CN105963762B - A kind of nontoxic dressing of wide spectrum of water dispersible abandonment and preparation method thereof - Google Patents
A kind of nontoxic dressing of wide spectrum of water dispersible abandonment and preparation method thereof Download PDFInfo
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- CN105963762B CN105963762B CN201610506336.4A CN201610506336A CN105963762B CN 105963762 B CN105963762 B CN 105963762B CN 201610506336 A CN201610506336 A CN 201610506336A CN 105963762 B CN105963762 B CN 105963762B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/62—Compostable, hydrosoluble or hydrodegradable materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/18—Formation of filaments, threads, or the like by means of rotating spinnerets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
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Abstract
The invention belongs to medical material tech fields, disclose a kind of nontoxic dressing of wide spectrum and preparation method thereof of water dispersible abandonment.The preparation method is that: by can the water-soluble and molten high-molecular compound deionized water dissolving of alcohol, obtain uniform high-molecular compound aqueous solution, Antibacterial Constituents are added into water-soluble polymers, it is stirred rear standing and defoaming, obtain the high-molecular compound aqueous solution containing antimicrobial component, then it is passed through into electrostatic spinning or centrifugal spinning, film forming is prepared on carrier, obtain antimicrobial compound film, antimicrobial compound film is crosslinked by crosslinking agent or ultraviolet radioactive, obtains the nontoxic dressing of wide spectrum of water dispersible abandonment.The present invention products therefrom good anti-bacterial effect and has no toxic side effect by the way that natural antibacterial active constituent is added, can be abandoned by being dumped after sterilization treatment by sewer, or directly by sewerage system after, handle conveniently, have a good application prospect.
Description
Technical field
The invention belongs to medical material tech fields, and in particular to a kind of nontoxic dressing of wide spectrum of water dispersible abandonment and its
Preparation method.
Background technique
Early in 1977, Japanese scholars S.Shima and H.Sakai were just screening Dragendorff from microorganism
During Positive (abbreviation DP) substance, it is found that one plant of actinomyces can generate a large amount of and in stable condition DP substances, leads to
Cross the analysis and structural analysis to acid hydrolysis products, it was demonstrated that the DP substance is a kind of homotype containing 25~30 lysine residues
Monomer-polymer, referred to as polylysine (ε-PL).Polylysine is the lysine polymers of straight-chain, it is a kind of flaxen
Powder has very strong water absorbing capacity.Polylysine is insensitive for pH value, will not be influenced easily by pH value, and have one
Fixed thermal stability (120 DEG C, 20min).As a kind of polypeptide, polylysine has certain bacteriostasis efficacy, at the beginning of the eighties
It is pure as biological preservative that the just great peace wood of well is risen by Japanese scholars first.It can be decomposed to form human body institute by reaction in human body
The lysine of one of the 8 kinds of amino acid needed, while being also that a kind of can add the amino acid in food by what the world was approved.It is poly-
Lysine has the biocidal property of wide spectrum, sharp candidiasis, production film pichia yeast, bacillus subtilis for saccharomyces；
Production moral bacillus, Escherichia coli in Gram-negative bacteria etc. cause food spoilage and the strain of poisoning to have stronger inhibition to make
With.
On the other hand, the plant extraction liquid with certain antibiotic and sterilizing or strong antioxidant action also more and more receives people's
Pay attention to, wherein using tea polyphenols, aloe, eucalyptus oil as Typical Representative.Wherein tea polyphenols are the general names of Polyphenols of Tea, packet
Include flavanol compound, anthocyanin class, flavonoids, flavonols and phenolic acid class etc..Predominantly flavanols (catechin) class, catechin account for
60~80%.Studies have shown that the removing toxic substances of tea polyphenols isoreactivity substance tool and radiation resistance, can effectively stop radioactive substance and invade
Enter marrow, and strontium 90 and Co 60 can be made to excrete rapidly, " radiation jinx " is described as by health and medical field, at the same its synthesis at
Divide shown antioxidation, especially ester catechin EGCG, reproducibility is even up to 100 times of the different bad hematic acid of L-.
Tea polyphenols also have bacteriostasis in addition to antioxidation, such as have suppression to staphylococcus, Escherichia coli, hay bacillus
Production is used.Peculiar smell in the adsorbable food of tea polyphenols, therefore there is certain deodorization.There is protection to the pigment in food
Effect, it can not only play the role of natural pigment, but also can prevent food from fading, and tea polyphenols also have the formation for inhibiting nitrite
And summation.Aloe bitter, it is cold in nature.Aloe includes anthraquinone derivative, aloe rheum officinale, saponin, amino acid and polysaccharide, has and disappears
Scorching and healing of wound effect, embedded biometric enzyme play the role of anti-inflammation and sterilization, and in amino acid by slowly hydrolyzing with skin
It under effect, is acted on collagen in cuticula, healing of wound, therefore there is application advantage in wound reparation.Eucalyptus oil belongs to nothing
Color has the smell like camphor and borneol, obtains by eucalyptus leaves, branch through steam distillation to weak yellow liquid.Eucalyptus oil is to control
It cures the wound mouth and best one of the essential oil of abscess, there is fabulous sterilizing ability.
Polyvinyl alcohol (PVA) be it is a kind of have good chemical and thermal stability, with semicrystalline structure hydrophily high score
Sub- polymer, its molecular structure is regular, and strand is submissive.PVA appearance is white solid, is divided into graininess, cotton-shaped and powder
It three kinds of shape, can be dissolved in 80~90 DEG C of water, the more high then solubility of water temperature is also bigger, and is practically insoluble in organic molten
Agent.This material has good biocompatibility and very high permeability, and easy to process.PVA is a kind of water-soluble poly
Object is closed, and can react to form gel with various crosslinking agents.Polyvinyl alcohol is few in number in water soluble polymer
One of biodegradable polymer, it has a good film forming, cohesive force, and non-toxic and tasteless, non-stimulated to skin
Property, skin allergy will not be caused.Using PVA as body of material, it can be used as preparing surgical wound dressings, negative pressure drainage with applying
Material.
Polyvinylpyrrolidone (PVP) is the high-molecular compound as made of N- vinylpyridine network alkanone homopolymerization, is white
Color, micro-yellow powder or transparency liquid, water-soluble and most of organic solvents.PVP is a kind of Green Polymer product, is weight
The water-soluble amide class fine chemicals wanted has very strong caking property, adsorptivity, and safe to the human body, nontoxic, therefore wide
It is general to be applied to the fields such as chemical industry, medicine, food processing, adhesive and cosmetics.
Gelatin is the product that collagen locally hydrolyzes, and amino acid composition is similar with collagen, and biocompatibility is good, and
And high, typical both sexes dielectric attribute of presentation of strong, good film-forming property, side-chain radical reactivity etc. is many excellent with hydrophily
Physical and chemical properties.Gelatin is dissolved in insoluble in absolute alcohol, acetone, benzene and most of nonpolar organic solvent
Water, formic acid, acetic acid and some polyalcohols aqueous solution.It is each that human body can be simulated by gelatin superfine fibers prepared by electrostatic spinning
The structure of the extracellular matrix of class loading and organ is widely used in biological medicine, the research field of organizational project.
The correct processing of surgical wound is the key that one of surgical operation therapy success or failure, and creating good healing is wound
The premise of body function rehabilitation afterwards, and the hot spot of wound healing is just being to speed up to the research of Wound dressing.With to wound healing
Research is goed deep into, and the people gradually recognize that using the purpose of dressing, dressing must also have certain not only for flap coverage
Antibacterial action, and help wound healing.Pervious viewpoint thinks create a dry environment as far as possible for wound, subtract
Few infection, promotes wound healing.But in recent years studies have shown that wound can heal more in wet environment
Fastly.Under the guidance of " wet wound healing " theory, with the development of material subject, revolutionary change is also had occurred in dressing materials
Change.Ideal dressing materials should have following functions: 1) temperature (37 DEG C) that wound can be made to keep constant；2) dressing and wound
Mouth contact surface need to keep certain humidity；3) extra exudate can be absorbed；4) there is good gas permeability；5) micro- life such as bacterium is prevented
Object, hazardous particle contaminated wound；6) it not will cause secondary damage when removing dressing.
Dressing with fibrous structure has advantage in terms of ventilative and drug effective use, it can keep wound one
Fixed humidity environment, so as to improve the microenvironment of wound reparation.
Electrostatic spinning is a kind of spinning process simple, flexible preparation fibre diameter is dozens to a few hundred nanometers, base
Present principles are: the polymer solution or melt of capillary outlet are deformed into taylor cone, when quiet under the action of high-voltage electrostatic field
When electric repulsion is more than the surface tension of drop, the top end of taylor cone just will form thread, and obtain in the movement of electric field
It further stretches, while with solvent volatilization (or melt is cooling), obtaining nanofiber.Electrostatic spinning has following obvious
Advantage: 1, high porosity；2, bigger serface；3, the diameter of electrospun fibers and structure and extracellular matrix have fine
Similitude.In view of a variety of advantages of electrostatic spinning, this experiment prepares the nontoxic dressing materials of antibacterial using this technology.Centrifugation
Spinning is another method that current preparation has fiber fines structural material, and fibre diameter obtained, which can arrive, is
Between 500nm~3 micron.Centrifugal spinning equipment is simple, but gained fiber has certain orientation.
Summary of the invention
Based on the above prior art, applied the primary purpose of the present invention is that the wide spectrum for providing a kind of water dispersible abandonment is nontoxic
The preparation method of material.
Another object of the present invention is to provide a kind of wide spectrums of water dispersible abandonment being prepared by the above method
Nontoxic dressing.
The object of the invention is achieved through the following technical solutions:
A kind of preparation method of the nontoxic dressing of wide spectrum of water dispersible abandonment, including following preparation step:
(1) by can the water-soluble and molten high-molecular compound deionized water dissolving of alcohol, obtain uniform high-molecular compound
Aqueous solution；
(2) Antibacterial Constituents are added into water-soluble polymers, are stirred rear standing and defoaming, obtain containing antibacterial at
The high-molecular compound aqueous solution divided；
(3) by the high-molecular compound aqueous solution containing antimicrobial component by electrostatic spinning or centrifugal spinning, on carrier
Preparation film forming, obtains antimicrobial compound film；
(4) antimicrobial compound film obtained by step (3) is crosslinked by cross-linking agents or ultraviolet radioactive, obtains water dispersible something lost
The nontoxic dressing of the wide spectrum of abandoning.
It is described can the water-soluble and molten high-molecular compound of alcohol include but is not limited to polyvinylpyrrolidone, polyoxyethylene
Alkene, polyvinyl alcohol, gelatin, alcohol contain intermingle with the water soluble nontoxic polymer such as amide, Zeinfilm.
Preferably, the mass concentration of high-molecular compound is 8%~45% in the high-molecular compound aqueous solution.
The antimicrobial component refers to the Antibacterial Constituents based on microorganism and plant extract, the Antibacterial Constituents
The including but not limited to natural antibacterials extract such as polylysine, Paeonol, tea polyphenols, aloe extract, eucalyptus oil.
Preferably, the additional amount of the antimicrobial component is the 0.1%~20% of water-soluble polymers quality.
Preferably, the carrier is spun lacing with excellent hydrophilic, hot rolling, Through-Air Thermal Bonded Nonwovens, or using from
Type paper；The material of the carrier includes but is not limited to wood pulp cellulose, regenerated celulose fibre, PVA fiber, acid fiber by polylactic, shell
One of glycan fiber, alginate fiber, soybean fiber, cotton fiber, bombax cotton, silk fiber are two or more
Mixing；The grammes per square metre of carrier material is 10g/m2-100g/m2。
Preferably, the crosslinking agent refers to aldehyde crosslinking agent or genipin cross-linked agent.By the appropriately crosslinked of crosslinking agent,
The water-soluble degree for reducing part aqueous polymerization, extend dressing materials uses the time.
A kind of nontoxic dressing of wide spectrum of water dispersible abandonment, is prepared by above method.
The nontoxic dressing of wide spectrum of the water dispersible abandonment is the fiber with abundant microcellular structure formed on carrier
The antimicrobial compound film of aggregate, wherein the fibre diameter of fiber assembly is 50~2000nm.
Preparation method of the invention and obtained product have the following advantages that and the utility model has the advantages that
(1) natural antibacterial active constituent, antibacterial effect is added in the nontoxic dressing of the wide spectrum of water dispersible abandonment of the invention
It well and has no toxic side effect, 99% or more is reached to the bacteriostasis rate of gram-positive bacteria and Gram-negative bacteria；
(2) the nontoxic dressing of wide spectrum of water dispersible abandonment of the invention use can the water-soluble and molten high-molecular compound of alcohol for
Material of main part and carrier with excellent hydrophilic directly pass through after being handled by high-temp steam sterilizing after use
Sewer dumps, or is directly abandoned by sewerage system；
(3) present invention obtains composite membrane using electrostatic spinning or centrifugal spinning technology, and gained composite membrane has high porosity
And bigger serface, and its fibre structure and extracellular matrix have good similitude, can be used for skin injury or operation
Skin afterwards restores the dressing with regeneration；
(4) antimicrobial compound film that preparation method of the invention obtains can be handed over further by cross-linking agents or ultraviolet radioactive
Connection, extend dressing materials uses the time.
Specific embodiment
Below with reference to embodiment, the present invention is described in further detail, and embodiments of the present invention are not limited thereto.
Embodiment 1
Polyvinyl alcohol (PVA1799, the degree of polymerization 1700, alcoholysis degree 99%) vacuum drying after (50 DEG C, 12h), using go from
Sub- water is solvent, stirs 2h after being warming up to 80 DEG C, and obtaining mass concentration is 10% uniform PVA aqueous solution；To the water-soluble liquid cooling of PVA
But it to after room temperature, then weighs a certain amount of polylysine and is added in PVA aqueous solution, stirring at normal temperature 0.5h obtains polylysine matter
Measure the PVA- polylysin solution that percentage composition is 0.1%, standing and defoaming 4h.The mixed solution prepared is used into syringe needle Static Spinning
Silk preparation PVA- polylysine functional membrane, distance is about 12cm between receiver board and syringe needle, receives substrate and uses cellulose
(100%), grammes per square metre 10g/m2Spun laced fabric, solution carries out electrospinning with the flow velocity of 0.4ml/h under 13kV voltage, and electrospinning is obtained
Tunica fibrosa be dried in vacuo, obtain composite cellulosic membrane.PVA- polylysine composite cellulosic membrane is carried out with glutaraldehyde steam
Crosslinking, crosslinking time are that for 24 hours, vacuum drying obtains a kind of nontoxic dressing of wide spectrum of water dispersible abandonment.
The fibre diameter of polyvinyl alcohol is about 50- in the nontoxic dressing of wide spectrum for the water dispersible abandonment that the present embodiment obtains
400nm is the composite membrane of the fiber assembly with abundant microcellular structure, simultaneously because the addition of polylysine is so that have good
Good bacteriostatic activity, reaches 99.5% to the bacteriostasis rate of gram-positive bacteria and Gram-negative bacteria, therefore this material is suitble to use
Make dressing materials.
Embodiment 2
Polyvinyl alcohol (PVA1788, the degree of polymerization 1700, alcoholysis degree 88%) vacuum drying after (50 DEG C, 12h), using go from
Sub- water is solvent, stirs 5h after being warming up to 60 DEG C, and obtaining mass concentration is 12% uniform PVA aqueous solution；To the water-soluble liquid cooling of PVA
But it to after room temperature, then weighs a certain amount of Paeonol and is added in PVA aqueous solution, stirring at normal temperature 3h obtains Paeonol quality percentage
The PVA- root bark of tree peony phenol solution that content is 0.5%, standing and defoaming 4h.The mixed solution prepared is prepared using syringe needle electrostatic spinning
PVA- Paeonol functional membrane, distance is about 10cm between receiver board and syringe needle, receives substrate and uses regenerated cellulose/soybean fiber
(weight ratio 70/30), grammes per square metre 100g/m2Spun laced fabric, solution carries out electrospinning with the flow velocity of 0.4ml/h under 15kV voltage,
The tunica fibrosa that electrospinning is obtained is dried in vacuo, and obtains composite cellulosic membrane.By the ultraviolet spoke of PVA- Paeonol composite cellulosic membrane
Capable crosslinking, crosslinking time 12h are injected, vacuum drying obtains a kind of nontoxic dressing of wide spectrum of water dispersible abandonment.
The fibre diameter of polyvinyl alcohol is about 200- in the nontoxic dressing of wide spectrum for the water dispersible abandonment that the present embodiment obtains
800nm is the composite membrane of the fiber assembly with abundant microcellular structure, simultaneously because the addition of Paeonol is so that have good
Bacteriostatic activity, 99.3% is reached to the bacteriostasis rate of gram-positive bacteria and Gram-negative bacteria, therefore this material is suitable as
Dressing materials.
Embodiment 3
Polyvinyl alcohol (PVA1699, the degree of polymerization 1600, alcoholysis degree 99%) vacuum drying after (50 DEG C, 12h), using go from
Sub- water is solvent, stirs 3h after being warming up to 70 DEG C, and obtaining mass concentration is 15% uniform PVA aqueous solution；To the water-soluble liquid cooling of PVA
But to after room temperature, then a certain amount of tea polyphenols is weighed and are added in PVA aqueous solution, stirring at normal temperature 1h obtains tea polyphenols quality percentage
The PVA- tea polyphenols solution that content is 1%, standing and defoaming 4h.The mixed solution prepared is prepared into PVA- using syringe needle electrostatic spinning
Tea polyphenols functional membrane, distance is about 10cm between receiver board and syringe needle, receives substrate and is formed using acid fiber by polylactic, grammes per square metre is
40g/m2Through-Air Thermal Bonded Nonwovens, solution carries out electrospinning, the tunica fibrosa that electrospinning is obtained with the flow velocity of 0.4ml/h under 14kV voltage
It is dried in vacuo, obtains composite cellulosic membrane.PVA- tea polyphenols composite cellulosic membrane is crosslinked with Geniposide, crosslinking time is
For 24 hours, it is dried in vacuo, obtains a kind of nontoxic dressing of wide spectrum of water dispersible abandonment.
The fibre diameter of polyvinyl alcohol is about 400- in the nontoxic dressing of wide spectrum for the water dispersible abandonment that the present embodiment obtains
1000nm is the composite membrane of the fiber assembly with abundant microcellular structure, simultaneously because the addition of tea polyphenols is so that have good
Good bacteriostatic activity, reaches 99.2% to the bacteriostasis rate of gram-positive bacteria and Gram-negative bacteria, therefore this material is suitble to use
Make dressing materials.
Embodiment 4
Polyvinyl alcohol (PVA1799, the degree of polymerization 1700, alcoholysis degree 99%) vacuum drying after (50 DEG C, 12h), using go from
Sub- water is solvent, stirs 5h after being warming up to 60 DEG C, and obtaining mass concentration is 10% uniform PVA aqueous solution；To the water-soluble liquid cooling of PVA
But it to after room temperature, then weighs a certain amount of aloe extract and is added in PVA aqueous solution, stirring at normal temperature 3h obtains aloe quality hundred
Dividing content is 0.5% PVA- aloe solution, standing and defoaming 4h.The mixed solution prepared is prepared using syringe needle electrostatic spinning
PVA- aloe functional membrane, distance is about 12cm between receiver board and syringe needle, receive substrate using release paper (cellulose fibre, gram
Weight is 30g/m2), solution carries out electrospinning with the flow velocity of 0.4ml/h under 15kV voltage, and the tunica fibrosa that electrospinning is obtained carries out true
Sky is dry, obtains composite cellulosic membrane.PVA- aloe composite cellulosic membrane is crosslinked with glutaraldehyde steam, crosslinking time be for 24 hours,
Vacuum drying, obtains a kind of nontoxic dressing of wide spectrum of water dispersible abandonment.
The fibre diameter of polyvinyl alcohol is about 600- in the nontoxic dressing of wide spectrum for the water dispersible abandonment that the present embodiment obtains
1200nm is the composite membrane of the fiber assembly with abundant microcellular structure, simultaneously because the addition of aloe is so that have good
Bacteriostatic activity, 99.6% is reached to the bacteriostasis rate of gram-positive bacteria and Gram-negative bacteria, therefore this material is suitable as
Dressing materials.
Embodiment 5
Polyvinyl alcohol (PVA1788, the degree of polymerization 1700, alcoholysis degree 88%) vacuum drying after (50 DEG C, 12h), using go from
Sub- water is solvent, stirs 5h after being warming up to 60 DEG C, and obtaining mass concentration is 10% uniform PVA aqueous solution；To the water-soluble liquid cooling of PVA
But it to after room temperature, then weighs a certain amount of Paeonol and is added in PVA aqueous solution, stirring at normal temperature 3h obtains Paeonol quality percentage
The PVA- root bark of tree peony phenol solution that content is 20%, standing and defoaming 4h.The mixed solution prepared is used into Free Surface electrostatic spinning system
Standby PVA- Paeonol functional membrane, receiving distance between substrate and metal is about 25cm, receives substrate and uses wood pulp/acid fiber by polylactic
(weight ratio 40/60), grammes per square metre 35g/m2Hot rolling cloth carries the metal fine of solution under 30kV voltage with 10r/min's
Revolving speed carries out Free Surface electrostatic spinning, and the tunica fibrosa that spinning is obtained is dried in vacuo, and obtains composite cellulosic membrane.By PVA-
Paeonol composite cellulosic membrane is crosslinked with ultraviolet radioactive, crosslinking time 12h, and vacuum drying obtains a kind of water dispersible something lost
The nontoxic dressing of the wide spectrum of abandoning.
The fibre diameter of polyvinyl alcohol is about 1200- in the nontoxic dressing of wide spectrum for the water dispersible abandonment that the present embodiment obtains
2000nm is the composite membrane of the fiber assembly with abundant microcellular structure, simultaneously because the addition of Paeonol is so that have good
Good bacteriostatic activity, reaches 99.5% to the bacteriostasis rate of gram-positive bacteria and Gram-negative bacteria, therefore this material is suitble to use
Make dressing materials.
Embodiment 6
Polyvinyl alcohol (PVA1799, the degree of polymerization 1700, alcoholysis degree 99%) vacuum drying after (50 DEG C, 12h), using go from
Sub- water is solvent, stirs 2h after being warming up to 80 DEG C, and obtaining mass concentration is 8% uniform PVA aqueous solution；To the water-soluble liquid cooling of PVA
But it to after room temperature, then weighs a certain amount of polylysine and is added in PVA aqueous solution, stirring at normal temperature 2h obtains polylysine quality
The PVA- polylysin solution that percentage composition is 2%, standing and defoaming 4h.The mixed solution prepared is prepared using centrifugal spinning
PVA- polylysine functional membrane, distance is about 30cm between receiver board and turntable, receives substrate and uses chitin fiber
(100%), grammes per square metre 50g/m2Spun laced fabric, turntable carry out centrifugal spinning, the fiber that spinning is obtained with the revolving speed of 5000r/min
Film is dried in vacuo, and composite cellulosic membrane is obtained.PVA- polylysine composite cellulosic membrane is crosslinked with Geniposide, when crosslinking
Between for for 24 hours, vacuum drying obtains a kind of nontoxic dressing of wide spectrum of water dispersible abandonment.
The fibre diameter of polyvinyl alcohol is about 800- in the nontoxic dressing of wide spectrum for the water dispersible abandonment that the present embodiment obtains
1600nm is the composite membrane of the fiber assembly with abundant microcellular structure, simultaneously because the addition of polylysine is so that have
Good bacteriostatic activity reaches 99.7% to the bacteriostasis rate of gram-positive bacteria and Gram-negative bacteria, therefore this material is suitble to
As dressing materials.
Embodiment 7
Polyvinylpyrrolidone (PVP, Mr=1.3 × 106G/mol after) being dried in vacuo (60 DEG C, 12h), using deionized water
For solvent, room temperature magnetic agitation 6h, obtaining mass concentration is 40% uniform PVP aqueous solution；Weigh a certain amount of polylysine
It is added in PVP aqueous solution, stirring at normal temperature 3h, obtains the PVP- polylysin solution that polylysine mass percentage is 0.5%,
Standing and defoaming 4h.The mixed solution prepared is prepared into PVP- polylysine functional membrane, receiver board and needle using syringe needle electrostatic spinning
Distance is about 10cm between head, receives substrate and uses alginate (100%), grammes per square metre 15g/m2Spun laced fabric, under 8kV voltage
Solution carries out electrospinning with the flow velocity of 0.4ml/h, and the tunica fibrosa that electrospinning is obtained is dried in vacuo, and obtains composite cellulosic membrane.It will
PVP- polylysine composite cellulosic membrane is crosslinked with ultraviolet radioactive, crosslinking time 12h, and vacuum drying, obtaining one kind can water
Disperse the nontoxic dressing of wide spectrum abandoned.
The fibre diameter of polyvinylpyrrolidone is about in the nontoxic dressing of wide spectrum for the water dispersible abandonment that the present embodiment obtains
The composite membrane of the fiber assembly with abundant microcellular structure for 500-900nm, simultaneously because the addition of polylysine so that
With good bacteriostatic activity, 99.1%, therefore this material are reached to the bacteriostasis rate of gram-positive bacteria and Gram-negative bacteria
It is suitable as dressing materials.
Embodiment 8
Polyvinylpyrrolidone (PVP, Mr=1.3 × 106G/mol after) being dried in vacuo (60 DEG C, 12h), using deionized water
For solvent, room temperature magnetic agitation 6h, obtaining mass concentration is 45% uniform PVP aqueous solution, then weighs a certain amount of Paeonol
It is added in PVP aqueous solution, stirring at normal temperature 2h, obtains the PVP- root bark of tree peony phenol solution that Paeonol mass percentage is 1%, stand de-
Steep 4h.The mixed solution prepared is prepared into PVP- Paeonol functional membrane, the spacing of receiver board and syringe needle using syringe needle electrostatic spinning
From about 12cm, receives substrate and use polylactic acid/regenerated cellulose (weight ratio 60/40), grammes per square metre 10g/m2Spun laced fabric,
Solution carries out electrospinning with the flow velocity of 0.4ml/h under 10kV voltage, and the tunica fibrosa that electrospinning is obtained is dried in vacuo, obtains compound
Tunica fibrosa.PVP- Paeonol composite cellulosic membrane is crosslinked with glutaraldehyde steam, crosslinking time is that for 24 hours, vacuum drying obtains
A kind of nontoxic dressing of wide spectrum of water dispersible abandonment.
The fibre diameter of polyvinylpyrrolidone is about in the nontoxic dressing of wide spectrum for the water dispersible abandonment that the present embodiment obtains
It is the composite membrane of the fiber assembly with abundant microcellular structure for 300-700nm, simultaneously because the addition of Paeonol is so that tool
There is good bacteriostatic activity, 99.5% is reached to the bacteriostasis rate of Lan Shi positive bacteria and Gram-negative bacteria, therefore this material is suitble to
As dressing materials.
Embodiment 9
After gelatin vacuum drying (40 DEG C, 12h), uses deionized water for solvent, stir 4h after being warming up to 40 DEG C, obtain matter
Amount concentration is 15% uniform aqueous gelatin solution；A certain amount of polylysine is weighed again to be added in aqueous gelatin solution, is stirred at 40 DEG C
3h is mixed, gelatin-polylysin solution that polylysine mass percentage is 2%, standing and defoaming 4h at 40 DEG C are obtained.It will prepare
Mixed solution gelatin-polylysine functional membrane is prepared using syringe needle electrostatic spinning, control spinning temperature at 40 DEG C, receiver board with
Distance is about 10cm between syringe needle, and receiving substrate using pure cotton fiber is raw material, grammes per square metre 25g/m2Spun laced fabric, in 15kV electricity
It depresses solution and electrospinning is carried out with the flow velocity of 0.4ml/h, the tunica fibrosa that electrospinning is obtained is dried in vacuo, and obtains composite fibre
Film.Gelatin-polylysine composite cellulosic membrane is crosslinked, crosslinking time 12h with ultraviolet radioactive, is dried in vacuo, obtains one
The nontoxic dressing of wide spectrum of the water dispersible abandonment of kind.
The fibre diameter of gelatin is about 100- in the nontoxic dressing of wide spectrum for the water dispersible abandonment that the present embodiment obtains
600nm is the composite membrane of the fiber assembly with abundant microcellular structure, simultaneously because the addition of polylysine is so that have good
Good bacteriostatic activity, reaches 99.7% to the bacteriostasis rate of gram-positive bacteria and Gram-negative bacteria, therefore this material is suitble to use
Make dressing materials.
Embodiment 10
After gelatin vacuum drying (40 DEG C, 12h), uses deionized water for solvent, stir 4h after being warming up to 40 DEG C, obtain matter
Amount concentration is 20% uniform aqueous gelatin solution；A certain amount of Paeonol is weighed again to be added in aqueous gelatin solution, is stirred at 40 DEG C
3h obtains gelatin-root bark of tree peony phenol solution that Paeonol mass percentage is 5%, standing and defoaming 4h at 40 DEG C.The mixing that will be prepared
Solution prepares gelatin-Paeonol functional membrane using centrifugal spinning, and control spinning temperature is at 40 DEG C, distance between receiver board and turntable
About 30cm receives substrate and uses wood pulp/soybean fiber/chitin fiber (weight ratio 30/30/40), grammes per square metre 60g/m2Water
Thorn cloth, turntable carry out centrifugal spinning with the revolving speed of 4000r/min, and the tunica fibrosa that spinning is obtained is dried in vacuo, is answered
Condensating fiber film.Gelatin-Paeonol composite cellulosic membrane is crosslinked, crosslinking time 12h with ultraviolet radioactive, is dried in vacuo, obtains
To a kind of nontoxic dressing of wide spectrum of water dispersible abandonment.
The fibre diameter of gelatin is about 600- in the nontoxic dressing of wide spectrum for the water dispersible abandonment that the present embodiment obtains
1300nm is the composite membrane of the fiber assembly with abundant microcellular structure, simultaneously because the addition of Paeonol is so that have good
Good bacteriostatic activity, reaches 99.8% to the bacteriostasis rate of gram-positive bacteria and Gram-negative bacteria, therefore this material is suitble to use
Make dressing materials.
Embodiment 11
After the vacuum drying of alcohol-soluble polyamide (50 DEG C, 12h), use deionized water: ethyl alcohol mass ratio is molten for the mixing of 1:1
Agent is solvent, stirs 3h after being warming up to 40 DEG C, and obtaining mass concentration is 10% uniform alcohol-soluble aqueous polyamide solution；It is molten to alcohol
Property aqueous polyamide solution be cooled to room temperature after, then weigh a certain amount of polylysine and be added in alcohol-soluble aqueous polyamide solution, often
Temperature stirring 3h, obtains alcohol-soluble polyamide-polylysin solution that polylysine mass percentage is 5%, standing and defoaming 4h.
The mixed solution prepared is prepared into alcohol-soluble polyamide-polylysine functional membrane using Free Surface electrostatic spinning, receives substrate
Distance is about 25cm between metal, receives substrate and uses polylactic acid, grammes per square metre 40g/m2Hot air cotton carries under 40kV voltage
The metal fine of solution carries out Free Surface electrostatic spinning with the revolving speed of 15r/min, and the tunica fibrosa that spinning is obtained carries out vacuum
It is dry, obtain composite cellulosic membrane.Alcohol-soluble polyamide-polylysine composite cellulosic membrane is crosslinked with ultraviolet radioactive, is crosslinked
Time is 12h, and vacuum drying obtains a kind of nontoxic dressing of wide spectrum of water dispersible abandonment.
The fibre diameter of alcohol-soluble polyamide is about in the nontoxic dressing of wide spectrum for the water dispersible abandonment that the present embodiment obtains
1000-1600nm is the composite membrane of the fiber assembly with abundant microcellular structure, simultaneously because the addition of polylysine so that
With good bacteriostatic activity, 99.5%, therefore this material are reached to the bacteriostasis rate of gram-positive bacteria and Gram-negative bacteria
It is suitable as dressing materials.
Embodiment 12
After the vacuum drying of alcohol-soluble zein (50 DEG C, 12h), uses deionized water for solvent, stirred after being warming up to 50 DEG C
3h is mixed, obtaining mass concentration is 8% uniform alcohol-soluble zein aqueous solution；It is cooled to alcohol-soluble zein aqueous solution
It after room temperature, then weighs a certain amount of aloe and is added in alcohol-soluble zein aqueous solution, stirring at normal temperature 4h obtains aloe quality hundred
Dividing content is 8% alcohol-soluble zein-aloe solution, standing and defoaming 4h.The mixed solution prepared is used into centrifugal spinning
Alcohol-soluble zein-aloe functional membrane is prepared, distance is about 30cm between receiver board and turntable, and it is fine using cotton to receive substrate
Dimension/bombax cotton/silk fiber (weight ratio 40/40/20), grammes per square metre 55g/m2Spun laced fabric, turntable is with the revolving speed of 6000r/min
Centrifugal spinning is carried out, the tunica fibrosa that spinning is obtained is dried in vacuo, and obtains composite cellulosic membrane.By alcohol-soluble zein-
Aloe composite cellulosic membrane is crosslinked with ultraviolet radioactive, and crosslinking time is that for 24 hours, vacuum drying obtains a kind of water dispersible abandonment
The nontoxic dressing of wide spectrum.
The fibre diameter of alcohol-soluble zein is about in the nontoxic dressing of wide spectrum for the water dispersible abandonment that the present embodiment obtains
It is the composite membrane of the fiber assembly with abundant microcellular structure for 1400-1900nm, simultaneously because the addition of aloe is so that tool
There is good bacteriostatic activity, 99.5% is reached to the bacteriostasis rate of gram-positive bacteria and Gram-negative bacteria, therefore this material is suitable
It shares and makees dressing materials.
Embodiment 13
Polyvinylpyrrolidone (PVP, Mr=2.0 × 106G/mol after) being dried in vacuo (60 DEG C, 12h), using deionized water
For solvent, room temperature magnetic agitation 6h, obtaining mass concentration is 45% uniform PVP aqueous solution, then weighs a certain amount of eucalyptus oil,
1% sorbester p18 is added in PVP aqueous solution, stirring at normal temperature 2h, and obtaining Paeonol eucalyptus oil mass percentage is 1%
PVP- eucalyptus fat liquor, standing and defoaming 4h.The mixed solution prepared is prepared into PVP- eucalyptus oil function using syringe needle electrostatic spinning
Film, distance is about 12cm between receiver board and syringe needle, receives substrate and uses release paper, solution is under 10kV voltage with 0.4ml/h
Flow velocity carry out electrospinning, the tunica fibrosa that electrospinning is obtained is dried in vacuo, and obtains composite cellulosic membrane.PVP- Paeonol is compound
For tunica fibrosa with after ultraviolet handled, vacuum drying obtains a kind of nontoxic dressing of wide spectrum of water dispersible abandonment.
The fibre diameter of polyvinylpyrrolidone is about in the nontoxic dressing of wide spectrum for the water dispersible abandonment that the present embodiment obtains
It is the composite membrane of the fiber assembly with abundant microcellular structure for 300-700nm, simultaneously because the addition of eucalyptus oil is so that tool
There is good bacteriostatic activity, 99.5% is reached to the bacteriostasis rate of gram-positive bacteria and Gram-negative bacteria, therefore this material is suitable
It shares and makees dressing materials.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (6)
1. a kind of preparation method of the nontoxic dressing of wide spectrum of water dispersible abandonment, which is characterized in that including following preparation step:
(1) by can the water-soluble and molten high-molecular compound deionized water dissolving of alcohol, it is water-soluble to obtain uniform high-molecular compound
Liquid；
(2) antimicrobial component is added into high-molecular compound aqueous solution, is stirred rear standing and defoaming, obtains containing antimicrobial component
High-molecular compound aqueous solution；
(3) the high-molecular compound aqueous solution containing antimicrobial component is prepared on carrier by electrostatic spinning or centrifugal spinning
Film forming, obtains antimicrobial compound film；
(4) antimicrobial compound film obtained by step (3) is crosslinked by cross-linking agents or ultraviolet radioactive, obtains water dispersible abandonment
The nontoxic dressing of wide spectrum；
It is described can the water-soluble and molten high-molecular compound of alcohol refer to polyvinylpyrrolidone, polyethylene glycol oxide, polyvinyl alcohol, bright
Glue, alcohol contain intermingle with amide or Zeinfilm；
The antimicrobial component refers to polylysine, Paeonol, tea polyphenols, aloe extract or eucalyptus oil；
The carrier is that grammes per square metre is 10g/m2-100g/m2The spun lacing with excellent hydrophilic, hot rolling, Through-Air Thermal Bonded Nonwovens,
Or release paper；The material of the carrier is wood pulp cellulose, regenerated celulose fibre, PVA fiber, acid fiber by polylactic, chitosan
One of fiber, alginate fiber, soybean fiber, cotton fiber, bombax cotton, silk fiber are two or more mixed
It closes.
2. a kind of preparation method of the nontoxic dressing of wide spectrum of water dispersible abandonment according to claim 1, it is characterised in that:
The mass concentration of high-molecular compound is 8%~45% in the high-molecular compound aqueous solution.
3. a kind of preparation method of the nontoxic dressing of wide spectrum of water dispersible abandonment according to claim 1, it is characterised in that:
The additional amount of the antimicrobial component is the 0.1%~20% of high-molecular compound aqueous solution quality.
4. a kind of preparation method of the nontoxic dressing of wide spectrum of water dispersible abandonment according to claim 1, it is characterised in that:
The crosslinking agent refers to aldehyde crosslinking agent or genipin cross-linked agent.
5. a kind of nontoxic dressing of wide spectrum of water dispersible abandonment, it is characterised in that: described in any item by Claims 1 to 4
Method is prepared.
6. a kind of nontoxic dressing of wide spectrum of water dispersible abandonment according to claim 5, it is characterised in that: it is described can moisture
The antimicrobial compound film that the nontoxic dressing of wide spectrum abandoned is the fiber assembly with abundant microcellular structure formed on carrier is dissipated,
Wherein the fibre diameter of fiber assembly is 50~2000nm.
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| CN107151865A (en) * | 2017-06-26 | 2017-09-12 | 苏州大学 | A kind of polyvinyl alcohol/tri-（Methylol）The preparation method of methylglycine gel nanofiber medical antibacterial dressing |
| CN107158447B (en) * | 2017-07-06 | 2023-11-17 | 华南理工大学 | Antibacterial zein dressing with controllable orientation and preparation method thereof |
| CN107488940A (en) * | 2017-09-13 | 2017-12-19 | 安徽农业大学 | A kind of method that electrostatic spinning prepares the degradable biological plasma membrane of PLA Tea Polyphenols |
| CN108893792B (en) * | 2018-07-13 | 2020-11-03 | 深圳大学 | Bioactive fiber, and preparation method, application and preparation system thereof |
| CN110124094A (en) * | 2019-04-19 | 2019-08-16 | 青岛大学 | A kind of Chinese herbal medicine based micro-nano fibre antibacterial dressing be prepared in situ and application method |
| CN110306290A (en) * | 2019-07-29 | 2019-10-08 | 广东工业大学 | A kind of preparation method of the anti-oxidant loaded nano tunica fibrosa of edible antibacterial |
| CN112376124A (en) * | 2020-11-20 | 2021-02-19 | 上海市第六人民医院 | Antibacterial dressing |
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