CN105964316A - 可编程微流体数字阵列 - Google Patents
可编程微流体数字阵列 Download PDFInfo
- Publication number
- CN105964316A CN105964316A CN201610459013.4A CN201610459013A CN105964316A CN 105964316 A CN105964316 A CN 105964316A CN 201610459013 A CN201610459013 A CN 201610459013A CN 105964316 A CN105964316 A CN 105964316A
- Authority
- CN
- China
- Prior art keywords
- valve
- input
- line
- group
- microfluidic device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
- B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00286—Reactor vessels with top and bottom openings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
- B01J2219/00317—Microwell devices, i.e. having large numbers of wells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00389—Feeding through valves
- B01J2219/00396—Membrane valves
- B01J2219/00398—Membrane valves in multiple arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00418—Means for dispensing and evacuation of reagents using pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/089—Virtual walls for guiding liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0427—Electrowetting
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Micromachines (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Control Of Fluid Pressure (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12080408P | 2008-12-08 | 2008-12-08 | |
US61/120,804 | 2008-12-08 | ||
US15784509P | 2009-03-05 | 2009-03-05 | |
US61/157,845 | 2009-03-05 | ||
US16066209P | 2009-03-16 | 2009-03-16 | |
US61/160,662 | 2009-03-16 | ||
US16611309P | 2009-04-02 | 2009-04-02 | |
US61/166,113 | 2009-04-02 | ||
CN200980154761.XA CN102281950B (zh) | 2008-12-08 | 2009-12-07 | 可编程微流体数字阵列 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200980154761.XA Division CN102281950B (zh) | 2008-12-08 | 2009-12-07 | 可编程微流体数字阵列 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105964316A true CN105964316A (zh) | 2016-09-28 |
Family
ID=42310101
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610459013.4A Pending CN105964316A (zh) | 2008-12-08 | 2009-12-07 | 可编程微流体数字阵列 |
CN200980154761.XA Expired - Fee Related CN102281950B (zh) | 2008-12-08 | 2009-12-07 | 可编程微流体数字阵列 |
CN201510158081.2A Expired - Fee Related CN104741159B (zh) | 2008-12-08 | 2009-12-07 | 可编程微流体数字阵列 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200980154761.XA Expired - Fee Related CN102281950B (zh) | 2008-12-08 | 2009-12-07 | 可编程微流体数字阵列 |
CN201510158081.2A Expired - Fee Related CN104741159B (zh) | 2008-12-08 | 2009-12-07 | 可编程微流体数字阵列 |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP2376227A4 (de) |
CN (3) | CN105964316A (de) |
SG (4) | SG10201404683TA (de) |
WO (1) | WO2010077618A1 (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6221654B1 (en) | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
US8052792B2 (en) | 2001-04-06 | 2011-11-08 | California Institute Of Technology | Microfluidic protein crystallography techniques |
DK1065378T3 (da) | 1999-06-28 | 2002-07-29 | California Inst Of Techn | Elastomere mikropumpe- og mikroventilsystemer |
US7306672B2 (en) | 2001-04-06 | 2007-12-11 | California Institute Of Technology | Microfluidic free interface diffusion techniques |
US7144616B1 (en) | 1999-06-28 | 2006-12-05 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US8709153B2 (en) | 1999-06-28 | 2014-04-29 | California Institute Of Technology | Microfludic protein crystallography techniques |
US7459022B2 (en) | 2001-04-06 | 2008-12-02 | California Institute Of Technology | Microfluidic protein crystallography |
US20050118073A1 (en) | 2003-11-26 | 2005-06-02 | Fluidigm Corporation | Devices and methods for holding microfluidic devices |
US7867763B2 (en) | 2004-01-25 | 2011-01-11 | Fluidigm Corporation | Integrated chip carriers with thermocycler interfaces and methods of using the same |
US7351376B1 (en) | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
EP1334347A1 (de) | 2000-09-15 | 2003-08-13 | California Institute Of Technology | Miniaturisierte querstromvorrichtungen und -verfahren |
AU2002230524A1 (en) | 2000-11-16 | 2002-05-27 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
US7691333B2 (en) | 2001-11-30 | 2010-04-06 | Fluidigm Corporation | Microfluidic device and methods of using same |
EP2666849A3 (de) | 2002-04-01 | 2014-05-28 | Fluidigm Corporation | Mikrofluidische Partikelanalysesysteme |
US8220494B2 (en) | 2002-09-25 | 2012-07-17 | California Institute Of Technology | Microfluidic large scale integration |
EP1551753A2 (de) | 2002-09-25 | 2005-07-13 | California Institute Of Technology | Hochintegriertes mikrofluidisches netzwerk |
EP1546412B1 (de) | 2002-10-02 | 2014-05-21 | California Institute Of Technology | MIKROFLUIDISCHE NUKLEINSûUREANALYSE |
US7604965B2 (en) | 2003-04-03 | 2009-10-20 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US8828663B2 (en) | 2005-03-18 | 2014-09-09 | Fluidigm Corporation | Thermal reaction device and method for using the same |
AU2004240944A1 (en) | 2003-05-20 | 2004-12-02 | Fluidigm Corporation | Method and system for microfluidic device and imaging thereof |
US7407799B2 (en) | 2004-01-16 | 2008-08-05 | California Institute Of Technology | Microfluidic chemostat |
EP2933630A3 (de) | 2004-06-07 | 2015-10-28 | Fluidigm Corporation | Optisches linsensystem und verfahren für mikrofluidische vorrichtungen |
EP1838431A4 (de) | 2004-12-03 | 2012-08-22 | California Inst Of Techn | Mikrofluidikvorrichtungen mit kreisläufen für chemische reaktionen |
US20080264863A1 (en) | 2004-12-03 | 2008-10-30 | California Institute Of Technology | Microfluidic Sieve Valves |
US7883669B2 (en) | 2005-04-20 | 2011-02-08 | Fluidigm Corporation | Analysis engine and database for manipulating parameters for fluidic systems on a chip |
EP1938101A2 (de) | 2005-09-13 | 2008-07-02 | Fluidigm Corporation | Mikrofluidische testvorrichtungen und -verfahren |
US7815868B1 (en) | 2006-02-28 | 2010-10-19 | Fluidigm Corporation | Microfluidic reaction apparatus for high throughput screening |
US8055034B2 (en) | 2006-09-13 | 2011-11-08 | Fluidigm Corporation | Methods and systems for image processing of microfluidic devices |
WO2008067552A2 (en) | 2006-11-30 | 2008-06-05 | Fluidigm Corporation | Method and apparatus for biological sample analysis |
US8157434B2 (en) | 2007-01-19 | 2012-04-17 | Fluidigm Corporation | High efficiency and high precision microfluidic devices and methods |
CN102056838B (zh) | 2008-04-11 | 2013-07-03 | 弗卢丁公司 | 微流体装置和方法 |
CN104043490A (zh) | 2008-07-25 | 2014-09-17 | 弗卢丁公司 | 用于制造集成流体芯片的方法和系统 |
WO2010017210A1 (en) | 2008-08-07 | 2010-02-11 | Fluidigm Corporation | Microfluidic mixing and reaction systems for high efficiency screening |
US8058630B2 (en) | 2009-01-16 | 2011-11-15 | Fluidigm Corporation | Microfluidic devices and methods |
US8551787B2 (en) | 2009-07-23 | 2013-10-08 | Fluidigm Corporation | Microfluidic devices and methods for binary mixing |
SG169918A1 (en) | 2009-10-02 | 2011-04-29 | Fluidigm Corp | Microfluidic devices with removable cover and methods of fabrication and application |
US9855735B2 (en) | 2009-11-23 | 2018-01-02 | Cyvek, Inc. | Portable microfluidic assay devices and methods of manufacture and use |
US9759718B2 (en) | 2009-11-23 | 2017-09-12 | Cyvek, Inc. | PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use |
JP5701894B2 (ja) | 2009-11-23 | 2015-04-15 | サイヴェク・インコーポレイテッド | アッセイを行う方法及び装置 |
US10065403B2 (en) | 2009-11-23 | 2018-09-04 | Cyvek, Inc. | Microfluidic assay assemblies and methods of manufacture |
US9651568B2 (en) | 2009-11-23 | 2017-05-16 | Cyvek, Inc. | Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays |
US9500645B2 (en) | 2009-11-23 | 2016-11-22 | Cyvek, Inc. | Micro-tube particles for microfluidic assays and methods of manufacture |
US9700889B2 (en) | 2009-11-23 | 2017-07-11 | Cyvek, Inc. | Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results |
WO2013134742A2 (en) | 2012-03-08 | 2013-09-12 | Cyvek, Inc | Micro-tube particles for microfluidic assays and methods of manufacture |
US9353406B2 (en) | 2010-10-22 | 2016-05-31 | Fluidigm Corporation | Universal probe assay methods |
CA2830533C (en) | 2011-03-22 | 2020-02-18 | Cyvek, Inc. | Microfluidic devices and methods of manufacture and use |
US9168531B2 (en) | 2011-03-24 | 2015-10-27 | Fluidigm Corporation | Method for thermal cycling of microfluidic samples |
US9644231B2 (en) | 2011-05-09 | 2017-05-09 | Fluidigm Corporation | Nucleic acid detection using probes |
EP2707507B1 (de) | 2011-05-09 | 2017-11-01 | Fluidigm Corporation | Probenbasierter nukleinsäurenachweis |
DE102012100824A1 (de) | 2012-02-01 | 2013-09-05 | Albert-Ludwigs-Universität Freiburg | Gemultiplexte Digital PCR |
CN104155462B (zh) * | 2014-08-19 | 2015-11-18 | 国家纳米科学中心 | 一种微流控免疫检测分析芯片及其分析仪器 |
US10228367B2 (en) | 2015-12-01 | 2019-03-12 | ProteinSimple | Segmented multi-use automated assay cartridge |
CN113664820B (zh) * | 2021-08-11 | 2022-08-16 | 华中科技大学 | 一种用于软体机器人逻辑控制的微流控芯片及软体机器人 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040112442A1 (en) * | 2002-09-25 | 2004-06-17 | California Institute Of Technology | Microfluidic large scale integration |
WO2005107938A2 (en) * | 2004-05-02 | 2005-11-17 | Fluidigm Corporation | Thermal reaction device and method for using the same |
WO2007084425A2 (en) * | 2006-01-19 | 2007-07-26 | Kionix Inc. | Flexible and modular microfluidic device |
US20080289710A1 (en) * | 1999-06-28 | 2008-11-27 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6923216B2 (en) * | 2003-04-15 | 2005-08-02 | Entegris, Inc. | Microfluidic device with ultraphobic surfaces |
EP1938101A2 (de) * | 2005-09-13 | 2008-07-02 | Fluidigm Corporation | Mikrofluidische testvorrichtungen und -verfahren |
US7766033B2 (en) * | 2006-03-22 | 2010-08-03 | The Regents Of The University Of California | Multiplexed latching valves for microfluidic devices and processors |
CN102056838B (zh) | 2008-04-11 | 2013-07-03 | 弗卢丁公司 | 微流体装置和方法 |
-
2009
- 2009-12-07 SG SG10201404683TA patent/SG10201404683TA/en unknown
- 2009-12-07 EP EP09836688A patent/EP2376227A4/de not_active Withdrawn
- 2009-12-07 CN CN201610459013.4A patent/CN105964316A/zh active Pending
- 2009-12-07 CN CN200980154761.XA patent/CN102281950B/zh not_active Expired - Fee Related
- 2009-12-07 SG SG10201404682WA patent/SG10201404682WA/en unknown
- 2009-12-07 WO PCT/US2009/067037 patent/WO2010077618A1/en active Application Filing
- 2009-12-07 SG SG10201404685PA patent/SG10201404685PA/en unknown
- 2009-12-07 SG SG2011041597A patent/SG172015A1/en unknown
- 2009-12-07 CN CN201510158081.2A patent/CN104741159B/zh not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080289710A1 (en) * | 1999-06-28 | 2008-11-27 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US20040112442A1 (en) * | 2002-09-25 | 2004-06-17 | California Institute Of Technology | Microfluidic large scale integration |
WO2005107938A2 (en) * | 2004-05-02 | 2005-11-17 | Fluidigm Corporation | Thermal reaction device and method for using the same |
WO2007084425A2 (en) * | 2006-01-19 | 2007-07-26 | Kionix Inc. | Flexible and modular microfluidic device |
Also Published As
Publication number | Publication date |
---|---|
SG172015A1 (en) | 2011-07-28 |
SG10201404685PA (en) | 2014-10-30 |
CN102281950A (zh) | 2011-12-14 |
CN102281950B (zh) | 2015-05-06 |
SG10201404683TA (en) | 2014-10-30 |
SG10201404682WA (en) | 2014-10-30 |
EP2376227A4 (de) | 2012-07-18 |
CN104741159A (zh) | 2015-07-01 |
CN104741159B (zh) | 2017-01-18 |
WO2010077618A1 (en) | 2010-07-08 |
EP2376227A1 (de) | 2011-10-19 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160928 |
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WD01 | Invention patent application deemed withdrawn after publication |