CN104611127A - Preparation method and application of medical tea oil - Google Patents
Preparation method and application of medical tea oil Download PDFInfo
- Publication number
- CN104611127A CN104611127A CN201510058728.4A CN201510058728A CN104611127A CN 104611127 A CN104611127 A CN 104611127A CN 201510058728 A CN201510058728 A CN 201510058728A CN 104611127 A CN104611127 A CN 104611127A
- Authority
- CN
- China
- Prior art keywords
- oil
- preparation
- tea
- temperature
- tea oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Fats And Perfumes (AREA)
Abstract
The invention relates to a preparation method and application of medical tea oil. The preparation method comprises the following steps: (1) performing refined extraction; (2) deacidifying, namely, agitating and heating tea essential oil, dissolving KOH with soft water to obtain an alkaline solution after the oil temperature raises to 70-75 DEG C, rapidly and uniformly spraying into soil, fully mixing, stopping agitating after nigre particles appear, heating to 80 DEG C, standing at the constant temperature for 12 hours to completely precipitate, transferring upper clear oil to a washing pot, heating the oil to 85 DEG C, adding hot water to wash, standing at the constant temperature for 1 hour, separating out the upper clear oil, and then dewatering and drying under a vacuum condition to obtain the deacidified oil; (3) discoloring; (4) deodorizing; and (5) fractionating. Compared with the prior art, the method focuses on the selection of technological conditions; the tea oil is heated to be 70 to 75 DEG C during deacidifying, then the alkaline solution is added, and the tea oil is precipitated at the constant temperature of 80 DEG C. The medical tea oil prepared under the technological conditions has the advantages that the fractionating is carried out at 19 to 21 DEG C, and the low-temperature winterization can be saved.
Description
Technical field
The invention belongs to pharmaceutical excipient preparing technical field, specifically, relate to a kind of preparation method and application of medical tea oil.
Background technology
Tea oil is the edible oil that wild camellia seed refines, and has another name called camellia seed oil, Camellia oil.The unsaturated fatty acids account of tea oil more than 85%, vitamin A and E content high, and storage tolerance, is easily absorbed by the body.Tea oil, can also prevention and therapy hypertension, cardiovascular disorder not containing harmful erucic acid, is the outstanding person in edible vegetable oil.Industrially, tea oil can be produced oleic acid and ester class thereof, produce soap and Vaseline etc., also can be made into stearic acid and glycerine.Pharmaceutically, tea oil can be used for making injection and modulation various ointment, pill etc., among the peoplely also scalds with tea oil treatment and burn and the tetter such as ringworm of the body, chronic eczema.At present, a lot of medicine is deposited because of deficiencies such as polarity is little, poorly water-solubles, a suitable for oral administration, thus causes there is the problems such as first pass effect is serious, bioavailability.Tea oil but has fabulous solvability for the medicine that polarity is little, after refining, can be used as medical tea oil.
Tea oil after special process is refined pharmaceutically can be used as oil for injection.Grease mainly contains two kinds of methods as injection: one is as can not the venoclysis oil of the patient that is critically ill of oral feeding and superelevation metabolism, usually makes fats emulsion; Two is the solvents as medicine, for improving the absorption of medicine in body, thus medicine is played one's part to the full in vivo.At present, tea oil mainly makes the second purposes, namely as the carrier of medicine.Injection tea oil is temporarily without national standard.Injection tea oil in foreign trade then mainly proposes higher requirement, especially color and luster and peroxide value two indexs to the color and luster of oil product, acid number, peroxide value and heavy metal and sanitary index etc.
At present, country to the requirement of salad oil is: 0 DEG C, keeps clarification, transparent in 5.5 h.As the one of salad oil, through refining tea oil when temperature is higher, outward appearance and transparency are all fine, but when winter, temperature was close to 0 DEG C, often may occurs cotton-shaped drift (according to chemically examining as solid fat), thus have a strong impact on the quality of product.Research finds, the injection liquid that the grease containing impurity is made can cause body pyrogen reaction, and serious threat is to the life security of patient.Therefore, by special refinery practice, the various impurity of tea oil must be removed, just can be used as the solvent of medicine.
Summary of the invention
For solving the problems of the technologies described above, the invention provides a kind of preparation method and application of safe, stable medical tea oil.
The preparation method of a kind of medical tea oil of the present invention, described preparation method comprises the steps:
1. essence is carried: shelled by tea seed, dry under 70 DEG C of-80 DEG C of conditions to constant weight, pulverize and sieve and control particle <0.8mm, taking camellia seed kernel powder loads in supercritical extraction tank, the pressure arranging extraction kettle is 20-35 Mpa, temperature is 30-45 DEG C, the pressure of separating still is 6-7Mpa, pass into through the liquefaction of liquefaction ice chest after reaching design temperature, preheater preheats and the CO2 again purified, boost to set(ting)value, reach Supercritical Conditions to extract, to be achieved impose a condition after continuous extraction 1-2 h, CO2 gasification Posterior circle uses, extraction liquid is released bottom separating still, obtain tea essential oil,
2. depickling: by tea essential oil stirring heating, treats that oil temperature rises to 75 DEG C, dissolves KOH and is made into alkali lye, be showered into equably in oil rapidly, fully mix with soft water, and when stopping stirring after generation soap stock particle, be warming up to 80 DEG C, constant temperature leaves standstill 12h and makes it precipitation completely; Upper strata edible vegetable oil is transferred to washing pot, and oil temperature is raised to 85 DEG C of heating water washings, and constant temperature leaves standstill 1h, isolates edible vegetable oil, dehydrates under vacuum, obtains depickling oil;
3. decolour: depickling oil is warming up to 75-80 DEG C of insulation, soaking time controls at 20-30min, sorbent material is added in insulation situation, after vacuumize, vacuum tightness is remained on 0.08MPa, with electric mixer, compound sample is stirred, churning time controls at 30min, be cooled to less than 50 DEG C, filter more than 2 times, then carry out centrifugal obtain decolour grease;
4. deodorization: by centrifugal for decolouring grease, filter after put into three-necked flask and nitrogen filled to it, by vacuum pump using circulatory water suction to 0.08Mpa, maintain 30min, open heating jacket and slowly heat flask to 230-240 DEG C, utilize water bath with thermostatic control to add the hot water of 95 DEG C wherein, stir with mechanical stirrer simultaneously, under the pressure of 0.08MPa, keep 5-8h, close heating jacket and make it slowly cool to 59-61 DEG C, take out, utilize vacuum pump aided filter, obtain deodorization grease;
5. divide and carry: deodorization grease is placed in refrigerator, control temperature is at 19-21 DEG C, and 5-6h is preserved in sealing, takes out and in the dark treats that its temperature rises to room temperature, filters and obtains medical tea oil, fills nitrogen and preserves.
The preparation method of a kind of medical tea oil of the present invention, described step 2. in the mass percentage concentration of alkali lye be 15%, its add-on be 0.02-0.03 that oil is heavy doubly.
The preparation method of a kind of medical tea oil of the present invention, described step sorbent material is 3. one or more in macroporous resin, activated carbon, diatomite or carclazyte.
The preparation method of a kind of medical tea oil of the present invention, the add-on of described step sorbent material is 3. the 4-8% that oil is heavy.
The application of the medical tea oil that preparation method of the present invention obtains, described medical tea oil is used as oil for injection.
The application of the medical tea oil that preparation method of the present invention obtains, described medical tea oil is used as the oil for injection of 9-O-demethyl bianfugenine.
Compared with prior art, the preparation method of medical tea oil of the present invention more focuses on the selection of processing condition, especially when carrying out acidifying to tea oil, first oil temperature is raised to 70-75 DEG C, then adds alkali lye, then 80 DEG C of constant temperature precipitations.Adopt medical tea oil prepared by these processing condition, need only carry out point carrying at 19-21 DEG C, low temperature winterization can be saved.
Embodiment
Below in conjunction with specific embodiment, the preparation method of medical tea oil of the present invention and application are described further, but protection scope of the present invention is not limited to this.
embodiment 1
A kind of preparation method of medical tea oil, described preparation method comprises the steps: that 1. essence is carried: shelled by tea seed, dry under 75 DEG C of conditions to constant weight, pulverize and sieve and control particle <0.8mm, taking camellia seed kernel powder loads in supercritical extraction tank, the pressure arranging extraction kettle is 30Mpa, temperature is 40 DEG C, the pressure of separating still is 6Mpa, pass into through the liquefaction of liquefaction ice chest after reaching design temperature, preheater preheats and the CO2 again purified, boost to set(ting)value, reach Supercritical Conditions to extract, to be achieved impose a condition after continuous extraction 2 h, CO2 gasification Posterior circle uses, extraction liquid is released bottom separating still, obtain tea essential oil, 2. depickling: by tea essential oil stirring heating, treats that oil temperature rises to 75 DEG C, dissolves KOH and is made into alkali lye, be showered into equably in oil rapidly, fully mix with soft water, and when stopping stirring after generation soap stock particle, be warming up to 80 DEG C, constant temperature leaves standstill 12h and makes it precipitation completely, upper strata edible vegetable oil is transferred to washing pot, and oil temperature is raised to 85 DEG C of heating water washings, and constant temperature leaves standstill 1h, isolates edible vegetable oil, dehydrates under vacuum, obtains depickling oil, 3. decolour: depickling oil is warming up to 75 DEG C of insulations, soaking time controls at 25min, sorbent material is added in insulation situation, after vacuumize, vacuum tightness is remained on 0.08MPa, with electric mixer, compound sample is stirred, churning time controls at 30min, be cooled to less than 50 DEG C, filter more than 2 times, then carry out centrifugal obtain decolour grease, 4. deodorization: by centrifugal for decolouring grease, filter after put into three-necked flask and nitrogen filled to it, by vacuum pump using circulatory water suction to 0.08Mpa, maintain 30min, open heating jacket and slowly heat flask to 235 DEG C, utilize water bath with thermostatic control to add the hot water of 95 DEG C wherein, stir with mechanical stirrer simultaneously, under the pressure of 0.08MPa, keep 6h, close heating jacket and make it slowly cool to 60 DEG C, take out, utilize vacuum pump aided filter, obtain deodorization grease, 5. divide and carry: deodorization grease is placed in refrigerator, control temperature is at 20 DEG C, and 6h is preserved in sealing, takes out and in the dark treats that its temperature rises to room temperature, filters and obtains medical tea oil, fills nitrogen and preserves.Described step 2. in the mass percentage concentration of alkali lye be 15%, its add-on is heavy 0.025 times of oil; Described step sorbent material is 3. activated carbon; The add-on of described step sorbent material be 3. oil heavy 6%.
embodiment 2
A kind of preparation method of medical tea oil, described preparation method comprises the steps: that 1. essence is carried: shelled by tea seed, dry under 70 DEG C of conditions to constant weight, pulverize and sieve and control particle <0.8mm, taking camellia seed kernel powder loads in supercritical extraction tank, the pressure arranging extraction kettle is 20Mpa, temperature is 30 DEG C, the pressure of separating still is 6Mpa, pass into through the liquefaction of liquefaction ice chest after reaching design temperature, preheater preheats and the CO2 again purified, boost to set(ting)value, reach Supercritical Conditions to extract, to be achieved impose a condition after continuous extraction 1h, CO2 gasification Posterior circle uses, extraction liquid is released bottom separating still, obtain tea essential oil, 2. depickling: by tea essential oil stirring heating, treats that oil temperature rises to 75 DEG C, dissolves KOH and is made into alkali lye, be showered into equably in oil rapidly, fully mix with soft water, and when stopping stirring after generation soap stock particle, be warming up to 80 DEG C, constant temperature leaves standstill 12h and makes it precipitation completely, upper strata edible vegetable oil is transferred to washing pot, and oil temperature is raised to 85 DEG C of heating water washings, and constant temperature leaves standstill 1h, isolates edible vegetable oil, dehydrates under vacuum, obtains depickling oil, 3. decolour: depickling oil is warming up to 75 DEG C of insulations, soaking time controls at 20min, sorbent material is added in insulation situation, after vacuumize, vacuum tightness is remained on 0.08MPa, with electric mixer, compound sample is stirred, churning time controls at 30min, be cooled to less than 50 DEG C, filter more than 2 times, then carry out centrifugal obtain decolour grease, 4. deodorization: by centrifugal for decolouring grease, filter after put into three-necked flask and nitrogen filled to it, by vacuum pump using circulatory water suction to 0.08Mpa, maintain 30min, open heating jacket and slowly heat flask to 230 DEG C, utilize water bath with thermostatic control to add the hot water of 95 DEG C wherein, stir with mechanical stirrer simultaneously, under the pressure of 0.08MPa, keep 5h, close heating jacket and make it slowly cool to 59 DEG C, take out, utilize vacuum pump aided filter, obtain deodorization grease, 5. divide and carry: deodorization grease is placed in refrigerator, control temperature is at 19 DEG C, and 5h is preserved in sealing, takes out and in the dark treats that its temperature rises to room temperature, filters and obtains medical tea oil, fills nitrogen and preserves.Described step 2. in the mass percentage concentration of alkali lye be 15%, its add-on is heavy 0.02 times of oil; Described step sorbent material is 3. carclazyte; The add-on of described step sorbent material be 3. oil heavy 4%.
embodiment 3
A kind of preparation method of medical tea oil, described preparation method comprises the steps: that 1. essence is carried: shelled by tea seed, dry under 70 DEG C of-80 DEG C of conditions to constant weight, pulverize and sieve and control particle <0.8mm, taking camellia seed kernel powder loads in supercritical extraction tank, the pressure arranging extraction kettle is 35 Mpa, temperature is 45 DEG C, the pressure of separating still is 7Mpa, pass into through the liquefaction of liquefaction ice chest after reaching design temperature, preheater preheats and the CO2 again purified, boost to set(ting)value, reach Supercritical Conditions to extract, to be achieved impose a condition after continuous extraction 2 h, CO2 gasification Posterior circle uses, extraction liquid is released bottom separating still, obtain tea essential oil, 2. depickling: by tea essential oil stirring heating, treats that oil temperature rises to 75 DEG C, dissolves KOH and is made into alkali lye, be showered into equably in oil rapidly, fully mix with soft water, and when stopping stirring after generation soap stock particle, be warming up to 80 DEG C, constant temperature leaves standstill 12h and makes it precipitation completely, upper strata edible vegetable oil is transferred to washing pot, and oil temperature is raised to 85 DEG C of heating water washings, and constant temperature leaves standstill 1h, isolates edible vegetable oil, dehydrates under vacuum, obtains depickling oil, 3. decolour: depickling oil is warming up to 80 DEG C of insulations, soaking time controls at 30min, sorbent material is added in insulation situation, after vacuumize, vacuum tightness is remained on 0.08MPa, with electric mixer, compound sample is stirred, churning time controls at 30min, be cooled to less than 50 DEG C, filter more than 2 times, then carry out centrifugal obtain decolour grease, 4. deodorization: by centrifugal for decolouring grease, filter after put into three-necked flask and nitrogen filled to it, by vacuum pump using circulatory water suction to 0.08Mpa, maintain 30min, open heating jacket and slowly heat flask to 240 DEG C, utilize water bath with thermostatic control to add the hot water of 95 DEG C wherein, stir with mechanical stirrer simultaneously, under the pressure of 0.08MPa, keep 8h, close heating jacket and make it slowly cool to 61 DEG C, take out, utilize vacuum pump aided filter, obtain deodorization grease, 5. divide and carry: deodorization grease is placed in refrigerator, control temperature is at 21 DEG C, and 6h is preserved in sealing, takes out and in the dark treats that its temperature rises to room temperature, filters and obtains medical tea oil, fills nitrogen and preserves.Described step 2. in the mass percentage concentration of alkali lye be 15%, its add-on is heavy 0.03 times of oil; Described step sorbent material is 3. diatomite and the carclazyte of 1:1; The add-on of described step sorbent material be 3. oil heavy 8%.
embodiment 4
Getting in phenylcarbinol 25ml, embodiment 3 the medical tea oil 1000ml obtained joins in a stainless steel vessel, stirs homogenizing.Add under continued mixing by being separated the 9-O-demethyl bianfugenine obtained in Root of Hernandialeaf Stephania.Under nitrogen protection, mixture is heated to 50 DEG C, to accelerate the dissolving of active compound.After complete dissolution, sterile filtration is carried out at same temperature 0.22um filter.By sterile solution packing, obtain anti-inflammatory drug 9-O-demethyl bianfugenine injection liquid.By pharmacological research, compared with the aqueous solution, the tea oil injection liquid of 9-O-demethyl bianfugenine has bland feature.
control group 1
Other processing condition are with embodiment 1,2. depickling: by tea essential oil stirring heating, treat that oil temperature rises to 70 DEG C, dissolve KOH with soft water and be made into alkali lye, be showered into equably in oil rapidly, fully mix, when stopping stirring after generation soap stock particle, be warming up to 80 DEG C, constant temperature leaves standstill 12h and makes it precipitation completely; Upper strata edible vegetable oil is transferred to washing pot, and oil temperature is raised to 85 DEG C of heating water washings, and constant temperature leaves standstill 1h, isolates edible vegetable oil, dehydrates under vacuum, obtains depickling oil.
quality examination
Color and luster measures with reference to GB/T 22460-2008 animal-plant oil lovibond test method of begging for; Transparency, smell, flavour measure with reference to the sensory test method of GB/T 5525-2008; Grease water and volatile matter measure with reference to GB/T 14489.1-2008; Refractive index measures with reference to GB/T 5527-2010 animal-plant oil refractive index; Iodine number measures with reference to GB/T 5532-2008 oil iv; Peroxide value measures with reference to GB/T 5538-2005; Acid number and acid test measure with reference to GB/T 5530-2005; Oil plant oleaginousness measures with reference to GB/T 10359-2008 Petroleum ether extraction method; Saponification value is with reference to GB/T 5534-2008 animal-plant oil soap value test; Heavy metal ion content uses atomic fluorescence spectroscopy and atomic absorption spectrometry to measure.Measurement result shows: in embodiment 1-3, and the above-mentioned Testing index of gained tea oil all meets the quality standard of oil for injection, and meets the quality standard of foreign trade (Japan) injection tea oil.In control group 1, all other indexs of gained tea oil also meet related quality criterion, but in freezing test (0 DEG C of refrigeration more than 5.5h), have more floss and separate out.
Claims (6)
1. a preparation method for medical tea oil, is characterized in that, described preparation method comprises the steps:
1. essence is carried: shelled by tea seed, dry under 70 DEG C of-80 DEG C of conditions to constant weight, pulverize and sieve and control particle <0.8mm, taking camellia seed kernel powder loads in supercritical extraction tank, the pressure arranging extraction kettle is 20-35 Mpa, temperature is 30-45 DEG C, the pressure of separating still is 6-7Mpa, passes into through the liquefaction of liquefaction ice chest, preheater preheats and the CO that again purifies after reaching design temperature
2, boost to set(ting)value, reach Supercritical Conditions and extract, to be achieved impose a condition after continuous extraction 1-2 h, CO
2gasification Posterior circle uses, and extraction liquid is released bottom separating still, obtains tea essential oil;
2. depickling: by tea essential oil stirring heating, treats that oil temperature rises to 75 DEG C, dissolves KOH and is made into alkali lye, be showered into equably in oil rapidly, fully mix with soft water, and when stopping stirring after generation soap stock particle, be warming up to 80 DEG C, constant temperature leaves standstill 12h and makes it precipitation completely; Upper strata edible vegetable oil is transferred to washing pot, and oil temperature is raised to 85 DEG C of heating water washings, and constant temperature leaves standstill 1h, isolates edible vegetable oil, dehydrates under vacuum, obtains depickling oil;
3. decolour: depickling oil is warming up to 75-80 DEG C of insulation, soaking time controls at 20-30min, sorbent material is added in insulation situation, after vacuumize, vacuum tightness is remained on 0.08MPa, with electric mixer, compound sample is stirred, churning time controls at 30min, be cooled to less than 50 DEG C, filter more than 2 times, then carry out centrifugal obtain decolour grease;
4. deodorization: by centrifugal for decolouring grease, filter after put into three-necked flask and nitrogen filled to it, by vacuum pump using circulatory water suction to 0.08Mpa, maintain 30min, open heating jacket and slowly heat flask to 230-240 DEG C, utilize water bath with thermostatic control to add the hot water of 95 DEG C wherein, stir with mechanical stirrer simultaneously, under the pressure of 0.08MPa, keep 5-8h, close heating jacket and make it slowly cool to 59-61 DEG C, take out, utilize vacuum pump aided filter, obtain deodorization grease;
5. divide and carry: deodorization grease is placed in refrigerator, control temperature is at 19-21 DEG C, and 5-6h is preserved in sealing, takes out and in the dark treats that its temperature rises to room temperature, filters and obtains medical tea oil, fills nitrogen and preserves.
2. the preparation method of a kind of medical tea oil according to claim 1, is characterized in that, described step 2. in the mass percentage concentration of alkali lye be 15%, its add-on be 0.02-0.03 that oil is heavy doubly.
3. the preparation method of a kind of medical tea oil according to claim 1, is characterized in that, described step sorbent material is 3. one or more in macroporous resin, activated carbon, diatomite or carclazyte.
4. the preparation method of a kind of medical tea oil according to claim 1, is characterized in that, the add-on of described step sorbent material is 3. the 4-8% that oil is heavy.
5. the application of medical tea oil that obtains of preparation method according to claim 1, it is characterized in that, described medical tea oil is used as oil for injection.
6. the application of medical tea oil that obtains of preparation method according to claim 1, it is characterized in that, described medical tea oil is used as the oil for injection of 9-O-demethyl bianfugenine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510058728.4A CN104611127A (en) | 2015-02-05 | 2015-02-05 | Preparation method and application of medical tea oil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510058728.4A CN104611127A (en) | 2015-02-05 | 2015-02-05 | Preparation method and application of medical tea oil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104611127A true CN104611127A (en) | 2015-05-13 |
Family
ID=53145781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510058728.4A Pending CN104611127A (en) | 2015-02-05 | 2015-02-05 | Preparation method and application of medical tea oil |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104611127A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107022412A (en) * | 2017-06-02 | 2017-08-08 | 安徽山美生物科技有限公司 | A kind of discoloration method of medical material level camellia seed oil |
| CN107216945A (en) * | 2017-07-25 | 2017-09-29 | 江西省科学院应用化学研究所 | A kind of preparation method of medicine injection tea oil |
| CN107267280A (en) * | 2017-06-28 | 2017-10-20 | 玉屏侗族自治县油茶产业发展领导小组办公室 | A kind of extracting technology of camellia oil |
| CN108085132A (en) * | 2017-12-27 | 2018-05-29 | 浙江康莱特药业有限公司 | A kind of coix seed oil refinery practice |
| CN108467783A (en) * | 2018-04-16 | 2018-08-31 | 天津科技大学 | A kind of preparation method of injection tea-seed oil |
| CN109054991A (en) * | 2018-08-31 | 2018-12-21 | 湖南华诚生物资源股份有限公司 | A method of extracting arhat fruit seed oil from arhat fruit seed |
| CN116098951A (en) * | 2023-02-23 | 2023-05-12 | 广东嘉博制药有限公司 | A multiple oil-fat emulsion injection containing tea oil |
| CN116515553A (en) * | 2022-11-28 | 2023-08-01 | 九江学院 | Preparation method and application of externally-applied active tea oil |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101194713A (en) * | 2007-12-18 | 2008-06-11 | 华南农业大学 | Method for processing edible camellia oil |
| CN103232889A (en) * | 2013-04-25 | 2013-08-07 | 湖北宜恒茶油产业科技有限责任公司 | Tea oil refining method |
| CN103834472A (en) * | 2014-02-12 | 2014-06-04 | 安徽省华银茶油有限公司 | Refining process for cosmetic camellia oil |
-
2015
- 2015-02-05 CN CN201510058728.4A patent/CN104611127A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101194713A (en) * | 2007-12-18 | 2008-06-11 | 华南农业大学 | Method for processing edible camellia oil |
| CN103232889A (en) * | 2013-04-25 | 2013-08-07 | 湖北宜恒茶油产业科技有限责任公司 | Tea oil refining method |
| CN103834472A (en) * | 2014-02-12 | 2014-06-04 | 安徽省华银茶油有限公司 | Refining process for cosmetic camellia oil |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107022412A (en) * | 2017-06-02 | 2017-08-08 | 安徽山美生物科技有限公司 | A kind of discoloration method of medical material level camellia seed oil |
| CN107267280A (en) * | 2017-06-28 | 2017-10-20 | 玉屏侗族自治县油茶产业发展领导小组办公室 | A kind of extracting technology of camellia oil |
| CN107267280B (en) * | 2017-06-28 | 2020-09-15 | 贵州黔玉油茶开发有限公司 | Camellia oil extraction process |
| CN107216945A (en) * | 2017-07-25 | 2017-09-29 | 江西省科学院应用化学研究所 | A kind of preparation method of medicine injection tea oil |
| CN108085132A (en) * | 2017-12-27 | 2018-05-29 | 浙江康莱特药业有限公司 | A kind of coix seed oil refinery practice |
| CN108467783A (en) * | 2018-04-16 | 2018-08-31 | 天津科技大学 | A kind of preparation method of injection tea-seed oil |
| CN109054991A (en) * | 2018-08-31 | 2018-12-21 | 湖南华诚生物资源股份有限公司 | A method of extracting arhat fruit seed oil from arhat fruit seed |
| CN116515553A (en) * | 2022-11-28 | 2023-08-01 | 九江学院 | Preparation method and application of externally-applied active tea oil |
| CN116098951A (en) * | 2023-02-23 | 2023-05-12 | 广东嘉博制药有限公司 | A multiple oil-fat emulsion injection containing tea oil |
| CN116098951B (en) * | 2023-02-23 | 2024-05-24 | 广东嘉博制药有限公司 | A multiple oil-fat emulsion injection containing tea oil |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104611127A (en) | Preparation method and application of medical tea oil | |
| CN102293292B (en) | Health tea with functions of yin nourishing and blood nourishing, and processing method thereof | |
| CN101337880B (en) | Process for extracting alpha-linolenic acid | |
| CN103059095B (en) | A kind of green extraction of yellow ginger resource comprehensive efficiency utilization | |
| WO2014071736A1 (en) | Method for extracting silkworm pupa oil | |
| CN105331438B (en) | A kind of method that semisolid aqueous enzymatic method prepares rapeseed oil | |
| CN106754100A (en) | A kind of preparation method of red date full juice fermented wine | |
| CN104840612A (en) | Low-sugar tea oil emulsion | |
| CN103040870A (en) | Method for extracting lipide from hippocampus or syngnathus bone meal with supercritical carbon dioxide | |
| KR101792875B1 (en) | A composition comprising red ginseng and lactic acid bacteria for preventing, improving or treating vascular disease | |
| CN106511610A (en) | Preparation method of sustained-release traditional Chinese medicine wine soaking medicine package for preventing cardiovascular and cerebrovascular diseases | |
| CN104862065A (en) | Celery seed oil extraction method | |
| CN101530432B (en) | Method for producing degreased concentrated solution of tussah male moth | |
| CN106754057A (en) | A kind of health care red starter glutinous wine and preparation method thereof | |
| CN107129865B (en) | Method for extracting cucurbitacin based on subcritical fluid and molecular distillation | |
| CN110025644A (en) | A kind of compound celery oil fat emulsion formulation and preparation method thereof with anti-aging effects | |
| CN101455399B (en) | Linoleate preparation method using highland barley bran oil | |
| CN105285978A (en) | Auxiliarily blood lipid lowering seal oil and purple perilla seed oil soft capsule | |
| CN105232802B (en) | Procyanidine composition with blood fat reducing effect and preparation method and application thereof | |
| CN109349364A (en) | A kind of reducing blood lipid, norcholesterol fortification oil producing method | |
| CN108186699A (en) | A kind of traditional Chinese medicine extraction composition dropping pills with anti-fatigue effect and preparation method thereof | |
| CN115645464B (en) | Traditional Chinese medicine composition for treating atherosclerosis and fatty liver and application thereof | |
| CN106490193A (en) | A kind of ready-mixed oil containing coix seed oil and preparation method thereof | |
| KR20010060384A (en) | A manufacturing method of sea slugs liquid from cooking in a double boiler | |
| CN105924539A (en) | Preparation method of polygonatum odoratum polysaccharide |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150513 |