CN105997536B - A kind of medical depilatory agent of animal and preparation method thereof - Google Patents
A kind of medical depilatory agent of animal and preparation method thereof Download PDFInfo
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- CN105997536B CN105997536B CN201610308265.7A CN201610308265A CN105997536B CN 105997536 B CN105997536 B CN 105997536B CN 201610308265 A CN201610308265 A CN 201610308265A CN 105997536 B CN105997536 B CN 105997536B
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- animal
- agent
- depilation
- depilatory agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q9/00—Preparations for removing hair or for aiding hair removal
- A61Q9/04—Depilatories
Abstract
The present invention provides a kind of medical depilatory agent of animal, and weight percentage is made of following raw material：Na2S：8%~12.5%；Thickener：5%~10%；Protective agent：5%~10%；Plasticizer：2.5%~5%；Surplus is water.The present invention also provides preparation methods.The medical depilatory agent of animal of the present invention both can guarantee depilatory agent and come into full contact with rapid depilation by de- animal hair and hair root; depilation range can be precisely determined again; and there is protective effect to animal skin; the hair of fracture is wiped together together with talcum powder after depilation; depilation is not only soon but also conveniently; depilation position is not stimulated, no obvious adverse reaction.The depilatory agent of the present invention is suitable for animal surgery operation and skin irritation test preserved skin.
Description
Technical field
The invention belongs to veterinary drug technical fields, and in particular to a kind of medical depilatory agent of animal.
Background technology
Animal surgery experiment needs the preserved skin that loses hair or feathers, the method for preserved skin generally to have safety razor preserved skin and chemical defleecing agent preserved skin
2 kinds.
Safety razor preserved skin method is easy to damage skin, other than macroscopic small notch and scratching acne, also skin table
The granular cell layer and stratum spinosum epidermidis of chrotoplast damage.With laser blood flowmeter measurement the result shows that safety razor preserved skin area skin has
Congested bleeding changes, with the tissue damage effect of safety razor preserved skin sometimes even than the range bigger of surgical injury, 20 after operation
Minute, safety razor preserved skin group skin blood flow has notch and scratches the preserved skin position of trace still greater than chemical defleecing agent group, then damages
Wound has reached dermal tissue or less.These damages, easily cause the pollution of hand postoperative wound.
There are many formula of chemical defleecing agent, generally 8% vulcanized sodium (Na2S·9H2 O) aqueous solution.In use by
Poor in the hair compatibility of aqueous solution and animal, solution is difficult the root for penetrating into animal hair in a short time, and dosage is larger
Or action time longer then easy burned skin, and the size also more difficult grasp for range of losing hair or feathers, it usually will appear depilation and do not do
Net phenomenon, and due to repeated multiple times wiping, hyperemia often occurs for skin.In order to solve the above problem someone be added in the solution starch,
Solution is tuned into scattered paste shape by the ingredients such as glycerine, sugar and borax, in order to be reinforced the affinity of solution and hair, be mitigated sulphur
Change stimulation of the sodium to skin.Somebody adds 40% alcohol to the mixing of 100ml solution with vulcanized sodium 10g, quick lime 15g
The hair compatibility of object, said preparation and animal is good, and the mobility of solution itself is also preferable, after with the contact of the hair of animal
Hair root can be rapidly permeated into, hair is sloughed, it is not only fast not only net but also economical, but since mobility is too strong, often exceed depilation range,
And the time slightly long stimulation plus alcohol, animal skin are easy congested and chap, influence surgical operation and scientific experimentation knot
Fruit.
It is 35 total from 1998 to depilatory agent disclosed in 2015 end of the year Chinese patent databases, in relation to the special of operation preserved skin
Profit only 1, remaining be essentially all cosmetically depilatory agent and as gross weight eat slaughtering after depilatory agent.
Invention content
In order to solve the problems in the existing technology, the present invention provides a kind of medical depilatory agents of animal, to depilation portion
Position does not stimulate, and no obvious adverse reaction can accurately control depilation range.For this purpose, the present invention also provides preparation methods.
The present invention provides a kind of medical depilatory agent of animal, and weight percentage is made of following raw material：
Na2S 8%~12.5%
Thickener 5%~10%
Protective agent 5%~10%
Plasticizer 2.5%~5%
Surplus is water.
Thickener is selected from a variety of thickeners such as methylcellulose, povidone and sodium carboxymethylcellulose, with product
It can compare with price, the thickener is preferably sodium carboxymethylcellulose.
Protective agent is selected from a variety of protective agents such as white bole, montmorillonite powder and talcum powder, with properties of product and price ratio
Compared with the protective agent is preferably talcum powder.
Plasticizer is screened from a variety of plasticizer such as glycerine, n-butanol, isopropanol and propylene glycol, with properties of product and
Price compares, and the plasticizer is preferably glycerine.
Preferably, it is 2 that the protective agent and plasticizer, which are amount ratio,:1.When the two dosage is 2:When 1, it is prepared
Depilatory agent mobility and best to the immersional wetting of hair root, and to the irritation of skin minimum.
The present invention also provides the preparation methods of the medical depilatory agent of above-mentioned animal, weigh Na in proportion2S, thickener, protection
Agent, plasticizer, add appropriate amount of water, are sufficiently stirred mixing, finally add water constant volume mixing to obtain the final product.
Ideal chemical defleecing agent should meet following standards：（1）Pharmacological property is stablized；（2）Without part and general toxicity；（3）It is long
Phase contacts without danger；（4）Low immunogenicity；（5）Hair removal effect is reliable；（6）Applied to infection site to organizing harmless effect.
Since depilatory agent depilation is mainly the chemolysis effect of vulcanized sodium, so when should shorten the stop of depilatory agent on the skin as possible
Between, it avoids, because of depilatory agent burned skin, wound infection after animal surgery, the application being caused to comply fully with above-mentioned requirements, depilatory agent
Not only there is in formula with proper amount of plasticizer glycerine and thickener water-soluble carboxymethyl sodium cellulosate protection skin, but also can slow down
The mobility of depilatory agent increases its viscosity；Depilatory agent is confined in the range of needing to lose hair or feathers by water-insoluble talcum powder, and point
It dissipates uniformly, not only can guarantee depilatory agent in this way and rapid depilation is come into full contact with by de- animal hair and hair root, but also can precisely determine de-
Hair range, and there is protective effect to animal skin, the hair of fracture is wiped together together with talcum powder after depilation, depilation was both fast
It is again convenient, depilation position is not stimulated, no obvious adverse reaction.The depilatory agent of the present invention is suitable for animal surgery operation and skin
Skin irritation test preserved skin.
Specific implementation mode
Embodiment below facilitates a better understanding of the present invention, but does not limit the present invention.Experiment in following embodiments
Method is unless otherwise specified conventional method.Test material as used in the following examples is unless otherwise specified city
It sells.
A kind of formula of medical animal depilatory agent of the present invention is as follows：
Na28~12.5g of S
5~10g of thickener
5~10g of protective agent
2.5~5g of plasticizer
Solvent（Water）It mends to 100mL.
A kind of preparation method of medical animal depilatory agent of the present invention is as follows：
Na is weighed by formula ratio2S, thickener, protective agent, plasticizer, add appropriate amount of water, are sufficiently stirred mixing, solution total amount
It is mended to 100mL mixings with water less than 100mL；For sterile filling in dry polyethylene bottle or vial, sealing is spare.
Thickener preferably carboxymethyl cellulose sodium.
Protective agent preferably talc powder.
Plasticizer preferably glycerine.
Embodiment 1
A kind of formula of medical animal depilatory agent of the present invention is as follows：
Na2S 12.5g
Sodium carboxymethylcellulose 10g
Talcum powder 10g
Glycerine 5g
Solvent（Water）It mends to 100mL.
A kind of preparation method of medical animal depilatory agent of the present invention is as follows：
Na is weighed by formula ratio2S, sodium carboxymethylcellulose, talcum powder, glycerine, add appropriate amount of water, are sufficiently stirred mixing, molten
Liquid insufficient total amount 100mL's is mended with water to 100mL mixings；Sterile filling is in dry polyethylene bottle or vial, envelope
Mouth is spare.
Embodiment 2
Compared with Example 1, only by Na2S recipe quantities are changed to 8g, and the medical depilatory agent of animal is prepared.
Embodiment 3
Compared with Example 1, only by Na2S recipe quantities are changed to 10g, and the medical depilatory agent of animal is prepared.
Embodiment 4
Compared with Example 1, sodium carboxymethylcellulose recipe quantity is only changed to 5g, the medical depilatory agent of animal is prepared.
Embodiment 5
Compared with Example 1, talcum powder recipe quantity is only changed to 5g, the medical depilatory agent of animal is prepared.
Embodiment 6
Compared with Example 1, glycerine recipe quantity is only changed to 2.5g, the medical depilatory agent of animal is prepared.
Embodiment 7
For medical depilatory agent feasibility prepared by the verification present invention, following pharmacological evaluations are completed.
1, the hair removal effect of comparing embodiment 1-6.
Sheep 30 is used with experiment, 6 groups is randomly divided into, every group 5, it is real that comparison is carried out with the depilation of sheep abdominal operation position
It tests, the depilatory agent that respectively prepared by Example 1-6 formulas, dipping depilatory agent with one piece of gauze of ovum garden clamp is uniformly coated in abdomen
Portion, area is 20cm × 30cm, and is clocked.The hair at observation depilation position occurs to dissolve and becomes paste, and timing terminates, and uses yarn
Cloth wipes the hair dissolved and remaining depilatory agent, is used in combination gauze gently to dry at depilation position, observation depilation average time
And unit consumption, the results detailed in Table 1.
16 kinds of depilatory agents of table compare sheep abdomen hair hair removal effect（n=5）
Experimental result is shown：Each experimental group loses hair or feathers the time in the range of 3.5~6.2min, unit area depilatory agent dosage
About 1.0 ml/cm2, depilation is clean, non-stimulated to sheep abdomen depilation area skin, and comparison among groups difference is not notable（P ＞
0.05）；From Na2S dosages consider that best preferred embodiment 2 is formulated.
2. the hair removal effect of comparing embodiment 2 and common depilatory agent.
Sheep 30 is used with experiment, is randomly divided into 3 groups, every group 10, with embodiment 2（Na2S contents 8%）、8%Na2S is water-soluble
Liquid, 8%Na2Depilatory agent prepared by three kinds of distinct methods of S+40% alcohol is lost hair or feathers with sheep abdominal operation position and carries out contrast experiment, is used
One piece of gauze of ovum garden clamp dips depilatory agent and is uniformly coated in abdomen, and area is 20cm × 30cm, and is clocked.Observe depilation portion
The hair of position occurs to dissolve and becomes paste, and timing terminates, and the hair dissolved and remaining depilatory agent are wiped with gauze, is used in combination
Gauze gently dries at depilation position, observation depilation average time and unit consumption, the results detailed in Table 2.
23 kinds of depilatory agents of table compare sheep abdomen hair hair removal effect（n=10）
Experimental result is shown：Lose hair or feathers 2 groups of average time embodiment and 8%Na2S+40% alcohol groups are better than Na2S aqueous solution groups（P
＜ 0.05）, three comparison among groups difference of unit area depilatory agent dosage is notable（P ＞ 0.05）, 2 groups of depilation range embodiment is better than
Na2S aqueous solutions group and 8%Na2S+40% alcohol groups（P ＜ 0.01）.
Finally it should be noted that：The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention,
Although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, still may be used
With technical scheme described in the above embodiments is modified or equivalent replacement of some of the technical features.
All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in the present invention's
Within protection domain.
Claims (3)
1. a kind of medical depilatory agent of animal, it is characterised in that：Weight percentage is made of following raw material：
Na2S 8%~12.5%
Thickener 5%~10%
Protective agent 5%~10%
Plasticizer 2.5%~5%
Surplus is water；
Wherein, the thickener is sodium carboxymethylcellulose；
The protective agent is talcum powder；
The plasticizer is glycerine.
2. the medical depilatory agent of animal according to claim 1, it is characterised in that：The protective agent and plasticizer are amount ratio
It is 2:1.
3. the preparation method of the medical depilatory agent of animal as claimed in claim 1 or 2, it is characterised in that：Na is weighed in proportion2S, increase
Thick dose, protective agent, plasticizer, add appropriate amount of water, be sufficiently stirred mixing, finally plus water constant volume mixing to obtain the final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610308265.7A CN105997536B (en) | 2016-05-11 | 2016-05-11 | A kind of medical depilatory agent of animal and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610308265.7A CN105997536B (en) | 2016-05-11 | 2016-05-11 | A kind of medical depilatory agent of animal and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN105997536A CN105997536A (en) | 2016-10-12 |
| CN105997536B true CN105997536B (en) | 2018-08-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610308265.7A Active CN105997536B (en) | 2016-05-11 | 2016-05-11 | A kind of medical depilatory agent of animal and preparation method thereof |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109498483A (en) * | 2018-12-14 | 2019-03-22 | 河南中医药大学 | A kind of anti-inflammatory depilation gel |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1715424A (en) * | 2005-06-21 | 2006-01-04 | 陈荣辉 | Environment friendly depilation composition and its depilation method in water bath |
| CN101005878A (en) * | 2004-08-26 | 2007-07-25 | 雷克特本克斯尔(英国)有限公司 | Depilatory composition in emulsion form, process for preparation and use |
| CN102860938A (en) * | 2012-10-12 | 2013-01-09 | 苏州谷力生物科技有限公司 | Hair removal agent |
-
2016
- 2016-05-11 CN CN201610308265.7A patent/CN105997536B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101005878A (en) * | 2004-08-26 | 2007-07-25 | 雷克特本克斯尔(英国)有限公司 | Depilatory composition in emulsion form, process for preparation and use |
| CN1715424A (en) * | 2005-06-21 | 2006-01-04 | 陈荣辉 | Environment friendly depilation composition and its depilation method in water bath |
| CN102860938A (en) * | 2012-10-12 | 2013-01-09 | 苏州谷力生物科技有限公司 | Hair removal agent |
Non-Patent Citations (1)
| Title |
|---|
| 动物实验用脱毛剂配方的改进;李峰等;《实用口腔医学杂志》;19981105;第298-299页. * |
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