CN105962891A - Contact-type excitation light source used for fluorescence imaging detecting system - Google Patents
Contact-type excitation light source used for fluorescence imaging detecting system Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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Abstract
The invention discloses a contact-type excitation light source used for a fluorescence imaging detecting system, belonging to an auxiliary device capable of enhancing the imaging effect of the fluorescence detection device. According to the design, the contact-type excitation light source is in direct contact with the skin or the surface of the body tissue, therefore, exciting light reflected by the skin and the surface of the other body tissue can be shielded by the device, while the fluorescence generated by the exciting light penetrating through the skin or the other body tissue which irradiates the IGG can penetrate through an observation channel in the center of the device and be received by the fluorescence detection device. With the adoption of the device, the useless exciting light reflected back to the fluorescence detection device by the skin or the surface of the body tissue is well blocked, therefore, the influences of the large amount of reflected exciting light on the picture are eliminated, the signal to noise ratio of the picture is improved, and the effect of the picture is enhanced. The contact-type excitation light source can be widely applied to the technical fields of sentinel node biopsy, heart bypass surgery, venous flap detection and the like.
Description
Technical field
The present invention relates to optical medical assistive device field, the contact excitation source of a kind of fluorescence imaging detecting system,
The auxiliary device of the fluorescence imaging effect of fluorescence detection device can be strengthened.It is applied to biopsy and other body groups of sentinel node
Fluorescence Increasing under knitting.
Background technology
Sentinel node is primaryTumorSpecial lymph node in drain regional lymph nodes, is primaryTumorThere is lymphatic metastasis institute
Must through first lymph node.The clinical practice of sentinel lymph node biopsy makes axillary gland not shiftBreast carcinomaPatient keeps away
Exempt from ALND, thus avoid corresponding postoperative complication such as upper limb lymphedema etc., greatly increase patient's
Quality of life, therefore suffer from the concern of people.
Having three kinds of methods at present to detect sentinel node: (1) blue dyes method, the method is the most traditional, uses the indigo plants such as methylene blue
Color stain, effect is bad, needs doctor to have the longest learning curve.(2) nucleic probe technique, because relating to radioelement,
Human body is had certain radiation effects, can environment be used the most cumbersome simultaneously, do not promote in clinic and open,
And device systems is more expensive.(3) fluorescent penetrant method, this is up-to-date a kind of quick, safe detection method, uses fluorescence inspection
Measurement equipment viewing indocyanine green (ICG) fluorescence, can be quickly found out sentinel node, and imaging is over the display.
ICG vein or be subcutaneously injected into internal after, rapidly and protein bound, ICG is produced by the excitation light irradiation of 700-800nm
The fluorescence of raw 800-900nm.Because ICG fluorescence belongs near infrared light, human eye cannot directly be observed, so needing fluoroscopic examination
Equipment is observed.Therefore fluorescent penetrant method image quality directly affects judgement and the surgical effect of sentinel node position.
Existing disclosed " lymph node detector " patent of invention CN1976639B, " Minimally Invasive Surgery location guide device " is invented
Patent 102988112B, and " for detecting equipment and the method for the NIR fluorescence at sentinel node " CN 104274156 A
Disclosed equipment is required at distance human body 5～30cm use on using, excitation light irradiation skin or other body groups
Knitting rear portion exciting light and penetrate skin exposure to ICG, a part is reflected by skin or other body tissue surfaces, reflects in a large number
Exciting light and ICG fluorescence together received by Infrared fluorescence detection equipment, cause ICG fluorescence the highest with the signal to noise ratio of exciting light,
Image quality can be disturbed, even if the exciting light using high performance optical filter (7) to stop that fluorescence detection device is received still can not
Reach good effect.Such as in SLND is performed the operation, the lymph node position of most of patients is relatively deep, at noinvasive
In the case of, use conventional fluorescent detection equipment to be difficult to observe the particular location of lymph node.Cause and need to repeatedly observe, and estimate pouring
Fawn on position, cause the loaded down with trivial details of operation and add the error possibility estimated.
Summary of the invention
For solving above-mentioned technical problem, the present invention uses a kind of new excitation light source device, auxiliary as conventional fluorescent navigator
Help device, the distance human body 5～30cm used in conventional art irradiate skin or the form of body tissue, change into and skin
Or the direct contact type of body tissue surface, the exciting light of such skin and the reflection of other body tissue surfaces can be hidden by device itself
Gear, and penetrate the excitation light irradiation of skin or other body tissues to fluorescence produced by ICG, but can be from the observation at device center
Passage is passed through, and is received by fluorescence detection device, utilize this device good blocked skin or body tissue surface reflection
Return the useless exciting light of fluorescence detection device, it is to avoid a large amount of reflected excitation light impacts on picture, improve the signal to noise ratio of image,
Enhance image effect.Further, since the improvement of this apparatus structure, such that it is able to use the optical filter of more low performance, reach equally
To the effect of good image, and then reduce production cost.
The contact excitation source of fluorescence imaging detecting system of the present invention, has shell, and the tail end at shell is provided with handle；
Handle is internally provided with supply module, light source driving circuit and radiator, and handle is provided with button；Also following architectural feature:
The test side of described shell is internally provided with light source supporting construction；
It is fixedly installed excitation source in described light source supporting construction；
The lower section of described excitation source is provided with the optical filter that the wavelength to excitation source is defined；
The test side of described shell is provided with observation passage；And observation passage runs through light source supporting construction and optical filter；Described shell
Test side in complete surround or have in the middle of Semi surrounding type observe the shape of passage, such as fork-shaped, semi-circular, circular rings, oval
Ring, straight-flanked ring etc..The purpose that arranges observing passage is, the fluorescence that both can have been sent by the body tissue containing fluorescent agent is by seeing
Examining passage and project outside, it is simple to the content needing observation is observed by fluorescence detection device, the most beneficially user is by seeing
Examine the operations such as object is marked by passage.
In 0～30 degree of angle between exciting light projecting direction and the perpendicular bisector of supporting construction of described excitation source；
The lower section of described optical filter is also respectively provided with inner side and is in the light band and be in the light band in outside along observing inside and outside passage.
For technique scheme, preferably in the case of, the width of described optical filter is in the light band less than inner side and is in the light in outside band
Spacing.So be conducive to reducing exciting light inside side block light belt by optical filter and be in the light the exciting light area of band projection in outside, keep away
Exempt from the impact on picture of a large amount of useless exciting light.
For technique scheme, preferably in the case of, described optical filter uses low pass or narrow band pass filter, and its cut-off wave is grown up
In the wavelength of excitation source, carry out bandwidth restriction for the exciting light that excitation source is sent.
For technique scheme, preferably in the case of, the crevice projection angle setting means of the excitation source of device of the present invention is
Fixed or adjustable；Carry out the setting of different angles according to the depth of focus needed for the body tissue being observed, thus adapt to
In different use environment.
For technique scheme, preferably in the case of, the quantity of described excitation source is determined by supporting construction, as required
Evenly distributed can be constituted by single or many.When using single light source when, can be to use modes such as coordinating light guide plate to light
It is diffused.
For technique scheme, preferably in the case of, described excitation source uses the light source of 700～800nm centre wavelengths to constitute,
Such as near infrared diode, laser diode or Halogen light etc..
For technique scheme, preferably in the case of, band is in the light in described inner side and is in the light in outside, and band is all dismountable, and all
Use the material that extrusion performance is good.
For technique scheme, preferably in the case of, described supply module as the electric power system of device of the present invention, for
Light source driving circuit and excitation source are powered, and battery specifically can be used to power or can be introduced confession by power interface form from other equipment
Electricity.
For technique scheme, preferably in the case of, described light source driving circuit is regulated by button, is used for driving exciting light
The unlatching in source, close or regulate excitating light strength；Described button can be, but not limited to mechanical type, touch, rocker-type, knob
Formula etc..In the case of You Xuan, light source driving circuit utilizes PWM mode that the brightness of excitation source is carried out multistage setting, and
Can control to close.
For technique scheme, preferably in the case of, described radiator is connected on light source driving circuit, and light source is driven electricity
The chip on road dispels the heat.
Device of the present invention can be widely used in the technical fields such as SLND, heart pass art, venous skin flap detection
In.Apparatus of the present invention coordinate traditional fluorescence detection device use, picture contrast and Observational depth can be increased, promote and see
Survey effect.Such as in the positioning operation of sentinel node, owing to oxter fat is thicker, often do not observe the concrete position of lymph node
Put, so can only can reduce the accurate of sentinel node position judgment by observation shallow-layer lymphatic vessel deduction out of shape lymph node position
Rate, adds operation risk, utilizes this device just can observe the lymph node of deeper inside before surgery, can accurately position,
Reducing operation risk, the safety to operation, convenience is all significantly increased.
Accompanying drawing explanation
Fig. 1. apparatus of the present invention use the side view of state；
Fig. 2. apparatus of the present invention top view；
Wherein: 1. shell；101. handle；102. observe passage；103. button；2. supply module；3. light source driving circuit；
4. radiator；5. light source supporting construction；6. excitation source；601. exciting light；602. fluorescence；7. optical filter；Side block in 701.
Light belt；Be in the light outside 702. band；8. the body tissue containing fluorescent agent.
Detailed description of the invention
Following non-limiting example can make those of ordinary skill in the art that the present invention is more fully understood, but not with any side
Formula limits the present invention.In the schematic diagram of device of the present invention, physical dimension does not all mark, the structure structure of this device of major embodiment
Make, during actual production uses, structure proportion and size can be adjusted as required.
Embodiment 1
In conjunction with accompanying drawing 1 and Fig. 2 of the present invention, device of the present invention has shell 1, and the tail end at shell 1 is provided with handle 101；
Handle 101 is internally provided with supply module 2, light source driving circuit 3 and radiator 4, and handle 101 is provided with button 103；Institute
The test side stating shell 1 is internally provided with light source supporting construction 5；It is fixedly installed excitation source 6 in described light source supporting construction 5；
The lower section of described excitation source 6 is provided with the optical filter 7 that the wavelength to excitation source 6 is defined；
The test side of described shell 1 is provided with observation passage 102；And observation passage 102 runs through light source supporting construction 5 and filters
Sheet 7；The test side circular rings of described shell 1.The purpose that arranges observing passage 102 is, both can be by the machine containing fluorescent agent
The fluorescence 602 that soma 8 sends projects outside by observing passage 102, it is simple in fluorescence detection device is to needing observation
Appearance is observed, and the most beneficially user operates by observing that object is marked by passage 102 and waiting.
In 0～30 degree of angle between exciting light 601 projecting direction and the perpendicular bisector of supporting construction 5 of described excitation source 6；
The lower section of described optical filter 7 is also respectively provided with inner side and is in the light band 701 and be in the light in outside along observing inside and outside passage 102
Band 702.
The width of described optical filter 7 less than inner side be in the light with 701 and outside be in the light with 702 spacing.So be conducive to by filter
Mating plate 7 reduces the inside side block light belt 701 of exciting light 601 and is in the light in outside with 702 projections exciting light areas, it is to avoid a large amount of
The impact on picture of the useless exciting light.
Described optical filter 7 uses narrow band pass filter, and its cutoff wavelength is more than the wavelength of excitation source 6, for excitation source 6
The exciting light 601 sent carries out bandwidth restriction.
The crevice projection angle setting means of the excitation source 6 of device of the present invention is fixed.
The quantity of described excitation source 6 is determined by supporting construction 5, can be arranged to make up by many as required.
Described excitation source 6 uses the light source near infrared diode of 700～800nm centre wavelengths to constitute.
Band 701 is in the light in described inner side and is in the light in outside, and band 702 is all dismountable, it is therefore an objective to is conveniently replaceable and uses due to long-time
And band 701 is in the light in aging inner side and is in the light band 702 in outside；Use the material that extrusion performance is good simultaneously.For being adjacent to skin
Surface or body tissue surface.Exciting light 601 is avoided to spill from side and affect the image-receptive effect of fluorescence detection device.
Described supply module 2, as the electric power system of device of the present invention, is powered for light source driving circuit 3 and excitation source 6,
Use and introduced power supply by power interface form from other equipment.
Described light source driving circuit 3 is regulated by button 103, utilizes PWM mode to carry out multistage to the brightness of excitation source 6
Arrange, and can control to close.
Described radiator 4 is connected on light source driving circuit 3, dispels the heat the chip of light source driving circuit 3.
Existing fluorescence detection device needs distance patient to keep 5～30cm distances, excitation source and fluorescence detection device in use
At same plane, unitary design.Excitation light irradiation is on skin, and a part penetrates skin and enters into and have the corresponding of fluorescent agent
Body tissue, fluorescent agent, by after the irradiation of exciting light, sends fluorescence, and the exciting light of such skin surface reflection is sent out with fluorescent agent
The fluorescence gone out, all can together be received to observation fluorescence detection device, even if having optical filter to intercept exciting light, the most not
The existence of exciting light can be completely cut off completely, picture can be carried out certain interference.
Device of the present invention specifically uses and skin or body tissue surface contact, i.e. inner side be in the light band 701 and outside be in the light
Band 702 is used for being adjacent to skin surface and body tissue surface, the reflection light on such excitation light irradiation to skin and body tissue surface
The structure of device the most described by the present invention self is blocked, and the observation passage 102 that centre is left but can pass through what body tissue sent
Fluorescence, so compares traditional device and substantially reduces the exciting light reflected into fluorescence detection device camera lens, adds picture contrast
Degree and Observational depth.
Claims (10)
1. a contact excitation source for fluorescence imaging detecting system, has shell (1), and the tail end at shell (1) is provided with
Handle (101)；Handle (101) is internally provided with supply module (2), light source driving circuit (3) and radiator (4),
Hands (101) is provided with button (103)；It is characterized in that:
The test side of described shell (1) is internally provided with light source supporting construction (5)；
It is fixedly installed excitation source (6) on described light source supporting construction (5)；
The optical filter (7) that the wavelength to excitation source (6) is defined it is provided with in the lower section of described excitation source (6)；
The test side of described shell (1) is provided with observation passage (102)；And observation passage (102) runs through light source supporting construction (5)
With optical filter (7)；The test side of described shell (1) is in the full shape surrounded or have observation passage (102) in the middle of Semi surrounding type；
In 0～30 degree of angle between exciting light (601) projecting direction and the perpendicular bisector of supporting construction (5) of described excitation source (6)；
The lower section of described optical filter (7) along observe be also respectively provided with inside and outside passage (102) inner side be in the light band (701) and
Be in the light band (702) in outside.
Contact excitation source the most according to claim 1, it is characterised in that: the width of described optical filter (7) is less than
The spacing of band (701) is in the light in inner side and is in the light in outside band (702).
Contact excitation source the most according to claim 1, it is characterised in that: described optical filter (7) use low pass or
Narrow band pass filter, its cutoff wavelength is more than the wavelength of excitation source (6).
Contact excitation source the most according to claim 1, it is characterised in that: the projectional angle of described excitation source (6)
Degree setting means is fixed or adjustable.
Contact excitation source the most according to claim 1, it is characterised in that: described excitation source (6) by single or
Many uniform arrangements.
Contact excitation source the most according to claim 1, it is characterised in that: described excitation source (6) uses
The light source of 700～800nm centre wavelengths is constituted.
Contact excitation source the most according to claim 1, it is characterised in that: be in the light band (701) and outer in described inner side
Side block light belt (702) is all dismountable, and uses the material that extrusion performance is good.
Contact excitation source the most according to claim 1, it is characterised in that: described supply module (2) is that light source drives
Galvanic electricity road (3) and excitation source (6) power supply.
Contact excitation source the most according to claim 1, it is characterised in that: described light source driving circuit (3) passes through
Button (103) regulates, and is used for driving the unlatching of excitation source (6), closing or regulate exciting light (601) intensity.
Contact excitation source the most according to claim 1, it is characterised in that: described radiator (4) is connected to light source
On drive circuit (3), the chip of light source driving circuit (3) is dispelled the heat.
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Cited By (7)
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| CN108498079A (en) * | 2018-05-08 | 2018-09-07 | 翰飞骏德（北京）医疗科技有限公司 | Recognition methods and the equipment of glimmering Control of Environment Pollution by Light medium vessels, lymphatic vessel and lymph node |
| CN109171661A (en) * | 2018-10-10 | 2019-01-11 | 南京诺源医疗器械有限公司 | Fluoroscopic visualization checks system excitation light source |
| CN109363768A (en) * | 2018-10-10 | 2019-02-22 | 南京诺源医疗器械有限公司 | 785nm wavelength light source near-infrared fluorescence imaging surgery guides system |
| CN110313892A (en) * | 2018-03-28 | 2019-10-11 | 上海交通大学 | The pathogenetic method and its application of Parkinson are judged based on body surface autofluorescence |
| CN111493827A (en) * | 2020-04-23 | 2020-08-07 | 南京诺源医疗器械有限公司 | Fluorescence radiography inspection system based on 785nm wavelength light source |
| CN112881348A (en) * | 2019-11-29 | 2021-06-01 | 中国科学院大连化学物理研究所 | Underwater fluorescence sensor |
| WO2024059055A1 (en) * | 2022-09-12 | 2024-03-21 | Behemoth Technologies Llc | Biopsy-capable dermatoscope |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110313892A (en) * | 2018-03-28 | 2019-10-11 | 上海交通大学 | The pathogenetic method and its application of Parkinson are judged based on body surface autofluorescence |
| CN108498079A (en) * | 2018-05-08 | 2018-09-07 | 翰飞骏德（北京）医疗科技有限公司 | Recognition methods and the equipment of glimmering Control of Environment Pollution by Light medium vessels, lymphatic vessel and lymph node |
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| CN109363768A (en) * | 2018-10-10 | 2019-02-22 | 南京诺源医疗器械有限公司 | 785nm wavelength light source near-infrared fluorescence imaging surgery guides system |
| CN112881348A (en) * | 2019-11-29 | 2021-06-01 | 中国科学院大连化学物理研究所 | Underwater fluorescence sensor |
| CN111493827A (en) * | 2020-04-23 | 2020-08-07 | 南京诺源医疗器械有限公司 | Fluorescence radiography inspection system based on 785nm wavelength light source |
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| WO2024059055A1 (en) * | 2022-09-12 | 2024-03-21 | Behemoth Technologies Llc | Biopsy-capable dermatoscope |
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