CN105998136A - 一种金银花鲜榨冷冻干燥粉末饮片及其制备工艺 - Google Patents
一种金银花鲜榨冷冻干燥粉末饮片及其制备工艺 Download PDFInfo
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Abstract
本发明公布了一种金银花鲜榨冷冻干燥粉末饮片及其制备工艺。该工艺在金银花药材采收后，净选、淋洗，并趁鲜压榨，滤取药汁。药渣再加水搅拌，过滤压榨。所得药汁合并后减压浓缩，冷冻干燥。同时，浓缩冷凝液分离挥发油，并与冷冻干燥物混合，过筛装袋。此法制备的金银花粉末饮片，最大限度的保留了药材中的有效成分。饮片便于储运，方便调剂，质量可控，疗效可靠，对保障中医药临床疗效具有重要的意义。本法的推广实施，将有显著的社会意义和经济效益。
Description
技术领域
本发明属于中药材加工领域，尤其涉及中药金银花饮片的加工工艺。
背景技术
中药金银花为忍冬科植物Lonicera japonica Thunb.的干燥花蕾或带初开的花。夏初花开放前采收，干燥。本品性寒，味甘，入肺、心、胃经，具有清热解毒、抗炎、补虚疗风的功效，主治胀满下疾、温病发热、热毒痈疡和肿瘤等症，对口渴作干、多汗烦闷、肠炎、菌痢、流脑、败血症、急性乳腺炎、丹毒、腮腺炎、皮肤感染等病症均有一定的疗效。
常用的金银花饮片的加工方式为：采收后除去杂质，晒干，打包储藏和运输。此类中药饮片，体积庞大，容易污染和霉变，卫生学条件差，质量很难保证，不利于配方调剂和确保其临床疗效。
目前，市场上也有金银花药材经过提取后制成的颗粒饮片销售。由于颗粒饮片制备过程中，提取不仅耗时耗能，而且因常用水做溶媒，药材中的非极性有效成分很难被提取出来。此外，由于提取用的金银花药材也是干燥并经过长时间储藏的，因此，有效成分的损失也是很大的。为了确保金银花药材的临床有效、质量稳定，一种新型的金银花饮片及其制备工艺亟待开发。
发明内容
本发明公布了 “一种金银花鲜榨冷冻干燥粉末饮片及其制备工艺”。本工艺可以最大限度的保留金银花药材中的极性和非极性有效成分，避免药材在现有的饮片加工和储运过程中引起的有效成分的丢失和药材品质的下降，减少药材受霉菌等的污染，对确保金银花饮片的质量稳定和临床安全有效具有重要的意义。
为了实现上述目的，本发明的技术方案为：
在金银花采收后，净选，洗涤，趁鲜压榨取汁，药渣加入1~3倍量的水，搅拌5~30min，板框压滤机压滤，所得药渣再压榨取汁，合并药汁并用80~200目筛网过滤。将所得的药液，40~65℃减压浓缩，所得相对密度为1.05~1.30的浸膏于-20~-80℃冰箱中冻结6~24小时，然后进行冷冻干燥，真空度为0.06~0.09MPa，温度为-20~-40℃，冻干时间为12~48小时，取出粉碎。另外，收集减压浓缩所得的金银花冷凝水，加入1%~5%重量的NaCl，搅拌使溶解后溶液置油水分离器中，于4℃~10℃环境下放置12~48小时，收集上层油，并往其中加入1%~5%重量的无水Na2SO4，振摇5~10min钟后，25℃以下室温放置1~6小时，过滤，得金银花挥发油，并将其与上述金银花冻干粉混合均匀，过40~100目筛，真空包装，即得金银花鲜榨冷冻干燥粉末饮片。
在产品包装袋的标签上，印刷上品名、药用部位、种植地、生产商、生产日期、主要成分含量、性味归经、功能主治、用法用量、毒副作用及禁忌证等信息。袋内附上金银花的薄层鉴别图谱和/或高效液相特征图谱，作为产品的“身份证”。此外，在产品的包装袋上，印有二维码，通过扫描可以链接获取产品的原植物照片、药材照片、饮片照片、性状及显微鉴别特征等信息。
本发明的有益之处在于：
新鲜金银花药材净选洗涤后直接切段压榨、过滤、减压浓缩、冷冻干燥、分离油、并将挥发油与冷冻干燥物混合，所得到的粉末饮片，可以最大限度地完整保留药材中的有效成分。这种饮片体积较之于传统饮片体积大大地减小，质量更加稳定，利于储运和临床调剂，具有十分显著的社会意义和经济意义。
具体实施方式
实施例1
将新鲜采集的金银花药材，净选，用水淋洗，趁鲜用压榨机压榨，取汁。所得药渣加2倍量的饮用水，搅拌20min，板框压滤机压榨取汁。所得药渣再用压榨机榨取药汁。将上述3次药汁合并，减压浓缩，温度设定为65℃。在浓缩所得浸膏相对密度为1.15时，置-80℃内冻结8小时后，取出，冷冻干燥，压力为0.09Mpa，温度为-40℃，时间为24小时。取出冻干物，低温研磨粉碎。另外，将减压浓缩时收集的金银花冷凝水，加入重量5%的NaCl，搅拌使溶解。将此溶液放置于油水分离器中，并于10℃环境中静置24小时，分离收集上层挥发油。往此挥发油中加入2%重量的无水Na2SO4，振摇10min钟后，25℃以下室温放置6小时，过滤，得金银花挥发油。将此挥发油与上述金银花冷冻干燥物混合均匀，过60目筛，装袋，1kg/袋，加入袋装抗氧化剂和干燥剂，真空封装，贴签即得成品。
实施例2
将新鲜采集的金银花药材，净选，用水淋洗，趁鲜用压榨机压榨，取汁。所得药渣加3倍量的饮用水，搅拌30min，板框压滤机压榨取汁。所得药渣再用压榨机榨取药汁。将上述3次药汁合并，减压浓缩，温度设定为60℃。在浓缩所得浸膏相对密度为1.10时，置-80℃内冻结12小时后，取出，冷冻干燥，压力为0.08Mpa，温度为-20℃，时间为48小时。取出冻干物，低温研磨粉碎。另外，将减压浓缩时收集的金银花冷凝水，加入重量3%的NaCl，搅拌使溶解。将此溶液放置于油水分离器中，并于10℃环境中静置24小时，分离收集上层挥发油。往此挥发油中加入5%重量的无水Na2SO4，振摇10min钟后，25℃以下室温放置8小时，过滤，得金银花挥发油。将此挥发油与上述金银花冷冻干燥物混合均匀，过80目筛，装袋，1kg/袋，加入袋装抗氧化剂和干燥剂，真空封装，贴签即得成品。
以上实施例，仅为说明本项发明的技术思想，不能凭此限定本发明的保护范围 凡是按照本发明提出的技术思想，在技术方案基础上所做的任何改动，均落入本发明保护的范围之内。
Claims (3)
1.一种金银花鲜榨冷冻干燥粉末饮片及其制备工艺，其特征在于：将金银花采收后，净选，洗涤，趁鲜压榨取汁，药渣加入1~3倍量的水，搅拌5~30min，板框压滤机压滤，所得药渣再压榨取汁，合并药汁并用80~200目筛网过滤。
2.根据权利要求1所述的一种金银花鲜榨冷冻干燥粉末饮片及其制备工艺，其特征在于：将权利要求1中所得的药液，40~65℃减压浓缩，所得相对密度为1.05~1.30的浸膏于-20~-80℃冰箱中冻结6~24小时，然后进行冷冻干燥，真空度为0.06~0.09MPa，温度为-20~-40℃，冻干时间为12~48小时，取出粉碎。
3.根据权利要求1所述的一种金银花鲜榨冷冻干燥粉末饮片及其制备工艺，其特征在于：收集权利要求2中的减压浓缩所得的金银花冷凝水，加入1%~5%重量的NaCl，搅拌使溶解后溶液置油水分离器中，于4℃~10℃环境下放置12~48小时，收集上层油，并往其中加入1%~5%重量的无水Na2SO4，振摇5~10min钟后，25℃以下室温放置1~6小时，过滤，得金银花挥发油，并将其与权利要2中的金银花冻干粉混合均匀，过40~100目筛，真空包装，即得金银花鲜榨冷冻干燥粉末饮片。
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107213195A (zh) * | 2017-06-18 | 2017-09-29 | 徐漫 | 一种藿香鲜榨冷冻干燥粉末饮片及其制备工艺 |
| CN107320514A (zh) * | 2017-08-25 | 2017-11-07 | 芜湖天成普阳中药科技有限公司 | 一种佩兰鲜榨冷冻干燥粉末饮片的制备工艺 |
| CN107334849A (zh) * | 2017-08-25 | 2017-11-10 | 芜湖天成普阳中药科技有限公司 | 一种橘叶鲜榨真空干燥粉末饮片及其制备工艺 |
| CN107375407A (zh) * | 2017-08-25 | 2017-11-24 | 徐漫 | 一种透骨草鲜榨冷冻干燥粉末饮片的制备工艺 |
| CN107375354A (zh) * | 2017-08-25 | 2017-11-24 | 徐自升 | 一种伸筋草鲜榨冷冻干燥粉末饮片的制备工艺 |
| CN107441143A (zh) * | 2017-08-25 | 2017-12-08 | 徐漫 | 一种绞股蓝鲜榨冷冻干燥粉末饮片的制备工艺 |
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| CN105596416A (zh) * | 2016-02-11 | 2016-05-25 | 徐自升 | 一种苏叶鲜榨冷冻干燥粉末饮片及其制备工艺 |
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| CN105596416A (zh) * | 2016-02-11 | 2016-05-25 | 徐自升 | 一种苏叶鲜榨冷冻干燥粉末饮片及其制备工艺 |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213195A (zh) * | 2017-06-18 | 2017-09-29 | 徐漫 | 一种藿香鲜榨冷冻干燥粉末饮片及其制备工艺 |
| CN107320514A (zh) * | 2017-08-25 | 2017-11-07 | 芜湖天成普阳中药科技有限公司 | 一种佩兰鲜榨冷冻干燥粉末饮片的制备工艺 |
| CN107334849A (zh) * | 2017-08-25 | 2017-11-10 | 芜湖天成普阳中药科技有限公司 | 一种橘叶鲜榨真空干燥粉末饮片及其制备工艺 |
| CN107375407A (zh) * | 2017-08-25 | 2017-11-24 | 徐漫 | 一种透骨草鲜榨冷冻干燥粉末饮片的制备工艺 |
| CN107375354A (zh) * | 2017-08-25 | 2017-11-24 | 徐自升 | 一种伸筋草鲜榨冷冻干燥粉末饮片的制备工艺 |
| CN107441143A (zh) * | 2017-08-25 | 2017-12-08 | 徐漫 | 一种绞股蓝鲜榨冷冻干燥粉末饮片的制备工艺 |
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