CN105963558A - 一种治疗儿童发热的植物提取物及其应用 - Google Patents
一种治疗儿童发热的植物提取物及其应用 Download PDFInfo
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Abstract
本发明提供了一种用于制备治疗儿童发热的保健品或药物的植物提取物,是由板蓝根、大青叶、金银花、连翘、栀子、牡丹皮、黄芩、柴胡、地龙和淡竹叶提取物按任意比例组成的混合物,所述混合物是上述中药植物混合后制备的提取物,或者是先分别制备各位中药提取物再将几种提取物混合制成。本发明还提供所述提取物在制备治疗儿童发热保健品或药物中的应用,是将所述提取物与药学上可接受的辅料制成的药物制剂;所述药物制剂是滴丸剂、片剂、胶囊剂、颗粒剂或其他常规药物制剂。本发明的提取物制备工艺严谨,结合中医药理论及多年的临床经验,组方更为科学合理,治疗针对性强,疗效显著。
Description
技术领域
本发明涉及一种用于制备治疗儿童发热保健品或药物的植物提取物的制备方法及应用,更具体地说是一种用于制备治疗儿童发热的中药材提取物的制备方法及应用。
背景技术
儿童发热是指机体在致热源作用下,使体温调节中枢的调定点上移而引起的调节性体温升高。当腋下温度超过37℃、口腔温度超过37.5℃或肛温38℃ 以上。一昼夜温度波动在1℃ 以上可称为发热。正常小儿体温(肛温)波动在36.9~37.5"C,腋下温度36.0~37.O'C。舌下温度较肛温低0.3~0.5℃。不同个体的正常体温,略有差异,故轻度增高并非全部有病理意义。
小儿体温的调节特点:小儿体温调节中枢功能不成熟,尤其在新生儿时期,且体表面积相对大,皮下脂肪较薄,容易散热。产热主要依靠棕色脂肪的代谢。所以体温容易随环境温度的变化而变化。“适中温度”又称中性温度,即指能维持正常的体核温度(也称体温,是指身体胸腔、腹腔和中枢神经的温度。其特点相对稳定,且较皮肤温度高)和皮肤温度(也称体壳温度,可受环境温度和衣着情况的影响,且低于体核温度的最适宜的环境温度。在此温度下。人耗氧量最少,新陈代谢率最低,蒸发散热亦少。一般而言,新生儿的中性温度较成人高,成人为25.0~30.O'C.新生儿出生时为33.0~35.0℃,当环境温度高于或低于中性温度时,在一定范围内机体可通过调节增加或皮肤散热使体温保持在正常范围内。如果环境温度高于调节极限,则体温升高。
发热的原因:发热的原因很多,但主要有两大类.即感染性因素和非感染性因素,发热以前者多见。当机体受到外来病原微生物(外致热原)的侵袭,或体内某些物质(内致热原)释放增加,产生发热效应,体温调节中枢将体温调定点上移,引起心跳加快、骨骼肌收缩等。使产热增加;末端血管收缩,汗毛孔关闭等,散热减少,体温上升。
中药复方制剂具有其自身的特点,如毒性小、整个治疗作用体现于各种成分的综合作用,疗效稳定等,且通过不同的作用途径治疗疾病。
发明内容
本发明的目的在于提供一种药效确切的用于制备治疗儿童发热保健品或药物的植物提取物配方。
本发明的另一目的是提供利用上述配方和制备方法制备的植物提取物的应用。
本发明通过以下技术方案实现上述目的:
一种用于制备治疗儿童发热药物的植物提取物,是由板蓝根、大青叶、金银花、连翘、栀子、牡丹皮、黄芩、柴胡、地龙和淡竹叶按一定比例组成的混合提取物,所述混合物是由板蓝根、大青叶、金银花、连翘、栀子、牡丹皮、黄芩、柴胡、地龙和淡竹叶植物混合后制备的提取物,或者是分别制备板蓝根、大青叶、金银花、连翘、栀子、牡丹皮、黄芩、柴胡、地龙和淡竹叶提取物再将几种提取物混合制成。
所述由由板蓝根、大青叶、金银花、连翘、栀子、牡丹皮、黄芩、柴胡、地龙和淡竹叶植物混合后制备的提取物的方法为:牡丹皮、连翘与柴胡植物,提取挥发油;提取挥发油后的药渣与板蓝根、大青叶、金银花、栀子、黄芩、地龙和淡竹叶植物加水煎煮二次,合并煎液,滤过,滤液浓缩至相对密度1.06~1.08,加乙醇重量比例至55%~60%,放置48小时,取上清液,浓缩至稠膏,加入适当比例蔗糖与淀粉,混匀,制成颗粒,干燥,再把挥发油喷入颗粒,混匀即得。
所述板蓝根、大青叶、金银花、连翘、栀子、牡丹皮、黄芩、柴胡、地龙和淡竹叶植物混合的质量百分比优选为:板蓝根10%~90%、大青叶10%~90%、金银花8%~90%、连翘8%~90%、栀子8%~90%、牡丹皮8%~90%、黄芩8%~90%、柴胡8%~90%、地龙8%~90%和淡竹叶8%~90%。;更优选的重量百分比为:板蓝根10%~50%、大青叶10%~50%、金银花8%~40%、连翘8%~40%、栀子8%~40%、牡丹皮8%~40%、黄芩8%~40%、柴胡8%~40%、地龙8%~40%和淡竹叶8%~40%。;最佳的重量百分比为:板蓝根15%、大青叶15%、金银花15%、连翘9%、栀子9%、牡丹皮9%、黄芩9%、柴胡9%、地龙8%和淡竹叶8%。
所述加水的加水量优选为混合物体积5~20倍量的水,浸泡时间优选1~4h,提取次数1~5次,每次提取0.5~3小时。
所述提取液过滤之前还可先在20-80℃条件下先将提取液放置一段时间,再用50-300目纱布过滤。本步骤更有利于提高制备的提取物的纯度,进而提高药效。
所述分别制备板蓝根、大青叶、金银花、连翘、栀子、牡丹皮、黄芩、柴胡、地龙和淡竹叶提取物的方法为:
在上述制备牡丹皮、连翘与柴胡提取物的步骤中:
所述用水加入其体积8~10倍量的体积水,浸泡时间1~1.5小时,提取挥发油1次,收集挥发油。
在上述制备提取挥发油后的药渣与板蓝根、大青叶、金银花、栀子、黄芩、地龙和淡竹叶提取物的步骤中:
所述用水提取提取挥发油后的药渣与板蓝根、大青叶、金银花、栀子、黄芩、地龙和淡竹叶,加入其体积8~10倍量的水进行提取,浸泡时间1~1.5小时,提取次数2~3次,每次提取0.5~2小时,将提取液合并,滤过,滤液浓缩至相对密度1.06~1.08,加乙醇重量比例至55%~60%,放置48小时,取上清液,浓缩至稠膏,加入适当比例蔗糖与淀粉,混匀,制成颗粒,干燥,再把挥发油喷入颗粒,混匀即得。
本发明按上述制备方法制备的混合提取物中含黄芩苷、栀子苷等成分,其中黄芩苷含量0.060%~0.085%,栀子苷0.03%~0.06%。
本发明所述的提取工艺中,介质乙醇或水与被提原料的比例采用本领域的习惯做法,即乙醇或水的用量单位为体积单位,被提原料的用量单位为重量单位。
本发明还提供所述提取物混合物在制备治疗儿童发热保健品或药物中的应用。
本发明所述的应用是由板蓝根、大青叶、金银花、连翘、栀子、牡丹皮、黄芩、柴胡、地龙和淡竹叶的提取物与药学上可接受的辅料制成的药物制剂,所述药物制剂可以是滴丸剂、片剂、胶囊剂、颗粒剂或其他任何已有的药物制剂。
所述滴丸剂主要是由板蓝根、大青叶、金银花、连翘、栀子、牡丹皮、黄芩、柴胡、地龙和淡竹叶的混合提取物与PEG4000制成。优选的方案是提取物的混合物与辅料按1:3的重量比例混合,再熔融,滴入冷却剂液体石蜡中制成,更具体的制备工艺可参考现有技术中滴丸剂的制备方法。
所述胶囊剂、片剂主要是由板蓝根、大青叶、金银花、连翘、栀子、牡丹皮、黄芩、柴胡、地龙和淡竹叶的混合提取物制成颗粒,再加入二氧化硅和硬脂酸镁装胶囊或压片、包衣制成,更具体的制备工艺可参考现有技术中胶囊、片剂的制备方法。
本发明的药物具有治疗儿童发热的作用,可以综合缓解儿童发热的各种症状。
与现有技术相比,本发明具有以下有益效果:
本发明的药物的组分少,制备工艺十分简单,结合中医药理论及多年的临床经验,组方更为科学合理,治疗针对性强,疗效显著。
具体实施方式
下面通过实施例的方式进一步说明本发明,并不因此将本发明限制在这些实施例的范围之内。所用原料:药材购自广州清平药材市场;广州南北行中药饮片有限公司。
实施例1
分别将制备牡丹皮9KG、连翘9KG与柴胡9KG加入其体积8~10倍量的体积水,浸泡时间1小时,提取挥发油1次,收集挥发油。
提取挥发油后的药渣与板蓝根15 KG、大青叶15 KG、金银花9KG、栀子9KG、黄芩9KG、地龙8KG和淡竹叶8KG,加入其体积8~10倍量的水进行提取,浸泡时间1小时,提取次数2次,每次提取2小时,将提取液合并,滤过,滤液浓缩至相对密度1.06~1.08,加乙醇重量比例至55%~60%,放置48小时,取上清液,浓缩至稠膏,干燥,粉碎。
将混合提取物与PEG4000按1:3的比例混合,再熔融,滴入冷却剂液体石蜡中制成滴丸。该制剂的用量为每天两次,每次0.5g,口服。
实施例2
分别将制备牡丹皮5KG、连翘5KG与柴胡5KG加入其体积8~10倍量的体积水,浸泡时间1小时,提取挥发油1次,收集挥发油。
提取挥发油后的药渣与板蓝根20 KG、大青叶20 KG、金银花9KG、栀子9KG、黄芩9KG、地龙9KG和淡竹叶9KG,加入其体积8~10倍量的水进行提取,浸泡时间1小时,提取次数2次,每次提取2小时,将提取液合并,滤过,滤液浓缩至相对密度1.06~1.08,加乙醇重量比例至55%~60%,放置48小时,取上清液,浓缩至稠膏,干燥,粉碎。
将混合提取物与PEG4000按1:3的比例混合,再熔融,滴入冷却剂液体石蜡中制成滴丸。该制剂的用量为每天两次,每次0.5g,口服。
实施例3
分别将制备牡丹皮9KG、连翘9KG与柴胡9KG加入其体积8~10倍量的体积水,浸泡时间1小时,提取挥发油1次,收集挥发油。
提取挥发油后的药渣与板蓝根15 KG、大青叶15 KG、金银花9KG、栀子9KG、黄芩9KG、地龙8KG和淡竹叶8KG,加入其体积8~10倍量的水进行提取,浸泡时间1小时,提取次数2次,每次提取2小时,将提取液合并,滤过,滤液浓缩至相对密度1.06~1.08,加乙醇重量比例至55%~60%,放置48小时,取上清液,浓缩至稠膏,加入适当比例蔗糖与淀粉,混匀,制成颗粒,干燥,再把挥发油喷入颗粒,混匀即得。
将混合提取物加入二氧化硅和硬脂酸镁压片、包衣制成1000片。该制剂的用量为每天两次,每次3片,口服。
实施例4
分别将制备牡丹皮9KG、连翘9KG与柴胡9KG加入其体积8~10倍量的体积水,浸泡时间1小时,提取挥发油1次,收集挥发油。
提取挥发油后的药渣与板蓝根15 KG、大青叶15 KG、金银花9KG、栀子9KG、黄芩9KG、地龙8KG和淡竹叶8KG,加入其体积8~10倍量的水进行提取,浸泡时间1小时,提取次数2次,每次提取2小时,将提取液合并,滤过,滤液浓缩至相对密度1.06~1.08,加乙醇重量比例至55%~60%,放置48小时,取上清液,浓缩至稠膏,加入适当比例蔗糖与淀粉,混匀,制成颗粒,干燥,再把挥发油喷入颗粒,混匀即得。
将混合提取物加入二氧化硅和硬脂酸镁装胶囊制成1000粒。该制剂的用量为每天两次,每次3粒,口服。
实施例5
分别将制备牡丹皮5KG、连翘5KG与柴胡5KG加入其体积8~10倍量的体积水,浸泡时间1小时,提取挥发油1次,收集挥发油。
提取挥发油后的药渣与板蓝根20 KG、大青叶20 KG、金银花9KG、栀子9KG、黄芩9KG、地龙9KG和淡竹叶9KG,加入其体积8~10倍量的水进行提取,浸泡时间1小时,提取次数2次,每次提取2小时,将提取液合并,滤过,滤液浓缩至相对密度1.06~1.08,加乙醇重量比例至55%~60%,放置48小时,取上清液,浓缩至稠膏,加入适当比例蔗糖与淀粉,混匀,制成颗粒,干燥,再把挥发油喷入颗粒,混匀即得。
将混合提取物加入二氧化硅和硬脂酸镁压片、包衣制成1000片。该制剂的用量为每天两次,每次3片,口服。
实施例6
分别将制备牡丹皮5KG、连翘5KG与柴胡5KG加入其体积8~10倍量的体积水,浸泡时间1小时,提取挥发油1次,收集挥发油。
提取挥发油后的药渣与板蓝根20 KG、大青叶20 KG、金银花9KG、栀子9KG、黄芩9KG、地龙9KG和淡竹叶9KG,加入其体积8~10倍量的水进行提取,浸泡时间1小时,提取次数2次,每次提取2小时,将提取液合并,滤过,滤液浓缩至相对密度1.06~1.08,加乙醇重量比例至55%~60%,放置48小时,取上清液,浓缩至稠膏,加入适当比例蔗糖与淀粉,混匀,制成颗粒,干燥,再把挥发油喷入颗粒,混匀即得。
将混合提取物加入二氧化硅和硬脂酸镁装胶囊制成1000粒。该制剂的用量为每天两次,每次3粒,口服。
Claims (7)
1.一种用于制备儿童发热的植物提取物,其特征在于由板蓝根、大青叶、金银花、连翘、栀子、牡丹皮、黄芩、柴胡、地龙和淡竹叶按一定比例组成的混合提取物,所述混合物是由板蓝根、大青叶、金银花、连翘、栀子、牡丹皮、黄芩、柴胡、地龙和淡竹叶混合后制备的提取物,或者是先分别制备板蓝根提取物、大青叶提取物、金银花提取物、连翘提取物、栀子提取物、牡丹皮提取物、黄芩提取物、柴胡提取物、地龙提取物、淡竹叶提取物再将几种提取物混合制成。
2.如权利要求1所述植物提取物,其特征在于所述将板蓝根提取物、大青叶提取物、金银花提取物、连翘提取物、栀子提取物、牡丹皮提取物、黄芩提取物、柴胡提取物、地龙提取物、淡竹叶提取物混合后制备提取物的步骤为:牡丹皮、连翘与柴胡植物,提取挥发油;提取挥发油后的药渣与板蓝根、大青叶、金银花、栀子、黄芩、地龙和淡竹叶植物加水煎煮二次,合并煎液,滤过,滤液浓缩至相对密度1.06~1.08,加乙醇重量比例至55%~60%,放置48小时,取上清液,浓缩至稠膏,加入适当比例蔗糖与淀粉,混匀,制成颗粒,干燥,再把挥发油喷入颗粒,混匀即得。
3.如权利要求2所述的提取物,其特征在于所述板蓝根、大青叶、金银花、连翘、栀子、牡丹皮、黄芩、柴胡、地龙和淡竹叶植物混合的质量百分比为:板蓝根10%~90%、大青叶10%~90%、金银花8%~90%、连翘8%~90%、栀子8%~90%、牡丹皮8%~90%、黄芩8%~90%、柴胡8%~90%、地龙8%~90%和淡竹叶8%~90%;
所述植物加水浸泡、提取的用量优选为药物体积5~20倍量的水或乙醇,浸泡时间优选1~4h,提取次数1~5次,每次提取0.5~3小时,提取液合并浓缩成浸膏。
4.如权利要求3所述植物提取物,其特征在于所述制备牡丹皮、连翘与柴胡植物提取挥发油的步骤中:
所述用水提取牡丹皮、连翘与柴胡,加入其体积8~10倍量的体积百分比水进行提取,先浸泡时间1~1.5小时,提取次数1次,每次提取1小时,收集挥发油。
5.如权利要求3所述植物提取物,其特征在于所述制备提取挥发油后的药渣与板蓝根、大青叶、金银花、栀子、黄芩、地龙和淡竹叶植物提取物的步骤中:
所述用提取挥发油后的药渣与板蓝根、大青叶、金银花、栀子、黄芩、地龙和淡竹叶植物,加入其体积8~10倍量的水进行提取,浸泡时间1~1.5小时,提取次数2~3次,每次提取0.5~2小时,将提取液合并浓缩成至相对密度1.06~1.08稠浸膏,加入适当比例蔗糖与淀粉,混匀,制成颗粒,干燥,再把挥发油喷入颗粒,混匀即得。
6.权利要求1所述提取物在制备治疗儿童发热保健品或药物中的应用,是将权利要求1所述提取物与药学上可接受的辅料制成的药物制剂;所述药物制剂是滴丸剂、片剂、胶囊剂、颗粒剂或其他常规药物制剂。
7.如权利要求6所述的应用,其特征在于所述滴丸剂是由权利要求1所述提取物与PEG4000和其他常规辅料按提取物:辅料=1:3的重量比例混合,再熔融,滴入冷却剂液体石蜡中制成;
所述片剂、胶囊是权利要求1所述提取物制备的颗粒:再加入硬脂酸镁和二氧化硅后装胶囊或压片、包衣制成。
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