CN105969519A - Preparation method of sesame oil for injection - Google Patents

Abstract

The invention discloses a preparation method of sesame oil for injection. The sesame oil for injection is prepared through acid degumming, alkali-refining and deacidification, adsorptive decolorization and deodorization processes, and the product technical indicators of the sesame oil are that: an iodine value is 111 g/100 g, a saponification value is 194 mg KOH/g, an acid value is 0.08 mg KOH/g, a peroxide value is 1.06 mmol/kg, the percentage of unsaponifiable matters is 0.56 percent, and the absorbance (450 nm) is 0.035. The physical and chemical indicators of the refined sesame oil meet the requirements of oil for injection. After being treated through the various refining processes, the sesame oil still contains a certain quantity of active ingredients: the contents of sesamin and sesamolin are 0.3470 percent and 0.1462 percent respectively and completely conform to the sesame oil for injection.

Description

A kind of preparation method of injection Oleum sesami

Technical field

The present invention relates to the preparation method of a kind of injection Oleum sesami.

Background technology

Oil for injection is the key component of intravenous fat emulsion injection, the most still the solvent of some fat-soluble medicine, In order to improve medicine absorption in body.Oil for injection is often with vegetable oil as raw material, such as Oleum Camelliae, soybean oil and Oleum Sesami etc., warp The techniques such as degumming, deacidification, decolouring and deodorize prepare, and need the peace carrying out animal and clinical trial to guarantee oil for injection simultaneously Quan Xing.Coldly-squeezed sesame oil is directly to be squeezed prepared by the Semen Sesami roasted without high temperature, lightly seasoned, color is shallow, transparency good, especially It is that distinctive lignanoids active component such as sesamin and sesamolin etc. make Oleum sesami have antioxidation, blood fat reducing, prevention Hypertension and anticancer etc. acts on.Due to the existence of this kind of material, produce oil for injection with coldly-squeezed sesame oil and may produce ratio Preferably positive effect.Abroad, by coldly-squeezed sesame oil by refining treatment, the medicine reaching pharmaceutical grade standard is produced Report with oil.

Oleum sesami has had bimillennium in the production history of China, and conventional production methods mainly has high temperature milling process, solvent Solvent extraction method, water substitution.In traditional method, Semen Sesami need to roast through high temperature, the most traditional water substitution need to through by rinsing, fry seed, Mill seed, convert slurry, stir the technique such as oil and oil separation by oscillation.Its Oleum sesami produced has strong fragrance and has deeper color and luster, Limit Oleum sesami to apply in the exploitation of other field.

Summary of the invention

It is an object of the invention to provide the preparation method of a kind of injection Oleum sesami, to solve above-mentioned background technology carries The problem gone out.

For achieving the above object, the present invention provides following technical scheme: the preparation method of a kind of injection Oleum sesami, the party Method is as follows

1). cold pressing Semen Sesami crude oil is heated to 60 DEG C, adds the citric acid solution 5.0g/kg of 45%, the amount of distilled water 2.5%, stir Mixing reaction 45min, then stand and make colloid settle, use centrifuging separation colloid, 85 DEG C of distillation washings, at 93 DEG C, vacuum takes off Water, obtains acid system degummed oil；

2). degumming Oleum sesami is heated to 70 DEG C, is subsequently adding concentration of lye 8 B é, excess alkali quantity 0.1%, stirring reaction 20min After, stopping stirring, stand and make oil soap separate, then 5000 r/min centrifugation 15 min, with equality of temperature distilled water by Semen Sesami Oil wash shows neutrality to scrub raffinate；

3). dry degumming, deacidification coldly-squeezed sesame oil are placed in and are preheated to 91 DEG C, adds kieselguhr and the active hargil of 3.7% With the decolorising agent of 1:4 mixing, stop heating after carrying out decoloring reaction 21min under vacuum, treat that oil temperature is less than 60 DEG C, Vacuum breaker sucking filtration must decolour Oleum sesami；

4). under 0.099 MPa vacuum condition, decolouring Oleum sesami is heated to 180 DEG C, is passed through steam, carry out constant temperature distillation 30 min, then, stop heating, and when oil temperature is less than 50 DEG C, vacuum breaker takes out Oleum sesami and i.e. obtains injection Oleum sesami.

Compared with prior art, the invention has the beneficial effects as follows: use the refinery practice route of the present invention to obtain Oleum sesami Product, its technical target of the product is: iodine number 111 g/100 g, saponification number 194 mg KOH/g, acid number 0.08 mg KOH/g, mistake Oxidation number 1.06 mmol/kg, non-saponifiable matter 0.56%, absorbance (450 nm) 0.035.The physical and chemical index of refined sesame meets The requirement of oil for injection.After various refinery practices process, Oleum sesami still contain a certain amount of active component: sesamin with Sesamolin, content is respectively 0.3470% and 0.1462%.

Detailed description of the invention

Below the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment It is only a part of embodiment of the present invention rather than whole embodiments.Based on the embodiment in the present invention, the common skill in this area The every other embodiment that art personnel are obtained under not making creative work premise, broadly falls into the scope of protection of the invention

The preparation method of a kind of injection Oleum sesami, the method is as follows

1). cold pressing Semen Sesami crude oil is heated to 60 DEG C, adds the citric acid solution 5.0g/kg of 45%, the amount of distilled water 2.5%, stir Mixing reaction 45min, then stand and make colloid settle, use centrifuging separation colloid, 85 DEG C of distillation washings, at 93 DEG C, vacuum takes off Water, obtains acid system degummed oil；

2). degumming Oleum sesami is heated to 70 DEG C, is subsequently adding concentration of lye 8 B é, excess alkali quantity 0.1%, stirring reaction 20min After, stopping stirring, stand and make oil soap separate, then 5000 r/min centrifugation 15 min, with equality of temperature distilled water by Semen Sesami Oil wash shows neutrality to scrub raffinate；

3). dry degumming, deacidification coldly-squeezed sesame oil are placed in and are preheated to 91 DEG C, adds kieselguhr and the active hargil of 3.7% With the decolorising agent of 1:4 mixing, stop heating after carrying out decoloring reaction 21min under vacuum, treat that oil temperature is less than 60 DEG C, Vacuum breaker sucking filtration must decolour Oleum sesami；

4). under 0.099 MPa vacuum condition, decolouring Oleum sesami is heated to 180 DEG C, is passed through steam, carry out constant temperature distillation 30 min, then, stop heating, and when oil temperature is less than 50 DEG C, vacuum breaker takes out Oleum sesami and i.e. obtains injection Oleum sesami.

Although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, permissible Understand and these embodiments can be carried out multiple change without departing from the principles and spirit of the present invention, revise, replace And modification, the scope of the present invention be defined by the appended.

Claims (1)

1. a preparation method for injection Oleum sesami, is characterized in that: the method is as follows

1). cold pressing Semen Sesami crude oil is heated to 60 DEG C, adds the citric acid solution 5.0g/kg of 45%, the amount of distilled water 2.5%, stir Mixing reaction 45min, then stand and make colloid settle, use centrifuging separation colloid, 85 DEG C of distillation washings, at 93 DEG C, vacuum takes off Water, obtains acid system degummed oil；

2). degumming Oleum sesami is heated to 70 DEG C, is subsequently adding concentration of lye 8 B é, excess alkali quantity 0.1%, stirring reaction 20min After, stopping stirring, stand and make oil soap separate, then 5000 r/min centrifugation 15 min, with equality of temperature distilled water by Semen Sesami Oil wash shows neutrality to scrub raffinate；

3). dry degumming, deacidification coldly-squeezed sesame oil are placed in and are preheated to 91 DEG C, adds kieselguhr and the active hargil of 3.7% With the decolorising agent of 1:4 mixing, stop heating after carrying out decoloring reaction 21min under vacuum, treat that oil temperature is less than 60 DEG C, Vacuum breaker sucking filtration must decolour Oleum sesami；

4). under 0.099 MPa vacuum condition, decolouring Oleum sesami is heated to 180 DEG C, is passed through steam, carry out constant temperature distillation 30 min, then, stop heating, and when oil temperature is less than 50 DEG C, vacuum breaker takes out Oleum sesami and i.e. obtains injection Oleum sesami.