CN105954476A - Simulated oral cavity - Google Patents
Simulated oral cavity Download PDFInfo
- Publication number
- CN105954476A CN105954476A CN201610555190.2A CN201610555190A CN105954476A CN 105954476 A CN105954476 A CN 105954476A CN 201610555190 A CN201610555190 A CN 201610555190A CN 105954476 A CN105954476 A CN 105954476A
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- tooth
- chewing
- chew
- mouthsimulator
- oral cavity
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Hydrology & Water Resources (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
Abstract
The invention discloses a simulated oral cavity which comprises a solution vessel (16) and an opening-closing guide groove (19). The solution vessel (16) is provided with a liquid inlet pipe (15) and a liquid outlet pipe (17). The opening-closing guide groove (19) is arranged in the solution vessel (16), and a pair of clamping assemblies (18) are arranged in the opening-closing guide groove (19). Each clamping assembly (18) is provided with a tooth plate (181), a clamping plate (182) fixed to the tooth plate (181) and a second permanent magnet (183) arranged at the bottom of the clamping plate (182). The simulated oral cavity is used for completely simulating parts of a chewing machine.
Description
Technical field
The invention belongs to bionic mechanical field, be specifically related to a kind of Mouthsimulator, it is used as full analogue simulation and chews
The parts of machine.
Background technology
Along with " Framework Convention on Tobacco Control " (FCTC) is about forbidding the taboo that tobacco smoke spreads in public places
Harmfulness of smoking is accepted extensively by promulgation and the people of order, also has country's great attention to lowering harm and decreasing coking,
One of the development of smokeless tobacco articles inevitable choice becoming tobacco business.Smoke-free tobacco product is a kind of logical
Cross non-burning approach and carry out the tobacco product of tobacco consumption.It mainly by chewing, smelling, suck, suck,
Consuming containing modes such as changes, it avoids the puzzlement of traditional cigarette " second hand smoking ", has good market prospect.
Packed buccal cigarette, it is increasingly subject to extensively close as smokeless tobacco staple product form containing changing cigarette and chewing tobacco
Note.When smoke-free tobacco product is consumed in the oral cavity, tobacco product is infiltrated by saliva, its main chemistry one-tenth
Separately begin discharge and enter human recycle system by different approaches.Speed and the content of chemical composition release are direct
Affect its organoleptic feature (such as impact strength, fragrance lasting) and safety.Therefore, its primary chemical is studied
Divide release characteristic and relevant influence factor thereof will assist in and realize the exploitation to smoke-free tobacco product and quality
Control.In order to study the release characteristic of main chemical compositions, need the process of edible smoke-free tobacco product is entered
The salivary component analysis that row is real-time.Based on this, smoke-free tobacco product needs the perseverance at simulation human oral cavity environment
Temperature condition carries out being fully contacted and accept chewing simulating, action containing change etc. so that it is main component can fully discharge
Out.
The device using Mouthsimulator configuration replaces human volunteer's experiment, is not affected by principal factors, controlled
Property strong, favorable reproducibility, but traditional chewing simulating device simply simply utilizes frame for movement Mouthsimulator tooth
The snap-action up and down of tooth, and actually people when chewing on things in addition to the snap-action up and down of tooth, also
Useful upper lower tooth is made by the left and right mill changing of the relative positions of chaw, and helps to coordinate promotion by chaw with tongue and the cheek
Gather and roll so that the action being engaged next time.As a example by chewing gum, tooth be engaged up and down stung flat
After slabbing, then go up about lower tooth wrong this of mill and be snapped the chewing gum of slabbing, then poly-by tongue and cheek side
Disturbance is made, and the chewing gum being snapped slabbing again can be gathered into lumps and be rolled, in order to carry out nozzle next time
Chew circulation.But existing chewing simulating machine can only simulate the snap-action up and down of tooth, it is impossible to a left side for simulation tooth
The right mill changing of the relative positions is made, and can not simulate tongue and above-mentioned the gathering and tumbling action of cheek side, i.e. can not be farthest
The chewing of simulation people.
Although additionally, also using artificial saliva in existing chewing simulating machine, but it uses quantitative people
The mode that work saliva is soaked, after i.e. soaking a period of time with the artificial saliva of the amount of determination, sample analysis thereinization
Learn material dissolution situation.And in the mastication processes of actual persons, be accompanied by the dynamically secretion of saliva and dynamically swallow
Action, i.e. saliva amount and be dissolved in the concentration of chemical substance therein and update at any time, existing chewing simulating
Machine can not imitate this dynamic updating process.
The invention aims to solve the problems referred to above, it is provided that one is fully simulated chews machine.
Summary of the invention
It is an object of the invention to be achieved through the following technical solutions:
A first aspect of the present invention relates to a kind of opening and closing left and right rotary components, and it includes following assembly:
Rotating basis 6, it can rotate in horizontal plane around axle 7；
Line slideway 4, its horizontal is fixed on described rotating basis 6, and this line slideway 4 is provided with by two-way
Two slide blocks 8 that screw mandrel 3 connects, each slide block 8 is respectively arranged with first permanent magnet 1；Described Bidirectional-screw 3 exists
Folding motor 2 drives lower drive said two slide block 8 to do open and close movement.
In a particular embodiment, described folding motor 2 drives described Bidirectional-screw 3 by belt pulley 9,
By the open and close movement that the convert rotational motion of described folding motor 2 is described Bidirectional-screw 3.
In a particular embodiment, the opening and closing left and right rotary components of the present invention also includes rotating stepper motor 10, uses
In driving the rotation in horizontal plane of the described rotating basis 6.
A second aspect of the present invention relates to a kind of Mouthsimulator, and it includes following assembly:
Solution ware 16, it has feed tube 15 and drain pipe 17；
Folding gathering sill 9, it is placed in described solution ware 16, and has a pair nip assemblies 18 in it；Wherein
Each nip assemblies 18 has dental lamina 181, be fixed on dental lamina 181 clamping plate 182 and being placed in bottom clamping plate 182
Second permanent magnet 183.
Preferably, there is bottom described solution ware 16 heating plate 13, and/or, described solution ware 16 sidewall has
Add heat pipe 14.
Wherein, described dental lamina 181 is assembled on described folding gathering sill 9 by slideable.
A third aspect of the present invention relates to one and chews machinery tooth, and it includes support 102 and is placed on support 102
On chew lifting motor 101 and be driven by it on chew lifting module 103, and with on chew lifting module
103 be connected and being vertically oriented of lifting therewith on chew lifting shaft 106, described on chew the end of lifting shaft 106
Tooth 107 is chewed on having by portion, described in chew machinery tooth and also include driving chew on described that lifting shaft 106 rotates upper
Chew rotary DC reducing motor 105.
Preferably, the top chewing lifting shaft 106 on described is provided with counterweight assembly 104.Counterweight assembly model
Enclose and be: 500g, 1Kg, 2Kg, 5Kg.Can be by replacing the weight of different quality during chewing simulating
Code, completes the loading of masticatory force, it is achieved the different occlusion dynamics of tooth by action of gravity.
Preferably, the end face chewing tooth 107 on described is plane or rough.Such as, tooth is above chewed
The end face of 107 is the different mould of plane or band wedge angle, can simulate stinging of human oral cavity difformity tooth
Conjunction action.
A fourth aspect of the present invention provides a kind of method of chewing simulating, and the method uses such as third aspect present invention
Described machinery tooth of chewing, wherein by chew lifting motor 101 drive chew lifting module 103 lift into
And chew on driving lifting shaft 106 and end thereof on chew the lifting of tooth 107, and other either statically or dynamically
Under chew tooth 108 and coordinate, to simulate the upper and lower snap-action of tooth；Chew rotary DC on wherein passing through and slow down electric
Machine 105 drive chew on described lifting shaft 106 and end thereof on chew the rotation of tooth 107, to simulate tooth
The left and right mill changing of the relative positions is made.
Preferably, the top chewing lifting shaft 106 on described is provided with counterweight assembly 104, different big with simulation
Little dental articulation dynamics.
Preferably, it is plane or rough by chewing the end face of tooth 107 on described, to simulate not similar shape
The snap-action of the tooth of shape.
Chewing tooth 108 under wherein said can be that the machinery tooth of chewing with the present invention is separately independently arranged, its class
Be similar to chopping block, itself or be static, or for motion, wherein said motion include move up and down and horizontal rotation.
Wherein, the lifting frequency range chewing lifting shaft 106 on described is 3 seconds/time～5min/ time, it is achieved simulation
The snap-action up and down of the different frequency of tooth during chewing.
The range chewing lifting shaft 106 on wherein said is: 0～100mm, can cover on Buccodental
The minimum and maximum scope of lower action.
The rotating range chewing lifting shaft 106 on wherein said is: 0～360 ° can cover Buccodental left and right moving
The minimum and maximum scope made.
A fifth aspect of the present invention relates to a kind of full analogue simulation and chews machine, and it includes above-described opening and closing left and right
Rotary components, Mouthsimulator and described chew machinery tooth, wherein said opening and closing left and right rotary components is placed in described mould
Intend below oral cavity, and wherein said first permanent magnet and the second permanent magnet be oppositely arranged up and down, described in chew
Chew tooth 107 on machinery tooth and be directed at the solution ware 16 of described Mouthsimulator, i.e. using described solution ware 16 as
Tooth 108 is chewed under described.
Preferably, the full analogue simulation of the present invention is chewed machine and is additionally provided with liquid collecting assembly 21, feed liquor peristaltic pump 2,2,
Going out liquid peristaltic pump 23, the inlet of wherein said feed liquor peristaltic pump 22 is connected to described liquid collecting assembly 21, goes out liquid
Mouth is connected to the feed tube 15 of described artificial oral-cavity, and the drain pipe 17 of wherein said artificial oral-cavity is connected to described
Go out liquid peristaltic pump 23.
Wherein said liquid collecting assembly 21 can be any container.But preferably, it is a N station rotary dish,
Each station is parallel to each other and is each provided with reagent bottle 25.This N station rotary dish can be at electric rotating machine 26 and belt
It is rotated about their axes, so that the reagent in the reagent bottle of each station is supplied to feed liquor peristaltic pump one by one under wheel 9 driving.
A kind of preferably N station rotary dish is 15 station rotary dishes, as shown in Figure 8.
The work process that the full analogue simulation of the present invention chews machine and each parts thereof is as follows:
First described Mouthsimulator is placed on the top of described opening and closing left and right rotary components, and makes the first permanent magnet
1 is oppositely arranged with the second permanent magnet about 183.Then by described chew machinery tooth on chew tooth 107 and be directed at institute
State the solution ware 16 of Mouthsimulator, i.e. under described, chew tooth 108 using described solution ware 16.
Put in described Mouthsimulator by chaw, such as chewing gum or buccal cigarette, then chew described in startup
Machinery tooth, then according to described in fourth aspect present invention to be engaged up and down by chaw and left and right mill mistake.
Meanwhile, starting described opening and closing left and right rotary components, described Bidirectional-screw 3 is at folding motor 2
Drive lower drive said two slide block 8 to do open and close movement, thus drive two blocks of described first permanent magnets 1 to do folding fortune
Dynamic, under the influence of magneticaction, two blocks of described second permanent magnets 183 also do open and close movement, and then drive described
Clamping plate 182 do open and close movement, to be placed on therebetween carried out clamping by chaw, thus simulate by chaw
Gather action.
Meanwhile, described rotating stepper motor 10 also drives the rotation in horizontal plane of the described rotating basis 6, described
Rotate and also drive the first rotary type permanent-magnet, and then drive the second rotary type permanent-magnet, and drive cleat assembly to rotate,
And then drive by the rotation of chaw, thus simulate by the tumbling action of chaw.
It is it desired to, it is also possible to start described feed liquor peristaltic pump 21 and go out liquid peristaltic pump 23, setting with independent of each other
Constant speed rate is supplied in described Mouthsimulator and discharges artificial saliva, swallows dynamic simulating salivation and saliva
Make, investigate by chaw dynamic saliva measure under process in leaching.Certainly, the full analogue simulation of the present invention is chewed
Machine can be simulated chewing operation the most completely under quantitative saliva static immersing.
The technological merit of the present invention is as follows:
The ingenious combination of each parts of the present invention, can comprehensive simulated human oral cavity right during laboratory rodent chow
By the occlusion up and down of chaw, left and right mill mistake, gather and tumbling action, can more system comprehensively simulate whole
Individual oral cavity, tongue, the cheek side, the cooperation entire exercise of tooth, complete simulate human oral cavity constantly chew food, extruding,
The process of turning food, makes foodstuff samples fragmentation more fully dissolve, promotes the main component in foodstuff samples to fill
Divide dissolution release.In preferred embodiments, moreover it is possible to simulation human oral cavity salivates and swallows the action of saliva.
The present invention can farthest reproduce mankind's chewing, is collecting mechanism, kinesiology, kinetics and machinery
The multinomial technology such as electronics is in the engineering science of one.
Accompanying drawing explanation
Fig. 1 is the structural representation of opening and closing left and right rotary components.
Fig. 2 is the structural representation of Mouthsimulator.
Fig. 3 is the figure of the installation relation showing opening and closing left and right rotary components and Mouthsimulator.
Fig. 4 is the structural representation of nip assemblies therein.
Fig. 5 is the explosive view of the structure showing Mouthsimulator.
Fig. 6 is the structural representation chewing machinery tooth.
Fig. 7 is the panorama sketch that the full analogue simulation of the present invention chews machine.
Fig. 8 is N station rotary dish exemplary plot.
In figure, reference implication is as follows:
1, the first permanent magnet；2, folding motor；3, Bidirectional-screw；4, line slideway；5, permanent magnetism
The tight block of iron clamp；6, rotating basis；7, axle；8, slide block；9, belt pulley；10, rotating stepper motor；11、
Solution ware collet；12, temperature sensor；13, heating plate；14, heat pipe is added；15, feed tube；16, molten
Liquid ware；17, drain pipe；18, nip assemblies；19, folding gathering sill.21, liquid collecting assembly；22, feed liquor
Peristaltic pump；23, liquid peristaltic pump is gone out；24, full analogue simulation chews machine host；25, reagent bottle；101, on
Chew lifting motor；102, support；103, lifting module is chewed on；104, counterweight assembly；105, Shang Zui
Chew rotary DC reducing motor；106, lifting shaft is chewed on；107, tooth is chewed on；108, tooth is chewed under；
181, dental lamina；182, clamping plate；183, the second permanent magnet.
Detailed description of the invention
It is further elucidated with the present invention below by the detailed description of specific embodiment, but is not to the present invention's
Limit.
Embodiment 1
Use machinery tooth of chewing as shown in Figure 6 that gum base type chewing tobacco is chewed.
Gum base type chewing tobacco one is put into solution ware, adds 10mL artificial saliva, arrange and chew machinery tooth work
Process is as follows: chooses 5Kg counterweight assembly 4 and is arranged on and chews on lifting shaft 6, arranges with 5 seconds frequencies once
Up and down occlusion 20 times, arrange each chewing upper chew lifting shaft decline 20mm time, rotates 180 °, reality
Existing left and right mill mistake.After occlusion and left and right grind wrong 20 times the most up and down, under the cooperation of other artificial tongues, gum base
The complete fragmentation of type chewing tobacco.Solution in solution ware is discharged and carries out Principle components analysis, and take out remaining gum base
Type chewing tobacco sample is further analyzed detection.
Embodiment 2
The full analogue simulation using the present invention chews machine to simulate the mastication processes of gum base type chewing tobacco.
One seed lac fundamental mode chewing tobacco is put in solution ware, injects 10ml artificial saliva, arrange and chew machinery tooth with 5
Second frequency corotating once is chewed 20 times up and down, starts described opening and closing left and right rotary components every 4 times, often revolves
Turn 45 ° to do and be once engaged, be engaged width 15mm, altogether occlusion 5 times.Extract after completing and solution is extracted to No. 2
Collect station.Second time reinjects 10ml artificial saliva, chews 10 times with 10 seconds frequency corotatings once, often
Starting opening and closing left and right rotary components every 5 times, often rotation 30 ° is done and is once engaged, and is engaged width 10mm, altogether occlusion
6 times.After completing, solution is extracted to No. 3 and collects station.Third time reinjects 10ml artificial saliva, with 5 seconds one
Secondary frequency is chewed 30 times the most up and down, starts opening and closing left and right rotary components every 5 times, and every half-twist does once
Occlusion, is engaged width 8mm, altogether occlusion 4 times.After completing, solution is extracted to No. 4 stations.Respectively to 2,3,
The nicotine in artificial saliva in No. 4 stations carries out detection and analyzes, and draws the nicotine stripping curve of gum base type chewing tobacco.
Claims (3)
1. a Mouthsimulator, it is characterised in that include following assembly:
Solution ware (16), it has feed tube (15) and drain pipe (17)；
Folding gathering sill (19), it is placed in described solution ware (16), and has a pair nip assemblies in it
(18)；Each of which nip assemblies (18) has dental lamina (181), the clamping plate being fixed on dental lamina (181)
(182) and be placed in clamping plate (182) bottom the second permanent magnet (183).
Mouthsimulator the most according to claim 1, it is characterised in that described solution ware (16) bottom tool
There is heating plate (13), and/or, described solution ware (16) sidewall has and adds heat pipe (14).
Mouthsimulator the most according to claim 1, it is characterised in that described dental lamina (181) can be slided
Dynamic formula is assembled on described folding gathering sill (19).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610555190.2A CN105954476B (en) | 2016-07-14 | 2016-07-14 | A kind of Mouthsimulator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610555190.2A CN105954476B (en) | 2016-07-14 | 2016-07-14 | A kind of Mouthsimulator |
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| Publication Number | Publication Date |
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| CN105954476A true CN105954476A (en) | 2016-09-21 |
| CN105954476B CN105954476B (en) | 2019-02-19 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610555190.2A Active CN105954476B (en) | 2016-07-14 | 2016-07-14 | A kind of Mouthsimulator |
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| Country | Link |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109270204A (en) * | 2018-09-30 | 2019-01-25 | 云南中烟工业有限责任公司 | A kind of mouthful with type smoke-free tobacco product nicotine oral cavity releasing research method |
| US11580883B1 (en) | 2022-01-26 | 2023-02-14 | NotCo Delaware, LLC | Compact dynamic simulator of the human gastrointestinal system |
| US11735067B1 (en) | 2022-03-22 | 2023-08-22 | NotCo Delaware, LLC | In vitro dynamic mouth simulator |
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| WO2012001314A1 (en) * | 2010-07-01 | 2012-01-05 | Ecole Nationale Vétérinaire, Agroalimentaire Et De L'alimentation, Nantes-Atlantique | Artificial mouth simulating chewing, and a method for analysing compounds that lead to sensory perception, in particular flavours, using one such artificial mouth |
| CN202330391U (en) * | 2011-11-17 | 2012-07-11 | 中国烟草总公司郑州烟草研究院 | Rotary pressing type chewing simulator |
| CN202330390U (en) * | 2011-11-17 | 2012-07-11 | 中国烟草总公司郑州烟草研究院 | Opposite-clamping type simulated chewing machine |
| CN102564846A (en) * | 2010-12-22 | 2012-07-11 | 首都医科大学附属北京口腔医院 | Constant temperature water bath circulation device simulating oral cavity environment and method for testing stress by utilizing same |
| CN102841028A (en) * | 2012-08-27 | 2012-12-26 | 南京理工大学 | Oral environment simulation test machine |
| CN103680282A (en) * | 2013-11-26 | 2014-03-26 | 南昌大学 | Device for simulating digestion in oral cavities and method for applying device |
| CN104698141A (en) * | 2015-03-25 | 2015-06-10 | 川渝中烟工业有限责任公司 | Device for simulating oral dissolution of gum-base tobacco product |
| CN206038631U (en) * | 2016-07-14 | 2017-03-22 | 云南中烟工业有限责任公司 | Simulation oral cavity |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE19614670A1 (en) * | 1996-04-13 | 1997-10-16 | Rosentritt Martin Dipl Ing Fh | Simulator for thermal and mechanical loadings on teeth |
| WO2012001314A1 (en) * | 2010-07-01 | 2012-01-05 | Ecole Nationale Vétérinaire, Agroalimentaire Et De L'alimentation, Nantes-Atlantique | Artificial mouth simulating chewing, and a method for analysing compounds that lead to sensory perception, in particular flavours, using one such artificial mouth |
| CN101948745A (en) * | 2010-09-09 | 2011-01-19 | 好维股份有限公司 | Artificial mouth simulating device |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109270204A (en) * | 2018-09-30 | 2019-01-25 | 云南中烟工业有限责任公司 | A kind of mouthful with type smoke-free tobacco product nicotine oral cavity releasing research method |
| CN109270204B (en) * | 2018-09-30 | 2021-08-03 | 云南中烟工业有限责任公司 | Oral cavity type smokeless tobacco product nicotine oral cavity release research method |
| US11580883B1 (en) | 2022-01-26 | 2023-02-14 | NotCo Delaware, LLC | Compact dynamic simulator of the human gastrointestinal system |
| US11735067B1 (en) | 2022-03-22 | 2023-08-22 | NotCo Delaware, LLC | In vitro dynamic mouth simulator |
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|---|---|
| CN105954476B (en) | 2019-02-19 |
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