CN105954476B - A kind of Mouthsimulator - Google Patents
A kind of Mouthsimulator Download PDFInfo
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- CN105954476B CN105954476B CN201610555190.2A CN201610555190A CN105954476B CN 105954476 B CN105954476 B CN 105954476B CN 201610555190 A CN201610555190 A CN 201610555190A CN 105954476 B CN105954476 B CN 105954476B
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- chewing
- tooth
- mouthsimulator
- solution ware
- tobacco
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
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- Health & Medical Sciences (AREA)
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- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Hydrology & Water Resources (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
Abstract
The invention discloses a kind of Mouthsimulators comprising with lower component: solution ware (16), with inlet tube (15) and outlet tube (17)；It opens and closes guide groove (19), is placed in the solution ware (16), and there is a pair of of nip assemblies (18) in it；Wherein each nip assemblies (18) have dental lamina (181), the clamping plate (182) being fixed on dental lamina (181) and the second permanent magnet (183) for being placed in clamping plate (182) bottom.The Mouthsimulator is used as the components of full analogue simulation chewing machine.
Description
Technical field
The invention belongs to bionic mechanical fields, and in particular to a kind of Mouthsimulator is used as the zero of full analogue simulation chewing machine
Component.
Background technique
With " Framework Convention on Tobacco Control " (FCTC) issuing in relation to the ban of forbidding tobacco smoke to spread in public places
Cloth and people accept extensively harmfulness of smoking, the great attention there are also country to lowering harm and decreasing coking, smokeless tobacco articles
Development has become one of inevitable choice of tobacco business.Smoke-free tobacco product is that one kind is disappeared by non-burning approach progress tobacco
The tobacco product taken.It mainly by chewing, smelling, sucking, mouth containing, containing change etc. modes consume, it avoids traditional cigarette " two
The puzzlement of hand cigarette " has good market prospects.
Packed buccal cigarette, the cigarette containing change and chewing tobacco are increasingly subject to extensive concern as smokeless tobacco staple product form.Nothing
When flue gas tobacco product is consumed in the oral cavity, tobacco product is infiltrated by saliva, and main chemical component starts to discharge and lead to
It crosses different approaches and enters human recycle system.The rate and content of chemical component release directly affect its organoleptic feature (as impacted
Intensity, fragrance lasting) and safety.Therefore, studying its main chemical compositions release characteristic and its relevant influence factor will have
Help realize that exploitation and quality to smoke-free tobacco product are controlled.In order to study the release characteristic of main chemical compositions, need
Real-time salivary component analysis is carried out to the process of edible smoke-free tobacco product.Based on this, smoke-free tobacco product needs
Simulation human oral cavity environment constant temperature come into full contact with and received chewing simulating, containing change etc. movement, make its mainly at
Dividing sufficiently to release.
It is tested, is not influenced by principal factors instead of human volunteer using the device of Mouthsimulator configuration, controllability is strong, weight
Existing property is good, but traditional chewing simulating device is that the simple occlusion up and down using mechanical structure Mouthsimulator tooth is dynamic
Make, and actually people is in chewing on things other than the snap-action up and down of tooth, also useful upper and lower tooth is to by chaw
The left and right mill changing of the relative positions is made, and promotes gathering and roll to be next time engaged by chaw with tongue and the cooperation of cheek side
Movement.By taking chewing gum as an example, after tooth is stung flat slabbing up and down, then wrong this of upper lower tooth or so mill is snapped slabbing
Chewing gum, then gather movement by what tongue and the cheek were helped, the chewing gum for being snapped slabbing can be gathered into lumps simultaneously again
Rolling, to carry out chewing cycle next time.But existing chewing simulating machine can only simulate the snap-action up and down of tooth, cannot
The left and right mill changing of the relative positions for simulating tooth is made, and can not simulate above-mentioned the gathering and tumbling action of tongue and cheek side, that is, be unable to maximum journey
Spend the chew of simulation people.
Although it is using quantitative artificial saliva in addition, also using artificial saliva in existing chewing simulating machine
The mode of immersion, i.e., after being soaked for a period of time with the artificial saliva of determining amount, sampling analysis chemical substance therein dissolves out situation.
And in the mastication processes of actual persons, it is along with the dynamic secretion of saliva and dynamic swallowing act, i.e. saliva measures and is dissolved in it
In the concentration of chemical substance update at any time, existing chewing simulating machine can not imitate this dynamic updating process.
The purpose of the present invention is to solve the above problems, provide a kind of fully simulated chewing chewing machine.
Summary of the invention
The purpose of the present invention is what is be achieved through the following technical solutions:
The first aspect of the present invention is related to a kind of opening and closing left and right rotary components comprising with lower component:
Rotating basis 6 can rotate in the horizontal plane around axis 7；
Linear guide 4, horizontal are fixed on the rotating basis 6, which, which is equipped with, leans on Bidirectional-screw 3
Two sliding blocks 8 of connection respectively have first permanent magnet 1 on each sliding block 8；The Bidirectional-screw 3 drives in folding stepper motor 2
The dynamic lower described two sliding blocks 8 of drive do open and close movement.
In a particular embodiment, the folding stepper motor 2 drives the Bidirectional-screw 3 by belt pulley 9, will be described
The rotary motion of folding stepper motor 2 is converted into the open and close movement of the Bidirectional-screw 3.
In a particular embodiment, opening and closing left and right rotary components of the invention further include rotating stepper motor 10, for driving
Move the rotation of the rotating basis 6 in the horizontal plane.
The second aspect of the present invention is related to a kind of Mouthsimulator comprising with lower component:
Solution ware 16, with inlet tube 15 and outlet tube 17；
Guide groove 9 is opened and closed, is placed in the solution ware 16, and there are a pair of of nip assemblies 18 in it；Wherein each folder
Seaming element 18 has dental lamina 181, the clamping plate 182 being fixed on dental lamina 181 and the second permanent magnet 183 for being placed in 182 bottom of clamping plate.
Preferably, 16 bottom of solution ware has heating plate 13, and/or, 16 side wall of solution ware has heating tube
14。
Wherein, the dental lamina 181 is assembled on the folding guide groove 9 by slideable.
The third aspect of the present invention is related to a kind of mechanical tooth of chewing comprising bracket 102 and the upper nozzle being placed on bracket 102
The upper chewing lifting mould group 103 chewing lifting motor 101 and being driven by it, and go up and down mould group 103 with upper chewing and be connected and therewith
The end of the upper chewing lifting shaft 106 of lifting being vertically oriented, the upper chewing lifting shaft 106 has upper chewing tooth 107, described
Chewing mechanical tooth further includes the upper chewing rotary DC decelerating motor 105 that the driving upper chewing lifting shaft 106 rotates.
Preferably, the top of the upper chewing lifting shaft 106 is provided with counterweight component 104.Counterweight component range is:
500g,1Kg,2Kg,5Kg.It can be completed by the counterweight of replacement different quality by gravity during chewing simulating
The different occlusion dynamics of tooth are realized in the load of masticatory force.
Preferably, the end face of the upper chewing tooth 107 is plane or rough.For example, the end of upper chewing tooth 107
Face is plane or the different molds with wedge angle, can simulate the snap-action of human oral cavity different shape tooth.
The fourth aspect of the present invention provides a kind of method of chewing simulating, and this method is used as described in third aspect present invention
Chewing machinery tooth, wherein by upper chewing lifting motor 101 driving on chewing lifting mould group 103 lifting drive on chew
The lifting of lifting shaft 106 and its upper chewing tooth 107 of end, and other lower chewing tooth 108 cooperation either statically or dynamically, with mould
Snap-action above and below quasi- tooth；Wherein by upper chewing rotary DC decelerating motor 105 drive the upper chewing lifting shaft 106 and
The rotation of the upper chewing tooth 107 of its end is made with simulating the left and right mill changing of the relative positions of tooth.
Preferably, the top of the upper chewing lifting shaft 106 is provided with counterweight component 104, it is different size of to simulate
Dental articulation dynamics.
Preferably, by the end face of the upper chewing tooth 107 to be plane or rough, to simulate tooth of different shapes
The snap-action of tooth.
Wherein the lower chewing tooth 108, which can be, chews what mechanical tooth was separately independently arranged with of the invention, is similar to
Chopping block, or be static, or be movement, wherein the sports bag includes up and down motion and horizontal rotation.
Wherein, the lifting frequency range of the upper chewing lifting shaft 106 is 3 seconds/time~5min/ times, realizes chewing simulating
During tooth different frequency snap-action up and down.
Wherein the range of the upper chewing lifting shaft 106 is that: 0~100mm can cover Buccodental up and down action
Minimum and maximum range.
Wherein the rotating range of the upper chewing lifting shaft 106 is: 0~360 ° can cover Buccodental or so movement
Minimum and maximum range.
The fifth aspect of the present invention is related to a kind of full analogue simulation chewing machine comprising above-described opening and closing left and right rotation
The mechanical tooth of component, Mouthsimulator and the chewing, wherein the opening and closing left and right rotary components are placed in below the Mouthsimulator, and
So that wherein first permanent magnet and the second permanent magnet are oppositely arranged up and down, the upper chewing tooth 107 for chewing mechanical tooth is right
The solution ware 16 of the quasi- Mouthsimulator, i.e., using the solution ware 16 as the lower chewing tooth 108.
Preferably, full analogue simulation chewing machine of the invention is additionally provided with liquid collecting component 21, feed liquor peristaltic pump 2,2, to go out liquid compacted
Dynamic pump 23, wherein the inlet of the feed liquor peristaltic pump 22 is connected to the liquid collecting component 21, liquid outlet is connected to described artificial
The inlet tube 15 in oral cavity, wherein the outlet tube 17 of the artificial oral-cavity is connected to the liquid peristaltic pump 23 out.
Wherein the liquid collecting component 21 can be any container.It but preferably, is a N station rotary disk, Mei Gegong
Position is parallel to each other and is each provided with reagent bottle 25.The N station rotary disk can be in the case where rotating electric machine 26 and belt pulley 9 drive around its axis
Rotation, is supplied to feed liquor peristaltic pump for the reagent in the reagent bottle of each station one by one.A kind of preferred N station rotary disk is
15 station rotary disks, as shown in Figure 8.
The course of work of full analogue simulation chewing machine and its each components of the invention is as follows:
The Mouthsimulator is placed on to the top of the opening and closing left and right rotary components first, and make the first permanent magnet 1 with
Second about 183 permanent magnet is oppositely arranged.Then the upper chewing tooth 107 for chewing mechanical tooth is directed at the Mouthsimulator
Solution ware 16, i.e., using the solution ware 16 as the lower chewing tooth 108.
It is put into the Mouthsimulator by chaw, such as chewing gum or buccal cigarette, it is mechanical then to start the chewing
Tooth, then according to wrong to occlusion above and below being carried out by chaw and left and right mill described in fourth aspect present invention.
At the same time, start the opening and closing left and right rotary components, the Bidirectional-screw 3 is in the case where folding stepper motor 2 drives
It drives described two sliding blocks 8 to do open and close movement, thus two blocks of first permanent magnets 1 is driven to do open and close movement, in magneticaction
Under the influence of, two blocks of second permanent magnets 183 also do open and close movement, and then the clamping plate 182 is driven to do open and close movement, to being placed on
Therebetween clamping is carried out by chaw, thus simulate and gather movement to by chaw.
Meanwhile the rotating stepper motor 10 also drives the rotation of the rotating basis 6 in the horizontal plane, the rotation
The first rotary type permanent-magnet is driven, and then drives the second rotary type permanent-magnet, and cleat assembly is driven to rotate, and then is driven by chaw
Rotation, thus simulate to by the tumbling action of chaw.
If desired, the feed liquor peristaltic pump 21 and out liquid peristaltic pump 23 can also be started, with setting speed independent of each other
Artificial saliva is supplied into the Mouthsimulator and be discharged to rate, and to simulate salivary secretion and saliva swallowing act, investigation is chewed
Process in leaching of the object in the case where dynamic saliva is measured.Certainly, full analogue simulation of the invention chewing machine also completely can be in quantitative saliva
Chewing simulating operation is carried out under static immersing.
Technological merit of the invention is as follows:
The ingenious combination of each components of the invention, can comprehensive simulated human oral cavity during laboratory rodent chow to by nozzle
It chews that the occlusion up and down of object, left and right mill is wrong, gathers and tumbling action, more system comprehensively can simulate whole oral cavity, tongue, the cheek
The cooperation entire exercise of side, tooth, complete the continuous chewing of simulation human oral cavity, extruding, turning food process, make foodstuff samples
More fully fragmentation is dissolved, and the main component in foodstuff samples is promoted to be fully dissolved out release.In preferred embodiments, moreover it is possible to mould
Quasi- human oral cavity salivates and swallows the movement of saliva.The present invention can farthest reproduce mankind's chew, be collection
The multinomial technology such as theory of mechanisms, kinematics, dynamics and mechatronics is in the engineering science of one.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of opening and closing left and right rotary components.
Fig. 2 is the structural schematic diagram of Mouthsimulator.
Fig. 3 is the figure for showing the installation relation of opening and closing left and right rotary components and Mouthsimulator.
Fig. 4 is the structural schematic diagram of nip assemblies therein.
Fig. 5 is the explosive view for showing the structure of Mouthsimulator.
Fig. 6 is the structural schematic diagram for chewing mechanical tooth.
Fig. 7 is the panorama sketch that full analogue simulation of the invention chews machine.
Fig. 8 is N station rotary disk exemplary diagram.
Appended drawing reference meaning is as follows in figure:
1, the first permanent magnet；2, stepper motor is opened and closed；3, Bidirectional-screw；4, linear guide；5, permanent magnet gripping block；6, it revolves
Turn pedestal；7, axis；8, sliding block；9, belt pulley；10, rotating stepper motor；11, solution ware collet；12, temperature sensor；13, add
Hot plate；14, heating tube；15, inlet tube；16, solution ware；17, outlet tube；18, nip assemblies；19, guide groove is opened and closed.21, collect
Liquid component；22, feed liquor peristaltic pump；23, go out liquid peristaltic pump；24, full analogue simulation chews machine host；25, reagent bottle；101, upper nozzle
Chew lifting motor；102, bracket；103, upper chewing goes up and down mould group；104, counterweight component；105, upper chewing rotary DC slows down electric
Machine；106, upper chewing lifting shaft；107, upper chewing tooth；108, lower chewing tooth；181, dental lamina；182, clamping plate；183, the second permanent magnetism
Iron.
Specific embodiment
Come that the present invention is furture elucidated below by the detailed description of specific embodiment, but is not to limit of the invention
System.
Embodiment 1
Gum base type chewing tobacco is carried out by chew using chewing machinery tooth as shown in Fig. 6.
It is put into solution ware by gum base type chewing tobacco one, 10mL artificial saliva is added, setting chews the mechanical tooth course of work such as
Under: it chooses 5Kg counterweight component 4 and is mounted on chewing lifting shaft 6, setting was engaged 20 times up and down with 5 seconds primary frequencies, setting
Each chew rotates 180 ° when upper chewing lifting shaft declines 20mm, realizes that left and right mill is wrong.Occlusion and left and right above and below so
After mill is 20 times wrong, under the cooperation of other artificial tongues, the complete fragmentation of gum base type chewing tobacco.Solution in solution ware is discharged and is carried out
Principle components analysis, and take out remaining gum base type chewing tobacco sample and be further analyzed detection.
Embodiment 2
The mastication processes of gum base type chewing tobacco are simulated using full analogue simulation chewing machine of the invention.
One gum base type chewing tobacco is put into solution ware, injects 10ml artificial saliva, it is primary with 5 seconds that mechanical tooth is chewed in setting
Frequency corotating chew 20 times up and down, start the opening and closing left and right rotary components every 4 times, primary occlusion is done in every 45 ° of rotation,
It is engaged width 15mm, is engaged 5 times altogether.It extracts after the completion and solution is extracted to No. 2 collection stations.It is artificial that 10ml is reinjected for the second time
Saliva was chewed 10 times with 10 seconds primary frequency corotatings, and every 5 starting opening and closing left and right rotary components, every 30 ° of rotation does one
Secondary occlusion is engaged width 10mm, is engaged 6 times altogether.Solution is extracted to No. 3 collection stations after the completion.Third time reinjects 10ml
Artificial saliva, every 5 starting opening and closing left and right rotary components, is often rotated by 90 ° with chewing 30 times up and down altogether of 5 seconds primary frequencies
Primary occlusion is done, width 8mm is engaged, is engaged 4 times altogether.Solution is extracted to No. 4 stations after the completion.Respectively to 2,3, No. 4 stations
In artificial saliva in nicotine tested and analyzed, draw gum base type chewing tobacco nicotine dissolution curve.
Claims (1)
1. a kind of Mouthsimulator, which is characterized in that including with lower component:
Solution ware (16), with inlet tube (15) and outlet tube (17)；Solution ware (16) bottom has heating plate (13),
And/or solution ware (16) side wall has heating tube (14)；
It opens and closes guide groove (19), is placed in the solution ware (16), and there is a pair of of nip assemblies (18) in it；It is wherein each
Nip assemblies (18) have dental lamina (181), the clamping plate (182) that is fixed on dental lamina (181) and be placed in clamping plate (182) bottom the
Two permanent magnets (183)；The dental lamina (181) is assembled on the folding guide groove (19) by slideable.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610555190.2A CN105954476B (en) | 2016-07-14 | 2016-07-14 | A kind of Mouthsimulator |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610555190.2A CN105954476B (en) | 2016-07-14 | 2016-07-14 | A kind of Mouthsimulator |
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| CN105954476A CN105954476A (en) | 2016-09-21 |
| CN105954476B true CN105954476B (en) | 2019-02-19 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109270204B (en) * | 2018-09-30 | 2021-08-03 | 云南中烟工业有限责任公司 | Oral cavity type smokeless tobacco product nicotine oral cavity release research method |
| US11580883B1 (en) | 2022-01-26 | 2023-02-14 | NotCo Delaware, LLC | Compact dynamic simulator of the human gastrointestinal system |
| US11735067B1 (en) | 2022-03-22 | 2023-08-22 | NotCo Delaware, LLC | In vitro dynamic mouth simulator |
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| CN104698141A (en) * | 2015-03-25 | 2015-06-10 | 川渝中烟工业有限责任公司 | Device for simulating oral dissolution of gum-base tobacco product |
| CN206038631U (en) * | 2016-07-14 | 2017-03-22 | 云南中烟工业有限责任公司 | Simulation oral cavity |
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|---|---|---|---|---|
| DE19614670A1 (en) * | 1996-04-13 | 1997-10-16 | Rosentritt Martin Dipl Ing Fh | Simulator for thermal and mechanical loadings on teeth |
| WO2012001314A1 (en) * | 2010-07-01 | 2012-01-05 | Ecole Nationale Vétérinaire, Agroalimentaire Et De L'alimentation, Nantes-Atlantique | Artificial mouth simulating chewing, and a method for analysing compounds that lead to sensory perception, in particular flavours, using one such artificial mouth |
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| CN202330391U (en) * | 2011-11-17 | 2012-07-11 | 中国烟草总公司郑州烟草研究院 | Rotary pressing type chewing simulator |
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