CN105963250A - Oral glucose solution and preparation method thereof - Google Patents
Oral glucose solution and preparation method thereof Download PDFInfo
- Publication number
- CN105963250A CN105963250A CN201610454687.5A CN201610454687A CN105963250A CN 105963250 A CN105963250 A CN 105963250A CN 201610454687 A CN201610454687 A CN 201610454687A CN 105963250 A CN105963250 A CN 105963250A
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- Prior art keywords
- oral glucose
- spice
- weight portion
- preparation
- component
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Abstract
The invention discloses an oral glucose solution and a preparation method thereof. The oral glucose solution is prepared from the following components in parts by weight: 75 parts of glucose, 0.45-0.50 part of citric acid, 0.50-0.55 part of mixed spices, 0.8-1.2 parts of carbon dioxide, and 225 parts of deionized purified water. The method comprises the following specific steps: S1, deionized purified water is heated to be sterilized, and citric acid is added and stirred; S2, glucose is added into a solution obtained in step S1, and stirring is performed continuously; S3, the mixed spices are added into a solution obtained in step S2, and stirring is performed continuously; S4, the pH value of a solution obtained in step S3 is regulated; S5, carbon dioxide is introduced into a solution obtained in step S4 in a pressurized manner; S6, a solution obtained in step S5 is filtered by a microporous filtering membrane, and then bottling, covering, lamp inspection and package are performed. In the invention, the oral glucose solution is taken conveniently, the dosage is accurate, the mouthfeel is good, the speed of relieving hypoglycemia is high, the preparation technology is simple, and the oral glucose solution and the preparation method thereof are suitable for industrialization.
Description
Technical field
The present invention relates to technical field of medicine, particularly relate to a kind of oral glucose solution and
Its preparation method.
Background technology
Oral glucose tolerance test, is to show disease population to take 75g glucose, then surveys its blood
Sugar change, observes patient and tolerates the ability of glucose, is the gold of the diagnosis diabetes generally acknowledged at present
Standard, when pathoglycemia increases but not yet reaches diabetes diagnostic criterion, for clear and definite be whether
Diabetes can use this test.Clinic substantially uses at present: dissolved by 75 grams of glucoses
In 250 milliliters of water, or directly drink with other glucose injections, but shortcoming is to take
Inconvenience, error is relatively big, and mouthfeel is poor.
Summary of the invention
The technical problem existed based on background technology, it is molten that the present invention proposes a kind of oral glucose
Liquid and preparation method thereof.
A kind of oral glucose solution that the present invention proposes, including the component of following weight portion: Portugal
Grape sugar 75 parts, citric acid 0.45-0.50 part, potpourri 0.50-0.55 part, titanium dioxide
Carbon 0.8-1.2 part and deionization pure water 225 parts.
Preferably, including the component of following weight portion: glucose 75 parts, citric acid 0.48 part,
Potpourri 0.51 part, carbon dioxide 1.0 parts and deionization pure water 225 parts.
Preferably, described deionization pure water electrical conductivity is not more than 5 μ s/cm, being administered orally of preparation
The pH value of glucose solution is 4.8-6.8.
A kind of preparation method of oral glucose solution, including step in detail below:
S1: first deionization pure water is pumped into material-compound tank and deionization pure water is heated to
75-85 DEG C of sterilizing 15 minutes, then joins sterilized deionization pure water by citric acid
In, finally it being sufficiently stirred for, mixing time is: 10-15 minute；
S2: joined by glucose in step S1 gained solution, keeps temperature 45-50 DEG C,
Continuing stirring, mixing time is: 10-15 minute；
S3: joined by potpourri in step S2 gained solution, keeps temperature 45-50 DEG C,
Continuing stirring, mixing time is: 8-10 minute；
S4: regulating step S3 gained solution ph is 4.8-6.8；
S5: the pressurization of step S4 gained solution is passed through carbon dioxide；
S6: by step S5 gained solution after filtering with microporous membrane, bottling, gland, lamp
Inspection and packaging.
Preferably, the component of the weight portion of the potpourri in described step S3 is: the heat of mixing
Band fruit flavor 0.12-0.15 part, mixing orange flavor 0.26-0.30 part and mixing certain kind of berries class are fragrant
Material 0.10-0.13 part.
Preferably, the component of the weight portion of described mixed tropical fruit flavor is: pineapple flavors
0.05-0.08 part and Fructus Mangifera Indicae spice 0.07-0.09 part, the weight portion of described mixing orange flavor
Component be: Fructus Citri Sarcodactylis spice 0.10-0.16 part and grapefruit perfume 0.15-0.21 part, institute
The component of the weight portion stating mixing certain kind of berries class spice is: strawberry flavor 0.04-0.07 part and blue berry are fragrant
Material 0.05-0.08 part.
Preferably, the component of the weight portion of described mixed tropical fruit flavor is: pineapple flavors
0.05 part and Fructus Mangifera Indicae spice 0.08 part, the component of the weight portion of described mixing orange flavor is:
Fructus Citri Sarcodactylis spice 0.11 part and grapefruit 0.16 part, the weight portion of described mixing certain kind of berries class spice
Component is: strawberry flavor 0.5 part and blue berry 0.6 part.
Preferably, in described step S5, the pressure of pressurization is 2-2.2 atmospheric pressure.
Preferably, in described step S6, the bottle capacity of bottling is 300mL, described bottle bag
Including bottle cap and bottle, described bottle cap links with bottle screw thread, described bottle is carved with 300mL and holds
Amount line, described bottle is callable disposable bottle.
In the present invention, taking convenience, use callable disposable bottle, uncap and can take；
Dosage is accurate, in each bottle intelligent machine equipped with 300mL solution, accurately, error
Little, and it is carved with 300mL capacity line on bottle, when solution does not arrive capacity line or exceedes capacity
During line, show that error occurs in intelligent machine makeup bottle；In good taste, use potpourri to regulate
Oral glucose solution mouthfeel, potpourri uses mixed tropical fruit flavor, mixing Citrus fragrant
Material and mixing certain kind of berries class spice mix, and mouthfeel is with having the fresh and sweet of fruit；Alleviate hypoglycemia
Speed is fast, is fully dissolved in deionization pure water by glucose, and the addition carbon dioxide that pressurizes,
Make glucose be easier to absorb dissolving, play the purpose of fine fast degradation blood glucose；Preparation technology
Simply, it is suitable for industrialization.
Accompanying drawing explanation
Fig. 1 is the bottle arrangement schematic diagram that the present invention proposes；
In figure: 1-bottle cap, 2-bottle, 3-300mL capacity line.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is explained orally further.
Glucose chooses Bei Yinmei, and company is Zhejiang Beiyinmei Industry And Trade Co., Ltd；Spinach
Trailing plants spice, Fructus Mangifera Indicae spice, Fructus Citri Sarcodactylis spice, grapefruit perfume, strawberry flavor and blue berry spice
It is all from Shanghai De Xin spice company limited；Deionization pure water uses and processes from river, Shandong one
The electronic and ionic equipment (EDI) of equipment company limited.
Embodiment 1
A kind of oral glucose solution that the present invention proposes, including the component of following weight portion: Portugal
Grape sugar 75 parts, citric acid 0.45 part, potpourri 0.50 part, carbon dioxide 0.8 part and
Deionization pure water 225 parts, deionization pure water electrical conductivity is 4 μ s/cm, being administered orally of preparation
The pH value of glucose solution is 6.0.
A kind of preparation method of oral glucose solution, including step in detail below:
S1: first deionization pure water is pumped into material-compound tank and deionization pure water is heated to
75-85 DEG C of sterilizing 15 minutes, then joins sterilized deionization pure water by citric acid
In, finally it being sufficiently stirred for, mixing time is: 10 minutes；
S2: joined by glucose in step S1 gained solution, keeps temperature 45 C, continues
Stirring, mixing time is: 10 minutes；
S3: joined by potpourri in step S2 gained solution, keeps temperature 45 C, continues
Continuous stirring, mixing time is: 8 minutes；
S4: regulating step S3 gained solution ph is 6.0；
S5: the pressurization of step S4 gained solution is passed through carbon dioxide；
S6: by step S5 gained solution after filtering with microporous membrane, bottling, gland, lamp
Inspection and packaging.
Wherein, the component of the weight portion of the potpourri in step S3 is: mixed tropical fruit
Spice 0.12 part, mixing orange flavor 0.26 part and mixing certain kind of berries class spice 0.10 part, mixing
The component of the weight portion of tropical fruit (tree) spice is: pineapple flavors 0.05 part and Fructus Mangifera Indicae spice 0.07
Part, the component of the weight portion of mixing orange flavor is: Fructus Citri Sarcodactylis spice 0.10 part and grapefruit
Spice 0.16 part, the component of weight portion of mixing certain kind of berries class spice is: strawberry flavor 0.04 part and
Blue berry spice 0.06 part.
And the pressure of pressurization is 2 atmospheric pressure in step S5, in step S6, the bottle of bottling holds
Amount is 300mL, and bottle is callable disposable bottle.
Embodiment 2
A kind of oral glucose solution that the present invention proposes, including the component of following weight portion: Portugal
Grape sugar 75 parts, citric acid 0.48 part, potpourri 0.53 part, carbon dioxide 1.0 parts and
Deionization pure water 225 parts, deionization pure water electrical conductivity is 4.5 μ s/cm, the mouth of preparation
The pH value taking glucose solution is 5.5.
A kind of preparation method of oral glucose solution, including step in detail below:
S1: first deionization pure water is pumped into material-compound tank and deionization pure water is heated to
75-85 DEG C of sterilizing 15 minutes, then joins sterilized deionization pure water by citric acid
In, finally it being sufficiently stirred for, mixing time is: 12 minutes；
S2: joined by glucose in step S1 gained solution, keeps temperature 47 DEG C, continues
Stirring, mixing time is: 12 minutes；
S3: joined by potpourri in step S2 gained solution, keeps temperature 47 DEG C, continues
Continuous stirring, mixing time is: 9 minutes；
S4: regulating step S3 gained solution ph is 5.5；
S5: the pressurization of step S4 gained solution is passed through carbon dioxide；
S6: by step S5 gained solution after filtering with microporous membrane, bottling, gland, lamp
Inspection and packaging.
Preferably, the component of the weight portion of the potpourri in described step S3 is: the heat of mixing
Band fruit flavor 0.14 part, mixing orange flavor 0.28 part and mixing certain kind of berries class spice 0.12 part,
The component of the weight portion of mixed tropical fruit flavor is: pineapple flavors 0.06 part and Fructus Mangifera Indicae spice
0.08 part, the component of the weight portion of mixing orange flavor is: Fructus Citri Sarcodactylis spice 0.13 part and Portugal
Grape Fructus Citri grandis spice 0.15 part, the component of the weight portion of mixing certain kind of berries class spice is: strawberry flavor 0.06
Part and blue berry spice 0.06 part.
And the pressure of pressurization is 2.1 atmospheric pressure in step S5, the bottle of bottling in step S6
Capacity is 300mL, and bottle is callable disposable bottle.
Embodiment 3
A kind of oral glucose solution that the present invention proposes, including the component of following weight portion: Portugal
Grape sugar 75 parts, citric acid 0.50 part, potpourri 0.55 part, carbon dioxide 1.2 parts and
Deionization pure water 225 parts, deionization pure water electrical conductivity is 5 μ s/cm, being administered orally of preparation
The pH value of glucose solution is 6.5.
A kind of preparation method of oral glucose solution, including step in detail below:
S1: first deionization pure water is pumped into material-compound tank and deionization pure water is heated to
75-85 DEG C of sterilizing 15 minutes, then joins sterilized deionization pure water by citric acid
In, finally it being sufficiently stirred for, mixing time is: 15 minutes；
S2: joined by glucose in step S1 gained solution, keeps temperature 50 C, continues
Stirring, mixing time is: 15 minutes；
S3: joined by potpourri in step S2 gained solution, keeps temperature 50 C, continues
Continuous stirring, mixing time is: 10 minutes；
S4: regulating step S3 gained solution ph is 6.5；
S5: the pressurization of step S4 gained solution is passed through carbon dioxide；
S6: by step S5 gained solution after filtering with microporous membrane, bottling, gland, lamp
Inspection and packaging.
Wherein, the component of the weight portion of the potpourri in step S3 is: mixed tropical fruit
Spice 0.15 part, mixing orange flavor 0.30 part and mixing certain kind of berries class spice 0.13 part, mixing
The component of the weight portion of tropical fruit (tree) spice is: pineapple flavors 0.7 part and Fructus Mangifera Indicae spice 0.08
Part, the component of the weight portion of mixing orange flavor is: Fructus Citri Sarcodactylis spice 0.14 part and grapefruit
Spice 0.16 part, the component of weight portion of mixing certain kind of berries class spice is: strawberry flavor 0.06 part and
Blue berry spice 0.07 part.
And the pressure of pressurization is 2.2 atmospheric pressure in step S5, the bottle of bottling in step S6
Capacity is 300mL, and bottle is callable disposable bottle.
In the present invention, taking convenience, use callable disposable bottle, uncap and can take；
Dosage is accurate, in each bottle intelligent machine equipped with 300mL solution, accurately, error
Little, and it is carved with 300mL capacity line on bottle, when solution does not arrive capacity line or exceedes capacity
During line, show that error occurs in intelligent machine makeup bottle；In good taste, use potpourri to regulate
Oral glucose solution mouthfeel, potpourri uses mixed tropical fruit flavor, mixing Citrus fragrant
Material and mixing certain kind of berries class spice mix, and mouthfeel is with having the fresh and sweet of fruit；Alleviate hypoglycemia
Speed is fast, is fully dissolved in deionization pure water by glucose, and the addition carbon dioxide that pressurizes,
Make glucose be easier to absorb dissolving, play the purpose of fine fast degradation blood glucose；Preparation technology
Simply, it is suitable for industrialization.
The above, the only present invention preferably detailed description of the invention, but the protection model of the present invention
Enclosing and be not limited thereto, any those familiar with the art is in the skill that the invention discloses
In the range of art, according to technical scheme and inventive concept equivalent in addition thereof or change
Become, all should contain within protection scope of the present invention.
Claims (9)
1. an oral glucose solution, it is characterised in that include the component of following weight portion:
Glucose 75 parts, citric acid 0.45-0.50 part, potpourri 0.50-0.55 part, dioxy
Change carbon 0.8-1.2 part and deionization pure water 225 parts.
A kind of oral glucose solution the most according to claim 1, it is characterised in that
Component including following weight portion: glucose 75 parts, citric acid 0.48 part, potpourri
0.51 part, carbon dioxide 1.0 parts and deionization pure water 225 parts.
A kind of oral glucose solution the most according to claim 1 and 2, its feature exists
In, described deionization pure water electrical conductivity is not more than 5 μ s/cm, and the oral glucose of preparation is molten
The pH value of liquid is 4.8-6.8.
The preparation method of a kind of oral glucose solution the most according to claim 1, bag
Include step in detail below:
S1: first deionization pure water is pumped into material-compound tank and deionization pure water is heated to
75-85 DEG C of sterilizing 15 minutes, then joins sterilized deionization pure water by citric acid
In, finally it being sufficiently stirred for, mixing time is: 10-15 minute；
S2: joined by glucose in step S1 gained solution, keeps temperature 45-50 DEG C,
Continuing stirring, mixing time is: 10-15 minute；
S3: joined by potpourri in step S2 gained solution, keeps temperature 45-50 DEG C,
Continuing stirring, mixing time is: 8-10 minute；
S4: regulating step S3 gained solution ph is 4.8-6.8；
S5: the pressurization of step S4 gained solution is passed through carbon dioxide；
S6: by step S5 gained solution after filtering with microporous membrane, bottling, gland, lamp
Inspection and packaging.
The preparation method of a kind of oral glucose solution the most according to claim 4, its
Being characterised by, the component of the weight portion of the potpourri in described step S3 is: mixed tropical
Fruit flavor 0.12-0.15 part, mixing orange flavor 0.26-0.30 part and mixing certain kind of berries class spice
0.10-0.13 part.
The preparation method of a kind of oral glucose solution the most according to claim 5, its
Being characterised by, the component of the weight portion of described mixed tropical fruit flavor is: pineapple flavors
0.05-0.08 part and Fructus Mangifera Indicae spice 0.07-0.09 part, the weight portion of described mixing orange flavor
Component be: Fructus Citri Sarcodactylis spice 0.10-0.16 part and grapefruit perfume 0.15-0.21 part, institute
The component of the weight portion stating mixing certain kind of berries class spice is: strawberry flavor 0.04-0.07 part and blue berry
0.05-0.08 part.
The preparation method of a kind of oral glucose solution the most according to claim 6, its
Being characterised by, the component of the weight portion of described mixed tropical fruit flavor is: pineapple flavors 0.05
Part and Fructus Mangifera Indicae spice 0.08 part, the component of the weight portion of described mixing orange flavor is: Fructus Citri Sarcodactylis
Citrus chachiensis Hort. spice 0.11 part and grapefruit 0.16 part, the component of the weight portion of described mixing certain kind of berries class spice
For: strawberry flavor 0.05 part and blue berry spice 0.06 part.
The preparation method of a kind of oral glucose solution the most according to claim 4, its
Being characterised by, in described step S5, the pressure of pressurization is 2-2.2 atmospheric pressure.
The preparation method of a kind of oral glucose solution the most according to claim 4, its
Being characterised by, in described step S6, the bottle capacity of bottling is 300mL, and described bottle includes
Bottle cap and bottle, described bottle cap links with bottle screw thread, and described bottle is carved with 300mL capacity
Line, described bottle is callable disposable bottle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610454687.5A CN105963250A (en) | 2016-06-21 | 2016-06-21 | Oral glucose solution and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610454687.5A CN105963250A (en) | 2016-06-21 | 2016-06-21 | Oral glucose solution and preparation method thereof |
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| CN105963250A true CN105963250A (en) | 2016-09-28 |
Family
ID=57021369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201610454687.5A Pending CN105963250A (en) | 2016-06-21 | 2016-06-21 | Oral glucose solution and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109865144A (en) * | 2019-03-26 | 2019-06-11 | 高鸿 | A kind of oral glucose tolerance test drink and its application method |
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| CN103704808A (en) * | 2013-12-14 | 2014-04-09 | 长泰县兴立食品技术研发中心 | Salt sports beverage and preparation technology thereof |
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| CN104800173A (en) * | 2015-02-16 | 2015-07-29 | 迈德同信武汉医学信息服务有限公司 | Novel prevention and emergency method for hypoglycemia symptoms |
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2016
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| CN104224701A (en) * | 2013-06-21 | 2014-12-24 | 哈药集团三精制药股份有限公司 | Zinc gluconate oral solution and preparation method thereof |
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