CN105998189A - Tablet health care product containing multivitamins and application of tablet health care product - Google Patents
Tablet health care product containing multivitamins and application of tablet health care product Download PDFInfo
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- CN105998189A CN105998189A CN201610302034.5A CN201610302034A CN105998189A CN 105998189 A CN105998189 A CN 105998189A CN 201610302034 A CN201610302034 A CN 201610302034A CN 105998189 A CN105998189 A CN 105998189A
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- vitamin
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- tablet health
- health care
- care product
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 16
- 239000003814 drug Substances 0.000 claims abstract description 16
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims abstract description 16
- 206010025323 Lymphomas Diseases 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 claims abstract description 10
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 8
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims abstract description 8
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 8
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 8
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000019155 vitamin A Nutrition 0.000 claims abstract description 8
- 239000011719 vitamin A Substances 0.000 claims abstract description 8
- 235000019158 vitamin B6 Nutrition 0.000 claims abstract description 8
- 239000011726 vitamin B6 Substances 0.000 claims abstract description 8
- 229940045997 vitamin a Drugs 0.000 claims abstract description 8
- 229940011671 vitamin b6 Drugs 0.000 claims abstract description 8
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims abstract description 7
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims abstract description 7
- 229930003471 Vitamin B2 Natural products 0.000 claims abstract description 7
- 229940079593 drug Drugs 0.000 claims abstract description 7
- 229960002477 riboflavin Drugs 0.000 claims abstract description 7
- 235000019164 vitamin B2 Nutrition 0.000 claims abstract description 7
- 239000011716 vitamin B2 Substances 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 34
- 210000004027 cell Anatomy 0.000 claims description 16
- 229940088594 vitamin Drugs 0.000 claims description 16
- 229930003231 vitamin Natural products 0.000 claims description 16
- 235000013343 vitamin Nutrition 0.000 claims description 16
- 239000011782 vitamin Substances 0.000 claims description 16
- 239000012567 medical material Substances 0.000 claims description 15
- -1 compound vitamin Chemical class 0.000 claims description 14
- 239000000047 product Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 210000002751 lymph Anatomy 0.000 claims description 10
- 244000025254 Cannabis sativa Species 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 8
- 238000000926 separation method Methods 0.000 claims description 8
- 229930003451 Vitamin B1 Natural products 0.000 claims description 7
- 229960003495 thiamine Drugs 0.000 claims description 7
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 7
- 235000010374 vitamin B1 Nutrition 0.000 claims description 7
- 239000011691 vitamin B1 Substances 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 230000001629 suppression Effects 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 2
- 229960003563 calcium carbonate Drugs 0.000 claims description 2
- 235000010216 calcium carbonate Nutrition 0.000 claims description 2
- 238000004364 calculation method Methods 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 238000000889 atomisation Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 abstract description 7
- 241001330502 Stephania Species 0.000 abstract description 3
- 230000002401 inhibitory effect Effects 0.000 abstract description 3
- 241001196073 Alsophila spinulosa Species 0.000 abstract description 2
- 241000737305 Spinulum annotinum Species 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 241000991004 Streptocaulon Species 0.000 abstract 1
- 229930003270 Vitamin B Natural products 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000019156 vitamin B Nutrition 0.000 abstract 1
- 239000011720 vitamin B Substances 0.000 abstract 1
- 229960004756 ethanol Drugs 0.000 description 11
- 238000002474 experimental method Methods 0.000 description 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 231100000614 poison Toxicity 0.000 description 4
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 239000012531 culture fluid Substances 0.000 description 3
- 229960000935 dehydrated alcohol Drugs 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
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- 230000008736 traumatic injury Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 241001529246 Platymiscium Species 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
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- 235000019425 dextrin Nutrition 0.000 description 2
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- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- WEEMDRWIKYCTQM-UHFFFAOYSA-N 2,6-dimethoxybenzenecarbothioamide Chemical compound COC1=CC=CC(OC)=C1C(N)=S WEEMDRWIKYCTQM-UHFFFAOYSA-N 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 208000000412 Avitaminosis Diseases 0.000 description 1
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- 241000345998 Calamus manan Species 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 244000050510 Cunninghamia lanceolata Species 0.000 description 1
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- 206010018404 Glucagonoma Diseases 0.000 description 1
- 206010021135 Hypovitaminosis Diseases 0.000 description 1
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- 241000195947 Lycopodium Species 0.000 description 1
- 241000195954 Lycopodium clavatum Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
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- 208000025747 Rheumatic disease Diseases 0.000 description 1
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- 229920002334 Spandex Polymers 0.000 description 1
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- 241000893966 Trichophyton verrucosum Species 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
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- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
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- 229940124584 antitussives Drugs 0.000 description 1
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- 230000010165 autogamy Effects 0.000 description 1
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- FCPVYOBCFFNJFS-LQDWTQKMSA-M benzylpenicillin sodium Chemical compound [Na+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 FCPVYOBCFFNJFS-LQDWTQKMSA-M 0.000 description 1
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- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 239000012738 dissolution medium Substances 0.000 description 1
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- 208000001848 dysentery Diseases 0.000 description 1
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- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
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- 229910052757 nitrogen Inorganic materials 0.000 description 1
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the field of traditional Chinese medicine, and discloses a tablet health care product containing multivitamins. Active ingredients contained in the tablet health care product are prepared from, by weight, 1.2 g of 4,000 international unit of vitamin A, 125 g of calcium carbonate, 1.6 g of vitamin B, 1.8 g of vitamin B2, 2.6 g of vitamin B6, 500 g of roots of stephania graciliflora Yamamoto, 400 g of roots of streptocaulon griffithii Hook.f., 500 g of herb of lycopodium annotinum L. and 600 g of main trunks of cyathea spinulosa Wall., and the active ingredients and other traditional Chinese medicine form a compound. The invention further discloses application of the tablet health care product in preparation of drugs for inhibiting mouse lymphoma Yac-1 cell proliferation.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of tablet health product containing compound vitamin.
Background technology
Compound vitamin is used for curing fatigue, and prevention is because of the vitamin deficiency caused by dietary unbalance.Sport-utility is transported for a long time
" loss " of prevention vitamin (A, B, D, PP) when moving or train.Risk is felt sick, vomiting, skeleton pain.Someone
Think that common people pass through normal meals, it is possible to reach Chinese Soclety of Nutrition to vitamin and the recommended intake of mineral, meet
The needs of health, need not take nutrient prime replenisher.Up to now, people the most do not find that it suppresses mouse lymph lymphoma Yac-1
The effect of cell proliferation.
Summary of the invention
Goal of the invention: in order to solve the problems referred to above, it is an object of the invention to provide a kind of tablet health product containing compound vitamin.
Technical scheme: it is an object of the invention to by following scheme realization:
A kind of tablet health product containing compound vitamin, its contained active component is extracted preparation by following raw materials in part by weight medicine proportioning
Form: 4000 iu vitamin A 1.2 grams, calcium carbonate 125 grams, vitamin B1 1.6 grams, vitamin B2 1.8
Gram, vitamin B6 2.6 grams, XIANHUA Radix Stephaniae Japonicae 500g, Radix Streptocauli Griffithii 400g, adhesion separation grass 500g, flying apsaras 600g.
The described tablet health product containing compound vitamin, preparation method step is: takes above-mentioned XIANHUA Radix Stephaniae Japonicae, Radix Streptocauli Griffithii, divide
Muscle grass, flying apsaras medical material merge, boiling twice, collecting decoction, and when being concentrated into 65 DEG C, relative density is 1.10-1.20,
Add ethanol, stirring, make alcohol content by volume percentage calculation reach 65-85%, stand, filter, filtrate reduced in volume to 65 DEG C
Time relative density be 1.20-1.30 and reclaim ethanol, by concentrated solution be spray-dried, gained granular powder is broken into dry extract, add
Vitamin A, calcium carbonate, vitamin B1, vitamin B2, vitamin B6 and adjuvant, pelletize, tabletting and get final product.
The described tablet health product containing compound vitamin, in preparation method, decocting condition is: amount of water is medical material weight for the first time
8-12 times amount, decoct 1-2h, amount of water is the 6-10 times amount of medical material weight for the second time, decoct 1-2h.
The described tablet health product containing compound vitamin, in preparation method, spray drying condition is: inlet temperature is 90-110 DEG C,
Leaving air temp is 60-90 DEG C, and temperature of charge is 60-90 DEG C, and atomizing pressure is 0.2-0.5 MPa, and spray velocity is 1-10ml/s.
The application in preparation suppression mouse lymph lymphoma Yac-1 cell proliferation of the described tablet health product containing compound vitamin.
XIANHUA Radix Stephaniae Japonicae is Menispermaceae stephania plant XIANHUA Radix Stephaniae Japonicae Stephania graciliflora Yamamoto, enters with root
Medicine.Autumn and winter excavate, and clean chopping, dry.Induce sweat, stomach invigorating, pain relieving, antiinflammatory.For catching a cold, stomatitis, laryngitis, stomach
Bitterly, asthma.
Radix Streptocauli Griffithii is that trailing plants rattan Ke Malian saddle platymiscium horse connects saddle Streptoculon griffithii Hook.f. and is used as medicine with root.The whole year can adopt,
Using fresh herb or dry use.Heat-clearing and toxic substances removing, scattered silt pain relieving.For cat fever, enteritis, dysentery, stomachache, treating swelling and pain by traumatic injury, poisonous snake
Bite.
Adhesion separation grass is that fern Lycopodiaceae Lycopodium plant China fir climing Lycopodium clavatum Lycopodium annotinum L. is with all herbal medicine.The four seasons can
Adopt, dry or dry in the shade.Expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation.For traumatic injury, waist-leg bones and muscles pain, rheumatic numbness.
Flying apsaras is Cyatheaceae Caulis cyatheae spinulosae platymiscium Caulis cyatheae spinulosae Cyathea spinulosa Wall., is used as medicine with trunk.The whole year can adopt, and cuts
Removing the hard crust of trunk, section is dried.Expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, clearing and antitussive.For rheumatic arthritis, traumatic injury damages
Wound, chronic bronchitis, cough due to lung-heat, oedema due to nephritis, prevents influenza；Put on the skin outside juice in stem and control ringworm.
Beneficial effect: XIANHUA Radix Stephaniae Japonicae, Radix Streptocauli Griffithii heat-clearing and toxic substances removing in we, scattered silt pain relieving is monarch drug, adhesion separation grass, flying apsaras
Expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation is ministerial drug, and all medicines are harmonious, and play heat-clearing and toxic substances removing, benefiting QI for activating blood circulation altogether, are used for suppressing mouse lymph lymphoma
Yac-1 cell proliferation.
Detailed description of the invention
Form by the following examples, is described in further detail the foregoing of the present invention again, but should this not understood
Scope for the above-mentioned theme of the present invention is only limitted to Examples below, and all technology realized based on foregoing of the present invention belong to this
The scope of invention.
Embodiment 1: take XIANHUA Radix Stephaniae Japonicae 500g, Radix Streptocauli Griffithii 400g, adhesion separation grass 500g, flying apsaras 600g medical material mixing,
Boiling twice, add water 8 times amount into medical material weight for the first time, decocts 1.5h, and add water into medical material weight 6 times for the second time
Amount, decocts 1h, collecting decoction, filters, and filtrate is concentrated into relative density 1.10 (65 DEG C), adds ethanol in proper amount and make alcohol content (body
Fraction) reach 65%, stir, stand 24 hours, filter, filtrate recycling ethanol is also concentrated into relative density 1.10 (65 DEG C)
Extractum, spray-dried (condition be inlet temperature be 100 DEG C, leaving air temp is 80 DEG C, and temperature of charge is 70 DEG C, mist
Changing pressure is 0.2 MPa, and spray velocity is 5ml/s.), it is ground into dry extract, adds 4000 iu vitamin A 1.2
Gram, calcium carbonate 125 grams, vitamin B1 1.6 grams, vitamin B2 1.8 grams, vitamin B6 2.6 grams, dextrin
50g, with appropriate 80% ethanol wet, soft material processed, crosses 14 mesh sieves and pelletizes, and 70 DEG C are dried, and 60 mesh granulate, tabletting obtains tablet.
Embodiment 2: take XIANHUA Radix Stephaniae Japonicae 500g, Radix Streptocauli Griffithii 400g, adhesion separation grass 500g, flying apsaras 600g medical material mixing,
Boiling twice, the 10 times amount into medical material weight that add water, decoct 2h, second time adds water 8 times amount into medical material weight,
Decocting 1h, collecting decoction, filter, filtrate is concentrated into relative density 1.15 (65 DEG C), adds ethanol in proper amount and make alcohol content (volume
Mark) reach 75%, stir, stand 24 hours, filter, filtrate recycling ethanol is also concentrated into relative density 1.25 (65 DEG C)
Extractum, spray-dried (condition be inlet temperature be 120 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 80 DEG C, mist
Changing pressure is 0.3 MPa, and spray velocity is 7.5/s.), it is ground into dry extract, adds 4000 iu vitamin A 1.2
Gram, calcium carbonate 125 grams, vitamin B1 1.6 grams, vitamin B2 1.8 grams, vitamin B6 2.6 grams, starch
50g, mix homogeneously, with appropriate 80% ethanol wet, soft material processed, cross 30 mesh sieves and pelletize, be dried in 70～80 DEG C, with 60
Mesh sieve granulate, tabletting, obtain finished product.
Embodiment 3: take XIANHUA Radix Stephaniae Japonicae 500g, Radix Streptocauli Griffithii 400g, adhesion separation grass 500g, flying apsaras 600g medical material mixing,
Boiling twice, add water 10 times amount into medical material weight for the first time, decocts 1.5h, and add water into medical material weight 8 for the second time
Times amount, decocts 1.5h, collecting decoction, filters, and filtrate is concentrated into relative density 1.15 (65 DEG C), adds ethanol in proper amount and make containing alcohol
Amount (volume fraction) reaches 75%, stirs, stands 24 hours, filters, and filtrate recycling ethanol is also concentrated into relative density 1.25
The extractum of (65 DEG C), spray-dried (condition be inlet temperature be 120 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 90 DEG C,
Atomizing pressure is 0.4 MPa, and spray velocity is 7.5/s.), it is ground into dry extract, crosses No. 6 sieves, add 4000 international single
Position vitamin A 1.2 grams, calcium carbonate 125 grams, vitamin B1 1.6 grams, vitamin B2 1.8 grams, vitamin B6 2.6
Gram, dextrin 50g, with appropriate 80% ethanol wet, soft material processed, cross 14 mesh sieves and pelletize, 70 DEG C are dried, 60 mesh granulate, pressure
Sheet obtains tablet.
Embodiment 4: the experimentation data of suppression mouse lymph lymphoma Yac-1 cell proliferation
Experiment cell strain: mouse lymph lymphoma Yac-1 cell, Nanjing Medical University's Experimental Animal Center laboratory cell storehouse,
DMEM+10%FBS cellar culture.
Drugs: prepare by embodiment 1 method.
Medicinal liquid liquid storage: weigh the 100mg present invention, is dissolved in 5ml dehydrated alcohol, and 0.2 μm filter filters, 500 μ l doff
Pipe subpackage ,-20 DEG C of storages, 0.2 μm filter filters dehydrated alcohol in case matched group is used simultaneously.
Experiment reagent: DMEM (GIBCO company Cat.No.12100-061Lot.No.758137)；Hyclone (Zhejiang
Sky over the river Hangzhoupro bio tech ltd Lot.No.100419)；NaHCO3 (the long hundred million chemical reagent company limited Cat. in Shanghai
No.11810-033 Lot.No.1088387)；Trypsin (AMRESCO company lot number: 2010/04)；EDTA
(AMRESCO company lot number: 2009/10)；Penicillin G Sodium Salt (AMRESCO company lot number:
2010242)；Streptomycin Sulfate (AMRESCO company lot number: 2010382)；Dehydrated alcohol (Nanjing chemistry
Reagent company limited lot number: 080310182)；MTT (Biosharp lot number: 0793)；PBS (laboratory autogamy)；
Experiment equipment: Lycra inverted microscope (Germany Leica model: DM1L)；Visible-ultraviolet light microwell plate detector is (beautiful
MD company of state model: SPECTRA MAX 190)；CO2 incubator (FORMA model: 3111)；Super-clean bench (Soviet Union
Safe and sound company of clean group manufactures model: SW-CJ-ZFD)；Pure water instrument (Spring company of U.S. model: S/N 020579)；
Accurate pipettor (Gilson Inc of France model: P2)；Electronic balance (Sai Duolisi company limited of Germany model: BT323S)；
Full-automatic high-pressure autoclave (SANYO company of Japan model: MLS-3020)；Table electrothermal air dry oven (upper Nereid
Closely knit test equipment company's model: DHG9123A)；Refrigerator (Siemens Company's model: KG18V21TI)；Liquid nitrogen container (CBS
Model: 2001)；Low speed centrifuge (Anting Scientific Instrument Factory, Shanghai's model: KA-1000)；0.2 μm filter (MILLIPORE
Model: SLGP033RB)；10cm culture dish (NEST company), 96 well culture plates (NEST company)；Cell counting count board；
Centrifuge tube, pipet, Tips are some.
Experimental technique: 1) mouse lymph lymphoma Yac-1 cell DMEM+10%FBS in 37 DEG C, 5%CO2 carries out often
Rule cultivate (10cm culture dish), when cell grows to logarithmic (log) phase, collect cell, discard culture fluid, and PBS rinses 3 times,
Add 3ml 0.25% trypsin-0.04%EDTA, after 37 DEG C of digestion 2min, be added thereto to 5ml complete medium
Neutralizing reaction, proceeded in centrifuge tube after piping and druming cell, 1000rpm is centrifuged 5min, adjusts concentration of cell suspension 3 × 104
Individual/ml.2) entering in 96 well culture plates by cell kind, every hole adds cell suspension 180 μ l, and culture plate puts into cell culture incubator
In (37 DEG C, 5%CO2) cellar culture.3) according to cell growth status, general long to 50%-70%, add the present invention
Solution, continues to cultivate 24h.4) add 20 μ l MTT solution (5mg/ml, i.e. 0.5%MTT) after 24h, continue to cultivate 4h.
5) after 4h, buckle method removes supernatant, pats dry gently with absorbent paper, and every hole adds 200 μ l dimethyl sulfoxide, puts low speed on shaking table
Vibration 10min, makes crystal fully dissolve.The light absorption value in each hole is measured at enzyme-linked immunosorbent assay instrument 490nm.6) simultaneously
Background (being not added with cell, only add culture fluid) is set, control wells (cell, the medicine dissolution medium of same concentrations, culture fluid,
MTT, dimethyl sulfoxide), often group sets 6 multiple holes.7) suppression ratio of cell is represented by result with medicine:
Cell proliferation suppression ratio (%)=(control wells OD value-dosing holes OD value)/control wells OD value × 100%.Experiment
It is repeated 3 times.
Statistical disposition: using the correlation analysis in Microsoft Excel 2003 software and Student t inspection, data are with mean
± S.D. represents.
Experimental result: statistical result showed after mtt assay experiment, compares with matched group, when dosage reaches 5mg/ml, to greatly
Ren Mus gland bites chromium glucagonoma PC12 cell inhibitory effect variant (P < 0.05), and dosage this difference when 10mg/ml has significantly
Property (P < 0.01), has pole significant difference (P < 0.001) when dosage reaches 15-20mg/ml.
Table 1 present invention is to mouse lymph lymphoma Yac-1 cell inhibitory effect influence research (X ± SD)
Note: compare with matched group, * P < 0.01；**P<0.001
Experiment conclusion: the present invention can suppress mouse lymph lymphoma Yac-1 cell proliferation, reduces mouse lymph lymphoma Yac-1 cell
Cell growing number, this effect is dose dependent.
Claims (5)
1. the tablet health product containing compound vitamin, it is characterised in that its contained active component is by following weight
Part crude drug proportioning is extracted and is prepared from: 4000 iu vitamin A 1.2 grams, calcium carbonate 125 grams, vitamin
B1 1.6 grams, vitamin B2 1.8 grams, vitamin B6 2.6 grams, XIANHUA Radix Stephaniae Japonicae 500g, Radix Streptocauli Griffithii 400g,
Adhesion separation grass 500g, flying apsaras 600g.
2. contain the tablet health product of compound vitamin as claimed in claim 1, it is characterised in that preparation method step is:
Take above-mentioned XIANHUA Radix Stephaniae Japonicae, Radix Streptocauli Griffithii, adhesion separation is careless, the medical material that flies to the sky merges, boiling twice, collecting decoction,
When being concentrated into 65 DEG C, relative density is 1.10-1.20, adds ethanol, stirring, makes alcohol content by volume percentage calculation reach
65-85%, stands, and filters, and during filtrate reduced in volume to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, by dense
Contracting liquid is spray-dried, and gained granular powder is broken into dry extract, adds vitamin A, calcium carbonate, vitamin B1, dimension life
Element B2, vitamin B6 and adjuvant, pelletize, tabletting and get final product.
3. contain the tablet health product of compound vitamin as claimed in claim 2, it is characterised in that preparation method decocts
Condition is: amount of water is the 8-12 times amount of medical material weight for the first time, decocts 1-2h, and amount of water is medical material weight for the second time
6-10 times amount, decoct 1-2h.
4. contain the tablet health product of compound vitamin as claimed in claim 2, it is characterised in that preparation method is sprayed
Drying condition is: inlet temperature is 90-110 DEG C, and leaving air temp is 60-90 DEG C, and temperature of charge is 60-90 DEG C, atomization
Pressure is 0.2-0.5 MPa, and spray velocity is 1-10ml/s.
5. the tablet health product containing compound vitamin as claimed in claim 1 increase at suppression mouse lymph lymphoma Yac-1 cell
Grow the application in medicine.
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| CN104664533A (en) * | 2015-03-21 | 2015-06-03 | 高萍 | Preparation method of health beverage |
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| CN101816428A (en) * | 2010-05-13 | 2010-09-01 | 山东森健生物科技发展有限公司 | Health-care food capable of bringing human body balanced nutrition |
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| CN103735947A (en) * | 2013-12-26 | 2014-04-23 | 赵鹏 | Traditional Chinese medicinal prescription for treating osteoporosis and preparation method thereof |
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