CN105998094A - Taxus chinensis and Chaga mixture for inhibiting re-growth of tumour cells - Google Patents
Taxus chinensis and Chaga mixture for inhibiting re-growth of tumour cells Download PDFInfo
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- CN105998094A CN105998094A CN201610504102.6A CN201610504102A CN105998094A CN 105998094 A CN105998094 A CN 105998094A CN 201610504102 A CN201610504102 A CN 201610504102A CN 105998094 A CN105998094 A CN 105998094A
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- ramulus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention relates to the technical field of anti-tumour medicaments, in particular to a taxus chinensis and Chaga mixture for inhibiting re-growth of tumour cells. The taxus chinensis and Chaga mixture for inhibiting the re-growth of the tumour cells is characterized by being prepared from the following components: 2 to 7 parts of taxus chinensis and 5 to 10 parts of inonotus obliquus. The inonotus obliquus provided by the invention is the inonotus obliquus in Siberia or northeast of China, and is also called Chaga; the taxus chinensis is of the Madia variety in Canada. According to the taxus chinensis and Chaga mixture for inhibiting the re-growth of the tumour cells, the inonotus obliquus and the taxus chinensis are sliced after impurities are screened, wherein the thickness is 1 to 3 mm, and the size is 1 to 5 cm; compared with the prior art, the taxus chinensis and Chaga mixture can effectively inhibit the re-growth of the tumour cells, and has the remarkable advantages of low cost, little side effects and the like.
Description
Technical field
The present invention relates to antitumor drug technical field, a kind of China fir young pilose antler mixture suppressing tumor cell regrowth.
Background technology
Siberia Inonqqus obliquus, is Muscovite a kind of Medicinal fungus, and its effective ingredient has caused the extensive attention of state's researcheres such as the U.S., Japan, Korea S.According to preliminary research, Inonqqus obliquus contains Inonqqus obliquus alcohol, oxidation triterpenoid compound, lanosterol, the acid of bolt bacterium, folic acid derivatives, aromatic vanillic acid, syringic acid etc..Nineteen fifty-five Moscow medical courses in general institute (The Medical Academy of Science
In Moscow) declaration Inonqqus obliquus is cancer-resisting substance, government permission Inonqqus obliquus can be used for pharmaceuticals exploitation, can be used to prevent and treat hepatocarcinoma, acquired immune deficiency syndrome (AIDS) and the poisoning of-157 escherichia coli.Inonqqus obliquus has high SOD activity, and kinds of tumor cells, such as mastocarcinoma, lip cancer, gastric cancer, parotid gland cancer, pulmonary carcinoma, skin carcinoma, rectal cancer, Huo Jinsi lymphatic cancer are had obvious inhibitory action；Prevent cancer cell metastasis and recurrence；And the radiotherapy of malignant tumor person, chemotherapy, the toleration of enhancing patient can be coordinated, alleviate toxic and side effects, and alleviate the peculiar pain of cancer patient.
Inonqqus obliquus is the common drug among the people of the states such as each republic of the former Soviet Union, Poland, Japan.The antivirus action of Inonqqus obliquus, also for reducing islets of langerhans toxicity, promotes that insulin secretion plays positive role.Callose in Inonqqus obliquus has high SOD activity, can not only effectively promote human body and remove the ability of multiple reactive oxygen free radical, and can also reduce the antioxidant system in human body, enhancing body oxidation resistance.Inonqqus obliquus, also known as the cleaning agent of blood blood vessel, notable to the prevention effect of hypertension.
The U.S. lists " special natural materials " in Inonqqus obliquus, as the following beverage of extraterrestrial.The research worker high evaluation Inonqqus obliquus of Japan, is referred to as one ' catholicon '.
Canada's Taxus media Taxus media (Taxus X media), it it is a kind of natural hybrid variety, its female parent is Japan Ramulus et folium taxi cuspidatae (T.cuspidata), and male parent is Taxus baccata (T.baccata), in the U.S., Canada's growth development history of existing nearly 100 years.More than 10 strain when Taxus media is had evolved to by selection and breeding, wherein, Taxus media is that U.S. FDA approval can serve as one of Ramulus et folium taxi cuspidatae extracting " paclitaxel ".
Taxus media is then that plant each several part all contains paclitaxel, and branch and leaf content reaches more than 0.03%, and root system part is up to 0.06%, and Herb is used for extracting paclitaxel, and plant utilization rate is high, and after its deep processing, mixed economy is worth higher.
Taxus media branch, leaf, root are to extract cancer therapy drug " paclitaxel 98% white crystals body." paclitaxel " has fabulous antitumaous effect, through clinical trial certificate, paclitaxel is the most effective in cure to kinds cancers such as advanced ovarian cancer, breast carcinoma, esophageal carcinoma, nasopharyngeal carcinoma, bladder cancer, lymphatic cancer, carcinoma of prostate, malignant melanoma and H/N tumors, upper gastrointestinal cancer, cellule type and lung cancer in non-cellule type, there is the antitumor mechanism of uniqueness and significant function of tumor inhibition, the organic cancer therapy drug of new type natural being the most popular on current international market, has specially good effect to antiinflammatory and arteriosclerosis after treating the complication of various diseases and bypass surgery.Paclitaxel is that treatment patient with advanced cancer is " last the most anti-
Line ".
In prior art, the extraction to the antineoplastic component paclitaxel of Ramulus et folium taxi cuspidatae uses industrial extraction method and chemical synthetic method.In Ramulus et folium taxi cuspidatae, content of taxol is low, and the conversion of 10-DAB needs to add chemical components, causes cost high, and waste is big.And paclitaxel is water insoluble, needs to add a large amount of ancillary drug for clinical chemotherapy, thus side effect is big.So developing a kind of extraction cost low, the little herb mixture of side effect is a direction.
Summary of the invention
The present invention is directed to shortcoming and defect present in prior art, it is proposed that the China fir young pilose antler mixture of the suppression tumor cell regrowth that a kind of low cost, side effect are little.
The present invention can be reached by following measures:
A kind of China fir young pilose antler mixture suppressing tumor cell regrowth, it is characterised in that comprise following component: Ramulus et folium taxi cuspidatae 2-7 part, Inonqqus obliquus 5-10 part.
Inonqqus obliquus of the present invention is Siberia or Manchurian Inonqqus obliquus, has another name called Phaeoporus obliquus, and described Ramulus et folium taxi cuspidatae is Canada's graceful ground subrace.
In the present invention, impurity is taken out in Inonqqus obliquus and Ramulus et folium taxi cuspidatae screening, and section, thickness is at 1mm-3mm, and size is at 1cm 5cm.
The invention allows for the preparation method of a kind of China fir young pilose antler mixture suppressing tumor cell regrowth, it is characterised in that comprise the following steps:
Step 1: Inonqqus obliquus and Ramulus et folium taxi cuspidatae being screened and take out impurity, section, thickness is at 1mm-3mm, and size is at 1cm 5cm；
Step 2: concoct Ramulus et folium taxi cuspidatae, puts into Ramulus et folium taxi cuspidatae and soaks in soak more than 30 minutes, take out after then Ramulus et folium taxi cuspidatae section being decocted more than 30 minutes with Chinese liquor, and airing is standby；Described soak uses the Chinese liquor of more than 30 degree to soak with following component and obtains: Radix Bupleuri 3-9 part, Radix Angelicae Sinensis 3-9 part, Radix Paeoniae Alba 2-8 part, Radix Ginseng 5-15 part, Radix Glycyrrhizae Preparata 3-12 part, Fructus Schisandrae Chinensis 2-10 part, Rhizoma Zingiberis 2-9 part；
Step 3: concoct Inonqqus obliquus, is immersed in Inonqqus obliquus section in soak more than 60 minutes, then Inonqqus obliquus section is taken out, airing standby；Described soak uses the Chinese liquor of more than 35 degree to soak with following component and obtains: Radix Rehmanniae Preparata 3-10 part, Cortex Cinnamomi 3-12 part, Herba Ephedrae 2-8 part, Semen Sinapis Albae 2-12 part, Rhizoma Zingiberis Recens charcoal 2-8 part, Radix Glycyrrhizae 3-12 part；
Step 4: by step 3
Ramulus et folium taxi cuspidatae mixing after concocting in Inonqqus obliquus and step 2, common input decocts in still, and 80-100 degree decocts 30-60 minute, detection, and packaging obtains finished product.
The present invention is compared with prior art, it is possible to effectively suppress the regrowth of tumor cell, has low cost, the side effect significantly advantage such as little.
Detailed description of the invention:
Below in conjunction with embodiment, the present invention is further illustrated.
Embodiment 1:
A kind of China fir young pilose antler mixture suppressing tumor cell regrowth, comprises following component: Ramulus et folium taxi cuspidatae 3-6 part, Inonqqus obliquus 6-8 part；Described Inonqqus obliquus is Siberia or Manchurian Inonqqus obliquus, has another name called Phaeoporus obliquus, and described Ramulus et folium taxi cuspidatae is Canada's graceful ground subrace；Impurity is taken out in described Inonqqus obliquus and Ramulus et folium taxi cuspidatae screening, and section, thickness is at 1mm-3mm, and size is at 1cm 5cm；In preparation process, first being put into by Ramulus et folium taxi cuspidatae and soak in soak more than 30 minutes, take out after then Ramulus et folium taxi cuspidatae section being decocted more than 30 minutes with Chinese liquor, airing is standby；Described soak uses the Chinese liquor of more than 30 degree to soak with following component and obtains: Radix Bupleuri 4-7 part, Radix Angelicae Sinensis 4-8 part, Radix Paeoniae Alba 3-6 part, Radix Ginseng 6-14 part, Radix Glycyrrhizae Preparata 4-10 part, Fructus Schisandrae Chinensis 3-9 part, Rhizoma Zingiberis 3-8 part；Then concoct Inonqqus obliquus, Inonqqus obliquus section be immersed in soak more than 60 minutes, then Inonqqus obliquus section is taken out, airing standby；Described soak uses the Chinese liquor of more than 35 degree to soak with following component and obtains: Radix Rehmanniae Preparata 4-8 part, Cortex Cinnamomi 4-10 part, Herba Ephedrae 3-7 part, Semen Sinapis Albae 3-10 part, Rhizoma Zingiberis Recens charcoal 3-7 part, Radix Glycyrrhizae 4-10 part；Ramulus et folium taxi cuspidatae mixing after concocting in Inonqqus obliquus in step 3 and step 2, common input decocts in still, and 80-100 degree decocts 30-60 minute, detection, and packaging obtains finished product.
Embodiment 2:
A kind of China fir young pilose antler mixture suppressing tumor cell regrowth, comprises following component: Ramulus et folium taxi cuspidatae 5 parts, Inonqqus obliquus 7 parts；Described Inonqqus obliquus is Siberia or Manchurian Inonqqus obliquus, has another name called Phaeoporus obliquus, and described Ramulus et folium taxi cuspidatae is Canada's graceful ground subrace；Impurity is taken out in described Inonqqus obliquus and Ramulus et folium taxi cuspidatae screening, and section, thickness is at 1mm-3mm, and size is at 1cm 5cm；In preparation process, first being put into by Ramulus et folium taxi cuspidatae and soak in soak more than 30 minutes, take out after then Ramulus et folium taxi cuspidatae section being decocted more than 30 minutes with Chinese liquor, airing is standby；Described soak uses the Chinese liquor of more than 30 degree to soak with following component and obtains: Radix Bupleuri 5-6 part, Radix Angelicae Sinensis 5-7 part, Radix Paeoniae Alba 4-5 part, Radix Ginseng 7-12 part, Radix Glycyrrhizae Preparata 6-8 part, Fructus Schisandrae Chinensis 4-8 part, Rhizoma Zingiberis 4-7 part；Then concoct Inonqqus obliquus, Inonqqus obliquus section be immersed in soak more than 60 minutes, then Inonqqus obliquus section is taken out, airing standby；Described soak uses the Chinese liquor of more than 35 degree to soak with following component and obtains: Radix Rehmanniae Preparata 5-7 part, Cortex Cinnamomi 5-8 part, Herba Ephedrae 4-6 part, Semen Sinapis Albae 4-8 part, Rhizoma Zingiberis Recens charcoal 3-7 part, Radix Glycyrrhizae 5-8 part；Ramulus et folium taxi cuspidatae mixing after concocting in Inonqqus obliquus in step 3 and step 2, common input decocts in still, and 80-100 degree decocts 30-60 minute, detection, and packaging obtains finished product.
The present invention is compared with prior art, it is possible to effectively suppress the regrowth of tumor cell, has low cost, the side effect significantly advantage such as little.
Claims (4)
1. the China fir young pilose antler mixture suppressing tumor cell regrowth, it is characterised in that comprise following component: Ramulus et folium taxi cuspidatae 2-7 part, Inonqqus obliquus 5-10 part.
A kind of China fir young pilose antler mixture suppressing tumor cell regrowth the most according to claim 1, it is characterised in that described Inonqqus obliquus is Siberia or Manchurian Inonqqus obliquus, has another name called Phaeoporus obliquus, described Ramulus et folium taxi cuspidatae is Canada's graceful ground subrace.
A kind of China fir young pilose antler mixture suppressing tumor cell regrowth the most according to claim 1, it is characterised in that impurity is taken out in Inonqqus obliquus and Ramulus et folium taxi cuspidatae screening, and section, thickness is at 1mm-3mm, and size is at 1cm 5cm.
4. the preparation method of the China fir young pilose antler mixture suppressing tumor cell regrowth, it is characterised in that comprise the following steps:
Step 1: Inonqqus obliquus and Ramulus et folium taxi cuspidatae being screened and take out impurity, section, thickness is at 1mm-3mm, and size is at 1cm 5cm；
Step 2: concoct Ramulus et folium taxi cuspidatae, puts into Ramulus et folium taxi cuspidatae and soaks in soak more than 30 minutes, take out after then Ramulus et folium taxi cuspidatae section being decocted more than 30 minutes with Chinese liquor, and airing is standby；Described soak uses the Chinese liquor of more than 30 degree to soak with following component and obtains: Radix Bupleuri 3-9 part, Radix Angelicae Sinensis 3-9 part, Radix Paeoniae Alba 2-8 part, Radix Ginseng 5-15 part, Radix Glycyrrhizae Preparata 3-12 part, Fructus Schisandrae Chinensis 2-10 part, Rhizoma Zingiberis 2-9 part；
Step 3: concoct Inonqqus obliquus, is immersed in Inonqqus obliquus section in soak more than 60 minutes, then Inonqqus obliquus section is taken out, airing standby；Described soak uses the Chinese liquor of more than 35 degree to soak with following component and obtains: Radix Rehmanniae Preparata 3-10 part, Cortex Cinnamomi 3-12 part, Herba Ephedrae 2-8 part, Semen Sinapis Albae 2-12 part, Rhizoma Zingiberis Recens charcoal 2-8 part, Radix Glycyrrhizae 3-12 part；
Step 4: the Ramulus et folium taxi cuspidatae mixing after concocting in the Inonqqus obliquus in step 3 and step 2, common input decocts in still, and 80-100 degree decocts 30-60 minute, detection, and packaging obtains finished product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610504102.6A CN105998094A (en) | 2016-07-01 | 2016-07-01 | Taxus chinensis and Chaga mixture for inhibiting re-growth of tumour cells |
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| CN201610504102.6A CN105998094A (en) | 2016-07-01 | 2016-07-01 | Taxus chinensis and Chaga mixture for inhibiting re-growth of tumour cells |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107823610A (en) * | 2017-12-05 | 2018-03-23 | 武振玉 | Antineoplastic pharmaceutical compositions and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1346659A (en) * | 2001-10-16 | 2002-05-01 | 邹跃翔 | Anticancer health-care Chinese yew composition |
| CN1994150A (en) * | 2006-12-14 | 2007-07-11 | 李仁贤 | Yew beverage |
| CN101791119A (en) * | 2010-02-03 | 2010-08-04 | 孟蒙 | Chaga nutrient composition |
| CN103893518A (en) * | 2014-04-28 | 2014-07-02 | 房良华 | Anti-tumor traditional Chinese medicine composition |
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2016
- 2016-07-01 CN CN201610504102.6A patent/CN105998094A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1346659A (en) * | 2001-10-16 | 2002-05-01 | 邹跃翔 | Anticancer health-care Chinese yew composition |
| CN1994150A (en) * | 2006-12-14 | 2007-07-11 | 李仁贤 | Yew beverage |
| CN101791119A (en) * | 2010-02-03 | 2010-08-04 | 孟蒙 | Chaga nutrient composition |
| CN103893518A (en) * | 2014-04-28 | 2014-07-02 | 房良华 | Anti-tumor traditional Chinese medicine composition |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107823610A (en) * | 2017-12-05 | 2018-03-23 | 武振玉 | Antineoplastic pharmaceutical compositions and preparation method thereof |
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Application publication date: 20161012 |