical composition treating facial neuritis, and this pharmaceutical composition is by following heavy
The medicine of amount part is made: Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 40-60 part, Radix Scutellariae 20-40 part, Flos Chrysanthemi 10-40 part, Rhizoma Osmundae
10-40 part, Flos Genkwa 5-25 part, Rhizoma Dioscoreae 20-50 part, Radix Angelicae Sinensis 10-50 part, Pericarpium Citri Reticulatae 10-40 part,
Semen Arecae 10-30 part, Fructus Amomi 10-30 part, Fructus Cnidii 10-30 part.
Preferably, pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 42-58
Part, Radix Scutellariae 22-38 part, Flos Chrysanthemi 15-35 part, Rhizoma Osmundae 15-35 part, Flos Genkwa 8-22 part, Rhizoma Dioscoreae 25-45
Part, Radix Angelicae Sinensis 15-45 part, Pericarpium Citri Reticulatae 12-38 part, Semen Arecae 12-28 part, Fructus Amomi 12-28 part, cnidium monnieri
Sub-12-28 part.
It is further preferred that pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Herba Androsaces Umbellatae (Herba Androsaces Coccineae)
45-55 part, Radix Scutellariae 25-35 part, Flos Chrysanthemi 18-32 part, Rhizoma Osmundae 18-32 part, Flos Genkwa 10-20 part,
Rhizoma Dioscoreae 28-42 part, Radix Angelicae Sinensis 20-40 part, Pericarpium Citri Reticulatae 15-35 part, Semen Arecae 15-25 part, Fructus Amomi 15-25
Part, Fructus Cnidii 15-25 part.
Further preferred, pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Herba Androsaces Umbellatae (Herba Androsaces Coccineae)
47-52 part, Radix Scutellariae 28-32 part, Flos Chrysanthemi 20-30 part, Rhizoma Osmundae 20-30 part, Flos Genkwa 12-18 part,
Rhizoma Dioscoreae 30-40 part, Radix Angelicae Sinensis 25-35 part, Pericarpium Citri Reticulatae 20-30 part, Semen Arecae 18-22 part, Fructus Amomi 18-22
Part, Fructus Cnidii 18-22 part.
Further preferred, pharmaceutical composition of the present invention is made up of the medicine of following weight portion: some ground
50 parts of prunus mume (sieb.) sieb.et zucc., Radix Scutellariae 30 parts, Flos Chrysanthemi 25 parts, Rhizoma Osmundae 25 parts, Flos Genkwa 15 parts, Rhizoma Dioscoreae 35 parts,
Radix Angelicae Sinensis 30 parts, Pericarpium Citri Reticulatae 25 parts, Semen Arecae 20 parts, Fructus Amomi 20 parts, Fructus Cnidii 20 parts.
Pharmaceutical composition of the present invention is possibly together with pharmaceutically acceptable carrier or diluent.
Pharmaceutical composition of the present invention is solid preparation or liquid preparation, described solid preparation be tablet,
Capsule, granule or pill；Described liquid preparation is oral liquid.
The preparation method of pharmaceutical composition of the present invention comprises the following steps:
By Herba Androsaces Umbellatae (Herba Androsaces Coccineae), Radix Scutellariae, Flos Chrysanthemi, Rhizoma Osmundae, Flos Genkwa, Chinese yam and angelica, Pericarpium Citri Reticulatae, Semen Arecae, sand
Core, Fructus Cnidii pulverize and sieve, and mix homogeneously with pharmaceutically acceptable carrier or diluent, are prepared as preparation.
The preparation method of pharmaceutical composition of the present invention comprises the following steps:
1) weight portion medicine is weighed；
2) by Herba Androsaces Umbellatae (Herba Androsaces Coccineae), Radix Scutellariae, Flos Chrysanthemi, Rhizoma Osmundae, Flos Genkwa, Rhizoma Dioscoreae boiling 2-5 time, every time
4-7 hour, collecting decoction, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Semen Arecae, Fructus Amomi, Fructus Cnidii are added the ethanol of 65-85% of 2-5 times amount,
Soaking 2-4 hour, filter, filtrate concentrates, and dry, pulverize into fine powder standby；Filtering residue adds 4-6 times
The water of amount, decocts 2-4 time, each 1-3 hour, filters, merging filtrate, concentrate drying, pulverizes
Become fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or
Diluent mix homogeneously, makes preparation.
Preferably, the preparation method of pharmaceutical composition of the present invention comprises the following steps:
1) weight portion medicine is weighed；
2) by Herba Androsaces Umbellatae (Herba Androsaces Coccineae), Radix Scutellariae, Flos Chrysanthemi, Rhizoma Osmundae, Flos Genkwa, Rhizoma Dioscoreae boiling 3 times, each 5
Hour, collecting decoction, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Semen Arecae, Fructus Amomi, Fructus Cnidii are added 3 times amount 75% ethanol, leaching
Steeping 3 hours, filter, filtrate concentrates, and dry, pulverize into fine powder standby；Filtering residue adds the water of 5 times amount,
Decoct 3 times, each 2 hours, filter, merging filtrate, concentrate drying, be ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or
Diluent mix homogeneously, makes preparation.
Described parts by weight can be unit of weight known to the field of medicaments such as μ g, mg, g, kg.
The implication of times amount refers to the weight ratio of medical material.
Described pharmaceutically acceptable carrier or diluent refer to the pharmaceutical carrier that pharmaceutical field is conventional, choosing
One or more in filler, binding agent, disintegrating agent, lubricant, surfactant or correctives.
Wherein said filler selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol,
Microcrystalline Cellulose or glucose etc.；
Described binding agent is selected from cellulose derivative, alginate, gelatin or polyvinylpyrrolidone etc.；
Described disintegrating agent selected from microcrystalline Cellulose, carboxymethyl starch sodium, polyvinylpyrrolidone, low take
For hydroxypropyl cellulose or cross-linking sodium carboxymethyl cellulose；
Described lubricant selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, silicon dioxide,
Pulvis Talci or magnesium stearate；
Described surfactant is selected from dodecylbenzene sodium sulfonate, stearic acid, PULLRONIC F68
Copolymer, fatty acid Pyrusussuriensis be smooth or Polysorbate (tween) etc.；
Described correctives is selected from aspartame, Sucralose or saccharin sodium.
The pharmaceutical composition of the treatment facial neuritis that the present invention provides has the advantages that
Treatment facial neuritis 270 example, patient's cardinal symptom: facial numbness is meciless, facial hemiparalysis, paralysis
Paralysis, can not frown, frown, grinningly, drum cheek, facial expression myoparalysis, volume stricture of vagina disappears, nasolabial fold
Shoal, ptosis of labial angle, time grinningly, bicker is askew to strong side, and total effective rate reaches 93.7%, and effect is obvious, and
And do not find untoward reaction and toxic and side effects, medicine composite for curing facial neuritis curative effect of the present invention is described
Significantly, there is good promotional value.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
Embodiment 1
Prescription: Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 40g, Radix Scutellariae 20g, Flos Chrysanthemi 10g, Rhizoma Osmundae 10g, Flos Genkwa 5g, Rhizoma Dioscoreae 20g,
Radix Angelicae Sinensis 10g, Pericarpium Citri Reticulatae 10g, Semen Arecae 10g, Fructus Amomi 10g, Fructus Cnidii 10g.
Preparation method:
1) weight portion medicine is weighed；
2) by Herba Androsaces Umbellatae (Herba Androsaces Coccineae), Radix Scutellariae, Flos Chrysanthemi, Rhizoma Osmundae, Flos Genkwa, Rhizoma Dioscoreae boiling 2 times, each 4
Hour, collecting decoction, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Semen Arecae, Fructus Amomi, Fructus Cnidii are added 2 times amount 65% ethanol, leaching
Steeping 2 hours, filter, filtrate concentrates, and dry, pulverize into fine powder standby；Filtering residue adds 4-6 times amount
Water, decocts 2 times, each 1 hour, filters, merging filtrate, concentrate drying, be ground into fine powder,
Standby；
4) by step 2), 3) standby fine powder mix homogeneously, add and account for mix homogeneously fine powder weight 1/5
Starch, load capsule, make capsule.
Embodiment 2
Prescription: Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 60g, Radix Scutellariae 40g, Flos Chrysanthemi 40g, Rhizoma Osmundae 40g, Flos Genkwa 25g, Rhizoma Dioscoreae
50g, Radix Angelicae Sinensis 50g, Pericarpium Citri Reticulatae 40g, Semen Arecae 30g, Fructus Amomi 30g, Fructus Cnidii 30g.
Preparation method:
1) weight portion medicine is weighed；
2) by Herba Androsaces Umbellatae (Herba Androsaces Coccineae), Radix Scutellariae, Flos Chrysanthemi, Rhizoma Osmundae, Flos Genkwa, Rhizoma Dioscoreae boiling 5 times, each 7
Hour, collecting decoction, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Semen Arecae, Fructus Amomi, Fructus Cnidii are added 5 times amount 85% ethanol, leaching
Steeping 4 hours, filter, filtrate concentrates, and dry, pulverize into fine powder standby；Filtering residue adds the water of 6 times amount,
Decoct 4 times, each 3 hours, filter, merging filtrate, concentrate drying, be ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add and account for mix homogeneously fine powder weight 2/5
Starch, load capsule, make capsule.
Embodiment 3
Prescription: Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 42g, Radix Scutellariae 22g, Flos Chrysanthemi 15g, Rhizoma Osmundae 15g, Flos Genkwa 8g, Rhizoma Dioscoreae 25g,
Radix Angelicae Sinensis 15, Pericarpium Citri Reticulatae 12g, Semen Arecae 12g, Fructus Amomi 12g, Fructus Cnidii 12g.
Preparation method:
1) weight portion medicine is weighed；
2) by Herba Androsaces Umbellatae (Herba Androsaces Coccineae), Radix Scutellariae, Flos Chrysanthemi, Rhizoma Osmundae, Flos Genkwa, Rhizoma Dioscoreae boiling 4 times, each 5
Hour, collecting decoction, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Semen Arecae, Fructus Amomi, Fructus Cnidii are added 3 times amount 75 ethanol, leaching
Steeping 3 hours, filter, filtrate concentrates, and dry, pulverize into fine powder standby；Filtering residue adds the water of 5 times amount,
Decoct 3 times, each 2 hours, filter, merging filtrate, concentrate drying, be ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add and account for mix homogeneously fine powder weight 1/5
Starch, tabletting, obtain the tablet of the application.
Embodiment 4
Prescription: Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 58g, Radix Scutellariae 38g, Flos Chrysanthemi 35g, Rhizoma Osmundae 35g, Flos Genkwa 22g, Rhizoma Dioscoreae
45g, Radix Angelicae Sinensis 45g, Pericarpium Citri Reticulatae 38g, Semen Arecae 28g, Fructus Amomi 28g, Fructus Cnidii 28g.
Preparation method:
1) weight portion medicine is weighed；
2) by Herba Androsaces Umbellatae (Herba Androsaces Coccineae), Radix Scutellariae, Flos Chrysanthemi, Rhizoma Osmundae, Flos Genkwa, Rhizoma Dioscoreae boiling 4 times, each 6
Hour, collecting decoction, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Semen Arecae, Fructus Amomi, Fructus Cnidii are added 4 times amount 80% ethanol, leaching
Steeping 3 hours, filter, filtrate concentrates, and dry, pulverize into fine powder standby；Filtering residue adds the water of 5 times amount,
Decoct 3 times, each 2 hours, filter, merging filtrate, concentrate drying, be ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add and account for mix homogeneously fine powder weight
The starch of 1/5, mixing, pelletize, be dried, granulate, obtain the granule of the application.
Embodiment 5
Prescription: Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 45g, Radix Scutellariae 25g, Flos Chrysanthemi 18g, Rhizoma Osmundae 18g, Flos Genkwa 10g, Rhizoma Dioscoreae
28, Radix Angelicae Sinensis 20g, Pericarpium Citri Reticulatae 15g, Semen Arecae 15g, Fructus Amomi 15g, Fructus Cnidii 15g.
Preparation method:
1) weight portion medicine is weighed；
2) by Herba Androsaces Umbellatae (Herba Androsaces Coccineae), Radix Scutellariae, Flos Chrysanthemi, Rhizoma Osmundae, Flos Genkwa, Rhizoma Dioscoreae boiling 3 times, each 5
Hour, collecting decoction, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Semen Arecae, Fructus Amomi, Fructus Cnidii are added 3 times amount 75% ethanol, leaching
Steeping 3 hours, filter, filtrate concentrates, and dry, pulverize into fine powder standby；Filtering residue adds the water of 5 times amount,
Decoct 3 times, each 2 hours, filter, merging filtrate, concentrate drying, be ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add and account for mix homogeneously fine powder weight
The starch of 1/5, is dried, tabletting, obtains the tablet of the application.
Embodiment 6
Prescription: Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 55g, Radix Scutellariae 35g, Flos Chrysanthemi 32g, Rhizoma Osmundae 32g, Flos Genkwa 20g, Rhizoma Dioscoreae
42g, Radix Angelicae Sinensis 40g, Pericarpium Citri Reticulatae 35g, Semen Arecae 25g, Fructus Amomi 25g, Fructus Cnidii 25g.
Preparation method:
1) weight portion medicine is weighed；
2) by Herba Androsaces Umbellatae (Herba Androsaces Coccineae), Radix Scutellariae, Flos Chrysanthemi, Rhizoma Osmundae, Flos Genkwa, Rhizoma Dioscoreae boiling 3 times, each 5
Hour, collecting decoction, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Semen Arecae, Fructus Amomi, Fructus Cnidii are added 3 times amount 75% ethanol, leaching
Steeping 3 hours, filter, filtrate concentrates, and dry, pulverize into fine powder standby；Filtering residue adds the water of 5 times amount,
Decoct 3 times, each 2 hours, filter, merging filtrate, concentrate drying, be ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add and account for mix homogeneously fine powder weight 1/5
Starch, mixing, pelletize, be dried, granulate, obtain the granule of the application.
Embodiment 7
Prescription: Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 47g, Radix Scutellariae 28g, Flos Chrysanthemi 20g, Rhizoma Osmundae 20g, Flos Genkwa 12g, Rhizoma Dioscoreae
30g, Radix Angelicae Sinensis 25g, Pericarpium Citri Reticulatae 20g, Semen Arecae 18g, Fructus Amomi 18g, Fructus Cnidii 18g.
Preparation method:
1) weight portion medicine is weighed；
2) by Herba Androsaces Umbellatae (Herba Androsaces Coccineae), Radix Scutellariae, Flos Chrysanthemi, Rhizoma Osmundae, Flos Genkwa, Rhizoma Dioscoreae boiling 3 times, each 5
Hour, collecting decoction, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Semen Arecae, Fructus Amomi, Fructus Cnidii are added 3 times amount 75% ethanol, leaching
Steeping 3 hours, filter, filtrate concentrates, and dry, pulverize into fine powder standby；Filtering residue adds the water of 5 times amount,
Decoct 3 times, each 2 hours, filter, merging filtrate, concentrate drying, be ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add and account for mix homogeneously fine powder weight 1/5
Starch, mixing, pelletize, be dried, granulate, obtain the granule of the application.
Embodiment 8
Prescription: Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 52g, Radix Scutellariae 32g, Flos Chrysanthemi 30g, Rhizoma Osmundae 30g, Flos Genkwa 18g, Rhizoma Dioscoreae
40g, Radix Angelicae Sinensis 35g, Pericarpium Citri Reticulatae 30g, Semen Arecae 22g, Fructus Amomi 22g, Fructus Cnidii 22g.
Preparation method:
1) weight portion medicine is weighed；
2) by Herba Androsaces Umbellatae (Herba Androsaces Coccineae), Radix Scutellariae, Flos Chrysanthemi, Rhizoma Osmundae, Flos Genkwa, Rhizoma Dioscoreae boiling 3 times, each 5
Hour, collecting decoction, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Semen Arecae, Fructus Amomi, Fructus Cnidii are added 3 times amount 75% ethanol, leaching
Steeping 3 hours, filter, filtrate concentrates, and dry, pulverize into fine powder standby；Filtering residue adds the water of 5 times amount,
Decoct 3 times, each 2 hours, filter, merging filtrate, concentrate drying, be ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add and account for mix homogeneously fine powder weight 2/5
Starch, load capsule, make capsule.
Embodiment 9
Prescription: Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 50g, Radix Scutellariae 30g, Flos Chrysanthemi 25g, Rhizoma Osmundae 25g, Flos Genkwa 15g, Rhizoma Dioscoreae
35g, Radix Angelicae Sinensis 30g, Pericarpium Citri Reticulatae 25g, Semen Arecae 20g, Fructus Amomi 20g, Fructus Cnidii 20g.
Preparation method:
1) weight portion medicine is weighed；
2) by Herba Androsaces Umbellatae (Herba Androsaces Coccineae), Radix Scutellariae, Flos Chrysanthemi, Rhizoma Osmundae, Flos Genkwa, Rhizoma Dioscoreae boiling 3 times, each 5
Hour, collecting decoction, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Semen Arecae, Fructus Amomi, Fructus Cnidii are added 3 times amount 75% ethanol, leaching
Steeping 3 hours, filter, filtrate concentrates, and dry, pulverize into fine powder standby；Filtering residue adds the water of 5 times amount,
Decoct 3 times, each 2 hours, filter, merging filtrate, concentrate drying, be ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add and account for mix homogeneously fine powder weight 2/5
Starch, load capsule, make capsule.
In order to sketch beneficial effects of the present invention further, inventor has done clinical trial, specific as follows:
One, physical data: admitted patient 270 example altogether.Wherein male 180 example, women 90 example.Year
Age the maximum 62 years old, reckling 20 years old；Course of disease elder 3 months, the shortest person 2 weeks.
Two, diagnostic criteria: all cases all meet infranuclear facial palsy in " neurological "
Diagnostic criteria.Clinical manifestation is that onset is unexpected, often finds when sleep is waken up that unilateral face is stiff, numb
Wood, paralyse, can not frown, frown, grinningly, the action such as bulging cheek, gargle and leak, catacleisis is not
Entirely, epiphora induced by wind, bicker is askew to strong side, and volume stricture of vagina disappears or shoals, widening of palpebral fissure, unilateral during the drum cheek
Bicker is leaked gas.Some patients is 2/3 taste after also ear, before ear and before face ache, or companion's Ipsilateral tongue
Feel and go down or disappear, hyperacusis.Ipsilateral facial expression myoparalysis, volume stricture of vagina disappears, and nasolabial fold shoals,
Ptosis of labial angle, time grinningly, bicker is askew to strong side.And got rid of other diseases and (include Ji Lan-Ba Lei
Syndrome, PFT, neural Lyme disease, diabetes, wound, parotid disease and otitis media etc.)
Cause the possibility of facial paralysis, in addition to peripheral facial paralysis, without other nervous system positive signs.Exclusion standard
Facial paralysis, infranuclear facial palsy that central facial palsy, Posterior fossa pathological changes cause surpass
Spend 3 months, with severe hypertension and the patient of other serious organic diseases.
Three, test method: be randomly divided into 9 groups, the drug regimen of embodiment of the present invention 1-9 is administered orally respectively
Thing, a 3g, one day 3 times, 4 weeks be a course for the treatment of.
Four, efficacy assessment standard
Cure: Ipsilateral facial perception recovers normal, and facial hemiparalysis disappears.
Effective: Ipsilateral facial perception recovers normal substantially, the most slight mouth is askew and hypophasis.
Effective: Ipsilateral facial perception takes a turn for the better, the most slight mouth is askew and hypophasis.
Invalid: after taking medicine, the state of an illness is not improved.
Five, experimental result
Most patients is using medicine within about 3 weeks, to have significantly sensation according to the inventive method,
Facial numbness is meciless, facial hemiparalysis, paralysis, can not frown, frown, grinningly, drum cheek etc. symptom
Alleviate, continued to take the 1-3 month, effect such as following table:
| Group | Clinical recovery | Effective | Effectively | Invalid | Add up to | Effective percentage (%) |
| Embodiment 1 | 14 | 8 | 6 | 2 | 30 | 93.3% |
| Embodiment 2 | 12 | 7 | 8 | 3 | 30 | 90.0% |
| Embodiment 3 | 15 | 5 | 8 | 2 | 30 | 93.3% |
| Embodiment 4 | 13 | 7 | 8 | 2 | 30 | 93.3% |
| Embodiment 5 | 15 | 9 | 5 | 1 | 30 | 96.7% |
| Embodiment 6 | 14 | 9 | 4 | 3 | 30 | 90.0% |
| Embodiment 7 | 16 | 8 | 5 | 1 | 30 | 96.7% |
| Embodiment 8 | 15 | 8 | 5 | 2 | 30 | 93.3% |
| Embodiment 9 | 14 | 10 | 5 | 1 | 30 | 96.7% |
Treatment facial neuritis 270 example, total effective rate reaches 93.7%, and effect is obvious, and does not finds bad
Reaction and toxic and side effects, illustrate that medicine composite for curing facial neuritis of the present invention is evident in efficacy, have good
Good promotional value.
Six, model case
1, certain female, 21 years old, was affected by the cold before two weeks and causes left side face apathetic, facial hemiparalysis,
Take the embodiment of the present invention 1 pharmaceutical composition, a 3g, one day 3 times, after 4 weeks, left side facial numbness
Meciless, facial hemiparalysis symptom alleviates, and continues to take February, recovers normal.
2, certain man, 52 years old, facial numbness was meciless, it is impossible to frown, and took the embodiment of the present invention 2 medicine
Compositions, a 3g, one day 3 times, after 3 weeks, symptom alleviates, and continues to take January, and facial perception is extensive
Multiple normal, can frown.
3, certain man, 55 years old, facial numbness was meciless, it is impossible to grinningly, rouses cheek, takes the embodiment of the present invention
3 pharmaceutical compositions, a 3g, one day 3 times, after 4 weeks, symptom alleviates, and continues to take 1.5 months, face
Sensory recovery is normal, can grinningly, drum cheek.
4, certain man, 58 years old, facial numbness was meciless, it is impossible to frown, grinningly, drum cheek, take the present invention
Embodiment 4 pharmaceutical composition, a 3g, one day 3 times, after 5 weeks, symptom alleviates, and continues to take February,
Facial perception recovers normal, can frown, grinningly, drum cheek.
5, certain man, 42 years old, facial numbness was meciless, gargles and leaks, hypophasis, epiphora induced by wind,
Taking the embodiment of the present invention 5 pharmaceutical composition, a 3g, one day 3 times, after 4 weeks, symptom alleviates, and continues
Continuing and take February, facial perception recovers normal, other glucose recovery.
6, certain female, 60 years old, facial expression myoparalysis, volume stricture of vagina disappeared.Take the embodiment of the present invention 6 medicine
Compositions, a 3g, one day 3 times, after 5 weeks, symptom alleviates, and continues to take February, facial perception
Recover normal, other glucose recovery.
7, certain man, 62 years old, facial expression myoparalysis, nasolabial fold shoaled, ptosis of labial angle, mouth time grinningly
Wai Xiangjian side, angle.Take the embodiment of the present invention 7 pharmaceutical composition, a 3g, one day 3 times, after 5 weeks,
Symptom alleviates, and continues to take February, and facial perception recovers normal, other glucose recovery.
8, certain female, 53 years old, facial numbness was meciless, hypophasis, and nasolabial fold shoals, and took this
Inventive embodiments 8 pharmaceutical composition, a 3g, one day 3 times, after 4 weeks, symptom alleviates, and continues to take 2
Month, facial perception recovers normal, other glucose recovery.
9, certain man, 63 years old, facial expression myoparalysis, nasolabial fold shoaled, ptosis of labial angle, mouth time grinningly
Wai Xiangjian side, angle.Take the embodiment of the present invention 9 pharmaceutical composition, a 3g, one day 3 times, after 4 weeks,
Symptom alleviates, and continues to take February, and facial perception recovers normal, other glucose recovery.
Although, used general explanation, detailed description of the invention and test, the present invention made
Detailed description, but on the basis of the present invention, it can be made some amendments or improve, this is right
It is apparent from for those skilled in the art.Therefore, without departing from theon the basis of the spirit of the present invention
These modifications or improvements, belong to the scope of protection of present invention.
Claims (10)
1. the pharmaceutical composition treating facial neuritis, it is characterised in that this pharmaceutical composition is by following
The medicine of weight portion is made: Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 40-60 part, Radix Scutellariae 20-40 part, Flos Chrysanthemi 10-40 part, pass through
Many 10-40 parts, Flos Genkwa 5-25 part, Rhizoma Dioscoreae 20-50 part, Radix Angelicae Sinensis 10-50 part, Pericarpium Citri Reticulatae 10-40 part,
Semen Arecae 10-30 part, Fructus Amomi 10-30 part, Fructus Cnidii 10-30 part.
Pharmaceutical composition the most according to claim 1, it is characterised in that this pharmaceutical composition by with
The medicine of lower weight portion is made: Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 42-58 part, Radix Scutellariae 22-38 part, Flos Chrysanthemi 15-35 part,
Rhizoma Osmundae 15-35 part, Flos Genkwa 8-22 part, Rhizoma Dioscoreae 25-45 part, Radix Angelicae Sinensis 15-45 part, Pericarpium Citri Reticulatae 12-38
Part, Semen Arecae 12-28 part, Fructus Amomi 12-28 part, Fructus Cnidii 12-28 part.
Pharmaceutical composition the most according to claim 2, it is characterised in that this pharmaceutical composition by with
The medicine of lower weight portion is made: Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 45-55 part, Radix Scutellariae 25-35 part, Flos Chrysanthemi 18-32 part,
Rhizoma Osmundae 18-32 part, Flos Genkwa 10-20 part, Rhizoma Dioscoreae 28-42 part, Radix Angelicae Sinensis 20-40 part, Pericarpium Citri Reticulatae 15-35
Part, Semen Arecae 15-25 part, Fructus Amomi 15-25 part, Fructus Cnidii 15-25 part.
Pharmaceutical composition the most according to claim 3, it is characterised in that this pharmaceutical composition by with
The medicine of lower weight portion is made: Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 47-52 part, Radix Scutellariae 28-32 part, Flos Chrysanthemi 20-30 part,
Rhizoma Osmundae 20-30 part, Flos Genkwa 12-18 part, Rhizoma Dioscoreae 30-40 part, Radix Angelicae Sinensis 25-35 part, Pericarpium Citri Reticulatae 20-30
Part, Semen Arecae 18-22 part, Fructus Amomi 18-22 part, Fructus Cnidii 18-22 part.
Pharmaceutical composition the most according to claim 4, it is characterised in that this pharmaceutical composition by with
The medicine of lower weight portion is made: Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 50 parts, Radix Scutellariae 30 parts, Flos Chrysanthemi 25 parts, Rhizoma Osmundae 25 parts,
Flos Genkwa 15 parts, Rhizoma Dioscoreae 35 parts, Radix Angelicae Sinensis 30 parts, Pericarpium Citri Reticulatae 25 parts, Semen Arecae 20 parts, Fructus Amomi 20 parts,
Fructus Cnidii 20 parts.
6. according to the pharmaceutical composition described in any one of claim 1-5, it is characterised in that this medicine
Compositions is possibly together with pharmaceutically acceptable carrier or diluent.
Pharmaceutical composition the most according to claim 6, it is characterised in that described pharmaceutical composition
For solid preparation or liquid preparation, described solid preparation is tablet, capsule, granule or pill；
Described liquid preparation is oral liquid.
8. the method preparing pharmaceutical composition described in any one of claim 1-5, its feature exists
In, the method comprises the following steps:
By Herba Androsaces Umbellatae (Herba Androsaces Coccineae), Radix Scutellariae, Flos Chrysanthemi, Rhizoma Osmundae, Flos Genkwa, Chinese yam and angelica, Pericarpium Citri Reticulatae, Semen Arecae, sand
Core, Fructus Cnidii pulverize and sieve, and mix homogeneously with pharmaceutically acceptable carrier or diluent, are prepared as preparation.
9. prepare the method for pharmaceutical composition described in any one of claim 1-5 for one kind, it is characterised in that
The method comprises the following steps:
1) weight portion medicine is weighed；
2) by Herba Androsaces Umbellatae (Herba Androsaces Coccineae), Radix Scutellariae, Flos Chrysanthemi, Rhizoma Osmundae, Flos Genkwa, Rhizoma Dioscoreae boiling 2-5 time, every time
4-7 hour, collecting decoction, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Semen Arecae, Fructus Amomi, Fructus Cnidii are added the ethanol of 65-85% of 2-5 times amount,
Soaking 2-4 hour, filter, filtrate concentrates, and dry, pulverize into fine powder standby；Filtering residue adds 4-6 times
The water of amount, decocts 2-4 time, each 1-3 hour, filters, merging filtrate, concentrate drying, pulverizes
Become fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or
Diluent mix homogeneously, makes preparation.
The preparation method of pharmaceutical composition the most according to claim 9, it is characterised in that the party
Method comprises the following steps:
1) weight portion medicine is weighed；
2) by Herba Androsaces Umbellatae (Herba Androsaces Coccineae), Radix Scutellariae, Flos Chrysanthemi, Rhizoma Osmundae, Flos Genkwa, Rhizoma Dioscoreae boiling 3 times, each 5
Hour, collecting decoction, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Semen Arecae, Fructus Amomi, Fructus Cnidii are added 3 times amount 75% ethanol, leaching
Steeping 3 hours, filter, filtrate concentrates, and dry, pulverize into fine powder standby；Filtering residue adds the water of 5 times amount,
Decoct 3 times, each 2 hours, filter, merging filtrate, concentrate drying, be ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or
Diluent mix homogeneously, makes preparation.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610338500.5A CN105999020A (en) | 2016-05-15 | 2016-05-15 | Facial neuritis treating pharmaceutical composition and preparation method thereof |
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| CN1548110A (en) * | 2003-05-24 | 2004-11-24 | 毛友昌 | Calculus-expelling Jinshi bolus and its prepn |
| CN101926903A (en) * | 2010-09-02 | 2010-12-29 | 姬利亚 | Chinese medicine preparation for curing facial paralysis |
| CN105521399A (en) * | 2016-01-18 | 2016-04-27 | 潘剑崎 | Traditional Chinese medicine for treating peripheral facial paralysis |
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2016
- 2016-05-15 CN CN201610338500.5A patent/CN105999020A/en active Pending
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|---|---|---|---|---|
| CN1548110A (en) * | 2003-05-24 | 2004-11-24 | 毛友昌 | Calculus-expelling Jinshi bolus and its prepn |
| CN101926903A (en) * | 2010-09-02 | 2010-12-29 | 姬利亚 | Chinese medicine preparation for curing facial paralysis |
| CN105521399A (en) * | 2016-01-18 | 2016-04-27 | 潘剑崎 | Traditional Chinese medicine for treating peripheral facial paralysis |
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Application publication date: 20161012 |