CN105968385A - Preparation method of lac aqueous dispersion and application of lac aqueous dispersion in coating - Google Patents
Preparation method of lac aqueous dispersion and application of lac aqueous dispersion in coating Download PDFInfo
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- CN105968385A CN105968385A CN201610373084.2A CN201610373084A CN105968385A CN 105968385 A CN105968385 A CN 105968385A CN 201610373084 A CN201610373084 A CN 201610373084A CN 105968385 A CN105968385 A CN 105968385A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2393/00—Characterised by the use of natural resins; Derivatives thereof
- C08J2393/02—Shellac
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Abstract
The invention discloses a lac aqueous dispersion which is prepared from, by mass, 5-50% of lac, 0.1-1.5% of emulsifying agent, 0.1-8.0% of basifier, 40-90% of water and 0.1-20% of ethyl alcohol. The lac aqueous dispersion contains the lac, the emulsifying agent, the basifier, the water and the ethyl alcohol, can be used for enteric or taste masking film coating production of food, medicine and dietary supplements. The lac aqueous dispersion is prepared in an emulsifying mode, the dispersion feature of lac is changed in a physical way, lac is finally dispersed in water, and no high-concentration organic solvent is adopted.
Description
Technical field
The invention belongs to drug coating, food coating, the technical field of dietary supplement coating, be specifically related to the preparation method of a kind of Lac aqueous dispersion and the application on coating thereof.
Background technology
Traditional Lac is required for when using using the ethanol being not less than 95% as solvent, soaks and dissolves overnight, after sieve, can be used for coating, and solid content is the lowest, and this makes:
1), coating process consume a large amount of ethanol, 1kg Lac need to consume the ethanol of the 95% of at least 12kg, and production cost increases；
2), a large amount of ethanol is used, even if increasing fixed assets investment when producing: set up explosion-proof workshop, buy antiknock device, take explosion precaution, but still have great potential safety hazard；
3), coating solid content low, cause the production time to extend, reduce labor productivity, improve production cost；
Traditional aqueous suspension is all while oil phase emulsifying, is added by aqueous phase；Emulsifying agent is added in aqueous phase.
Conventional enteric solubility coating material does not complys with the requirement of the dietary supplement of America and Europe.A lot of dietary supplement, as fish oil soft capsule etc. uses the form of soft capsule, if using ethanol as solvent coating, can make capsule become fragile, and after long-term placement, capsule is easy to crack, thus affects product quality.
Summary of the invention
For problems of the prior art, the present invention provides the preparation method of a kind of Lac aqueous dispersion and the application on coating thereof.
For achieving the above object, the present invention is by the following technical solutions:
A kind of Lac aqueous dispersion, the composition of this Lac aqueous dispersion includes Lac, emulsifying agent, basifier, water and ethanol, described Lac content is 5%-50%, emulsifier content is 0.1-1.5%, basifier content is 0.1-8.0%, the content of water is 40%-90%, the content of ethanol is 0.1-20%, and described percentage ratio is all the percentage ratio relative to Lac aqueous dispersion quality.
Described Lac content is 10%-25%, emulsifier content is 1%-1.5%, basifier content is 5.0%-7.5%, the content of water is 60%-75%, the content of ethanol is 5%-15%.
Described Lac content is 15%, emulsifier content is 1.5%, basifier content is 5.5%, the content of water is 68%, the content of ethanol is 10%.
Described Lac is at least one in lac, bleaching shellac.
Described emulsifying agent is that esters nonionic surfactant, Sulfates anion surfactant, Sulfonates anion surfactant, carbon number are the linear of 2-20 and branched carboxylic acids, carbon number are the linear of 2-20 and branched fatty alcohol.
Described esters nonionic surfactant is one or more in polyoxyethylene oleic acid ester, polyoxyethylene stearic acid ester, Span40, Span60, Span80, Tween40, Tween60, Tween80 or the dilute Oleum Ricini of polyoxy second；Described Sulfates anion surfactant is sodium lauryl sulphate；Described Sulfonates anion surfactant is one or more in dodecylbenzene sodium sulfonate, sodium butylnaphthalenesulfonate or petroleum sodium sulfonate；Described carbon number is the linear of 2-20 and branched carboxylic acids is at least one in oleic acid, linoleic acid, linolenic acid, Oleum Cocois, Oleum Ricini, Oleum Gossypii semen Flos Carthami oil；Described carbon number is the linear of 2-20 and branched fatty alcohol is one or more in cetyl alcohol, positive octadecanol, tertiary hexadecanol and tertiary octadecanol.
Described basifier is one or more in sodium, potassium, sodium oxide, sodium hydroxide, potassium hydroxide, ammonia, ammonia, potassium hydrogen phosphate, dipotassium hydrogen phosphate, potassium phosphate, dibastic sodium phosphate, disodium hydrogen phosphate, sodium phosphate, magnesium oxide, barium hydroxide, sodium carbonate, sodium bicarbonate, diisopropylamine；Described basifier is the pH value that can regulate water to all substances of pH value >=7.
The preparation method of a kind of Lac aqueous dispersion, this preparation method comprises the steps:
The first step, being dissolved in ethanol water by Lac, soaked overnight obtains liquid A；The consumption of wherein said Lac is 10%-90%；In ethanol water, the concentration of ethanol is not less than 50%；The consumption of ethanol water is 10%-90%；The percentage ratio of described consumption is all the percentage ratio relative to liquid A quality；
Second step, liquid A obtained by the first step add emulsifying agent, stirs, as oil phase；Wherein the consumption of liquid A is 98.5%-99.9%, and the consumption of emulsifying agent is 0.1-1.5%；The percentage ratio of described consumption is all the percentage ratio relative to oil phase quality；
3rd step, take purified water, add basifier, as aqueous phase；Wherein the consumption of purified water is 86%-99.9%, and the consumption of basifier is 0.1-14%；The percentage ratio of described consumption is all the percentage ratio relative to aqueous phase quality；
The oil phase that 4th step, the aqueous phase the 3rd step prepared and second step prepare presses 1:1～1:3 mixing, and emulsification pretreatment i.e. obtains Lac aqueous dispersion.
The dynamic viscosity of described Lac aqueous dispersion is 10-200mPa.s.
In described 3rd step, basifier part adds or all adds in purified water；Or emulsification pretreatment limit, limit adds in the 4th step.
In described 3rd step when aqueous phase ceaselessly emulsifying, being slowly added to oil phase, the speed that described oil phase adds should control at 0.1-550g/min/kg suspension；The speed of aqueous phase emulsifying is 1000-30000rpm；As a example by preparation 500g Lac aqueous dispersion, the speed that oil phase adds should control at 0.1-275g/min/kg.
A kind of Lac aqueous dispersion enteric coating in preparation pharmaceutical preparation, food or health product, dietary supplement, the application in taste masking.
Compared with prior art, the invention have the benefit that Lac aqueous dispersion the most of the present invention, containing Lac, emulsifying agent, basifier, water, ethanol, can be used for food, medicine, the enteric of dietary supplement or taste masking film coating and produces；2. the present invention is prepared by the method for emulsifying, for physically change Lac dispersing characteristic so that it is be finally dispersed in water, it is to avoid use high levels of organic solvents；3. the Lac aqueous dispersion of the present invention meets European Union, the requirement of American diet supplement, may be used for medicine, food, the enteric coating of dietary supplement or taste masking coating；Its ratio with organic solvent as solvent, use Lac coating product, produce feasible, quality is more stable.
Detailed description of the invention
Further illustrate technical scheme by embodiment below, but protection scope of the present invention is not intended to be limited thereto.
Embodiment
1
The present embodiment Lac aqueous dispersion, the composition of this Lac aqueous dispersion includes Lac, emulsifying agent, basifier, water and ethanol, described Lac content is 5%, emulsifier content is 0.1%, basifier content is 0.1%, the content of water is 90%, the content of ethanol is 4.8%, and described percentage ratio is all the percentage ratio relative to Lac aqueous dispersion quality.
In the present embodiment, Lac selects lac, and polyoxyethylene oleic acid ester selected by emulsifying agent, and basifier selects sodium oxide and the mixture of sodium hydroxide.
In the present embodiment, the preparation method of Lac aqueous dispersion comprises the steps:
The first step, being dissolved in ethanol water by Lac, soaked overnight obtains liquid A；The consumption of wherein said Lac is 10%%；In ethanol water, the concentration of ethanol is not less than 50%；The consumption of ethanol water is 90%；The percentage ratio of described consumption is all the percentage ratio relative to liquid A quality；
Second step, liquid A obtained by the first step add emulsifying agent, stirs, as oil phase；Wherein the consumption of liquid A is 98.5%, and the consumption of emulsifying agent is 1.5%；The percentage ratio of described consumption is all the percentage ratio relative to oil phase quality；
3rd step, take purified water, add basifier, as aqueous phase；Wherein the consumption of purified water is 86%, and the consumption of basifier is 14%, and basifier all adds in purified water；The percentage ratio of described consumption is all the percentage ratio relative to aqueous phase quality；
The oil phase that 4th step, the aqueous phase the 3rd step prepared and second step prepare presses 1:1 mixing, during the ceaselessly emulsifying of described aqueous phase, is slowly added to oil phase, and the speed that described oil phase adds should control at 200g/min/kg suspension；The speed of aqueous phase emulsifying is 1000rpm, and emulsification pretreatment i.e. obtains Lac aqueous dispersion, system the dynamic viscosity of this Lac aqueous dispersion be 100mPa.s.
The present embodiment Lac aqueous dispersion enteric coating in preparation pharmaceutical preparation, food or health product, dietary supplement, the application in taste masking.
Embodiment
2
The present embodiment Lac aqueous dispersion, the composition of this Lac aqueous dispersion includes Lac, emulsifying agent, basifier, water and ethanol, described Lac content is 10%, emulsifier content is 1.2%, basifier content is 5%, the content of water is 78.8%, the content of ethanol is 5%, and described percentage ratio is all the percentage ratio relative to Lac aqueous dispersion quality.
In the present embodiment, Lac selects bleaching shellac, and the mixture of Span60 and Span80 selected by emulsifying agent, Span60 and Span80 is used in mixed way according to 1:1, and diisopropylamine selected by basifier.
In the present embodiment, the preparation method of Lac aqueous dispersion comprises the steps:
The first step, being dissolved in ethanol water by Lac, soaked overnight obtains liquid A；The consumption of wherein said Lac is 50%；In ethanol water, the concentration of ethanol is not less than 50%；The consumption of ethanol water is 50%；The percentage ratio of described consumption is all the percentage ratio relative to liquid A quality；
Second step, liquid A obtained by the first step add emulsifying agent, stirs, as oil phase；Wherein the consumption of liquid A is 99%, and the consumption of emulsifying agent is 1 %；The percentage ratio of described consumption is all the percentage ratio relative to oil phase quality；
3rd step, take purified water, add basifier, as aqueous phase；Wherein the consumption of purified water is 89%, and the consumption of basifier is 11%, and basifier all adds in purified water；The percentage ratio of described consumption is all the percentage ratio relative to aqueous phase quality；
The oil phase that 4th step, the aqueous phase the 3rd step prepared and second step prepare presses 1:2 mixing, during the ceaselessly emulsifying of described aqueous phase, is slowly added to oil phase, and the speed that described oil phase adds should control at 500g/min/kg suspension；The speed of aqueous phase emulsifying is 2000rpm, and emulsification pretreatment i.e. obtains Lac aqueous dispersion, system the dynamic viscosity of this Lac aqueous dispersion be 150mPa.s.
The present embodiment Lac aqueous dispersion enteric coating in preparation pharmaceutical preparation, food or health product, dietary supplement, the application in taste masking.
Embodiment
3
The present embodiment Lac aqueous dispersion, the composition of this Lac aqueous dispersion includes Lac, emulsifying agent, basifier, water and ethanol, described Lac content is 15%, emulsifier content is 1.5%, basifier content is 5.5%, the content of water is 68%, the content of ethanol is 10%, and described percentage ratio is all the percentage ratio relative to Lac aqueous dispersion quality.
In the present embodiment, Lac selects bleaching shellac, and sodium lauryl sulphate selected by emulsifying agent, and basifier selects potassium phosphate, dibastic sodium phosphate, disodium hydrogen phosphate, the mixture of sodium phosphate.
In the present embodiment, the preparation method of Lac aqueous dispersion comprises the steps:
The first step, being dissolved in ethanol water by Lac, soaked overnight obtains liquid A；The consumption of wherein said Lac is 80%；In ethanol water, the concentration of ethanol is not less than 50%；The consumption of ethanol water is 20%；The percentage ratio of described consumption is all the percentage ratio relative to liquid A quality；
Second step, liquid A obtained by the first step add emulsifying agent, stirs, as oil phase；Wherein the consumption of liquid A is 99.9%, and the consumption of emulsifying agent is 0.1 %；The percentage ratio of described consumption is all the percentage ratio relative to oil phase quality；
3rd step, take purified water, add basifier, as aqueous phase；Wherein the consumption of purified water is 95%, and the consumption of basifier is 5%, is added in purified water by the basifier of half amount；The percentage ratio of described consumption is all the percentage ratio relative to aqueous phase quality；
The oil phase that 4th step, the aqueous phase the 3rd step prepared and second step prepare presses 1:1.5 mixing, during the ceaselessly emulsifying of described aqueous phase, is slowly added to oil phase, and the speed that described oil phase adds should control at 50g/min/kg suspension；The basifier of half amount being added and emulsification pretreatment limit, limit adds, the speed of aqueous phase emulsifying is 2500rpm, and emulsification pretreatment i.e. obtains Lac aqueous dispersion, system the dynamic viscosity of this Lac aqueous dispersion be 180mPa.s.
The present embodiment Lac aqueous dispersion enteric coating in preparation pharmaceutical preparation, food or health product, dietary supplement, the application in taste masking.
Embodiment
4
The present embodiment Lac aqueous dispersion, the composition of this Lac aqueous dispersion includes Lac, emulsifying agent, basifier, water and ethanol, described Lac content is 25%, emulsifier content is 1.5%, basifier content is 7.5%, the content of water is 60%, the content of ethanol is 6%, and described percentage ratio is all the percentage ratio relative to Lac aqueous dispersion quality.
In the present embodiment, Lac selects lac, and emulsifying agent selects oleic acid, linoleic acid, linolenic mixture, and basifier selects sodium carbonate, the mixture of sodium bicarbonate.
In the present embodiment, the preparation method of Lac aqueous dispersion comprises the steps:
The first step, being dissolved in ethanol water by Lac, soaked overnight obtains liquid A；The consumption of wherein said Lac is 90%；In ethanol water, the concentration of ethanol is not less than 50%；The consumption of ethanol water is 10%；The percentage ratio of described consumption is all the percentage ratio relative to liquid A quality；
Second step, liquid A obtained by the first step add emulsifying agent, stirs, as oil phase；Wherein the consumption of liquid A is 99.5%, and the consumption of emulsifying agent is 0.5 %；The percentage ratio of described consumption is all the percentage ratio relative to oil phase quality；
3rd step, take purified water, add basifier, as aqueous phase；Wherein the consumption of purified water is 99%, and the consumption of basifier is 1%, is added in purified water by the basifier of 2/3rds amounts；The percentage ratio of described consumption is all the percentage ratio relative to aqueous phase quality；
The oil phase that 4th step, the aqueous phase the 3rd step prepared and second step prepare presses 1:2.5 mixing, during the ceaselessly emulsifying of described aqueous phase, is slowly added to oil phase, and the speed that described oil phase adds should control at 550g/min/kg suspension；The basifier of 1/3rd amounts being added and emulsification pretreatment limit, limit adds, the speed of aqueous phase emulsifying is 20000rpm, and emulsification pretreatment i.e. obtains Lac aqueous dispersion, system the dynamic viscosity of this Lac aqueous dispersion be 150mPa.s.
The present embodiment Lac aqueous dispersion enteric coating in preparation pharmaceutical preparation, food or health product, dietary supplement, the application in taste masking.
Embodiment
5
The present embodiment Lac aqueous dispersion, the composition of this Lac aqueous dispersion includes Lac, emulsifying agent, basifier, water and ethanol, described Lac content is 50%, emulsifier content is 1%, basifier content is 4%, the content of water is 40%, the content of ethanol is 5%, and described percentage ratio is all the percentage ratio relative to Lac aqueous dispersion quality.
In the present embodiment, Lac selects lac, and emulsifying agent selects cetyl alcohol, the mixture of positive octadecanol, and basifier selects sodium bicarbonate, the mixture of diisopropylamine.
In the present embodiment, the preparation method of Lac aqueous dispersion comprises the steps:
The first step, being dissolved in ethanol water by Lac, soaked overnight obtains liquid A；The consumption of wherein said Lac is 60%；In ethanol water, the concentration of ethanol is not less than 50%；The consumption of ethanol water is 40%；The percentage ratio of described consumption is all the percentage ratio relative to liquid A quality；
Second step, liquid A obtained by the first step add emulsifying agent, stirs, as oil phase；Wherein the consumption of liquid A is 98.8%, and the consumption of emulsifying agent is 1.2%；The percentage ratio of described consumption is all the percentage ratio relative to oil phase quality；
3rd step, take purified water, add basifier, as aqueous phase；Wherein the consumption of purified water is 99.8%, and the consumption of basifier is 0.2%, is added in purified water by the basifier of 1/4th amounts；The percentage ratio of described consumption is all the percentage ratio relative to aqueous phase quality；
The oil phase that 4th step, the aqueous phase the 3rd step prepared and second step prepare presses 1:3 mixing, during the ceaselessly emulsifying of described aqueous phase, is slowly added to oil phase, and the speed that described oil phase adds should control at 55g/min/kg suspension；The basifier of residue 3/4ths amount being added and emulsification pretreatment limit, limit adds, the speed of aqueous phase emulsifying is 30000rpm, and emulsification pretreatment i.e. obtains Lac aqueous dispersion, system the dynamic viscosity of this Lac aqueous dispersion be 200mPa.s.
The present embodiment Lac aqueous dispersion enteric coating in preparation pharmaceutical preparation, food or health product, dietary supplement, the application in taste masking.
Claims (12)
1. a Lac aqueous dispersion, it is characterized in that, the composition of this Lac aqueous dispersion includes Lac, emulsifying agent, basifier, water and ethanol, described Lac content is 5%-50%, emulsifier content is 0.1-1.5%, basifier content is 0.1-8.0%, the content of water is 40%-90%, the content of ethanol is 0.1-20%, and described percentage ratio is all the percentage ratio relative to Lac aqueous dispersion quality.
Lac aqueous dispersion the most according to claim 1, it is characterised in that described Lac content is 10%-25%, emulsifier content is 1%-1.5%, basifier content is 5.0%-7.5%, the content of water is 60%-75%, the content of ethanol is 5%-15%.
Lac aqueous dispersion the most according to claim 1, it is characterised in that described Lac content is 15%, emulsifier content is 1.5%, basifier content is 5.5%, the content of water is 68%, the content of ethanol is 10%.
Lac aqueous dispersion the most according to claim 1, it is characterised in that described Lac is at least one in lac, bleaching shellac.
Lac aqueous dispersion the most according to claim 1, it is characterized in that, described emulsifying agent is that esters nonionic surfactant, Sulfates anion surfactant, Sulfonates anion surfactant, carbon number are the linear of 2-20 and branched carboxylic acids, carbon number are the linear of 2-20 and branched fatty alcohol.
Lac aqueous dispersion the most according to claim 1, it is characterized in that, described esters nonionic surfactant is one or more in polyoxyethylene oleic acid ester, polyoxyethylene stearic acid ester, Span40, Span60, Span80, Tween40, Tween60, Tween80 or the dilute Oleum Ricini of polyoxy second；Described Sulfates anion surfactant is sodium lauryl sulphate；Described Sulfonates anion surfactant is one or more in dodecylbenzene sodium sulfonate, sodium butylnaphthalenesulfonate or petroleum sodium sulfonate；Described carbon number is the linear of 2-20 and branched carboxylic acids is at least one in oleic acid, linoleic acid, linolenic acid, Oleum Cocois, Oleum Ricini, Oleum Gossypii semen Flos Carthami oil；Described carbon number is the linear of 2-20 and branched fatty alcohol is one or more in cetyl alcohol, positive octadecanol, tertiary hexadecanol and tertiary octadecanol.
Lac aqueous dispersion the most according to claim 1, it is characterized in that, described basifier is one or more in sodium, potassium, sodium oxide, sodium hydroxide, potassium hydroxide, ammonia, ammonia, potassium hydrogen phosphate, dipotassium hydrogen phosphate, potassium phosphate, dibastic sodium phosphate, disodium hydrogen phosphate, sodium phosphate, magnesium oxide, barium hydroxide, sodium carbonate, sodium bicarbonate, diisopropylamine.
8. the preparation method of the Lac aqueous dispersion as described in arbitrary in claim 1 ~ 7, it is characterised in that this preparation method comprises the steps:
The first step, being dissolved in ethanol water by Lac, soaked overnight obtains liquid A；The consumption of wherein said Lac is 10%-90%；In ethanol water, the concentration of ethanol is not less than 50%；The consumption of ethanol water is 10%-90%；The percentage ratio of described consumption is all the percentage ratio relative to liquid A quality；
Second step, liquid A obtained by the first step add emulsifying agent, stirs, as oil phase；Wherein the consumption of liquid A is 98.5%-99.9%, and the consumption of emulsifying agent is 0.1-1.5%；The percentage ratio of described consumption is all the percentage ratio relative to oil phase quality；
3rd step, take purified water, add basifier, as aqueous phase；Wherein the consumption of purified water is 86%-99.9%, and the consumption of basifier is 0.1-14%；The percentage ratio of described consumption is all the percentage ratio relative to aqueous phase quality；
The oil phase that 4th step, the aqueous phase the 3rd step prepared and second step prepare presses 1:1～1:3 mixing, and emulsification pretreatment i.e. obtains Lac aqueous dispersion.
The preparation method of Lac aqueous dispersion the most according to claim 8, it is characterised in that the dynamic viscosity of described Lac aqueous dispersion is 10 ~ 200mPa.s.
The preparation method of Lac aqueous dispersion the most according to claim 8, it is characterised in that in described 3rd step, basifier part adds or all adds in purified water；Or emulsification pretreatment limit, limit adds in the 4th step.
The preparation method of 11. Lac aqueous dispersions according to claim 10, it is characterised in that in described 4th step when aqueous phase ceaselessly emulsifying, is slowly added to oil phase, and the speed that described oil phase adds should control at 0.1-550g/min/kg suspension；The speed of aqueous phase emulsifying is 1000-30000rpm.
In 12. such as claim 1 ~ 7 arbitrary as described in Lac aqueous dispersion enteric coating in preparation pharmaceutical preparation, food or health product, dietary supplement, the application in taste masking.
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| CN201610373084.2A CN105968385B (en) | 2016-05-31 | 2016-05-31 | A kind of preparation method of shellac aqueous dispersion and its application in coating |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1159286A (en) * | 1997-01-31 | 1997-09-17 | 屠乐平 | Antistaling agent for fruits and vegetables and production method thereof |
| CN1805735A (en) * | 2003-06-12 | 2006-07-19 | 朴源琫 | A composition for an enteric coating of natural product containing lectin |
| CN1810278A (en) * | 2005-01-28 | 2006-08-02 | 北京北大药业有限公司 | Enteric coated Chinese medicine composition for treating cervical and lumbar spondylopathy |
| CN101049380A (en) * | 2007-05-11 | 2007-10-10 | 张冰文 | Enteric solubility soft capsule containing camellia oil, and preparation method |
-
2016
- 2016-05-31 CN CN201610373084.2A patent/CN105968385B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1159286A (en) * | 1997-01-31 | 1997-09-17 | 屠乐平 | Antistaling agent for fruits and vegetables and production method thereof |
| CN1805735A (en) * | 2003-06-12 | 2006-07-19 | 朴源琫 | A composition for an enteric coating of natural product containing lectin |
| CN1810278A (en) * | 2005-01-28 | 2006-08-02 | 北京北大药业有限公司 | Enteric coated Chinese medicine composition for treating cervical and lumbar spondylopathy |
| CN101049380A (en) * | 2007-05-11 | 2007-10-10 | 张冰文 | Enteric solubility soft capsule containing camellia oil, and preparation method |
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